Projects per year
Personal profile
Biography
Professor Patrick Kwan
Department of Neuroscience research groups - Kwan Lab
Patrick Kwan is a clinician-researcher and an international authority in epileptology and antiepileptic drug development. He is a Professor of Neurology in the Department of Neuroscience within the School of Translational Medicine, and Co-Director of Monash Institute of Medical Engineering, a unique cross-faculty platform that provides training and support for research and commercialisation of medtech solutions for unmet clinical needs.
In his clinical role, he is the former Head of Epilepsy and currently a Consultant Neurologist at Alfred Health with main clinical interest in epilepsy.
He is an elected Fellow of the Australian Academy of Health and Medical Sciences. He was previously Chair of Neurology at the Department of Medicine (Royal Melbourne Hospital), University of Medicine (2011-2017). He served as Chair of the Medical Therapies Commission of the International League Against from 2013 to 2017.
Professor Kwan’s research portfolio encompasses both applied basic science and clinical aspects to improve the treatment outcomes of epilepsy. His research goal is to realise personalised epilepsy management through understanding the long term outcomes, identifying factors that affect treatment response and mechanisms of drug resistance, and discovering novel molecular targets for the treatment and prevention of epilepsy. He has a particular interest in harnessing technologies to solve clinical problems. He supervises a highly multidisciplinary, integrated research team that spans across genomics, human stem cells, animal models, bioengineering, artificial intelligence, bio-databanks and clinical trials. He has extensive national and international collaborations in academia, hospitals and MedTech industry.
He has published more than 410 peer-reviewed articles in leading journals including the New England Journal of Medicine, Lancet, British Medical Journal, Lancet Neurology, JAMA Neurology and Brain, that have been cited for more than 41,000 times. H-index 82. He is among Stanford University World's Top 2% Scientists. linkedin.com/in/patrick-kwan-2967056b; X: @patrick_kwan
Research interests
1. Use of Artificial intelligence (AI) models in epilepsy including prediction of treatment outcomes, analysis of imaging, EEG, genomics, wearable data, and the ethical dilemmas (representative article: https://jamanetwork.com/journals/jamaneurology/fullarticle/2795867)
2. Stem cell-derived neuronal platform for disease modelling and personalised drug discovery (https://www.monash.edu/medicine/news/latest/2021-articles/transforming-the-paradigm-of-epilepsy-care-with-precision-medicine2)
3. Biosensors for point-of-care molecular diagnosis and pharmacogenetic screening (https://doi.org/10.1016/j.bios.2018.01.063; https://doi.org/10.1016/j.bios.2022.114410; https://doi.org/10.1038/s41598-021-94652-0)
4. Next generation non-invasive wearables for seizure and health monitoring (https://doi.org/10.1212/WNL.0000000000200794)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Clinical Medicine, MB, BChir, University of Cambridge
Medicine and Therapeutics, PhD, University of Glasgow
Preclinical Medicine, BMedSci, University of Nottingham
External positions
Honorary Clinical Professor, University College London
1 Dec 2021 → 30 Nov 2026
Head of Epilepsy, Alfred Hospital
2 Oct 2017 → 30 Apr 2023
Research area keywords
- Epilepsy
- Point-of-care Diagnostics
- Machine and Deep Learning Models
- stem cell research
- Genomics & Transcriptomics
- Outcomes Research
- Wearable Sensors
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Translational Drug Screening using SYNGAP-1 Patients’ iPSCs-derived Neuronal Disease Model for Clinical Trials of Precision Medicine
Javaid, S. (Primary Chief Investigator (PCI)), Antonic-Baker, A. (Chief Investigator (CI)), Kwan, P. (Chief Investigator (CI)) & O'Brien, T. (Chief Investigator (CI))
