• 15 Innovation Walk, Level 3, Rm-376

    3800 Clayton

    Australia

Accepting PhD Students

20072021
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Personal profile

Biography

 

 

Partha Pratim Das. PhD 

Principal Investigator/ Lab Head
Epigenetics and Gene Regulation Laboratory Monash Biomedicine Discovery Institute Department of Anatomy and Developmental Biology Monash University 

Education

1) PhD, Molecular and Developmental Biology

Summa cum laude

Wellcome Trust/ Cancer Research UK Gurdon Institute, University of Cambridge, UK; and University of Gottingen, Germany (2009)

 

2) MSc, Molecular Biology

International Max Planck Research School For Molecular Biology, Gottingen & University of Gottingen, Germany (2004)

 

3) MSc, Zoology and Molecular Biology

Department of Zoology, University of Pune, India (2002) 

 

Research experience chronology 

1) Post-doctoral Research Fellow, Supervisor: Stuart Orkin, MD
Boston Children’s Hospital/Dana Farber Cancer Center, Harvard Medical School, Boston, MA, USA (March 2010 - December 2016)

2) Graduate student, Supervisor: Eric Miska, PhD
Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK (April 2005-July, 2009)

3) Research student, Supervisor: Ludger Hengst, PhD
Max Planck Institute For Biochemistry, Martinsried, Germany (September 2003-March 2005)

4) Research student, Supervisor: Dileep Deobagkar, PhD
Department of Zoology, University of Pune, India (June 2001-July 2002) 

 

Honours & Accolades

-London Law Trust Medal Fellowship at King’s College London (2016-2018) to start up the independent lab

-Cancer Research UK (2005- 2009)

-Max Planck Research fellowships (2003 Sep -2005 Mar)
-Max Planck Research fellowships (Sep 2002- Aug 2003) during the study of MSc

 

Publications 

1. Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nature Genetics (2017 Apr;49(4):625-634)

2. Beyaz S, Kim JH, Pinello L, Hu Y, Kerenyi MA, Das PP, Barnitz RA, Xifaras ME, Dogum R, Huang J, Haining WN, Yilmaz O, Yuan GC, Orkin SH, Winau F. UTX controls lineage-specific epigenetic program and development of iNKT cells. Nature Immunology (2017 Feb;18(2):184-195)

3. Xie H, Peng C, Huang J, Li BE, Kim W, Smith EC, Fujiwara Y, Qi J, Cheloni G, Das PP, Nguyen M, Li S, Bradner JE, Orkin SH. Chronic myelogenous leukemia-initiating cells require Polycomb group protein EZH2. Cancer Discovery (2016 Sep 14. pii: CD-15- 1439 2016)

4. Das PP, Hendrix DA, Apostolou E, Buchner AH, Canver MC, Beyaz S, Ljuboja D, Kuintzle R, Kim W, Karnik R, Shao Z, Xie H, Xu J, De Los Angeles A, Zhang Y, Choe J, Jun DL, Shen X, Gregory RI, Daley GQ, Meissner A, Kellis M, Hochedlinger K, Kim J, Orkin SH. PRC2 is required to maintain expression of the maternal Gtl2-Rian-Mirg locus by preventing de novo DNA methylation in mouse embryonic stem cells. Cell Reports (2015 Sep 1;12(9):1456-70)

5. Kim PG, Das PP, Rowe RG, Nakano H, Chou SS, Ross SJ, Chen MJ, Sakamoto KM, Zon LI, Nakano A, Orkin SH, Daley GQ. Flow-induced Protein Kinase A/ CREB pathway acts via BMP signalling to promote AGM hematopoiesis. J Exp Med (2015 May 4;212(5):633-48)

6. Maier VK, Feeney CM, Taylor JE, Creech AL, Qiao JW, Szanto, Das PP, Chevrier N, Cifuentes-Rojas C, Orkin SH, Carr SA, Ja e JD, Mertins P, Lee JT. Quantitative and functional proteomics identify ZNF518B as a positive regulator of G9A histone methyltransferase. Mol Cell Proteomics (2015 Jun;14(6):1435-46)

7. Das PP, Shao Z, Beyaz S, Apostolou E, Pinello L, Los Angeles AD, O’Brien K, Atsma JM, Fujiwara Y, Nguyen M, Ljuboja D, Guo G, Woo A, Yuan GC, Onder T, Daley GQ, Hochedlinger K, Kim J, Orkin SH. Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cells identity. Molecular Cell (2014 Jan 9; 53(1): 32-48)

