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Personal profile

Biography

Orlagh is a Postdoctoral Fellow and Nanomedicine team lead in the Porter Group at Monash Institute of Pharmaceutical Sciences (MIPS). Orlagh commenced her studies at MIPS after five years in startup companies in Dublin. Her postgraduate studies involved the use of PEGylation strategies to influence the rate of digestion of triglycerides, thereby improving the oral bioavailability of poorly water soluble drugs.

More recently, Orlagh's research interests have expanded into cancer and autoimmunity. Specifically, to improve accumulation of nanocarriers and macromolecules at their active site. This is achieved with multiple strategies, including active targeting, stromal modification and manipulation of physicochemical characteristics. Additionally, she is examining how these high molecular weight therapeutics can be redirected to the lymphatic system to better treat lymph-resident diseases.

 

Research area keywords

  • Lymphatic Transport
  • Interstitial Drug Delivery
  • Oral Drug Delivery
  • Targeted Drug Delivery
  • Nanomedicines
  • Dendrimers
  • Lipid-Based Formulation Design
  • Pharmacokinetics
  • Biodistribution
  • Bioavailability Enhancement

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Research Output 2014 2019

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats

Kaminskas, L. M., Williams, C. C., Leong, N. J., Chan, L. J., Butcher, N. J., Feeney, O. M., Porter, C. J. H., Tyssen, D., Tachedjian, G. & Ascher, D. B., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 218-226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering Biocoatings to Prolong Drug Release from Supraparticles

Ma, Y., Cortez-Jugo, C., Li, J., Lin, Z., Richardson, R. T., Han, Y., Zhou, J., Björnmalm, M., Feeney, O. M., Zhong, Q. Z., Porter, C. J. H., Wise, A. K. & Caruso, F., 1 Jan 2019, In : Biomacromolecules. 20, 9, p. 3425-3434 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats

Haque, S., Feeney, O., Meeusen, E., Boyd, B. J., McIntosh, M. P., Pouton, C. W., Whittaker, M. & Kaminskas, L. M., 10 Aug 2019, In : Journal of Controlled Release. 307, p. 32-43 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Removal of interstitial hyaluronan with recombinant human hyaluronidase improves the systemic and lymphatic uptake of cetuximab in rats

Styles, I. K., Feeney, O. M., Nguyen, T-H., Brundel, D., Kang, D. W., Clift, R., McIntosh, M. P. & Porter, C. J. H., 10 Dec 2019, In : Journal of Controlled Release. 315, p. 85-96 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Ma, Y., Björnmalm, M., Wise, A. K., Cortez-Jugo, C., Revalor, E., Ju, Y., Feeney, O. M., Richardson, R. T., Hanssen, E., Shepherd, R. K., Porter, C. J. H. & Caruso, F., 19 Sep 2018, In : ACS Applied Materials and Interfaces. 10, 37, p. 31019-31031 13 p.

Research output: Contribution to journalArticleResearchpeer-review