Projects per year
Personal profile
Biography
Throughout evolution, Nature has developed various mechanisms to produce, modify and transport biomolecules in specific cells. Inspired by these mechanisms, our research utilizes a multidisciplinary approach to develop new therapeutics. Our main goal is to develop oligonucleotides and peptide-based therapeutics.
Considering the challenging chemistry associated with oligonucleotides and peptides that present different reactive functional groups, the newly developed chemistry needs to be selective, quantitative and bio-compatible, therefore our research also focuses on creating new chemistry tools for the selective modification of oligonucleotides and peptides, for efficient drug delivery into specific cells.
Research interests
1) Peptide Nucleic Acids (PNAs) as antisense antibiotics
2) Backbone modified antisense oligonucleotides
3) Polymyxin based antibiotic drug development
External positions
Honorary Fellow
26 Aug 2017 → 1 Jan 2018Keywords
- Peptide Chemistry
- Oligonucleotides
- Organic chemistry
- Medicinal Chemistry
- Pharmacology
- Pharmacy
- Drug Development
- Drug Delivery
- Drug Design
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2019 2022
- 1 Active
Targeting pan-drug resistant (PDR) Gram-negative pathogens with novel anti-sense drug technology
1/01/19 → 31/12/22
Project: Research
Research Output 2013 2019
Rapid Photolysis‐Mediated Folding of Disulfide‐Rich Peptides
Patil, N. A., Karas, J. A., Wade, J. D., Hossain, M. A. & Tailhades, J., 28 Mar 2019, (Accepted/In press) In : Chemistry - A European Journal. 6 p.Research output: Contribution to journal › Article › Research › peer-review
Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates
Patil, N. A., Karas, J. A., Turner, B. J. & Shabanpoor, F., 15 Jan 2019, (Accepted/In press) In : Bioconjugate Chemistry. 7 p.Research output: Contribution to journal › Article › Research › peer-review
Amyloid aggregation and membrane activity of the antimicrobial peptide uperin 3.5
Martin, L. L., Kubeil, C., Piantavigna, S., Tikkoo, T., Gray, N. P., John, T., Calabrese, A. N., Liu, Y., Hong, Y., Hossain, M. A., Patil, N., Abel, B., Hoffmann, R., Bowie, J. H. & Carver, J. A., 1 May 2018, In : Peptide Science. 110, 3, 9 p., e24052.Research output: Contribution to journal › Article › Research › peer-review
Combination of valproic acid and morpholino splice-switching oligonucleotide produces improved outcomes in spinal muscular atrophy patient-derived fibroblasts
Farrelly-Rosch, A., Lau, C. L., Patil, N., Turner, B. J. & Shabanpoor, F., 1 Sep 2017, In : Neurochemistry International. 108, p. 213-221 9 p.Research output: Contribution to journal › Article › Research › peer-review
Relaxin family peptides: structure–activity relationship studies
Patil, N. A., Rosengren, K. J., Separovic, F., Wade, J. D., Bathgate, R. A. D. & Hossain, M. A., May 2017, In : British Journal of Pharmacology. 174, 10, p. 950-961 12 p.Research output: Contribution to journal › Review Article › Other › peer-review
Open Access
File
Prizes
Albert Shimmins Postgraduate Writing Up Award
Nitin Patil (Recipient), 15 Jul 2016
Prize: Prize (including medals and awards)
American Peptide Symposium Student Travel Award
Nitin Patil (Recipient), 2015
Prize: Prize (including medals and awards)
Best Research Article Award
Nitin Patil (Recipient), 24 May 2017
Prize: Prize (including medals and awards)
Bridging Postdoctoral Research Fellow
Nitin Patil (Recipient), 1 Feb 2018
Prize: Competitive Fellowships
Activities 2014 2019
Bioorganic Chemistry (Journal)
Nitin Patil (Peer reviewer)2019 → …
Activity: Publication peer-review and editorial work types › Peer review responsibility
Opportunities to reduce drug resistance and the role of international collaboration in AMR
Nitin Patil (Contributor)31 Jan 2019
Activity: Community Talks, Presentations, Exhibitions and Events › Public lecture/debate/seminar
MNHS Graduate Research Mentoring Program
Nitin Patil (Mentor)2019 → …
Activity: Teaching Engagements › Mentor/ Internship supervision
Biochemistry (Journal)
Nitin Patil (Peer reviewer)2018 → …
Activity: Publication peer-review and editorial work types › Peer review responsibility
Peptide Users Group Spring Symposium 2018
Nitin Patil (Organiser)9 Nov 2018
Activity: Participating in or organising an event types › Contribution to conference
Press / Media
Monash BDI researchers secure six NHMRC Fellowships
15/08/18
1 item of media coverage
Press/Media: Article/Feature