8. Guo G, Luc S, Marco E, Lin TW, Peng C, Kerenyi MA, Beyaz S, Kim W, Xu J, Das PP, Ne T, Zou K, Yuan GC, Orkin SH. Mapping the hematopoietic hierarchy by single-cell analysis of the cell surface repertoire. Cell Stem Cell (2013 Oct 3; 13(4): 492-505)

9. Lykke-Andersen K, Gilchrist MJ, Grabarek JB, Das PP, Miska EA, Zernicka-Goetz M. Maternal Argonaute 2 is essential for early mouse development at the maternal-zygotic transition. MBC (2008 Oct; 19(10): 4383-92)

10. Das PP, Bagijn MP, Goldstein LD, Woolford JR, Lehrbach NJ, Sapetschnig A, Buhecha HR, Gilchrist MJ, Howe KL, Stark R, Mat- thews N, Berezikov E, Ketting RF, Tavare S, Miska EA. Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Molecular Cell (2008 Jul 11; 31(1): 79-90)

11. Hayashi K, Chuva de Sousa Lopes SM, Kaneda M, Tang F, Hajkova P, Lao K, O’Carroll D, Das PP, Tarakhovsky A, Miska EA, Surani MA. MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS ONE (2008 Mar 5; 3(3): e1738)

12. Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S, Das PP, Miska EA, Rodriguez A, Bradley A, Smith KG, Rada C, Enright AJ, Toellner KM, Maclennan IC, Turner M. microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity (2007 Dec; 27(6): 847-59)

13. O’carroll D, Mecklenbrauker I, Das PP, Santana A, Koenig U, Enright AJ, Miska EA, Tarakhovsky. A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes & Development (2007 Aug 15; 21(16): 1999-2004)

14. Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DR, van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley. A Requirement of bic/microRNA-155 for normal immune function. Science (2007 Apr 27; 316(5824): 608-11)

15. Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setien F, Casado S, Suarez-Gauthier A, Sanchez-Cespedes M, Gitt A, Spiteri I, Das PP, Caldas C, Miska EA, Esteller M. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Research (2007 Feb 15; 67(4): 1424-9) 

Keywords

  • Epigenetics, Epitranscriptomics, Embryonic stem cells, Regulatory elements, Genome editing, RNA editing, Neuroscience, Cancer, Computational biology

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2019 2021

Research Output 2007 2018

Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

Voon, H. P. J., Udugama, M., Lin, W., Hii, L., Law, R. H. P., Steer, D. L., Das, P. P., Mann, J. R. & Wong, L. H., 1 Dec 2018, In : Nature Communications. 9, 1, 10 p., 3142.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells

Beyaz, S., Kim, J. H., Pinello, L., Xifaras, M. E., Hu, Y., Huang, J., Kerenyi, M. A., Das, P. P., Barnitz, R. A., Herault, A., Dogum, R., Haining, W. N., Yilmaz, Ö. H., Passegue, E., Yuan, G. C., Orkin, S. H. & Winau, F., 1 Feb 2017, In : Nature Immunology. 18, 2, p. 184-195 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

Canver, M. C., Lessard, S., Pinello, L., Wu, Y., Ilboudo, Y., Stern, E. N., Needleman, A. J., Galactéros, F., Brugnara, C., Kutlar, A., McKenzie, C., Reid, M., Chen, D. D., Das, P. P., A Cole, M., Zeng, J., Kurita, R., Nakamura, Y., Yuan, G. C., Lettre, G. & 2 othersBauer, D. E. & Orkin, S. H., Apr 2017, In : Nature Genetics. 49, 4, p. 625-634 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic myelogenous leukemia-initiating cells require polycomb group protein EZH2

Xie, H., Peng, C., Huang, J., Li, B. E., Kim, W., Smith, E. C., Fujiwara, Y., Qi, J., Cheloni, G., Das, P. P., Nguyen, M., Li, S., Bradner, J. E. & Orkin, S. H., 1 Nov 2016, In : Cancer Discovery. 6, 11, p. 1237-1247 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence

Kim, P. G., Nakano, H., Das, P. P., Chen, M. J., Rowe, R. G., Chou, S. S., Ross, S. J., Sakamoto, K. M., Zon, L. I., Schlaeger, T. M., Orkin, S. H., Nakano, A. & Daley, G. Q., 4 May 2015, In : Journal of Experimental Medicine. 212, 5, p. 633-648 16 p.

Research output: Contribution to journalArticleResearchpeer-review