Projects per year
Personal profile
Biography
Patricia received her PhD in 2014 from the University of Melbourne where she investigated the mechanisms underlying the Human leukocyte antigen (HLA)-associated drug hypersensitivity reaction abacavir hypersensitivity syndrome in the laboratory of Prof James McCluskey. These studies provided the first molecular level demonstration of a small molecule drug interacting with the HLA and caused a paradigm shift in the fields of antigen processing & presentation and drug hypersensitivity (Nature 2012). On completion of her PhD, she moved to the laboratory of Prof Tony Purcell at Monash University where she has continued to investigate HLA-associated disease, utilising a combination of mass spectrometry and functional immunology. She was appointed as a BDI Group Leader in 2021. Her current research focuses on the interplay between genetic factors (HLA polymorphisms, antigen processing machinery) and environmental factors (therapeutic drugs, infection) in peptide presentation by the HLA molecules. Key projects include investigation of influenza immunity, T cell mediated drug hypersensitivity and Type 1 Diabetes.
Research area keywords
- Human Leukocyte Antigen
- Infection and immunity
- Mass spectrometry
- Drug hypersensitivity
- Proteomics
- Antigen Processing and Presentation
- Influenza
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Novel interferon treatment to mitigate serious viral infections
De Weerd, N. (Primary Chief Investigator (PCI)), O'Keeffe, M. (Chief Investigator (CI)), Hertzog, P. (Chief Investigator (CI)), Bardin, P. (Chief Investigator (CI)), Thomas, B. (Chief Investigator (CI)), Garama, D. (Chief Investigator (CI)), Leong, P. (Chief Investigator (CI)), Werder, R. B. (Associate Investigator (AI)), MacDonald, M. I. (Associate Investigator (AI)), Bourke, J. (Associate Investigator (AI)), Illing, P. (Associate Investigator (AI)) & Gough, D. (Associate Investigator (AI))
1/01/26 → 31/12/29
Project: Research
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Non-canonical antigen sources for cross-strain protective influenza immunity
Illing, P. (Primary Chief Investigator (PCI)), Braun, A. (Chief Investigator (CI)), Lahoud, M. (Associate Investigator (AI)), O'Keeffe, M. (Associate Investigator (AI)), Kedzierska, K. (Associate Investigator (AI)), Purcell, A. (Associate Investigator (AI)) & Mifsud, N. (Associate Investigator (AI))
1/01/24 → 31/12/27
Project: Research
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The "dark immunopeptidome" as a source of CD8 T cell epitopes in type 1 diabetes
DiLorenzo, T. P. (Primary Chief Investigator (PCI)), Purcell, A. (Chief Investigator (CI)), Illing, P. (Chief Investigator (CI)), Li, C. (Chief Investigator (CI)), Nakayama, M. (Chief Investigator (CI)) & Kent, S. (Chief Investigator (CI))
1/02/23 → 31/01/26
Project: Research
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A universal platform for affinity purification of RNA
Zhang, Q. (Primary Chief Investigator (PCI)), Davidovich, C. (Chief Investigator (CI)), Knott, G. (Chief Investigator (CI)) & Illing, P. (Chief Investigator (CI))
21/10/22 → 30/11/25
Project: Research
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Investigation of small molecule interactions with the human leukocyte antigen and their role in non-infectious disease
Illing, P. (Primary Chief Investigator (PCI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/14 → 31/12/17
Project: Research
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Evidence of focusing the MHC class I immunopeptidome by tapasin
Darley, R., Illing, P. T., Duriez, P., Bailey, A., Purcell, A. W., van Hateren, A. & Elliott, T., 2025, In: Frontiers in Immunology. 16, 16 p., 1563789.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
HLA-A*02:01 Presents Penicillin-Modified Cysteinylated Peptides for T Cell Recognition
Goh, S. J. R. (Leading Author), Lu, H. H. W., Scull, K. E., Pandey, K., Dorvash, M., Deckert, K., Puy, R., O'Hehir, R. E., Purcell, A. W. (Leading Author), Mifsud, N. A. (Leading Author) & Illing, P. T. (Leading Author), Nov 2025, In: Allergy. 80, 11, p. 3165-3177 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Peptide selectivity of killer cell immunoglobulin-like receptors differs with allotypic variation in HLA class I
Saunders, P. M. (Leading Author), Illing, P. T. (Leading Author), Coin, L., Wong, S. C., Oates, C. V. L., Purcell, A. W. & Brooks, A. G. (Leading Author), Apr 2025, In: Journal of Immunology. 214, 4, p. 747-761 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Link opens in a new tab Citations (Scopus) -
CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age
Menon, T. (Leading Author), Illing, P. T. (Leading Author), Chaurasia, P. (Leading Author), McQuilten, H. A., Shepherd, C., Rowntree, L. C., Petersen, J., Littler, D. R., Khuu, G., Huang, Z., Allen, L. F., Rockman, S., Crowe, J., Flanagan, K. L., Wakim, L. M., Nguyen, T. H. O., Mifsud, N. A., Rossjohn, J. (Leading Author), Purcell, A. W. (Leading Author) & van de Sandt, C. E. (Leading Author) & 1 others, , 29 Apr 2024, In: Nature Communications. 15, 1, 21 p., 3387.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Link opens in a new tab Citations (Scopus) -
Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs
Cornforth, T. V., Moyo, N., Cole, S., Lam, E. P. S., Lobry, T., Wolchinsky, R., Lloyd, A., Ward, K., Denham, E. M., Masi, G., Qing Yun, P. T., Moore, C., Dhaouadi, S., Besra, G. S., Veerapen, N., Illing, P. T., Vivian, J. P., Raynes, J. M., Le Nours, J. & Purcell, A. W. & 7 others, , 2024, In: Frontiers in Oncology. 14, 15 p., 1419528.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Link opens in a new tab Citations (Scopus)