Patrick Sexton

Projects

Projects per year 2004 2006 2007 2019 2021 2027

• 1 Not started
• 9 Active
• 38 Finished

Projects per year

Search results

• Active

  NHMRC Equipment Grant - Glacios 200kV FEG Cryo Transmission Electron Microscope

  Sexton, P.

  1/11/23 → 31/12/24

  Project: Research

• Structural characterization of GLP-1 peptide agonists in complex with GLP-1R and amylin-receptor antibody in complex with amylin receptors

  Wootten, D., Sexton, P., Zhang, C., Belousoff, M., Reedtz-Runge, S. & Glendorf, T.

  1/10/23 → 31/12/24

  Project: Research

• Structure determination of GPCR heteromers

  Sexton, P., Wootten, D., Belousoff, M. & Shepard, R.

  27/07/23 → 26/07/27

  Project: Research

• Development of approaches for inactive, antagonist bound GPCR structures determination

  Wootten, D., Sexton, P., Belousoff, M., Johnson, R. & Han, S.

  22/02/22 → 21/02/26

  Project: Research

• Impact of membrane composition on cholecystokinin receptor structure and function

  Miller, L. J. & Sexton, P.

  1/01/22 → 30/11/25

  Project: Research

• Cryo‐EM structure determination of G protein‐coupled receptors

  Sexton, P., Wootten, D., Belousoff, M., Nar, H., Weichert, D., Ebenhoch, R., Ou, Q. & Lee, D.

  21/09/21 → 21/09/25

  Project: Research

• Optimisation of GPCR expression, purification and structure determination

  Sexton, P., Wootten, D., Belousoff, M., Tovey, J. C., Williams, P. & Apelbaum, A.

  7/04/21 → 6/04/25

  Project: Research

• Development of approaches for orphan GPCR structure determination

  Sexton, P., Wootten, D., Belousoff, M., Zhang, C., Russell, I. C. & Flocco, M.

  7/04/21 → 6/04/25

  Project: Research

• ARC Industrial Transformation Training Centre for Cryo-Electron Microscopy of Membrane Proteins for Drug Discovery

  Sexton, P., Rouiller, I., Wootten, D., van Oijen, A., Parker, M. W., Lucet, I., Griffin, M. D. W., Adams, D. J., Czabotar, P. E., Flocco, M., Han, S., Shepherd, R., Ciferri, C., Williams, P. A., Brown, D., Schreuder, H., Reedtz-Runge, S., Drinkwater, C., Howard, B. L., Betigeri, G., Pryor, E. & How, J.

  Boehringer Ingelheim (Germany), AstraZeneca (United Kingdom)

  23/03/21 → 22/03/26

  Project: Research

• Not started

  Nano-Bioscience Imaging Facility

  Caruso, F., Davis, T., Kent, S., Porter, C., Johnston, A., Qiao, G., Sexton, P., Crampin, E. J., Boyd, B., Cavalieri, F. & Hodgkin, P. D.

  Project: Other

• Finished

  Probing the role of dynamics in protein modulation of GPCR phenotype

  Sexton, P. & Josephs, T.

  1/06/21 → 31/12/23

  Project: Research

• HDX - the missing link in Victorian structural biology platforms

  Parker, M., Rouiller, I., Maher, M., Sexton, P., Gooley, P. R., Williamson, N. A., Peat, T., Nebl, T., Bathgate, R. A. D., Garama, D., Oakhill, J., Kvansakul, M., Langendorf, C. G. & Czabotar, P. E.

  1/01/21 → 31/12/21

  Project: Research

• New generation direct electron detector for cryo-electron microscopy

  Ramm, G., Whisstock, J., Lucet, I., Boecking, T., Landsberg, M. J., Alexandrov, K., Dunstone, M., Curmi, P. M. G., Lawrence, M. C., Lithgow, T., Watterson, D., Sexton, P. & Hankamer, B. D.

