1986 …2023

Research output per year

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Research Output

'Ins and outs' of seven-transmembrane receptor signalling to ERK

Werry, T. D., Sexton, P. M. & Christopoulos, A., 2005, In : Trends in Endocrinology & Metabolism. 16, 1, p. 26 - 33 8 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling

Pham, V., Dong, M., Wade, J. D., Miller, L. J., Morton, C. J., Ng, H., Parker, M. W. & Sexton, P. M., 2005, In : Journal of Biological Chemistry. 280, 31, p. 28610 - 28622 13 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Interaction studies of multiple binding sites on M4 muscarinic acetylcholine receptors

Lanzafame, A. A., Sexton, P. M. & Christopoulos, A., 2006, In : Molecular Pharmacology. 70, 2, p. 736 - 746 11 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

International union of basic and clinical pharmacology. XC. Multisite pharmacology: Recommendations for the nomenclature of receptor allosterism and allosteric ligands

Christopoulos, A., Changeux, J-P., Catterall, W. A., Fabbro, D., Burris, T. P., Cidlowski, J. A., Olsen, R. W., Peters, J. A., Neubig, R., Pin, J. P., Sexton, P., Kenakin, T. P., Ehlert, F. J., Spedding, M. & Langmead, C. J., 2014, In : Pharmacological Reviews. 66, 4, p. 918 - 947 30 p.

Research output: Contribution to journalArticleResearchpeer-review

118 Citations (Scopus)

International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors

Poyner, D. R., Sexton, P. M., Marshall, I., Smith, D. M., Quirion, R., Born, W., Muff, R., Fischer, J. A. & Foord, S. M., 2002, In : Pharmacological Reviews. 54, 2, p. 233 - 246 14 p.

Research output: Contribution to journalArticleResearchpeer-review

602 Citations (Scopus)

Introduction

Sexton, P. M., 1 Jan 2002, In : Receptors and Channels. 8, 3-4, p. 135-136 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

2 Citations (Scopus)

In vitro autoradiographic localization of amylin binding sites in rat brain

Sexton, P. M., Paxinos, G., Kenney, M. A., Wookey, P. J. & Beaumont, K., 1 Jan 1994, In : Neuroscience. 62, 2, p. 553-567 15 p.

Research output: Contribution to journalArticleResearchpeer-review

214 Citations (Scopus)

In vitro autoradiographic localization of ANP receptors in rat kidney and adrenal gland

Chai, S. Y., Sexton, P. M., Allen, A. M., Figdor, R. & Mendelsohn, F. A., 26 Nov 1986, In : American Journal of Physiology-Renal, Fluid and Electrolyte Physiology. 250, 4

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain

Paxinos, G., Chai, S. Y., Christopoulos, G., Huang, X-F., Toga, A. W., Wang, H. Q. & Sexton, P. M., 2004, In : Journal of Chemical Neuroanatomy. 27, 4, p. 217 - 236 20 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

In vitro autoradiographic localization of calcitonin binding sites in human medulla oblongata

Sexton, P. M., Paxinos, G., Huang, XF. F. & Mendelsohn, F. A. O., 1 Jan 1994, In : The Journal of Comparative Neurology. 341, 4, p. 449-463 15 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

In vitro autoradiographic localization of the calcitonin receptor isoforms, C1a and C1b, in rat brain

Hilton, J. M., Chai, S. Y. & Sexton, P. M., 1 Jan 1995, In : Neuroscience. 69, 4, p. 1223-1237 15 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Involvement of the sigma1 (sigma1) receptor in the anti-amnesic, but not antidepressant-like, effects of the aminotetrahydrofuran derivative ANAVEX1-41

Espallergues, J., Lapalud, P., Christopoulos, A., Avlani, V. A., Sexton, P., Vamvakides, A. & Maurice, T., 2007, In : British Journal of Pharmacology. 152, 2, p. 267 - 279 13 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Isoforms of the rat calcitonin receptor: Consequences for ligand binding and signal transduction

Houssami, S., Findlay, D. M., Brady, C. L., Myers, D. L., Martin, T. J. & Sexton, P. M., 1 Jan 1994, In : Endocrinology. 135, 1, p. 183-190 8 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)

Isoform-specific biased agonism of histamine H3 receptor agonists

Riddy, D. M., Cook, A. E., Diepenhorst, N. A., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Feb 2017, In : Molecular Pharmacology. 91, 2, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Isoform-specific bias of histamine H3 receptor agonists

Riddy, D., Cook, A. E., Diepenhorst, N., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R., Charman, W., Sexton, P. M., Christopoulos, A. & Langmead, C., 2016.

