1986 …2023

Research output per year

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Research Output

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Article

Calcitonin receptor antibodies in the identification of osteoclasts

Quinn, J. M. W., Morfis, M., Lam, M. H. C., Elliott, J., Kartsogiannis, V., Williams, E. D., Gillespie, M. T., Martin, T. J. & Sexton, P. M., 1 Jan 1999, In : Bone. 25, 1, p. 1-8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

Calcitonin receptors of human osteoclastoma

Nicholson, G. C., Horton, M. A., Sexton, P. M., D'Santos, C. S., Moseley, J. M., Kemp, B. E., Pringle, J. A. S. & Martin, T. J., 1 Jan 1987, In : Hormone and Metabolic Research. 19, 11, p. 585-589 5 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Calcium inflow in cells transfected with cloned rat and porcine calcitonin receptors

Findlay, D. M., Houssami, S., Sexton, P. M., Brady, C. L., Martin, T. J. & Myers, D. E., 16 Mar 1995, In : BBA - Molecular Cell Research. 1265, 2-3, p. 213-219 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

Central nervous system binding sites for calcitonin and calcitonin gene-related peptide

Sexton, P. M., 1 Jun 1991, In : Molecular Neurobiology. 5, 2-4, p. 251-273 23 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Characterization of amylin and calcitonin receptor binding in the mouse α-thyroid-stimulating hormone thyrotroph cell line

Perry, K. J., Quiza, M., Myers, D. E., Morfis, M., Christopoulos, G. & Sexton, P. M., 1 Jan 1997, In : Endocrinology. 138, 8, p. 3486-3496 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
40 Citations (Scopus)

Characterization of binding sites for amylin, calcitonin, and CGRP in primate kidney

Chai, S. Y., Christopoulos, G., Cooper, M. E. & Sexton, P. M., 1 Jan 1998, In : American Journal of Physiology-Renal Physiology. 274, 1 43-1, p. F51-F62

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2

Werry, T. D., Gregory, K. J., Sexton, P. M. & Christopoulos, A., 2005, In : Journal of Neurochemistry. 93, p. 1603 - 1615 13 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1

Hager, M. V., Clydesdale, L., Gellman, S. H., Sexton, P. M. & Wootten, D., 15 Jul 2017, In : Biochemical Pharmacology. 136, p. 99-108 10 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

Dal Maso, E., Just, R., Hick, C., Christopoulos, A., Sexton, P. M., Wootten, D. & Furness, S. G. B., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 111-129 19 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Chicken osteoclasts do not possess calcitonin receptors

Nicholson, G. C., Moseley, J. M., Sexton, P. M. & Martin, T. J., 1 Jan 1987, In : Journal of Bone and Mineral Research. 2, 1, p. 53-59 7 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Cloning and characterization of an abundant subtype of the human calcitonin receptor

Kuestner, R. E., Elrod, R. D., Grant, F. J., Hagen, F. S., Kuijper, J. L., Matthewes, S. L., O'Hara, P. J., Sheppard, P. O., Stroop, S. D., Thompson, D. L., Whitmore, T. E., Findlay, D. M., Houssami, S., Sexton, P. M. & Moore, E. E., 1 Aug 1994, In : Molecular Pharmacology. 46, 2, p. 246-255 10 p.

Research output: Contribution to journalArticleResearchpeer-review

143 Citations (Scopus)

Co-expressed class B G protein-coupled secretin and GLP-1 receptors self- and cross-associate: impact on pancreatic islets

Harikumar, K. G., Lau, S., Sexton, P. M., Wootten, D. & Miller, L. J., 1 Jun 2017, In : Endocrinology. 158, 6, p. 1685-1700 16 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Comparative distribution of receptors for amylin and the related peptides calcitonin gene related peptide and calcitonin in rat and monkey brain

Christopoulos, G., Paxinos, G., Huang, X. F., Beaumont, K., Toga, A. W. & Sexton, P. M., 1 Jan 1995, In : Canadian Journal of Physiology and Pharmacology. 73, 7, p. 1037-1041 5 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs

Sexton, P., Morfis, M., Tilakaratne, N., Hay, D. L., Udawela, M., Christopoulos, G. & Christopoulos, A., 2006, In : Annals of the New York Academy of Sciences. 1070, p. 90 - 104 15 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Consequences of splice variation on secretin family G protein-coupled receptor function

Furness, S. G. B., Wootten, D. L., Christopoulos, A. & Sexton, P. M., 2012, In : British Journal of Pharmacology. 166, 1, p. 98 - 109 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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27 Citations (Scopus)

