Projects per year
Personal profile
Biography
Dr Murthi is a Senior Research Fellow within the Fibrosis Laboratory at the Department of Pharmacology. Dr Murthi is working with A/Prof Chrishan Samuel on the NHMRC funded project on "enhancing the anti-fibrotic and regenerative capcity of bone-marrow derived stem cells". Dr Murthi will also "evaluate the peptide-based anti-fibrotics in treating cardiac, kidney and lung fibrosis".
Dr Murthi is a reproductive biologist and placentologist with research expertise in placental development and function in human idiopathic fetal growth restriction (FGR) and has generated more than 100 publications in this field. FGR significantly contributes to higher incidence of metabolic, renal and cardiovascular diseases (CVD) later in life. Dr Murthi's long term research aim is to develop and deliver novel peptides as targted therapeutics to improve cardiac and vascular structure and function in individuals with FGR. A more detailed knowledge of underlying disease mechanisms is likely to advance prevention and treatment of FGR and its complications, and thereby improve long-term out-comes for patients with FGR.
Dr Murthi was awarded a PhD in 1995 from the University of Melbourne under the supervision of Prof Richard Larkins. From 2000 to 2014, Dr Murthi was employed at the Department of Obstetrics and Gynaecology, University of Melbourne and the Department of Maternal-Fetal Medicine, Royal Women's Hospital. In 2015-2018, she was recruited to Monash University within the Department of Medicine, School of Clinical Sciences and the Ritchie Centre, Hudson Institute of Medical Research as a Senior Research Fellow and as a Teaching Associate.
Dr Murthi also serves on the editorial boards of reproductive biology journals, Placenta and International Journal of Reproductive Sciences and Scientific Reprots. She is the elected secretary of International Federation of Placental Associations (IFPA) and act as a chair person of the IFPA award committee.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Education, Graduate Certificate in Higher Education, Victoria University
Award Date: 15 May 2020
Medicine, PhD, University of Melbourne
Award Date: 4 Nov 1994
Medicine, MPhil, University of Madras
Award Date: 3 Jun 1988
Biochemistry, MSc, University of Madras
Award Date: 30 Dec 1986
Zoology, BSc, University of Madras
Award Date: 15 Jun 1984
Network
Projects
- 6 Finished
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Ferring Innovation Grant for Racial Equality in Reproductive Medicine and Maternal Health: Inflammasomes, novel regulators of placental inflammation and placental ageing in early-onset preeclampsia: potential biomarkers to identify ethnic disparity in preeclampsia
Murthi, P., Kumar, B., Samuel, C., Chakraborty, A., Brennecke, S. P. & Karanam, V.
1/12/21 → 1/11/22
Project: Research
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Biodistribution of Cynata-MSCs following intra-muscular injection to mice
22/04/19 → 30/06/19
Project: Research
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Investigating the role of novel peptide receptor as an effective target to improve placental function in preeclampsia.
1/01/17 → 31/12/17
Project: Research
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Investigating the role of altered proteoglycan function in diabetic placental vasculopathy
Murthi, P. & Said, J. M.
1/03/15 → 3/03/15
Project: Research
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A Novel Approach to Enhance the Regenerative Potential of Circulating Endothelial Progenitor Cells in Patients with End-Stage Kidney Disease
Badawi, A., Jefferson, O. C., Huuskes, B. M., Ricardo, S. D., Kerr, P. G., Samuel, C. S. & Murthi, P., Apr 2022, In: Biomedicines. 10, 4, 13 p., 883.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
The Placental NLRP3 Inflammasome and Its Downstream Targets, Caspase-1 and Interleukin-6, Are Increased in Human Fetal Growth Restriction: Implications for Aberrant Inflammation-Induced Trophoblast Dysfunction
Alfian, I., Chakraborty, A., Yong, H. E. J., Saini, S., Lau, R. W. K., Kalionis, B., Dimitriadis, E., Alfaidy, N., Ricardo, S. D., Samuel, C. S. & Murthi, P., 1 May 2022, In: Cells. 11, 9, 25 p., 1413.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt-induced hypertension
Li, Y., Shen, M., Ferens, D., Broughton, B. R. S., Murthi, P., Saini, S., Widdop, R. E., Ricardo, S. D., Pinar, A. A. & Samuel, C. S., Mar 2021, In: British Journal of Pharmacology. 178, 5, p. 1164-1181 18 p.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
Significance of the placental barrier in antenatal viral infections
Yong, H. E. J., Chan, S-Y., Chakraborty, A., Rajaraman, G., Ricardo, S., Benharouga, M., Alfaidy, N., Staud, F. & Murthi, P., 1 Dec 2021, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867, 12, 8 p., 166244.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Decreased Placental FPR2 in Early Pregnancies That Later Developed Small-For-Gestation Age: A Potential Role of FPR2 in the Regulation of Epithelial-Mesenchymal Transition
Murthi, P., Rajaraman, G., Erwich, J. J. H. M. & Dimitriadis, E., 10 Apr 2020, In: Cells. 9, 4, 19 p., 921.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile4 Citations (Scopus)