Research output: Contribution to conferencePoster

20 Citations (Scopus)

Ligand-dependent modulation of G protein conformation alters drug efficacy

Furness, S. G. B., Liang, Y-L., Nowell, C. J., Halls, M. L., Wookey, P. J., Dal Maso, E., Inoue, A., Christopoulos, A., Wootten, D. & Sexton, P. M., 20 Oct 2016, In : Cell. 167, 3, p. 739-749 11 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Light-activated chimeric GPCRs: limitations and opportunities

Tichy, A-M., Gerrard, E. J., Sexton, P. M. & Janovjak, H., 1 Aug 2019, In : Current Opinion in Structural Biology. 57, p. 196-203 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-, IL-1 and RANKL

Suda, K., Woo, J-T., Takami, M., Sexton, P. M. & Nagai, K., 2002, In : Journal of Cellular Physiology. 190, p. 101 - 108 8 p.

Research output: Contribution to journalArticleResearchpeer-review

93 Citations (Scopus)

Localization and characterizarion of renal calcitonin receptors by in vitro autoradiography

Sexton, P. M., Adam, W. R., Moseley, J. M., Martin, T. J. & Mendelsohn, F. A. O., 1 Jan 1987, In : Kidney International. 32, 6, p. 862-868 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
45 Citations (Scopus)

Localization and Regulation of Renal Receptors for Angiotensin II and Atrial Natriuretic Peptide

Sexton, P. M., Zhuo, J. & Mendelsohn, F. A. O., 1 Jan 1992, In : Tohoku Journal of Experimental Medicine. 166, 1, p. 41-56 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

Localization of binding sites for calcitonin gene-related peptide in rat brain by in vitro autoradiography

Sexton, P. M., McKenzie, J. S., Mason, R. T., moseley, J. M., Martin, T. J. & Mendelsohn, F. A. O., 1 Jan 1986, In : Neuroscience. 19, 4, p. 1235-1245 11 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

Bradley, S. J., Bourgognon, J. M., Sanger, H. E., Verity, N., Mogg, A. J., White, D. J., Butcher, A. J., Moreno, J. A., Molloy, C., Macedo-Hatch, T., Edwards, J. M., Wess, J., Pawlak, R., Read, D. J., Sexton, P. M., Broad, L. M., Steinert, J. R., Mallucci, G. R., Christopoulos, A., Felder, C. C. & 1 others, Tobin, A. B., 1 Feb 2017, In : Journal of Clinical Investigation. 127, 2, p. 487-499 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
26 Citations (Scopus)

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping

Dong, M., Xu, X., Ball, A. M., Makhoul, J. A., Lam, P. CH., Pinon, D. I., Orry, A., Sexton, P. M., Abagyan, R. & Miller, L. J., 2012, In : The FASEB Journal. 26, 12, p. 5092 - 5105 14 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Measurement of ligand-G protein-coupled receptor interactions

Leach, K., Valant, C., Sexton, P. M. & Christopoulos, A., 25 Jan 2010, G Protein-Coupled Receptors: Essential Methods. Poyner, D. R. & Wheatley, M. (eds.). Chichester UK: Wiley-Blackwell, p. 1-29 29 p. (Proteins & Macromolecules).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2 Citations (Scopus)

Mechanisms of ERK1/2 regulation by seven-transmembrane-domain receptors

Werry, T. D., Christopoulos, A. & Sexton, P. M., 2006, In : Current Pharmaceutical Design. 12, 14, p. 1683 - 1702 20 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Mechanisms of signalling and biased agonism in G protein-coupled receptors

Wootten, D. L., Christopoulos, A., Marti-Solano, M., Babu, M. M. & Sexton, P. M., Oct 2018, In : Nature Reviews Molecular Cell Biology. 19, 10, p. 638-653 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
74 Citations (Scopus)

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lane, J. R. D., Mistry, S. N., Lopez Munoz, L., Sexton, P., Scammells, P. J., Christopoulos, A. & Canals, M., 2014, In : Journal of Biological Chemistry. 289, 48, p. 33701 - 33711 11 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discovery

Koole, C. R., Savage, E. E., Christopoulos, A., Miller, L. J., Sexton, P. & Wootten, D. L., 2013, In : Molecular Endocrinology. 27, 8, p. 1234 - 1244 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Modulating receptor function through RAMPs: can they represent drug targets in themselves?

