Nitin Patil

Research output

Research output per year 2013 2015 2016 2017 2019 2020 2022 2022

• 23 Article
• 4 Review Article

Research output per year

Research output per year

Search results

• 2022

  An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates

  Patil, N. A., Thombare, V. J., Li, R., He, X., Lu, J., Yu, H. H., Wickremasinghe, H., Pamulapati, K., Azad, M. A. K., Velkov, T., Roberts, K. D. & Li, J., 15 Mar 2022, In: Frontiers in Chemistry. 10, 10 p., 843163.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

• A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

  Roberts, K. D., Zhu, Y., Azad, M. A. K., Han, M. L., Wang, J., Wang, L., Yu, H. H., Horne, A. S., Pinson, J. A., Rudd, D., Voelcker, N. H., Patil, N. A., Zhao, J., Jiang, X., Lu, J., Chen, K., Lomovskaya, O., Hecker, S. J., Thompson, P. E., Nation, R. L. & 4 others, Dudley, M. N., Griffith, D. C., Velkov, T. & Li, J., 2022, In: Nature Communications. 13, 1, 15 p., 1625.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  1 Citation (Scopus)
• 2021

  2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease

  Patil, N. A., Quek, J. P., Schroeder, B., Morewood, R., Rademann, J., Luo, D. & Nitsche, C., 13 May 2021, In: ACS Medicinal Chemistry Letters. 12, 5, p. 732–737 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  8 Citations (Scopus)

• A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threateningAcinetobacter baumannii

  Jiang, X., Patil, N. A., Azad, M. A. K., Wickremasinghe, H., Yu, H., Zhao, J., Zhang, X., Li, M., Gong, B., Wan, L., Ma, W., Thompson, P. E., Yang, K., Yuan, B., Schreiber, F., Wang, L., Velkov, T., Roberts, K. D. & Li, J., 28 Sep 2021, In: Chemical Science. 12, 36, p. 12211-12220 10 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  4 Citations (Scopus)
• 2020

  Molecular dynamics simulations informed by membrane lipidomics reveal the structure-interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii

  Jiang, X., Yang, K., Yuan, B., Han, M., Zhu, Y., Roberts, K. D., Patil, N. A., Li, J., Gong, B., Hancock, R. E. W., Velkov, T., Schreiber, F., Wang, L. & Li, J., Dec 2020, In: Journal of Antimicrobial Chemotherapy. 75, 12, p. 3534-3543 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  10 Citations (Scopus)

• Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance

  Zhu, Y., Lu, J., Han, M-L., Jiang, X., Azad, M. A. K., Patil, N. A., Lin, Y-W., Zhao, J., Hu, Y., Yu, H. H., Chen, K., Boyce, J. D., Dunstan, R. A., Lithgow, T., Barlow, C. K., Li, W., Schneider-Futschik, E. K., Wang, J., Gong, B., Sommer, B. & 6 others, Creek, D. J., Fu, J., Wang, L., Schreiber, F., Velkov, T. & Li, J., 5 Aug 2020, In: Advanced Science. 7, 15, 13 p., 2000704.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  21 Citations (Scopus)

• Simulations of octapeptin-outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency

  Jiang, X., Yang, K., Yuan, B., Gong, B., Wan, L., Patil, N. A., Swarbrick, J. D., Roberts, K. D., Schreiber, F., Wang, L., Velkov, T. & Li, J., 20 Nov 2020, In: Journal of Biological Chemistry. 295, 47, p. 15902-15912 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  6 Citations (Scopus)
• 2019

  Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides

  Patil, N. A., Karas, J. A., Wade, J. D., Hossain, M. A. & Tailhades, J., 26 Jun 2019, In: Chemistry - A European Journal. 25, 36, p. 8599-8603 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  5 Citations (Scopus)

• The Adsorption of Amyloidogenic Peptides to Functionalized Surfaces Is Biased by Charge and Hydrophilicity

  John, T., Greene, G. W., Patil, N. A., Dealey, T. J. A., Hossain, M. A., Abel, B. & Martin, L. L., 12 Nov 2019, In: Langmuir. 35, 45, p. 14522-14531 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  10 Citations (Scopus)

• The Kinetics of Amyloid Fibrillar Aggregation of Uperin 3.5 Is Directed by the Peptide's Secondary Structure

  John, T., Dealey, T. J. A., Gray, N. P., Patil, N. A., Hossain, M. A., Abel, B., Carver, J. A., Hong, Y. & Martin, L. L., 6 Aug 2019, In: Biochemistry. 58, 35, p. 3656-3668 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  9 Citations (Scopus)

• Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates

  Patil, N. A., Karas, J. A., Turner, B. J. & Shabanpoor, F., 20 Mar 2019, In: Bioconjugate Chemistry. 30, 3, p. 793-799 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  13 Citations (Scopus)
• 2018

  Amyloid aggregation and membrane activity of the antimicrobial peptide uperin 3.5

  Martin, L. L., Kubeil, C., Piantavigna, S., Tikkoo, T., Gray, N. P., John, T., Calabrese, A. N., Liu, Y., Hong, Y., Hossain, M. A., Patil, N., Abel, B., Hoffmann, R., Bowie, J. H. & Carver, J. A., 1 May 2018, In: Peptide Science. 110, 3, 9 p., e24052.

