Personal profile
Biography
The Gilan laboratory at the Australian Centre for Blood Diseases explores the epigenetic landscapes of leukaemia cells and the role they play in the response and resistance to therapy, adaptation and the maintenance of the leukaemic and stem-like state. Ultimately the goal is to develop strategies to reset the cells back to the normal state for therapeutic benefit.
Research area keywords
- Haematopoiesis
- AML
- Mixed Lineage Leukaemia
- Chromatin biology
- gene regulation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Epigenetic targeting of Multiple Myeloma
Gruber, E. (Primary Chief Investigator (PCI)), Gilan, O. (Associate Investigator (AI)), Kats, L. (Associate Investigator (AI)), Vassiliadis, D. (Associate Investigator (AI)) & Herold, M. (Associate Investigator (AI))
1/01/25 → 31/12/28
Project: Research
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Understanding and targeting self-renewal in aggressive blood cancers
Gilan, O. (Primary Chief Investigator (PCI)), Kats, L. (Chief Investigator (CI)), Gruber, E. (Chief Investigator (CI)), Myers, S. (Associate Investigator (AI)) & Dawson, M. (Associate Investigator (AI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/23 → 31/12/26
Project: Research
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Enhancing the efficacy of Menin inhibition in Acute Leukaemia
Gilan, O. (Primary Chief Investigator (PCI))
1/01/22 → 31/12/24
Project: Research
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Epigenetic therapies to differentiate and eradicate leukaemia stem cells
Gilan, O. (Primary Chief Investigator (PCI))
NHMRC - National Health and Medical Research Council (Australia)
1/06/21 → 31/12/21
Project: Research
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Development and characterisation of next generation BET inhibitors
Gilan, O. (Primary Chief Investigator (PCI))
1/10/20 → 1/10/24
Project: Research
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mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
Williams, T. D., Michalak, E. M., Carey, K. T., Lam, E. Y. N., Anderson, A., Griesbach, E., Chan, Y. C., Papasaikas, P., Tan, V. W. T., Ngo, L., MacPherson, L., Gilan, O., Rucinski, A., Rutkowska-Klute, A., Zinn, N., Grandi, P., Bantscheff, M., Prinjha, R. K., Dawson, S. J. & Chao, J. A. & 2 others, , 2 Jan 2025, In: Molecular Cell. 85, 1, p. 117-131.e7 23 p.Research output: Contribution to journal › Article › Research › peer-review
13 Link opens in a new tab Citations (Scopus) -
Chromatin-based memory as a self-stabilizing influence on cell identity
Bell, C. C., Faulkner, G. J. & Gilan, O. (Leading Author), Dec 2024, In: Genome Biology. 25, 1, 13 p., 320.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access8 Link opens in a new tab Citations (Scopus) -
Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription
Bell, C. C., Balic, J. J., Talarmain, L., Gillespie, A., Scolamiero, L., Lam, E. Y. N., Ang, C. S., Faulkner, G. J., Gilan, O. & Dawson, M. A., Jun 2024, In: Nature Genetics. 56, 6, p. 1181-1192 12 p.Research output: Contribution to journal › Article › Research › peer-review
16 Link opens in a new tab Citations (Scopus) -
Erratum: CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity (Cell Reports (2023) 42(8), (S2211124723010252), (10.1016/j.celrep.2023.113014))
House, I. G., Derrick, E. B., Sek, K., Chen, A. X. Y., Li, J., Lai, J., Todd, K. L., Munoz, I., Michie, J., Chan, C. W., Huang, Y. K., Chan, J. D., Petley, E. V., Tong, J., Nguyen, D. M., Engel, S., Savas, P., Hogg, S. J., Vervoort, S. J. & Kearney, C. J. & 9 others, , 27 Feb 2024, In: Cell Reports. 43, 2, 1 p., 113793.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity
House, I. G., Derrick, E. B., Sek, K., Chen, A. X. Y., Li, J., Lai, J., Todd, K. L., Munoz, I., Michie, J., Chan, C. W., Huang, Y. K., Chan, J. D., Petley, E. V., Tong, J., Nguyen, D. M., Engel, S., Savas, P., Hogg, S. J., Vervoort, S. J. & Kearney, C. J. & 9 others, , 29 Aug 2023, In: Cell Reports. 42, 8, 27 p., 113014.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Link opens in a new tab Citations (Scopus)