Nitin Patil

Dr

Accepting PhD Students

20132022
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Personal profile

Biography

Throughout evolution, Nature has developed various mechanisms to produce, modify and transport biomolecules in specific cells. Inspired by these mechanisms, our research utilizes a multidisciplinary approach to develop new therapeutics. Our main goal is to develop oligonucleotides and peptide-based therapeutics.

Considering the challenging chemistry associated with oligonucleotides and peptides that present different reactive functional groups, the newly developed chemistry needs to be selective, quantitative and bio-compatible, therefore our research also focuses on creating new chemistry tools for the selective modification of oligonucleotides and peptides, for efficient drug delivery into specific cells.

Research interests

1) Peptide Nucleic Acids (PNAs) as antisense antibiotics

2) Backbone modified antisense oligonucleotides

3) Polymyxin based antibiotic drug development

External positions

Honorary Fellow

26 Aug 20171 Jan 2018

Keywords

  • Peptide Chemistry
  • Oligonucleotides
  • Organic chemistry
  • Medicinal Chemistry
  • Pharmacology
  • Pharmacy
  • Drug Development
  • Drug Delivery
  • Drug Design

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Projects 2019 2022

Research Output 2013 2019

Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides

Patil, N. A., Karas, J. A., Wade, J. D., Hossain, M. A. & Tailhades, J., 26 Jun 2019, In : Chemistry - A European Journal. 25, 36, p. 8599-8603 5 p.

Research output: Contribution to journalArticleResearchpeer-review

The Kinetics of Amyloid Fibrillar Aggregation of Uperin 3.5 Is Directed by the Peptide's Secondary Structure

John, T., Dealey, T. J. A., Gray, N. P., Patil, N. A., Hossain, M. A., Abel, B., Carver, J. A., Hong, Y. & Martin, L. L., 6 Aug 2019, In : Biochemistry. 58, 35, p. 3656-3668 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates

Patil, N. A., Karas, J. A., Turner, B. J. & Shabanpoor, F., 20 Mar 2019, In : Bioconjugate Chemistry. 30, 3, p. 793-799 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Amyloid aggregation and membrane activity of the antimicrobial peptide uperin 3.5

Martin, L. L., Kubeil, C., Piantavigna, S., Tikkoo, T., Gray, N. P., John, T., Calabrese, A. N., Liu, Y., Hong, Y., Hossain, M. A., Patil, N., Abel, B., Hoffmann, R., Bowie, J. H. & Carver, J. A., 1 May 2018, In : Peptide Science. 110, 3, 9 p., e24052.

Research output: Contribution to journalArticleResearchpeer-review

Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts

Farrelly-Rosch, A., Lau, C. L., Patil, N., Turner, B. J. & Shabanpoor, F., 1 Sep 2017, In : Neurochemistry International. 108, p. 213-221 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

Albert Shimmins Postgraduate Writing Up Award

Nitin Patil (Recipient), 15 Jul 2016

Prize: Prize (including medals and awards)

American Peptide Symposium Student Travel Award

Nitin Patil (Recipient), 2015

Prize: Prize (including medals and awards)

Best Research Article Award

Nitin Patil (Recipient), 24 May 2017

Prize: Prize (including medals and awards)

Bio21 Student Travel Award

Nitin Patil (Recipient), 2015

Prize: Prize (including medals and awards)

Bridging Postdoctoral Research Fellow

Nitin Patil (Recipient), 1 Feb 2018

Prize: Competitive Fellowships

Activities 2014 2019

Bioorganic Chemistry (Journal)

Nitin Patil (Peer reviewer)
2019 → …

Activity: Publication peer-review and editorial work typesPeer review responsibility

Opportunities to reduce drug resistance and the role of international collaboration in AMR

Nitin Patil (Contributor)
31 Jan 2019

Activity: Community Talks, Presentations, Exhibitions and EventsPublic lecture/debate/seminar

MNHS Graduate Research Mentoring Program

Nitin Patil (Mentor)
2019 → …

Activity: Teaching EngagementsMentor/ Internship supervision

International Journal of Antimicrobial Agents (Journal)

Nitin Patil (Peer reviewer)
2018 → …

Activity: Publication peer-review and editorial work typesPeer review responsibility

Biochemistry (Journal)

Nitin Patil (Peer reviewer)
2018 → …

Activity: Publication peer-review and editorial work typesPeer review responsibility

Press / Media

Monash BDI researchers secure six NHMRC Fellowships

Nitin Patil

15/08/18

1 item of media coverage

Press/Media: Article/Feature