Projects per year
Personal profile
Biography
Throughout evolution, Nature has developed various mechanisms to produce, modify and transport biomolecules in specific cells. Inspired by these mechanisms, our research utilizes a multidisciplinary approach to develop new therapeutics. Our main goal is to develop oligonucleotides and peptide-based therapeutics.
Considering the challenging chemistry associated with oligonucleotides and peptides that present different reactive functional groups, the newly developed chemistry needs to be selective, quantitative and bio-compatible, therefore our research also focuses on creating new chemistry tools for the selective modification of oligonucleotides and peptides, for efficient drug delivery into specific cells.
Research interests
1) Peptide Nucleic Acids (PNAs) as antisense antibiotics
2) Backbone modified antisense oligonucleotides
3) Polymyxin based antibiotic drug development
External positions
Honorary Fellow
26 Aug 2017 → 1 Jan 2018Research area keywords
- Peptide Chemistry
- Oligonucleotides
- Organic chemistry
- Medicinal Chemistry
- Pharmacology
- Pharmacy
- Drug Development
- Drug Delivery
- Drug Design
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
- 2 Active
Integrating AI, Big Data and Smart Drug Design against 'Superbugs'
Song, J., Li, J., Patil, N., Schmidt, D. & Thompson, P.
1/01/20 → 31/12/22
Project: Research
Targeting pan-drug resistant (PDR) Gram-negative pathogens with novel anti-sense drug technology
1/01/19 → 31/12/22
Project: Research
Research Output
Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance
Zhu, