Projects per year
Personal profile
Biography
Professor Patrick Kwan
Department of Neuroscience research groups - Kwan Lab
Patrick Kwan is a clinician-researcher and an international authority in epileptology and antiepileptic drug development. He is a Professor of Neurology in the Department of Neuroscience within the Central Clinical School, and Co-Director of Monash Institute of Medical Engineering, a unique cross-faculty platform that supports research and promotes commercialisation of engineering solutions for unmet clinical needs.
In his clinical role, he is a Consultant Neurologist at Alfred Health with main clinical interest in epilepsy.
He is an elected Fellow of the Australian Academy of Health and Medical Sciences. He was previously Chair of Neurology at the Department of Medicine (Royal Melbourne Hospital), University of Medicine (2011-2017). He served as Chair of the Medical Therapies Commission of the International League Against from 2013 to 2017.
Professor Kwan’s research portfolio encompasses both applied basic science and clinical aspects to improve the treatment outcomes of epilepsy. His research goal is to realise personalised epilepsy management through understanding the long term outcomes, identifying factors that affect treatment response and mechanisms of drug resistance, and discovering novel molecular targets for the treatment and prevention of epilepsy. He has a particular interest in harnessing technologies to solve clinical problems. He supervises a highly multidisciplinary, integrated research team that spans across genomics, human stem cells, animal models, bioengineering, artificial intelligence, bio-databanks and clinical trials. He has extensive national and international collaborations in academia, hospitals and MedTech industry.
He has published more than 340 peer-reviewed articles in leading journals including the New England Journal of Medicine, Lancet, British Medical Journal, Lancet Neurology, JAMA Neurology and Brain, that have been cited for more than 31,000 times. H-index 73. He ranks top 0.01% of more than 120,000 published authors worldwide on epilepsy. Twitter: @patrick_kwan
Research interests
1. Use of Artificial intelligence (AI) models in epilepsy including prediction of treatment outcomes, analysis of imaging, EEG, genomics, wearable data, and the ethical dilemmas (representative article: https://jamanetwork.com/journals/jamaneurology/fullarticle/2795867)
2. Stem cell-derived neuronal platform for disease modelling and personalised drug discovery (https://www.monash.edu/medicine/news/latest/2021-articles/transforming-the-paradigm-of-epilepsy-care-with-precision-medicine2)
3. Biosensors for point-of-care molecular diagnosis and pharmacogenetic screening (https://doi.org/10.1016/j.bios.2018.01.063; https://doi.org/10.1016/j.bios.2022.114410; https://doi.org/10.1038/s41598-021-94652-0)
4. Next generation non-invasive wearables for seizure and health monitoring (https://doi.org/10.1212/WNL.0000000000200794)
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Clinical Medicine, MB, BChir, University of Cambridge
Medicine and Therapeutics, PhD, University of Glasgow
Preclinical Medicine, BMedSci, University of Nottingham
External positions
Honorary Clinical Professor, University College London
1 Dec 2021 → 30 Nov 2026
Head of Epilepsy, Alfred Hospital
2 Oct 2017 → 30 Apr 2023
Research area keywords
- Epilepsy
- Point-of-care Diagnostics
- Machine and Deep Learning Models
- stem cell research
- Genomics & Transcriptomics
- Outcomes Research
- Wearable Sensors
Collaborations and top research areas from the last five years
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A Multicenter, Open-label, Long-term, Safety, Tolerability, and Efficacy Study of XEN1101 in Adults Diagnosed With Epilepsy
Kwan, P., Wijayath, M. & Wong, T.
24/06/23 → 24/06/25
Project: Research
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A Randomized, Double-blind, Placebo-Controlled, Multicenter, Phase 3 Study to Evaluate the Safety, Tolerability, and Efficacy of XEN1101 as Adjunctive Therapy in Primary Generalized Tonic-Clonic Seizures
Kwan, P., Perucca, P., Nicolo, J., D'Souza, W. J. & Reutens, D.
24/06/23 → 25/06/25
Project: Research
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Drug screening using Homer1 patient’s iPSCs-derived neurons for clinical trials of precision medicine
Javaid, S., Rollo, B., Antonic-Baker, A., Kwan, P. & O'Brien, T.
17/04/23 → 30/09/24
Project: Research
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Author Correction: Variants in SART3 cause a spliceosomopathy characterised by failure of testis development and neuronal defects (Nature Communications, (2023), 14, 1, (3403), 10.1038/s41467-023-39040-0)
Ayers, K. L., Eggers, S., Rollo, B. N., Smith, K. R., Davidson, N. M., Siddall, N. A., Zhao, L., Bowles, J., Weiss, K., Zanni, G., Burglen, L., Ben-Shachar, S., Rosensaft, J., Raas-Rothschild, A., Jørgensen, A., Schittenhelm, R. B., Huang, C., Robevska, G., van den Bergen, J., Casagranda, F., & 23 others , Dec 2023, In: Nature Communications. 14, 1, 1 p., 3566.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Automated interictal epileptiform discharge detection from scalp EEG using scalable time-series classification approaches
Nhu, D., Janmohamed, M. M. A., Shakhatreh, L. I. K., Gonen, O., Perucca, P., Gilligan, A., Kwan, P., O'Brien, T. J., Tan, C. W. & Kuhlmann, L., 5 Jan 2023, In: International Journal of Neural Systems. 33, 1, 19 p., 2350001.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta-analysis
Liu, Z., Thergarajan, P., Antonic-Baker, A., Chen, Z., Sparks, P. B., Lannin, N. A., Kwan, P., Jones, N. C., Casillas-Espinosa, P. M., Perucca, P., O'Brien, T. J. & Sivathamboo, S., Mar 2023, In: Epilepsia Open. 8, 1, p. 46-59 14 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus) -
Childhood trauma in patients with epileptic vs nonepileptic seizures
Yang, T., Roberts, C., Winton-Brown, T., Lloyd, M., Kwan, P., O'Brien, T. J., Velakoulis, D., Rayner, G. & Malpas, C. B., Jan 2023, In: Epilepsia. 64, 1, p. 184-195 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Comorbidities in newly diagnosed epilepsy: Pre-existing health conditions are common and complex across age groups
McIntosh, A. M., Carney, P. W., Tan, K. M., Hakami, T. M., Perucca, P., Kwan, P., O'Brien, T. J. & Berkovic, S. F., Jan 2023, In: Epilepsy & Behavior. 138, 9 p., 108960.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)
Prizes
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Developing Predictive Biomarkers of Epilepsy Seizures
Sivathamboo, Shobi (Recipient), O'Brien, Terence (Recipient), Kwan, Patrick (Recipient), Vasa, Rajesh (Recipient), Mouzakis, Kon (Recipient), Jones, Nigel (Recipient), Goldin, Jeremy (Recipient), Pastorello, Nicola (Recipient) & Mitrevska, Maria (Recipient), 20 Dec 2016
Prize: Prize (including medals and awards)
Press/Media
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The acid test: The case for accurate and quick mobile point-of-care COVID testing
Patrick Kwan, Zanfina Ademi Delaney, Mark Howard, James McMahon & Tuncay Alan
11/08/21
1 Media contribution
Press/Media: Article/Feature