1986 …2023
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Research Output 1986 2019

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2008

Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding

Dong, M., Lam, P. C-H., Pinon, D. I., Sexton, P., Abagyan, R. & Miller, L. J., 2008, In : Molecular Pharmacology. 74, 2, p. 413 - 422 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The effects of C-terminal truncation of receptor activity modifying proteins on the induction of amylin receptor phenotype from human CTb receptors

Udawela, M., Christopoulos, G., Morfis, M., Tilakaratne, N., Christopoulos, A. & Sexton, P., 2008, In : Regulatory Peptides. 145, p. 65 - 71 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions

Avlani, V. A., McLoughlin, D. J., Sexton, P. & Christopoulos, A., 2008, In : Journal of Pharmacology and Experimental Therapeutics. 325, 3, p. 927 - 934 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology

Leach, K., Sexton, P. & Christopoulos, A., 2007, In : Trends in Pharmacological Sciences. 28, 8, p. 382 - 389 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric modulation of G protein-coupled receptors

May, L. T., Leach, K., Sexton, P. M. & Christopoulos, A., 2007, In : Annual Review of Pharmacology and Toxicology. 47, p. 1 - 51 51 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric modulation of muscarinic acetylcholine receptors

Gregory, K. J., Sexton, P. & Christopoulos, A., 2007, In : Current Neuropharmacology. 5, 3, p. 157 - 167 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands

Avlani, V. A., Gregory, K. J., Morton, C. J., Parker, M. W., Sexton, P. & Christopoulos, A., 2007, In : Journal of Biological Chemistry. 282, 35, p. 25677 - 25686 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs

Bisson, W. H., Cheltsov, A. V., Bruey-Sedano, N., Lin, B., Chen, J., Goldberger, N., May, L. T., Christopoulos, A., Dalton, J. T., Sexton, P., Zhang, X-K. & Abagyan, R., 2007, In : Proceedings of the National Academy of Sciences. 104, 29, p. 11927 - 11932 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Fluorescence resonance energy transfer analysis of secretin docking to its receptor: Mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues

Harikumar, K. G., Lam, P. C-H., Dong, M., Sexton, P., Abagyan, R. & Miller, L. J., 2007, In : Journal of Biological Chemistry. 282, 45, p. 32834 - 32843 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional selectivity and classical concepts of quantitative pharmacology

Urban, J. D., Clarke, W. P., von Zastrow, M., Nichols, D. E., Kobilka, B., Weinstein, H., Javitch, J. A., Roth, B. L., Christopoulos, A., Sexton, P. M., Miller, K. J., Spedding, M. & Mailman, R. B., 2007, In : Journal of Pharmacology and Experimental Therapeutics. 320, 1, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Involvement of the sigma1 (sigma1) receptor in the anti-amnesic, but not antidepressant-like, effects of the aminotetrahydrofuran derivative ANAVEX1-41

Espallergues, J., Lapalud, P., Christopoulos, A., Avlani, V. A., Sexton, P., Vamvakides, A. & Maurice, T., 2007, In : British Journal of Pharmacology. 152, 2, p. 267 - 279 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular approximations between residues 21 and 23 of secretin and its receptor: Development of a model for peptide docking with the amino terminus of the secretin receptor

Dong, M., Lam, P. C-H., Gao, F., Hosohata, K., Pinon, D. I., Sexton, P., Abagyan, R. & Miller, L. J., 2007, In : Molecular Pharmacology. 72, 2, p. 280 - 290 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin receptors - new drug targets for multiple disease states

van der Westhuizen, E. T., Summers, R. J., Halls, M. L., Bathgate, R. & Sexton, P., 2007, In : Current Drug Targets. 8, 1, p. 91 - 104 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors

May, L. T., Avlani, V. A., Langmead, C. J., Herdon, H. J., Wood, M. D., Sexton, P. & Christopoulos, A., 2007, In : Molecular Pharmacology. 72, 2, p. 463 - 476 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The relaxin family peptide receptor 3 activates extracellular signal-regulated kinase 1/2 through a protein kinase C-dependent mechanism

van der Westhuizen, E. T., Werry, T. D., Sexton, P. & Summers, R. J., 2007, In : Molecular Pharmacology. 71, 6, p. 1618 - 1629 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