Constitutive formation of oligomeric complexes between family B G protein-coupled vasoactive intestinal polypeptide and secretin receptors

Harikumar, K. G., Morfis, M. M., Lisenbee, C. S., Sexton, P. M. & Miller, L. J., 2006, In : Molecular Pharmacology. 69, 1, p. 363 - 373 11 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands

Avlani, V. A., Gregory, K. J., Morton, C. J., Parker, M. W., Sexton, P. & Christopoulos, A., 2007, In : Journal of Biological Chemistry. 282, 35, p. 25677 - 25686 10 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

Liang, Y-L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T. S., Radjainia, M., Plitzko, J. M., Baumeister, W., Miller, L. J., Hay, D. L., Christopoulos, A., Reynolds, C. A., Wootten, D. & Sexton, P. M., 27 Sep 2018, In : Nature. 561, 7724, p. 492-497 6 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Hollingsworth, S. A., Kelly, B., Valant, C., Michaelis, J. A., Mastromihalis, O., Thompson, G., Venkatakrishnan, A. J., Hertig, S., Scammells, P. J., Sexton, P. M., Felder, C. C., Christopoulos, A. & Dror, R. O., 1 Dec 2019, In : Nature Communications. 10, 1, p. 1-9 9 p., 3289.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Crystal structure of the M5 muscarinic acetylcholine receptor

Vuckovic, Z., Gentry, P. R., Berizzi, A. E., Hirata, K., Varghese, S., Thompson, G., van der Westhuizen, E. T., Burger, W. A. C., Rahmani, R., Valant, C., Langmead, C. J., Lindsley, C. W., Baell, J. B., Tobin, A. B., Sexton, P. M., Christopoulos, A. & Thal, D. M., 17 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 51, p. 26001-26007 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Thal, D. M., Sun, B., Feng, D., Nawaratne, V., Leach, K., Felder, C. C., Bures, M. G., Evans, D. A., Weis, W. I., Bachhawat, P., Kobilka, T. S., Sexton, P. M., Kobilka, B. K. & Christopoulos, A., 17 Mar 2016, In : Nature. 531, 7594, p. 335-340 6 p.

Research output: Contribution to journalArticleResearchpeer-review

139 Citations (Scopus)

Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor

Pham, V., Zhu, Y., Dal Maso, E., Reynolds, C. A., Deganutti, G., Atanasio, S., Hick, C. A., Yang, D., Christopoulos, A., Hay, D. L., Furness, S. G. B., Wang, M-W., Wootten, D. & Sexton, P. M., 18 Mar 2019, In : ACS Pharmacology and Translational Sciences. 2, 3, p. 183-197 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Decreased atrial natriuretic peptide binding in renal medulla in rats with chronic heart failure

Tsunoda, K., Mendelsohn, F. A. O., Sexton, P. M., Siew Yeen Chai, Y. C., Hodsman, G. P. & Johnston, C. I., 1 Jan 1988, In : Circulation Research. 62, 1, p. 155-161 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
59 Citations (Scopus)

Delineating the mode of action of adenosine A1 receptor allosteric modulators

Valant, C., Aurelio, L., Urmaliya, V., White, P., Scammells, P., Sexton, P. & Christopoulos, A., 2010, In : Molecular Pharmacology. 78, 3, p. 444 - 455 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)
Open Access
File
6 Citations (Scopus)

Detection of novel functional selectivity at M3 muscarinic acetylcholine receptors using a Saccharomyces cerevisiae platform

Stewart, G. D., Sexton, P. & Christopoulos, A., 2010, In : ACS Chemical Biology. 5, 4, p. 365 - 375 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding

Dong, M., Vattelana, A. M., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P., Haines, D. R. & Miller, L. J., 2015, In : Molecular Pharmacology. 87, 1, p. 130-140 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Development of a photoactivatable allosteric ligand for the M1 muscarinic acetylcholine receptor

Davie, B. J., Sexton, P., Capuano, B., Christopoulos, A. & Scammells, P. J., 2014, In : ACS Chemical Neuroscience. 5, 10, p. 902 - 907 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands

Wootten, D. L., Savage, E. E., Willard, F. S., Bueno, A. B., Sloop, K. W., Christopoulos, A. & Sexton, P., 2013, In : Molecular Pharmacology. 83, 4, p. 822 - 834 13 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)
4 Citations (Scopus)
Open Access
File
11 Citations (Scopus)

