Throughout evolution, Nature has developed various mechanisms to produce, modify and transport biomolecules in specific cells. Inspired by these mechanisms, our research utilizes a multidisciplinary approach to develop new therapeutics. Our main goal is to develop oligonucleotides and peptide-based therapeutics.

Considering the challenging chemistry associated with oligonucleotides and peptides that present different reactive functional groups, the newly developed chemistry needs to be selective, quantitative and bio-compatible, therefore our research also focuses on creating new chemistry tools for the selective modification of oligonucleotides and peptides, for efficient drug delivery into specific cells.

1) Peptide Nucleic Acids (PNAs) as antisense antibiotics

2) Backbone modified antisense oligonucleotides

3) Polymyxin based antibiotic drug development