A critical role for the short intracellular C terminus in receptor activity-modifying protein function

Udawela, M., Christopoulos, G., Morfis, M., Christopoulos, A., Ye, S., Tilakaratne, N. & Sexton, P. M., 2006, In : Molecular Pharmacology. 70, 5, p. 1750 - 1760 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs

Sexton, P., Morfis, M., Tilakaratne, N., Hay, D. L., Udawela, M., Christopoulos, G. & Christopoulos, A., 2006, In : Annals of the New York Academy of Sciences. 1070, p. 90 - 104 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Constitutive formation of oligomeric complexes between family B G protein-coupled vasoactive intestinal polypeptide and secretin receptors

Harikumar, K. G., Morfis, M. M., Lisenbee, C. S., Sexton, P. M. & Miller, L. J., 2006, In : Molecular Pharmacology. 69, 1, p. 363 - 373 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors

Udawela, M., Christopoulos, G., Tilakaratne, N., Christopoulos, A., Albiston, A. L. & Sexton, P. M., 2006, In : Molecular Pharmacology. 69, 6, p. 1984 - 1989 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Effective GPCR screening using ERK 1/2: applying SureFire to detect ERK 1/2 phosphorylation

Osmond, R. W., Dyer, A. R., Sexton, P. M., Christopoulos, A. & Crouch, M. F., 2006, In : Genetic Engineering News. 26, 1, p. 27 - 28 2 p.

Research output: Contribution to journalArticleResearchpeer-review

GPCR modulation by RAMPs

Hay, D. L., Poyner, D. R. & Sexton, P. M., 2006, In : Pharmacology and Therapeutics. 109, 1-2, p. 173 - 197 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction studies of multiple binding sites on M4 muscarinic acetylcholine receptors

Lanzafame, A. A., Sexton, P. M. & Christopoulos, A., 2006, In : Molecular Pharmacology. 70, 2, p. 736 - 746 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanisms of ERK1/2 regulation by seven-transmembrane-domain receptors

Werry, T. D., Christopoulos, A. & Sexton, P. M., 2006, In : Current Pharmaceutical Design. 12, 14, p. 1683 - 1702 20 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2

Werry, T. D., Gregory, K. J., Sexton, P. M. & Christopoulos, A., 2005, In : Journal of Neurochemistry. 93, p. 1603 - 1615 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of urea pretreatment on the binding properties of adenosine A 1 receptors

May, L. T., Sexton, P. M. & Christopoulos, A., 2005, In : British Journal of Pharmacology. 146, 8, p. 1119 - 1129 11 p.

Research output: Contribution to journalArticleResearchpeer-review

G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

Kostenis, E., Milligan, G., Christopoulos, A., Sanchez-Ferrer, C. F., Heringer-Walther, S., Sexton, P. M., Gembardt, F., Kellett, E., Martini, L., Vanderheyden, P., Schultheiss, H-P. & Walther, T., 2005, In : Circulation. 111, p. 1806 - 1813 8 p.

Research output: Contribution to journalArticleResearchpeer-review

G-Protein-coupled receptor-protein interactions: basis for new concepts on receptor structure and function

Tilakaratne, N. & Sexton, P. M., 2005, In : Clinical and Experimental Pharmacology and Physiology. 32, 11, p. 979 - 987 9 p.

Research output: Contribution to journalArticleResearchpeer-review

'Ins and outs' of seven-transmembrane receptor signalling to ERK

Werry, T. D., Sexton, P. M. & Christopoulos, A., 2005, In : Trends in Endocrinology and Metabolism. 16, 1, p. 26 - 33 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling

Pham, V., Dong, M., Wade, J. D., Miller, L. J., Morton, C. J., Ng, H., Parker, M. W. & Sexton, P. M., 2005, In : Journal of Biological Chemistry. 280, 31, p. 28610 - 28622 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptide-oligonucleotide hybrids in antisense therapy

Pierce, T. L., White, A. R., Tregear, G. W. & Sexton, P. M., 2005, In : Mini reviews in medicinal chemistry. 5, 1, p. 41 - 55 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes

Hay, D. L., Christopoulos, G., Christopoulos, A., Poyner, D. R. & Sexton, P. M., 2005, In : Molecular Pharmacology. 67, 5, p. 1655 - 1665 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Allosteric modulation of G protein-coupled receptors

May, L. T., Avlani, V. A., Sexton, P. & Christopoulos, A., 2004, In : Current Pharmaceutical Design. 10, 17, p. 2003 - 2013 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Amylin receptors: Molecular composition and pharmacology

Hay, D. L., Christopoulos, G., Christopoulos, A. & Sexton, P., 2004, In : Biochemical Society Transactions. 32, Pt 5, p. 865 - 867 3 p.