1/10/25 → 1/10/26
Project: Research
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BrainAssure: A low-cost Electrochemical sensor based point-of-care platform for monitoring brain health
Jones, A. (Primary Chief Investigator (PCI)), Kwan, P. (Chief Investigator (CI)), Hossain, M. (Chief Investigator (CI)), O'Brien, T. (Chief Investigator (CI)) & Walsh, R. (Partner Investigator (PI))
4/08/25 → 3/08/26
Project: Research
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Connect-TBI: Connect-TBI: A National Informatics and Data-Driven Approach to Improve Care for Moderate to Severe TBI
Gabbe, B. (Primary Chief Investigator (PCI)), Udy, A. (Chief Investigator (CI)), Hellewell, S. C. (Chief Investigator (CI)), Powell, D. (Chief Investigator (CI)), Vallmuur, K. (Chief Investigator (CI)), Fitzgerald, M. (Chief Investigator (CI)), Lannin, N. (Chief Investigator (CI)), Ryder, C. (Chief Investigator (CI)), Cameron, P. (Chief Investigator (CI)), Holland, A. J. A. (Chief Investigator (CI)), Kwan, P. (Chief Investigator (CI)), Ponsford, J. (Chief Investigator (CI)), Kilkenny, M. (Chief Investigator (CI)), Law, M. (Chief Investigator (CI)), Jeffree, R. L. (Chief Investigator (CI)), Balogh, Z. J. (Chief Investigator (CI)), Caeyenberghs, K. (Chief Investigator (CI)), Ge, Z. (Chief Investigator (CI)), Cooper, J. (Chief Investigator (CI)), Barlow, K. M. (Chief Investigator (CI)), Nasrallah, F. (Chief Investigator (CI)), McNamara, R. (Chief Investigator (CI)), Plummer, M. P. (Chief Investigator (CI)), Bellomo, R. (Chief Investigator (CI)), O'Brien, T. (Chief Investigator (CI)), Curtis, K. A. (Chief Investigator (CI)), Reade, M. (Chief Investigator (CI)), Dipnall, J. (Chief Investigator (CI)), Parizel, P. M. (Chief Investigator (CI)), Teague, W. (Chief Investigator (CI)), Jeffcote, T. (Chief Investigator (CI)), Newcombe, V. (Chief Investigator (CI)), O'Reilly, G. (Chief Investigator (CI)), Scheinberg, A. (Chief Investigator (CI)), Battistuzzo, C. (Chief Investigator (CI)), Honeybul, S. (Chief Investigator (CI)), Keeves, J. (Chief Investigator (CI)), Young, J. T. (Chief Investigator (CI)), Secombe, P. (Chief Investigator (CI)), Litton, E. (Chief Investigator (CI)), Williams, G. P. (Chief Investigator (CI)), Hassett, L. (Chief Investigator (CI)), Reeder, S. (Chief Investigator (CI)), Singh, P. (Chief Investigator (CI)), Alexander, T. (Chief Investigator (CI)), Powell, B. (Chief Investigator (CI)), Burns, B. (Chief Investigator (CI)), Farquharson, S. (Associate Investigator (AI)), Campbell, L. T. (Associate Investigator (AI)), Hansen, M. (Associate Investigator (AI)), Delaney, A. (Associate Investigator (AI)), Read, D. J. (Associate Investigator (AI)), Parr, M. (Associate Investigator (AI)), Ellis, D. Y. (Associate Investigator (AI)), Moore, J. W. (Associate Investigator (AI)), Ownsworth, T. (Associate Investigator (AI)), King, K. (Associate Investigator (AI)), Higgins, L. (Associate Investigator (AI)), Nehme, Z. (Associate Investigator (AI)), Anstey, J. R. (Associate Investigator (AI)), Weeden, M. (Associate Investigator (AI)), Wake, E. (Associate Investigator (AI)), Noonan, M. (Associate Investigator (AI)), To, M.-S. (Associate Investigator (AI)), Taylor, J. (Associate Investigator (AI)), Wagland , J. (Associate Investigator (AI)) & Clavisi, O. (Project Manager)
Australian National Imaging Facility (NIF), Connectivity Traumatic Brain Injury Australia Limited, Transport Accident Commission (TAC), Australia and New Zealand Intensive Care Society (ANZICS)
1/07/25 → 30/06/30
Project: Research
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Diagnosing brain bleed using a drop of blood
Kwan, P. (Primary Chief Investigator (PCI)), Abdul Halim, Z. (Chief Investigator (CI)), Yan, B. (Chief Investigator (CI)) & Skafidas, S. (Chief Investigator (CI))
17/06/25 → 1/07/27
Project: Research
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Electroencephalogram (EEG) in autoimmune encephalitis diagnosis and prognosis.