  Research output: Contribution to journal › Article › Research › peer-review
  16 Citations (Scopus)
• 2017

  Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts

  Farrelly-Rosch, A., Lau, C. L., Patil, N., Turner, B. J. & Shabanpoor, F., 1 Sep 2017, In: Neurochemistry International. 108, p. 213-221 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  13 Citations (Scopus)

• Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor

  Ang, S. Y., Hutchinson, D. S., Patil, N., Evans, B. A., Bathgate, R. A. D., Halls, M. L., Hossain, M. A., Summers, R. J. & Kocan, M., 1 May 2017, In: British Journal of Pharmacology. 174, 10, p. 1077-1089 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  21 Citations (Scopus)

• The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4

  Ang, S. Y., Hutchinson, D. S., Evans, B. A., Hossain, M. A., Patil, N., Bathgate, R. A. D., Kocan, M. & Summers, R. J., Jan 2017, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 1, p. 105-111 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  6 Citations (Scopus)
• 2016

  A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides

  Patil, N. A., Tailhades, J., Karas, J. A., Separovic, F., Wade, J. D. & Hossain, M. A., 14 Nov 2016, In: Angewandte Chemie - International Edition. 55, 47, p. 14552-14556 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  15 Citations (Scopus)

• A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

  Hossain, M. A., Kocan, M., Yao, S. T., Royce, S. G., Nair, V. B., Siwek, C., Patil, N. A., Harrison, I. P., Rosengren, K. J., Selemidis, S., Summers, R. J., Wade, J. D., Bathgate, R. A. D. & Samuel, C. S., 2016, In: Chemical Science. 7, 6, p. 3805-3819 15 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  46 Citations (Scopus)

• Engineering of a novel simplified human insulin-like peptide 5 agonist

  Patil, N. A., Hughes, R. A., Rosengren, K. J., Kocan, M., Ang, S. Y., Tailhades, J., Separovic, F., Summers, R. J., Grosse, J., Wade, J., Bathgate, R. A. D. & Hossain, M. A., 10 Mar 2016, In: Journal of Medicinal Chemistry. 59, 5, p. 2118-2125 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  17 Citations (Scopus)

• The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

  Sethi, A., Bruell, S., Patil, N., Hossain, M. A., Scott, D. J., Petrie, E. J., Bathgate, R. A. D. & Gooley, P. R., 18 Apr 2016, In: Nature Communications. 7, 11 p., 11344.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  25 Citations (Scopus)

• The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity

  Patil, N. A., Bathgate, R. A. D., Kocan, M., Ang, S. Y., Tailhades, J., Separovic, F., Summers, R., Grosse, J., Hughes, R. A., Wade, J. D. & Hossain, M. A., 1 Apr 2016, In: Amino Acids. 48, 4, p. 987-992 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  11 Citations (Scopus)

• Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability

  Karas, J. A., Patil, N. A., Tailhades, J., Sani, M-A., Scanlon, D. B., Forbes, B. E., Gardiner, J., Separovic, F., Wade, J. D. & Hossain, M. A., 14 Nov 2016, In: Angewandte Chemie - International Edition. 55, 47, p. 14743-14747 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  26 Citations (Scopus)
• 2015

  Site of fluorescent label modifies interaction of melittin with live cells and model membranes

  Jamasbi, E., Ciccotosto, G. D., Tailhades, J., Robins-Browne, R. M., Ugalde, C. L., Sharples, R. A., Patil, N., Wade, J. D., Hossain, M. A. & Separovic, F., Oct 2015, In: BBA Biomembranes. 1848, 10, p. 2031-2039 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  12 Citations (Scopus)
• 2013

  Minimum active structure of insulin-like peptide 5

  Belgi, A., Bathgate, R., Kocan, M., Patil, N., Zhang, S., Tregear, G. W., Wade, J. D. & Hossain, M. A., 2013, In: Journal of Medicinal Chemistry. 56, 23, p. 9509 - 9516 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  21 Citations (Scopus)