Sexton, P. M., Poyner, D. R., Simms, J. W., Christopoulos, A. & Hay, D. L., 2009, In : Drug Discovery Today. 14, 7-8, p. 413 - 419 7 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids

Wootten, D., Simms, J., Koole, C., Woodman, O., Summers, R., Christopoulos, A. & Sexton, P., 2011, In : Journal of Pharmacology and Experimental Therapeutics. 336, 2, p. 540 - 550 11 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Molecular approximations between residues 21 and 23 of secretin and its receptor: Development of a model for peptide docking with the amino terminus of the secretin receptor

Dong, M., Lam, P. C-H., Gao, F., Hosohata, K., Pinon, D. I., Sexton, P., Abagyan, R. & Miller, L. J., 2007, In : Molecular Pharmacology. 72, 2, p. 280 - 290 11 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor

Harikumar, K. G., Cawston, E. E., Lam, P. C. H., Patil, A., Orry, A., Henke, B., Abagyan, R., Christopoulos, A., Sexton, P. & Miller, L. J., 2013, In : Journal of Biological Chemistry. 288, 29, p. 21082 - 21095 14 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor

Cawston, E. E., Lam, P. C. H., Harikumar, K. G., Dong, M., Ball, A. M., Augustine, M. L., Akgun, E., Portoghese, P. S., Orry, A., Abagyan, R., Sexton, P. M. & Miller, L., 2012, In : Journal of Biological Chemistry. 287, 22, p. 18618 - 18635 18 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors

Ma, S., Shen, Q., Zhao, L. H., Mao, C., Zhou, X. E., Shen, D. D., de Waal, P. W., Bi, P., Li, C., Jiang, Y., Wang, M. W., Sexton, P. M., Wootten, D., Melcher, K., Zhang, Y. & Xu, H. E., 6 Feb 2020, In : Molecular Cell. 77, 3, p. 669-680.e4 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

Desai, A. J., Mechin, I., Nagarajan, K., Valant, C., Wootten, D., Lam, P. C. H., Orry, A., Abagyan, R., Nair, A., Sexton, P. M., Christopoulos, A. & Miller, L. J., 1 Mar 2019, In : Molecular Pharmacology. 95, 3, p. 245-259 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor

Harikumar, K. G., Simms, J., Christopoulos, G., Sexton, P. M. & Miller, L. J., 15 Dec 2009, In : Biochemistry. 48, 49, p. 11773-11785 13 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the

Dong, M., Lam, P., Pinon, D., Orry, A., Sexton, P., Abagyan, R. & Miller, L. J., 2011, In : Journal of Biological Chemistry. 286, 27, p. 23888 - 23899 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor

Abdul Ridha, A., Lopez, L., Keov, P., Thal, D., Mistry, S. N., Sexton, P., Lane, J. R. D., Canals, M. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 9, p. 6067 - 6079 13 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Molecular mechanism of action of triazolobenzodiazepinone agonists of the type 1 cholecystokinin receptor. Possible cooperativity across the receptor homodimeric complex

Desai, A. J., Lam, P. C. H., Orry, A., Abagyan, R., Christopoulos, A., Sexton, P. & Miller, L. J., 2015, In : Journal of Medicinal Chemistry. 58, 24, p. 9562-9577 16 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties

Leach, K., Loiacono, R. E., Felder, C. C., McKinzie, D. L., Mogg, A., Shaw, D. B., Sexton, P. M. & Christopoulos, A., 2010, In : Neuropsychopharmacology. 35, 4, p. 855 - 869 15 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)

Molecular mechanisms of action of M5 muscarinic acetylcholine receptor allosteric modulators

Berizzi, A. E., Gentry, P. R., Rueda, P., Hoedt, S. D., Sexton, P. M., Langmead, C. J. & Christopoulos, A., 1 Oct 2016, In : Molecular Pharmacology. 90, 4, p. 427-436 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor

Keov, P., Lopez, L., Devine, S., Valant, C., Lane, J. R. D., Scammells, P. J., Sexton, P. & Christopoulos, A., 2014, In : Journal of Biological Chemistry. 289, 34, p. 23817 - 23837 21 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Molecular pharmacology of the calcitonin receptor

Purdue, B. W., Tilakaratne, N. & Sexton, P., 2002, In : Receptors and Channels. 8, 3 & 4, p. 243 - 255 13 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions

Tsend-Ayush, E., He, C., Myers, M. A., Andrikopoulos, S., Wong, N., Sexton, P. M., Wootten, D., Forbes, B. E. & Grutzner, F., 29 Nov 2016, In : Scientific Reports. 6, 12 p., 37744.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Mouse receptor-activity-modifying proteins 1, -2 and -3: Amino acid sequence, expression and function

Husmann, K., Sexton, P. M., Fischer, J. A. & Born, W., 25 Apr 2000, In : Molecular and Cellular Endocrinology. 162, 1-2, p. 35-43 9 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product

Christopoulos, G., Perry, K. J., Morfis, M., Tilakaratne, N., Gao, Y., Fraser, N. J., Main, M. J., Foord, S. M. & Sexton, P. M., 1 Jan 1999, In : Molecular Pharmacology. 56, 1, p. 235-242 8 p.

Research output: Contribution to journalArticleResearchpeer-review

366 Citations (Scopus)

Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product.

Zumpe, E. T., Tilakaratne, N., Fraser, NJ., Christopoulos, G., Foord, S. M. & Sexton, P., 7 Jan 2000, In : Biochemical and Biophysical Research Communications. 267, 1, p. 368-372

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)