Research output: Contribution to journalArticleOther

Calcitonin

Findlay, D. M. & Sexton, P. M., 2004, In : Growth Factors. 22, 4, p. 217 - 224 8 p.

Research output: Contribution to journalArticleResearchpeer-review

G-protein-coupled receptor allosterism: the promise and the problem(s)

Christopoulos, A., May, L. T., Avlani, V. A. & Sexton, P. M., 2004, In : Biochemical Society Transactions. 32, Pt 5, p. 873 - 877 5 p.

Research output: Contribution to journalArticleOther

Hematological defects in the oc/oc mouse, a model of infantile malignant osteopetrosis

Blin-Wakkach, C., Blin-Wakkach, A., Sexton, P., Rochet, N. & Carle, G. F., 2004, In : Leukemia. 18, 9, p. 1505 - 1511 7 p.

Research output: Contribution to journalArticleResearchpeer-review

In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain

Paxinos, G., Chai, S. Y., Christopoulos, G., Huang, X-F., Toga, A. W., Wang, H. Q. & Sexton, P. M., 2004, In : Journal of Chemical Neuroanatomy. 27, 4, p. 217 - 236 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein-coupled receptors

Pham, V. I. & Sexton, P. M., 2004, In : Journal of Peptide Science. 10, 4, p. 179 - 203 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of serotonin 5-HT{2C} receptors by chronic ligand exposure

Devlin, M. G., Smith, N. J., Ryan, O. M., Guida, E., Sexton, P. M. & Christopoulos, A., 2004, In : European Journal of Pharmacology. 498, 1-3, p. 59 - 69 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Spatial proximity between a photolabile residue in position 19 of salmon calcitonin and the amino terminus of the human calcitonin receptor

Pham, V., Wade, J. D., Purdue, B. W. & Sexton, P. M., 2004, In : Journal of Biological Chemistry. 279, 8, p. 6720 - 6729 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The receptor activity modifying protein family of G protein coupled receptor accessory proteins

Udawela, M., Hay, D. L. & Sexton, P. M., 2004, In : Seminars in Cell and Developmental Biology. 15, 3, p. 299 - 308 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Application of photoaffinity crosslinking in determining the interaction between calcitonin and its receptor

Pham, V., Wade, J. D. & Sexton, P. M., 1 Nov 2003, In : Letters in Peptide Science. 10, 5-6, p. 447-453 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel receptor partners and function of receptor activity-modifying proteins

Christopoulos, A., Christopoulos, G., Morfis, M., Udawela, M., Laburthe, M., Couvineau, A., Kuwasako, K., Tilakaratne, N. & Sexton, P. M., 2003, In : Journal of Biological Chemistry. 278, 5, p. 3293 - 3297 5 p.

Research output: Contribution to journalArticleResearchpeer-review

RAMPs: 5 years on, where to now?

Morfis, M., Christopoulos, A. & Sexton, P., 2003, In : Trends in Pharmacological Sciences. 24, 11, p. 596 - 601 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors

Poyner, D. R., Sexton, P. M., Marshall, I., Smith, D. M., Quirion, R., Born, W., Muff, R., Fischer, J. A. & Foord, S. M., 2002, In : Pharmacological Reviews. 54, 2, p. 233 - 246 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-, IL-1 and RANKL

Suda, K., Woo, J-T., Takami, M., Sexton, P. M. & Nagai, K., 2002, In : Journal of Cellular Physiology. 190, p. 101 - 108 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular pharmacology of the calcitonin receptor

Purdue, B. W., Tilakaratne, N. & Sexton, P., 2002, In : Receptors and Channels. 8, 3 & 4, p. 243 - 255 13 p.

Research output: Contribution to journalArticleResearchpeer-review