Projects per year
Personal profile
Biography
Professor Patrick Kwan
Department of Neuroscience research groups - Kwan Lab
Patrick Kwan is a Professor of Neurology in the Department of Neuroscience within the Central Clinical School, and Consultant Neurologist and Head of Epilepsy at Alfred Health.
In addition, he is Co-Director of Monash Institute of Medical Engineering (MIME), a unique cross-faculty platform that supports research and promotes commercialisation of engineering solutions for unmet clinical needs.
He is a medical specialist in neurology and an international authority in epileptology and antiepileptic drug development. He is an elected Fellow of the Australian Academy of Health and Medical Sciences.
Professor Kwan’s research portfolio encompasses both applied basic science and clinical aspects to improve the treatment outcomes of epilepsy. His research goal is to realise personalised epilepsy management through understanding the long term outcomes, identifying factors that affect treatment response and mechanisms of drug resistance, and discovering novel molecular targets for the treatment and prevention of epilepsy. He has a particular interest in harnessing technologies to solve clinical problems. He supervises a highly multidisciplinary, integrated research team that spans across genomics, human stem cells, animal models, bioengineering, artificial intelligence, bio-databanks and clinical trials. He has extensive national and international collaborations in academia, hospitals and MedTech industry.
He has published more than 300 peer-reviewed articles that have been cited for more than 27,000 times. He ranks top 0.01% of 115,891 published authors worldwide on epilepsy. @patrick_kwan
Research interests
1. Artificial intelligence models for personalised outcomes prediction and treatment selection
2. Stem cell-derived neuronal platform for disease modelling and personalised drug discovery
3. Biosensors for point-of-care molecular diagnosis and pharmacogenetic screening
4. Next generation non-invasive wearables for seizure and health monitoring
Education/Academic qualification
Clinical Medicine, MB, BChir, University of Cambridge
Medicine and Therapeutics, PhD, University of Glasgow
Preclinical Medicine, BMedSci, University of Nottingham
External positions
Honorary Clinical Professor, University College London
1 Dec 2021 → 30 Nov 2026
Head of Epilepsy, Alfred Health
2 Oct 2017 → …
Research area keywords
- Epilepsy
- Point-of-care Diagnostics
- Machine and Deep Learning Models
- stem cell research
- Genomics & Transcriptomics
- Outcomes Research
- Wearable Sensors
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Human high-throughput in-vitro phenotypic screening for new epilepsy drugs
Rollo, B., Kwan, P., O'Brien, T., Langmead, C., Baell, J., Casillas-Espinosa, P., May, L., Ayers, K. L. & Sumer, H.
1/06/22 → 1/01/23
Project: Research
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Machine learning models for personalised epilepsy management
Kwan, P., Chen, B., Zhang, D., Foster, E., Haffari, R., Vaughan, D., Lawn, N. D., Perucca, P., Nicolo, J., Carney, P., Brodie, M. J., Ge, Z. & Anderson, A.
1/01/22 → 31/12/24
Project: Research
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3D printer - Stratasys Objet30 Pro:
Kwan, P., O'Brien, T., Jones, N., Casillas-Espinosa, P., Hudson, M., Wright, D., Alan, T., French, C., Chan, J. & Jayawardena, A.
1/10/21 → 31/12/22
Project: Research
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Stakeholder perspectives on Machine learning clinical decision support in epilepsy
Kwan, P., Sparrow, R., Reeder, S., Ge, Z., Foster, E. & Howard, M.
23/08/21 → 23/12/22
Project: Research
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Alpha-lipoic acid analogues in the regulation of redox balance in epilepsy: A molecular docking and simulation study
Javaid, M. S., Antonic-Baker, A., Pitsillou, E., Liang, J., French, C., Hung, A., O'Brien, T. J., Kwan, P., Karagiannis, T. C. & Anderson, A., May 2022, In: Journal of Molecular Graphics and Modelling. 112, 8 p., 108116.Research output: Contribution to journal › Article › Research › peer-review
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Asymmetric distribution of enlarged perivascular spaces in centrum semiovale may be associated with epilepsy after acute ischemic stroke
Yu, N., Sinclair, B., Posada, L. M. G., Chen, Z., Di, Q., Lin, X., Kolbe, S., Hlauschek, G., Kwan, P. & Law, M., Mar 2022, In: CNS Neuroscience and Therapeutics. 28, 3, p. 343-353 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies
Altmann, A., Ryten, M., Di Nunzio, M., Ravizza, T., Tolomeo, D., Reynolds, R. H., Somani, A., Bacigaluppi, M., Iori, V., Micotti, E., Di Sapia, R., Cerovic, M., Palma, E., Ruffolo, G., Botía, J. A., Absil, J., Alhusaini, S., Alvim, M. K. M., Auvinen, P., Bargallo, N. & 82 others, , Feb 2022, In: Neuropathology and Applied Neurobiology. 48, 1, 15 p., e12758.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Industry Viable Electrochemical DNA Detection Sensor Architecture via a Stem-Loop Methylene Blue Redox Reporter and Rapid in Situ Probe Immobilization Method for Pharmacogenetic Biomarker Testing Application
Jayawardena, A., Tan, S. M., Richardson, M. B., Chan, J., Thissen, H., Voelcker, N. H. & Kwan, P., Jan 2022, In: Journal of the Electrochemical Society. 169, 1, 6 p., 017508.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Interictal EEG and ECG for SUDEP Risk Assessment: A Retrospective Multicenter Cohort Study
Chen, Z., Hsieh, A., Sun, G., Bergey, G., Berkovic, S. F., Perucca, P., D'Souza, W. J., Elder, C., Farooque, P., Johnson, E., Barnard, S., Nightscales, R., Kwan, P., Moseley, B., O'Brien, T. J., Sivathamboo, S., Laze, J., Friedman, D., Devinsky, O. & The MS-BioS Study Group, 18 Mar 2022, In: Frontiers in Neurology. 13, 11 p., 858333.Research output: Contribution to journal › Article › Research › peer-review
Open Access
Prizes
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Developing Predictive Biomarkers of Epilepsy Seizures
Sivathamboo, Shobi (Recipient), O'Brien, Terence (Recipient), Kwan, Patrick (Recipient), Vasa, R. (Recipient), Mouzakis, K. (Recipient), Jones, Nigel (Recipient), Goldin, J. (Recipient), Pastorello, N. (Recipient) & Mitrevska, M. (Recipient), 20 Dec 2016
Prize: Prize (including medals and awards)
Press / Media
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The acid test: The case for accurate and quick mobile point-of-care COVID testing
Patrick Kwan, Zanfina Ademi Delaney, Mark Howard, James McMahon & Tuncay Alan
11/08/21
1 Media contribution
Press/Media: Article/Feature