  3/07/20 → 15/06/21

  Project: Research

• ACCS: The Australian Characterisation Commons at Scale

  Powell, D., Goscinski, W., Bonnington, P., Quenette, S., Abbott, D. F., Abramson, D., Ali, R., Andrade, J., Barth, M., Betbeder-Matibet, L., Beves, J., Bond, C., Boyd, B., Bryant, G., Cairney, J., Colmer, T., Egan, G., Etheridge, J., Frazier, J., Galloway, G., Gentle, I., Gilbert, A., Gray, M., Hilder, E., Janke, A., Johnstone, T., Kemp, C., Lay, P., Love, S., Martinez, P. A., Mehnert, A., Moffat, B. A., Mulvaney, P., Raston, C. L., Thordarson, P., Weyland, M., Oijen, A. V., Sexton, P., Sullivan, R. P., Ward, N., Warr, G., Wepf, R., Wilson, L., Whisstock, J. & Yen, L.

  AARNet Pty Ltd, Australian National Imaging Facility (NIF), University of Melbourne, University of South Australia, Flinders University, Monash University – Internal University Contribution, QCIF - Queensland Cyber Infrastructure Foundation Ltd, RMIT University, University of New South Wales (UNSW), University of Queensland , University of Sydney, University of Western Australia, University of Wollongong

  7/02/20 → 31/12/23

  Project: Research

• Molecular basis of activation of the prototypic class B G protein-coupled secretin receptor

  Miller, L. J. & Sexton, P.

  1/09/19 → 31/08/23

  Project: Research

• NHMRC Research Fellowship

  Sexton, P.

  1/01/19 → 31/12/23

  Project: Research

• Translating membrane proteins into therapeutics; from bedside to bench

  Sexton, P., Christopoulos, A., Pantelis, C. & Parton, R. G.

  1/01/19 → 31/12/23

  Project: Research

• NHMRC Equipment Grant - Promethion High-Definition Multiplexed Respirometry System

  Sexton, P., Christopoulos, A., Wootten, D. & Langmead, C.

  Monash University – Internal Faculty Contribution, Monash University – Internal Department Contribution

  1/01/19 → 31/12/19

  Project: Research

• Male contraception through pharmacological blockade of sperm transport

  Ventura, S., Baell, J., Charman, S. & Sexton, P.

  Male Contraceptive Initiative

  1/08/18 → 31/05/20

  Project: Research

• NHMRC Equipment Grant - FLIPR Tetra high-throughput cellular screening system

  Sexton, P., Christopoulos, A., Leach, K., Gregory, K., Veldhuis, N., Poole, D. & Langmead, C.

  1/01/18 → 31/12/18

  Project: Research

• Discovery and dissemination of the concept of allosteric binding sites on G protein- coupled receptors (GPCRs) as a novel avenue for drug discovery

  Christopoulos, A. & Sexton, P.

  1/01/17 → 31/12/17

  Project: Research

• A structural understanding of class B G protein-coupled receptor function

  Sexton, P., Kobilka, B., Skiniotis, G. & Furness, S.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/17 → 31/12/21

  Project: Research

• Collaborative Network to Define the Molecular Determinants of G Protein Coupled Receptor Clinical Efficacy

  Christopoulos, A., Sexton, P. & Tobin, A. B.

  1/11/16 → 31/10/21

  Project: Research

• The Janus face of G Protein-Coupled Receptors: Implications for Disease Mechanisms and Opportunities for Drug Discovery

  Sexton, P., Bunnett, N., Christopoulos, A. & Summers, R.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/14 → 31/12/18

  Project: Research

• Understanding the structural basis for Family B G protein-coupled receptor function

  Sexton, P., Furness, S., Kobilka, B. & Wootten, D.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/14 → 31/12/16

  Project: Research

• Understanding the Physiological Role of Ligand Bias Signalling at the Glucagon-Like Peptide-1 Receptor

  Sexton, P., Christopoulos, A., Dodson Michael, M., Sloop, K., Willard, F. & Wootten, D.

  Eli Lilly Australia Pty Ltd

  11/12/13 → 10/12/15

  Project: Research

• Subtype selectivity and functional bias of VPAC receptor positive allosteric modulators (PAMs) for understanding models of pulmonary disease

  Sexton, P., Christopoulos, A., Le, G. & Meutermans, W.

  Australian Research Council (ARC), Sustainable Nutrition Group Ltd

  17/02/13 → 17/02/16

  Project: Research

• The design of functional antagonists of the S1P, modulators with selective exposure to lymphatic tissue through directed gastro-intestinal uptake.

