If you made any changes in Pure these will be visible here soon.

Research Output

2020

Immunopeptidomic Analysis Reveals That Deamidated HLA-bound Peptides Arise Predominantly from Deglycosylated Precursors

Mei, S., Ayala, R., Ramarathinam, S. H., Illing, P. T., Faridi, P., Song, J., Purcell, A. W. & Croft, N. P., 1 Jul 2020, In : Molecular & Cellular Proteomics. 19, 7, p. 1236-1247 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA-B*57:01 binding and T-cell activation

Thomson, P. J., Illing, P. T., Farrell, J., Alhaidari, M., Bell, C. C., Berry, N., O’Neill, P. M., Purcell, A. W., Park, K. B. & Naisbitt, D. J., Mar 2020, In : Allergy. 75, 3, p. 636-647 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The complexity of T cell–mediated penicillin hypersensitivity reactions

Goh, S. J. R., Tuomisto, J. E. E., Purcell, A. W., Mifsud, N. A. & Illing, P. T., 8 May 2020, (Accepted/In press) In : Allergy. 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

The molecular basis of how buried human leukocyte antigen polymorphism modulates natural killer cell function

Saunders, P. M., MacLachlan, B. J., Pymm, P., Illing, P. T., Deng, Y., Wong, S. C., Oates, C. V. L., Purcell, A. W., Rossjohn, J., Vivian, J. P. & Brooks, A. G., 26 May 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 21, p. 11636-11647 12 p., A63.

Research output: Contribution to journalArticleResearchpeer-review

2019

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Koutsakos, M., McWilliam, H. E. G., Aktepe, T. E., Fritzlar, S., Illing, P. T., Mifsud, N. A., Purcell, A. W., Rockman, S., Reading, P. C., Vivian, J. P., Rossjohn, J., Brooks, A. G., Mackenzie, J. M., Mintern, J. D., Villadangos, J. A., Nguyen, T. H. O. & Kedzierska, K., 29 May 2019, In : Frontiers in Immunology. 10, 12 p., 1158.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

HLA-associated antiepileptic drug-induced cutaneous adverse reactions

Mullan, K. A., Anderson, A., Illing, P. T., Kwan, P., Purcell, A. W. & Mifsud, N. A., Jun 2019, In : HLA. 93, 6, p. 417-435 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Human CD8 + T cell cross-reactivity across influenza A, B and C viruses

Koutsakos, M., Illing, P. T., Nguyen, T. H. O., Mifsud, N. A., Crawford, J. C., Rizzetto, S., Eltahla, A. A., Clemens, E. B., Sant, S., Chua, B. Y., Wong, C. Y., Allen, E. K., Teng, D., Dash, P., Boyd, D. F., Grzelak, L., Zeng, W., Hurt, A. C., Barr, I., Rockman, S. & 17 others, Jackson, D. C., Kotsimbos, T. C., Cheng, A. C., Richards, M., Westall, G. P., Loudovaris, T., Mannering, S. I., Elliott, M., Tangye, S. G., Wakim, L. M., Rossjohn, J., Vijaykrishna, D., Luciani, F., Thomas, P. G., Gras, S., Purcell, A. W. & Kedzierska, K., 18 Feb 2019, In : Nature Immunology. 20, p. 613-625 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
24 Citations (Scopus)
Open Access
4 Citations (Scopus)
2018

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Faridi, P., Li, C., Ramarathinam, S. H., Vivian, J. P., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Hertzog, P. J., Ternette, N., Rossjohn, J., Croft, N. P. & Purcell, A. W., 12 Oct 2018, In : Science Immunology. 3, 28, 12 p., eaar3947.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Employing proteomics in the study of antigen presentation: an update

Ramarathinam, S. H., Croft, N. P., Illing, P. T., Faridi, P. & Purcell, A. W., 13 Aug 2018, In : Expert Review of Proteomics. 15, 8, p. 637-645 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Illing, P. T., Pymm, P., Croft, N. P., Hilton, H. G., Jojic, V., Han, A. S., Mendoza, J. L., Mifsud, N. A., Dudek, N. L., McCluskey, J., Parham, P., Rossjohn, J., Vivian, J. P. & Purcell, A. W., 8 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4693.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Identification of native and posttranslationally modified HLA-B*57:01- restricted HIV envelope derived epitopes using immunoproteomics

