Padma Murthi

Dr

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Personal profile

Biography

Dr Murthi is a Senior Research Fellow within the Fibrosis Laboratory at the Department of Pharmacology. Dr Murthi is working with A/Prof Chrishan Samuel on the NHMRC funded project on "enhancing the anti-fibrotic and regenerative capcity of bone-marrow derived stem cells". Dr Murthi will also "evaluate the peptide-based anti-fibrotics in treating cardiac, kidney and lung fibrosis".

Dr Murthi is a reproductive biologist and placentologist with research expertise in placental development and function in human idiopathic fetal growth restriction (FGR) and has generated more than 100 publications in this field. FGR significantly contributes to higher incidence of metabolic, renal and cardiovascular diseases (CVD) later in life. Dr Murthi's long term research aim is to develop and deliver novel peptides as targted therapeutics to improve cardiac and vascular structure and function in individuals with FGR. A more detailed knowledge of underlying disease mechanisms is likely to advance prevention and treatment of FGR and its complications, and thereby improve long-term out-comes for patients with FGR.

Dr Murthi was awarded a PhD in 1995 from the University of Melbourne under the supervision of Prof Richard Larkins. From 2000 to 2014, Dr Murthi was employed at the Department of Obstetrics and Gynaecology, University of Melbourne and the Department of Maternal-Fetal Medicine, Royal Women's Hospital. In 2015-2018, she was recruited to Monash University within the Department of Medicine, School of Clinical Sciences and the Ritchie Centre, Hudson Institute of Medical Research as a Senior Research Fellow and as a Teaching Associate. 

Dr Murthi also serves on the editorial boards of reproductive biology journals, Placenta and International Journal of Reproductive Sciences and Scientific Reprots. She is the elected secretary of International Federation of Placental Associations (IFPA) and act as a chair person of the IFPA award committee.

Education/Academic qualification

Biochemistry, MSc, University of Madras, Chennai, India

Medicine, MPhil, University of Madras, Chennai, India

Medicine, PhD, The University of Melbourne

Zoology, BSc, University of Madras, Chennai, India

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Projects 2015 2019

Research Output 2001 2019

Decreased placental glypican expression is associated with human fetal growth restriction

Gunatillake, T., Chui, A., Fitzpatrick, E., Ignjatovic, V., Monagle, P., Whitelock, J., Zanten, D., Eijsink, J., Borg, A., Stevenson, J., Brennecke, S. P., Erwich, J. J. H. M., Said, J. M. & Murthi, P., 15 Jan 2019, In : Placenta. 76, p. 6-9 4 p.

Research output: Contribution to journalArticleResearchpeer-review

NLRP7 is increased in human idiopathic fetal growth restriction and plays a critical role in trophoblast differentiation

Abi Nahed, R., Reynaud, D., Borg, A. J., Traboulsi, W., Wetzel, A., Sapin, V., Brouillet, S., Dieudonné, M. N., Dakouane-Giudicelli, M., Benharouga, M., Murthi, P. & Alfaidy, N., 7 Mar 2019, In : Journal of Molecular Medicine. 97, 3, p. 355-367 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Placental serotonin systems in pregnancy metabolic complications associated with maternal obesity and gestational diabetes mellitus

Murthi, P. & Vaillancourt, C., 7 Feb 2019, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Study of Human T21 Placenta Suggests a Potential Role of Mesenchymal Spondin-2 in Placental Vascular Development

Gerbaud, P., Murthi, P., Guibourdenche, J., Guimiot, F., Sarazin, B., Evain-Brion, D., Badet, J. & Pidoux, G., 1 Mar 2019, In : Endocrinology. 160, 3, p. 684-698 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Sulforaphane improves endothelial function and reduces placental oxidative stress in vitro

Cox, A. G., Gurusinghe, S., Abd Rahman, R., Leaw, B., Chan, S. T., Mockler, J. C., Murthi, P., Marshall, S. A., Lim, R. & Wallace, E. M., 1 Apr 2019, In : Pregnancy Hypertension. 16, p. 1-10 10 p.

Research output: Contribution to journalArticleResearchpeer-review