Projects per year
Personal profile
Biography
Throughout evolution, Nature has developed various mechanisms to produce, modify and transport biomolecules in specific cells. Inspired by these mechanisms, our research utilizes a multidisciplinary approach to develop new therapeutics. Our main goal is to develop oligonucleotides and peptide-based therapeutics.
Considering the challenging chemistry associated with oligonucleotides and peptides that present different reactive functional groups, the newly developed chemistry needs to be selective, quantitative and bio-compatible, therefore our research also focuses on creating new chemistry tools for the selective modification of oligonucleotides and peptides, for efficient drug delivery into specific cells.
Research interests
1) Peptide Nucleic Acids (PNAs) as antisense antibiotics
2) Backbone modified antisense oligonucleotides
3) Polymyxin based antibiotic drug development
External positions
Honorary Fellow
26 Aug 2017 → 1 Jan 2018
Research area keywords
- Peptide Chemistry
- Oligonucleotides
- Organic chemistry
- Medicinal Chemistry
- Pharmacology
- Pharmacy
- Drug Development
- Drug Delivery
- Drug Design
Network
Projects
- 2 Active
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Integrating AI, Big Data and Smart Drug Design against 'Superbugs'
Song, J., Li, J., Patil, N., Schmidt, D. & Thompson, P.
1/01/20 → 31/12/23
Project: Research
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Targeting pan-drug resistant (PDR) Gram-negative pathogens with novel anti-sense drug technology
1/01/19 → 31/12/22
Project: Research
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Conjugation approaches for peptide-mediated delivery of oligonucleotides therapeutics
Patil, N. A., 2022, In: Australian Journal of Chemistry. 75, 2, p. 24-33 10 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease
Patil, N. A., Quek, J. P., Schroeder, B., Morewood, R., Rademann, J., Luo, D. & Nitsche, C., 13 May 2021, In: ACS Medicinal Chemistry Letters. 12, 5, p. 732–737 6 p.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threateningAcinetobacter baumannii
Jiang, X., Patil, N. A., Azad, M. A. K., Wickremasinghe, H., Yu, H., Zhao, J., Zhang, X., Li, M., Gong, B., Wan, L., Ma, W., Thompson, P. E., Yang, K., Yuan, B., Schreiber, F., Wang, L., Velkov, T., Roberts, K. D. & Li, J., 28 Sep 2021, In: Chemical Science. 12, 36, p. 12211-12220 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Molecular dynamics simulations informed by membrane lipidomics reveal the structure-interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii
Jiang, X., Yang, K., Yuan, B., Han, M., Zhu, Y., Roberts, K. D., Patil, N. A., Li, J., Gong, B., Hancock, R. E. W., Velkov, T., Schreiber, F., Wang, L. & Li, J., Dec 2020, In: Journal of Antimicrobial Chemotherapy. 75, 12, p. 3534-3543 10 p.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance
Zhu, Y., Lu, J., Han, M-L., Jiang, X., Azad, M. A. K., Patil, N. A., Lin, Y-W., Zhao, J., Hu, Y., Yu, H. H., Chen, K., Boyce, J. D., Dunstan, R. A., Lithgow, T., Barlow, C. K., Li, W., Schneider-Futschik, E. K., Wang, J., Gong, B., Sommer, B. & 6 others, , 5 Aug 2020, In: Advanced Science. 7, 15, 13 p., 2000704.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile21 Citations (Scopus)
Prizes
-
Albert Shimmins Postgraduate Writing Up Award
Patil, Nitin (Recipient), 15 Jul 2016
Prize: Prize (including medals and awards)
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American Peptide Symposium Student Travel Award
Patil, Nitin (Recipient), 2015
Prize: Prize (including medals and awards)
-
Best Research Article Award
Patil, Nitin (Recipient), 24 May 2017
Prize: Prize (including medals and awards)
-
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Bridging Postdoctoral Research Fellow
Patil, Nitin (Recipient), 1 Feb 2018
Prize: Competitive Fellowships
Activities
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Bioorganic Chemistry (Journal)
Nitin Patil (Peer reviewer)
2019 → …Activity: Publication peer-review and editorial work types › Peer review responsibility
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MNHS Graduate Research Mentoring Program
Nitin Patil (Mentor)
2019 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Mentor/ Internship supervision
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Communications Biology (Journal)
Nitin Patil (Peer reviewer)
1 Dec 2019 → …Activity: Publication peer-review and editorial work types › Peer review responsibility
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Organic Letters (Journal)
Nitin Patil (Peer reviewer)
1 Dec 2019 → …Activity: Publication peer-review and editorial work types › Peer review responsibility
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Opportunities to reduce drug resistance and the role of international collaboration in AMR
Nitin Patil (Contributor)
31 Jan 2019Activity: Community Talks, Presentations, Exhibitions and Events › Public lecture/debate/seminar
Press / Media
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Monash BDI researchers secure six NHMRC Fellowships
15/08/18
1 item of Media coverage
Press/Media: Article/Feature