Discovery and Optimization of Potent and CNS Penetrant M5-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold

Bender, A. M., Cho, H. P., Nance, K. D., Lingenfelter, K. S., Luscombe, V. B., Gentry, P. R., Voigtritter, K., Berizzi, A. E., Sexton, P. M., Langmead, C. J., Christopoulos, A., Locuson, C. W., Bridges, T. M., Chang, S., O'Neill, J. C., Zhan, X., Niswender, C. M., Jones, C. K., Conn, P. J. & Lindsley, C. W., 18 Jul 2018, In : ACS Chemical Neuroscience. 9, 7, p. 1572-1581 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs

Bisson, W. H., Cheltsov, A. V., Bruey-Sedano, N., Lin, B., Chen, J., Goldberger, N., May, L. T., Christopoulos, A., Dalton, J. T., Sexton, P., Zhang, X-K. & Abagyan, R., 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 29, p. 11927 - 11932 6 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors

Udawela, M., Christopoulos, G., Tilakaratne, N., Christopoulos, A., Albiston, A. L. & Sexton, P. M., 2006, In : Molecular Pharmacology. 69, 6, p. 1984 - 1989 6 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity

Diepenhorst, N. A., Leach, K., Keller, A. N., Rueda, P., Cook, A. E., Pierce, T. L., Nowell, C., Pastoureau, P., Sabatini, M., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4095-4108 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation

Houssami, S., Findlay, D. M., Brady, C. L., Martin, T. J., Epand, R. M., Moore, E. E., Murayama, E., Tamura, T., Orlowski, R. C. & Sexton, P. M., 1 Jan 1995, In : Molecular Pharmacology. 47, 4, p. 798-809 12 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination

Liang, Y-L., Zhao, P., Draper-Joyce, C. J., Baltos, J-A., Glukhova, A., Truong, T. T., May, L. T., Christopoulos, A., Wootten, D., Sexton, P. & Furness, S., 2018, In : ACS Pharmacology and Translational Sciences. 1, 1, p. 12-20 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Effective GPCR screening using ERK 1/2: applying SureFire to detect ERK 1/2 phosphorylation

Osmond, R. W., Dyer, A. R., Sexton, P. M., Christopoulos, A. & Crouch, M. F., 2006, In : Genetic Engineering News. 26, 1, p. 27 - 28 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A1 adenosine receptor modulation

Aurelio, L., Valant, C., Flynn, B., Sexton, P., White, J., Christopoulos, A. & Scammells, P., 2010, In : Journal of Medicinal Chemistry. 53, p. 6550 - 6559 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Effects of urea pretreatment on the binding properties of adenosine A 1 receptors

May, L. T., Sexton, P. M. & Christopoulos, A., 2005, In : British Journal of Pharmacology. 146, 8, p. 1119 - 1129 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Electrophoretic mobility and glycosylation characteristics of heterogeneously expressed calcitonin receptors

Quiza, M., Dowton, M., Perry, K. J. & Sexton, P. M., 1 Jan 1997, In : Endocrinology. 138, 2, p. 530-539 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
16 Citations (Scopus)

Emerging paradigms in GPCR allostery: implications for drug discovery

Wootten, D. L., Christopoulos, A. & Sexton, P., 2013, In : Nature Reviews Drug Discovery. 12, 8, p. 630 - 644 15 p.

Research output: Contribution to journalArticleResearchpeer-review

242 Citations (Scopus)

Endogenous allosteric modulators of G protein-coupled receptors

Van Der Westhuizen, E. T., Valant, C., Sexton, P. & Christopoulos, A., 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 2, p. 246 - 260 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
64 Citations (Scopus)

Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders

Leach, K., Sexton, P., Christopoulos, A. & Conigrave, A., 2014, In : British Journal of Pharmacology. 171, 5, p. 1142 - 1155 14 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Evidence for a new subclass of calcitonin/ calcitonin gene-related peptide binding site in rat brain

Sexton, P. M., McKenzie, J. S. & Mendelsohn, F. A. O., 1 Jan 1988, In : Neurochemistry International. 12, 3, p. 323-335 13 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Extracellular loop 2 of the adenosine A1 receptor has a key role in orthosteric ligand affinity and agonist efficacy

Nguyen, A. T. N., Baltos, J-A., Thomas, T., Nguyen, T. D., Lopez Munoz, L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A. & May, L. T., 1 Dec 2016, In : Molecular Pharmacology. 90, 6, p. 703-714 12 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)