Projects per year
Personal profile
Biography
Dr Casillas-Espinosa was trained as a medical doctor (MD) at the University of Guadalajara, Mexico, before moving to Australia to study his PhD with Prof Terence O'Brien at the University of Melbourne.
Dr Casillas-Espinosa is a Lab Head of the neuroscience department at Monash University and a NHMRC Early Career Fellow. He has an impressive track record at this stage of his career with multiple publications and international presentations, many of which relate to the preclinical development of new epilepsy therapies and chronic animal models. He is an emerging leader in the field of epilepsy, biomarkers and drug development within just four years of the completion of my PhD (Top 0.50% Worldwide Epilepsy Experts, expertscape.com). His Lab group focuses on finding novel disease-modifying treatments and targets of brain diseases using multi-omics and computational approaches. Dr Casillas-Espinosa's group uses a wide range of models of epilepsy, stroke and traumatic brain injury, from molecular and cellular assays of neuropathology to neurobehavioural assessments and advanced neuroimaging techniques (MRI, DTI, PET). I have successfully obtained competitive grants, resulting in high-impact publications and one patent (PCT/US2017/000097), and ongoing clinical trials of novel therapies. Dr Casillas-Espinosa has a growing international reputation, evidenced by his increasing number of international competitive prizes, awards, and invited talks. CI Casillas-Espinosa is involved in invitation-only committees of the International League Against Epilepsy (ILAE). He is the Global Secretary of the Young Epilepsy Section of the ILAE.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Network
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Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy
May, L., Webb, G., Carlsson, J., Baltos, J., Nguyen, A., Christopoulos, A., Miao, Y., O'Brien, T., Rollo, B., Casillas-Espinosa, P., Gregory, K., Scammells, P. & Nguyen, T.
1/01/22 → 31/12/25
Project: Research
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Reversing post-traumatic epilepsy
Casillas-Espinosa, P., O'Brien, T., Shah, A., Anderson, A., Huang, E., Shultz, S., Jones, N. & Schittenhelm, R.
30/09/21 → 30/09/24
Project: Research
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Human high-throughput in-vitro phenotypic screening for new epilepsy drugs
Rollo, B., Kwan, P., O'Brien, T., Langmead, C., Baell, J., Casillas-Espinosa, P., May, L., Ayers, K. L. & Sumer, H.
1/06/22 → 1/01/23
Project: Research
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Translational platform for epilepsy therapy and biomarker discovery
Galanopoulou, A. S., Moshe, S., Mowrey, W., Branch, C., Fleysher, R., Cui , M., Staba, R. J., Mazarati, A., Sankar, R., Agoston, D., Duncan, D., Cabeen, R., Coles, L., O'Brien, T., Toga, A. W., Bragin, A., Engel, J., Vespa, P., Harris, N., Wright, D., Jones, N., Shultz, S., Casillas-Espinosa, P., Hudson, M., Ali, I. & Braine, E.
NIH - National Institutes of Health (United States of America)
15/04/22 → 31/03/23
Project: Research
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3D printer - Stratasys Objet30 Pro:
Kwan, P., O'Brien, T., Jones, N., Casillas-Espinosa, P., Hudson, M., Wright, D., Alan, T., French, C., Chan, J. & Jayawardena, A.
1/10/21 → 31/12/22
Project: Research
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Cardiac structural and functional abnormalities in epilepsy: A systematic review and meta-analysis
Liu, Z., Thergarajan, P., Antonic-Baker, A., Chen, Z., Sparks, P. B., Lannin, N. A., Kwan, P., Jones, N. C., Casillas-Espinosa, P. M., Perucca, P., O'Brien, T. J. & Sivathamboo, S., Mar 2023, In: Epilepsia Open. 8, 1, p. 46-59 14 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Ccr2 Gene Ablation Does Not Influence Seizure Susceptibility, Tissue Damage, or Cellular Inflammation after Murine Pediatric Traumatic Brain Injury
Sharma, R., Chu, E., Dill, L. K., Shad, A., Zamani, A., O'Brien, T. J., Casillas-Espinosa, P. M., Shultz, S. R. & Semple, B. D., 1 Feb 2023, In: Journal of Neurotrauma. 40, 3-4, p. 365-382 18 p.Research output: Contribution to journal › Article › Research › peer-review
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An Integrated Multi-Omic Network Analysis Identifies Seizure-Associated Dysregulated Pathways in the GAERS Model of Absence Epilepsy
Harutyunyan, A., Chong, D., Li, R., Shah, A. D., Ali, Z., Huang, C., Barlow, C. K., Perucca, P., O’brien, T. J., Jones, N. C., Schittenhelm, R. B., Anderson, A. & Casillas-Espinosa, P. M., 1 Jun 2022, In: International Journal of Molecular Sciences. 23, 11, 19 p., 6063.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Early life adversity accelerates epileptogenesis and enhances depression-like behaviors in rats
Rupasinghe, R., Dezsi, G., Ozturk, E., Carron, S., Hudson, M. R., Casillas-Espinosa, P. M. & Jones, N. C., Aug 2022, In: Experimental Neurology. 354, 10 p., 114088.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
International Post Stroke Epilepsy Research Consortium (IPSERC): A consortium to accelerate discoveries in preventing epileptogenesis after stroke
Mishra, N. K., Engel, J., Liebeskind, D. S., Sharma, V. K., Hirsch, L. J., Kasner, S. E., French, J. A., Devinsky, O., Friedman, A., Dawson, J., Quinn, T. J., Selim, M., de Havenon, A., Yasuda, C. L., Cendes, F., Benninger, F., Zaveri, H. P., Burneo, J. G., Srivastava, P., Bhushan Singh, M., & 24 others , Feb 2022, In: Epilepsy and Behavior. 127, 5 p., 108502.Research output: Contribution to journal › Editorial › Other › peer-review
2 Citations (Scopus)
Prizes
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American Epilepsy Society Young investigator award
Casillas-Espinosa, Pablo (Recipient), 2016
Prize: Prize (including medals and awards)
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ILAE Latin America Travel grant
Casillas-Espinosa, Pablo (Recipient), 2020
Prize: Prize (including medals and awards)
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Inaugural ILAE WONOEP Raman Sankar Fellowship
Casillas-Espinosa, Pablo (Recipient), 2019
Prize: Prize (including medals and awards)
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Monash University Travel Grant
Casillas-Espinosa, Pablo (Recipient), Nov 2018
Prize: Prize (including medals and awards)
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The American Epilepsy Peter Baldwin Award
Casillas-Espinosa, Pablo (Recipient), 3 Dec 2018
Prize: Prize (including medals and awards)
Activities
- 5 Membership of an advisory panel/policy group/ board
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International League Against Epilepsy (ILAE) (External organisation)
Pablo Casillas-Espinosa (Member)
30 Sep 2021 → 30 Sep 2023Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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The Epilepsy Society of Australia (External organisation)
Pablo Casillas-Espinosa (Member)
1 Nov 2019 → …Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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International League Against Epilepsy (ILAE) (External organisation)
Pablo Casillas-Espinosa (Member)
30 Sep 2018 → 30 Sep 2023Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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International League Against Epilepsy (ILAE) (External organisation)
Pablo Casillas-Espinosa (Member)
2018Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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International League Against Epilepsy (ILAE) (External organisation)
Pablo Casillas-Espinosa (Member)
2017 → 2023Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
Press/Media
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New Drug could stop Brain trauma in patients with Epilepsy
25/12/19
1 Media contribution
Press/Media: Article/Feature