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Personal profile

Biography

Orlagh is a Postdoctoral Fellow and Nanomedicine team lead in the Porter Group at Monash Institute of Pharmaceutical Sciences (MIPS). Prior to award of her PhD, Orlagh worked as a research analyst in the pharmaceutical industry in Ireland for over five and a half years and as research assistant on industrial collaborations in Monash for four years. As a result, she maintains a strong translational focus to her work.

Orlagh’s research covers drug delivery more broadly, and specifically, enhancing oral uptake, lymphatic exposure and targeting of therapies for cancer and autoimmune diseases. This is achieved with multiple strategies, including active targeting, stromal modification and manipulation of physicochemical characteristics. Orlagh has extensive experience in preclinical study design and has established multiple disease models to examine new drug delivery strategies, including solid and disseminated cancers as well as collagen induced arthritis.

Research area keywords

  • Lymphatic Transport
  • Targeted Drug Delivery
  • Oral Drug Delivery
  • Macromolecules
  • Nanomedicines
  • Pharmacokinetics
  • Biodistribution
  • Bioavailability Enhancement
  • Cancer
  • Autoimmune Diseases

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Research Output

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats

Kaminskas, L. M., Williams, C. C., Leong, N. J., Chan, L. J., Butcher, N. J., Feeney, O. M., Porter, C. J. H., Tyssen, D., Tachedjian, G. & Ascher, D. B., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 218-226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Engineering Biocoatings to Prolong Drug Release from Supraparticles

Ma, Y., Cortez-Jugo, C., Li, J., Lin, Z., Richardson, R. T., Han, Y., Zhou, J., Björnmalm, M., Feeney, O. M., Zhong, Q. Z., Porter, C. J. H., Wise, A. K. & Caruso, F., 1 Jan 2019, In : Biomacromolecules. 20, 9, p. 3425-3434 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats

Haque, S., Feeney, O., Meeusen, E., Boyd, B. J., McIntosh, M. P., Pouton, C. W., Whittaker, M. & Kaminskas, L. M., 10 Aug 2019, In : Journal of Controlled Release. 307, p. 32-43 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Removal of interstitial hyaluronan with recombinant human hyaluronidase improves the systemic and lymphatic uptake of cetuximab in rats

Styles, I. K., Feeney, O. M., Nguyen, T-H., Brundel, D., Kang, D. W., Clift, R., McIntosh, M. P. & Porter, C. J. H., 10 Dec 2019, In : Journal of Controlled Release. 315, p. 85-96 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Ma, Y., Björnmalm, M., Wise, A. K., Cortez-Jugo, C., Revalor, E., Ju, Y., Feeney, O. M., Richardson, R. T., Hanssen, E., Shepherd, R. K., Porter, C. J. H. & Caruso, F., 19 Sep 2018, In : ACS Applied Materials & Interfaces. 10, 37, p. 31019-31031 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)