Ramarathinam, S. H., Gras, S., Alcantara, S., Yeung, A. W. S., Mifsud, N. A., Sonza, S., Illing, P., Glaros, E. N., Center, R. J., Thomas, S. R., Kent, S. J., Ternette, N., Purcell, D. F. J., Rossjohn, J. & Purcell, A. W., Jun 2018, In : Proteomics. 18, 12, 11 p., 1700253.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2017

MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape

Pymm, P., Illing, P. T., Ramarathinam, S. H., O'Connor, G. M., Hughes, V. A., Hitchen, C., Price, D. A., Ho, B. K., McVicar, D. W., Brooks, A. G., Purcell, A. W., Rossjohn, J. & Vivian, J. P., Apr 2017, In : Nature Structural & Molecular Biology. 24, 4, p. 387-394 8 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C∗06: 02 molecule

Mobbs, J. I., Illing, P. T., Dudek, N. L., Brooks, A. G., Baker, D. G., Purcell, A. W., Rossjohn, J. & Vivian, J. P., 20 Oct 2017, In : The Journal of Biological Chemistry. 292, 42, p. 17203-17215 13 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The role of HLA genes in pharmacogenomics: unravelling HLA associated adverse drug reactions

Illing, P. T., Purcell, A. W. & McCluskey, J., Aug 2017, In : Immunogenetics. 69, 8-9, p. 617-630 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

25 Citations (Scopus)
2016

Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions

Illing, P. T., Mifsud, N. A. & Purcell, A. W., Oct 2016, In : Current Opinion in Immunology. 42, p. 31-40 10 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

21 Citations (Scopus)

HLA and Drug Hypersensitivity

Illing, P. T., Mifsud, N. A., Vivian, J. P. & Purcell, A. W., 27 Apr 2016, Molecular Immunology. Academic Press, Vol. 2. p. 310-317 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2015

A comprehensive analysis of peptides presented by HLA-A1

Giam, K. L., Ayala-Perez, R., Illing, P. T. T., Schittenhelm, R. B., Croft, N. P., Purcell, A. W. & Dudek, N. L., 2015, In : Tissue Antigens. 85, 6, p. 492 - 496 5 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2014

The cellular redox environment alters antigen presentation

Trujillo, J. A., Croft, N. P., Dudek, N. L., Channappanavar, R., Theodossis, A., Webb, A. I., Dunstone, M. A., Illing, P. TT., Butler, N. S., Fett, C., Tscharke, D. C., Rossjohn, J., Perlman, S. & Purcell, A. W., 2014, In : The Journal of Biological Chemistry. 289, 40, p. 27979 - 27991 13 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2013

Human leukocyte antigen-associated drug hypersensitivity

Illing, P. T., Vivian, J. P., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2013, In : Current Opinion in Immunology. 25, 1, p. 81 - 89 9 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)
2012

Constitutive and inflammatory immunopeptidome of pancreatic beta-cells

Dudek, N. L., Tan, C. T., Gorasia, D. G., Croft, N. P., Illing, P. T. & Purcell, A. W., 2012, In : Diabetes. 61, 11, p. 3018 - 3025 8 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex

Bharadwaj, M., Illing, P., Theodossis, A., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2012, In : Annual Review of Pharmacology and Toxicology. 52, p. 401 - 431 31 p.

Research output: Contribution to journalArticleResearchpeer-review

123 Citations (Scopus)

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

Illing, P. T., Vivian, J. P., Dudek, N. L., Kostenko, L., Chen, Z., Bharadwaj, M., Miles, J. J., Kjer-Nielsen, L., Gras, S., Williamson, N. A., Burrows, S. R., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2012, In : Nature. 486, 7404, p. 554 - 558 5 p.

Research output: Contribution to journalArticleResearchpeer-review

419 Citations (Scopus)

Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

Reantragoon, R., Kjer-Nielsen, L., Patel, O. G., Chen, Z., Illing, P. T., Bhati, M., Kostenko, L., Bharadwaj, M., Meehan, B., Hansen, T. H., Godfrey, D. I., Rossjohn, J. & McCluskey, J., 2012, In : Journal of Experimental Medicine. 209, 4, p. 761 - 774 14 p.

Research output: Contribution to journalArticleResearchpeer-review

109 Citations (Scopus)
2010

Personalized medicine for HLA-associated drug-hypersensitivity reactions

Bharadwaj, M., Illing, P. & Kostenko, L., 1 Sep 2010, In : Personalized Medicine. 7, 5, p. 495-516 22 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)