  Flynn, B., Porter, C. & Sexton, P.

  Multiple Sclerosis Research Australia (trading as National Multiple Sclerosis Research Foundation Limited)

  1/08/11 → 31/07/12

  Project: Research

• Molecular characterisation of the glucagon-like peptide 1 receptor

  Sexton, P., Simms, J. & Canals, M.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/11 → 31/12/13

  Project: Research

• Characterisation of BETP analogues to the GLP1 receptor

  Sexton, P.

  5/10/10 → 5/10/17

  Project: Research

• High throughput analysis and screening facility

  Sexton, P., Beddoe, T., Charman, W., Christopoulos, A., Drummond, G., Hertzog, P., Mackay, C., Scammells, P. & Whisstock, J.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/12/09 → 30/11/10

  Project: Research

• Understanding and predicting small molecule binding to G protein-coupled receptors (GPCRs)

  Sexton, P. & Abagyan, R.

  Australian Research Council (ARC)

  5/01/09 → 31/12/11

  Project: Research

• Understanding G Protein-coupled receptors (GPCRs): Accelerating discovery from concept to clinic

  Sexton, P., Christopoulos, A. & Summers, R.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/09 → 31/12/13

  Project: Research

• High Content Cell Signaling Discovery and Screening Facility

  Hertzog, P., Adler, B., Berndt, M., Sexton, P., Trounson, A. & Williams, B.

  Australian Research Council (ARC), Monash University, Victorian Infectious Diseases Reference Laboratory

  17/03/08 → 31/12/08

  Project: Research

• Microplate Reader for Medical Research

  Sexton, P.

  Jack Brockhoff Foundation

  15/12/07 → 30/06/08

  Project: Research

• Essential equipment for medical research.

  Sexton, P.

  Equity Trustees Foundation

  18/10/07 → 31/12/07

  Project: Research

• High-content analysis facility for medical research

  Sexton, P.

  L E W Carty Charitable Fund

  1/07/07 → 30/06/08

  Project: Research

• High Content Analysis Facility

  Sexton, P.

  Ian Potter Foundation

  4/04/07 → 4/04/08

  Project: Research

• Analysis of calcitonin receptor binding and function.

  Sexton, P., Abagyan, R. & Miller, L.

  National Health and Medical Research Council (NHMRC) (Australia)

  2/01/07 → 31/12/08

  Project: Research

• Understanding selective drug signalling at G protein-coupled receptors.

  Sexton, P., Christopoulos, A. & Tobin, A. B.

  National Health and Medical Research Council (NHMRC) (Australia)

  2/01/07 → 31/12/08

  Project: Research

• Molecular characterisation of receptor activity modifying proteins (RAMPS)

  Sexton, P., Christopoulos, A. & Simms, J.

  National Health and Medical Research Council (NHMRC) (Australia)

  2/01/07 → 31/12/08

  Project: Research

• Optimised screening for allosteric modulators of G protein coupled receptors

  Christopoulos, A. & Sexton, P.

  1/01/07 → 31/03/08

  Project: Research

• Allosteric regulation of G protein-coupled receptors

  Christopoulos, A., Abagyan, R., Sexton, P. & Tobin, A. B.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/06 → 31/12/08

  Project: Research

• Purchase of essential equipment for drug discovery biology research.

  Sexton, P.

  Equity Trustees Foundation

  1/01/06 → 31/12/10

  Project: Research

• NHMRC Principal Research Fellow

  Sexton, P.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/06 → 31/12/18

  Project: Research

• Novel modes of regulating serotonin 5HT2c receptors

  Christopoulos, A. & Sexton, P.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/06 → 31/12/08

  Project: Research

• Molecular mechanisms underlying G protein coupled receptor signaling

  Sexton, P., Christopoulos, A., Eidne, K. & Summers, R.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/04 → 31/12/06

  Project: Research

• Molecular pharmacology of receptor activity modifying protein (RAMP) action

  Sexton, P., Christopoulos, A., Summers, R. & Tilakaratne, N.

  National Health and Medical Research Council (NHMRC) (Australia)

  1/01/04 → 31/12/06

  Project: Research