Projects per year
Personal profile
Biography
The Gilan laboratory at the Australian Centre for Blood Diseases explores the epigenetic landscapes of leukaemia cells and the role they play in the response and resistance to therapy, adaptation and the maintenance of the leukaemic and stem-like state. Ultimately the goal is to develop strategies to reset the cells back to the normal state for therapeutic benefit.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Haematopoiesis
- AML
- Mixed Lineage Leukaemia
- Chromatin biology
- gene regulation
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Understanding and targeting self-renewal in aggressive blood cancers
Gilan, O., Kats, L., Gruber, E., Myers, S. & Dawson, M. A.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/23 → 31/12/26
Project: Research
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Development and characterisation of next generation BET inhibitors
1/10/20 → 1/10/24
Project: Research
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Comparative cofactor screens show the influence of transactivation domains and core promoters on the mechanisms of transcription
Bell, C. C., Balic, J. J., Talarmain, L., Gillespie, A., Scolamiero, L., Lam, E. Y. N., Ang, C. S., Faulkner, G. J., Gilan, O. & Dawson, M. A., Jun 2024, In: Nature Genetics. 56, 6, p. 1181-1192 12 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity
House, I. G., Derrick, E. B., Sek, K., Chen, A. X. Y., Li, J., Lai, J., Todd, K. L., Munoz, I., Michie, J., Chan, C. W., Huang, Y. K., Chan, J. D., Petley, E. V., Tong, J., Nguyen, D. M., Engel, S., Savas, P., Hogg, S. J., Vervoort, S. J., Kearney, C. J., & 9 others, 29 Aug 2023, In: Cell Reports. 42, 8, 27 p., 113014.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
CRISPR–ChIP reveals selective regulation of H3K79me2 by Menin in MLL leukemia
Gilan, O., Talarmain, L., Bell, C. C., Neville, D., Knezevic, K., Ferguson, D. T., Boudes, M., Chan, Y. C., Davidovich, C., Lam, E. Y. N. & Dawson, M. A., Oct 2023, In: Nature Structural & Molecular Biology. 30, 10, p. 1592-1606 40 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes
Sparbier, C. E., Gillespie, A., Gomez, J., Kumari, N., Motazedian, A., Chan, K. L., Bell, C. C., Gilan, O., Chan, Y. C., Popp, S., Gough, D. J., Eckersley-Maslin, M. A., Dawson, S. J., Lehner, P. J., Sutherland, K. D., Ernst, P., McGeehan, G. M., Lam, E. Y. N., Burr, M. L. & Dawson, M. A., Feb 2023, In: Nature Cell Biology. 25, 2, p. 258-272 15 p.Research output: Contribution to journal › Article › Research › peer-review
19 Citations (Scopus) -
CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity
Watt, A. C., Cejas, P., DeCristo, M. J., Metzger-Filho, O., Lam, E. Y. N., Qiu, X., BrinJones, H., Kesten, N., Coulson, R., Font-Tello, A., Lim, K., Vadhi, R., Daniels, V. W., Montero, J., Taing, L., Meyer, C. A., Gilan, O., Bell, C. C., Korthauer, K. D., Giambartolomei, C., & 13 others, Jan 2021, In: Nature Cancer. 2, 1, p. 34-48 15 p.Research output: Contribution to journal › Article › Research › peer-review
61 Citations (Scopus)