Tan, T. (Primary Chief Investigator (PCI)), Monif, M. (Associate Investigator (AI)), Wesselingh, R. (Associate Investigator (AI)), Seery, N. (Associate Investigator (AI)), Kwan, P. (Chief Investigator (CI)) & O'Brien, T. (Chief Investigator (CI))
1/01/25 → 1/01/26
Project: Research
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Association between enlarged perivascular space (ePVS) density and stereo-electroencephalography (SEEG) biomarkers of epileptogenicity
Bunyamin, J., Sinclair, B., Wittayacharoenpong, T., Sagar, P., Pham, W., Chen, Z., Bosak, N., Laing, J., Gutman, M., Hunn, M., Kwan, P., O'Brien, T. J., Law, M. & Neal, A., 2025, (Accepted/In press) In: Epilepsia. 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Association between local gray matter volume differences and stereo-electroencephalography-defined epileptogenicity
Bunyamin, J., Sinclair, B., Wittayacharoenpong, T., Nazem-Zadeh, M., Sagar, P., Bosak, N., Chen, Z., Laing, J., Gutman, M., Hunn, M., Law, M., Kwan, P., O'Brien, T. J. & Neal, A., 2025, (Accepted/In press) In: Epilepsia. 16 p.Research output: Contribution to journal › Article › Research › peer-review
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Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy
Chen, J., Ngo, A., Rodriguez-Cruces, R., Royer, J., Caligiuri, M. E., Gambardella, A., Concha, L., Keller, S. S., Cendes, F., Yasuda, C. L., Alvim, M. K. M., Bonilha, L., Gleichgerrcht, E., Focke, N. K., Kreilkamp, B. A. K., Domin, M., Von Podewils, F., Langner, S., Rummel, C. & Wiest, R. & 68 others, , 23 Sept 2025, In: Neurology. 105, 6, 12 p., e213688.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Crosstalk Between the Nervous System and Colorectal Cancer
Li, X., Ye, C., Wang, M., Kwan, P., Tian, X. & Zhang, Y., 2025, In: Neuroscience Bulletin. 41, 1, p. 93–106 14 p.Research output: Contribution to journal › Review Article › Research › peer-review
6 Citations (Scopus) -
Do the third-generation antiseizure medications provide the “magic bullet” for drug-resistant epilepsy? Focus on cenobamate
Kwan, P. & Brodie, M. J., Mar 2025, In: Epilepsia. 66, S1, p. 1-3 3 p.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access2 Citations (Scopus)
Prizes
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Developing Predictive Biomarkers of Epilepsy Seizures
Sivathamboo, S. (Recipient), O'Brien, T. (Recipient), Kwan, P. (Recipient), Vasa, R. (Recipient), Mouzakis, K. (Recipient), Jones, N. (Recipient), Goldin, J. (Recipient), Pastorello, N. (Recipient) & Mitrevska, M. (Recipient), 20 Dec 2016
Prize: Prize (including medals and awards)
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Press/Media
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The acid test: The case for accurate and quick mobile point-of-care COVID testing
Kwan, P., Ademi Delaney, Z., Howard, M., McMahon, J. & Alan, T.
11/08/21
1 Media contribution
Press/Media: Article/Feature