Projects per year
Personal profile
Biography
The Gilan laboratory at the Australian Centre for Blood Diseases explores the epigenetic landscapes of leukaemia cells and the role they play in the response and resistance to therapy, adaptation and the maintenance of the leukaemic and stem-like state. Ultimately the goal is to develop strategies to reset the cells back to the normal state for therapeutic benefit.
Research area keywords
- Haematopoiesis
- AML
- Mixed Lineage Leukaemia
- Chromatin biology
- gene regulation
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Development and characterisation of next generation BET inhibitors
30/03/20 → 29/03/24
Project: Research
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CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity
Watt, A. C., Cejas, P., DeCristo, M. J., Metzger-Filho, O., Lam, E. Y. N., Qiu, X., BrinJones, H., Kesten, N., Coulson, R., Font-Tello, A., Lim, K., Vadhi, R., Daniels, V. W., Montero, J., Taing, L., Meyer, C. A., Gilan, O., Bell, C. C., Korthauer, K. D., Giambartolomei, C. & 13 others, , Jan 2021, In: Nature Cancer. 2, 1, p. 34-48 15 p.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus) -
Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy
He, M. Y., Halford, M. M., Liu, R., Roy, J. P., Grant, Z. L., Coultas, L., Thio, N., Gilan, O., Chan, Y. C., Dawson, M. A., Achen, M. G. & Stacker, S. A., Dec 2021, In: Communications Biology. 4, 1, 15 p., 878.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
An Erg-driven transcriptional program controls B cell lymphopoiesis
Ng, A. P., Coughlan, H. D., Hediyeh-zadeh, S., Behrens, K., Johanson, T. M., Low, M. S. Y., Bell, C. C., Gilan, O., Chan, Y-C., Kueh, A. J., Boudier, T., Feltham, R., Gabrielyan, A., DiRago, L., Hyland, C. D., Ierino, H., Mifsud, S., Viney, E., Willson, T., Dawson, M. A. & 8 others, , 15 Jun 2020, In: Nature Communications. 11, 1, 14 p., 3013.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
Principles and mechanisms of non-genetic resistance in cancer
Bell, C. C. & Gilan, O., 18 Feb 2020, In: British Journal of Cancer. 122, 4, p. 465-472 8 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access43 Citations (Scopus) -
Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation
Gilan, O., Rioja, I., Knezevic, K., Bell, M. J., Yeung, M. M., Harker, N. R., Lam, E. Y. N., Chung, C., Bamborough, P., Petretich, M., Urh, M., Atkinson, S. J., Bassil, A. K., Roberts, E. J., Vassiliadis, D., Burr, M. L., Preston, A. G. S., Wellaway, C., Werner, T., Gray, J. R. & 17 others, , 24 Apr 2020, In: Science. 368, 6489, p. 387-394 8 p.Research output: Contribution to journal › Article › Research › peer-review
149 Citations (Scopus)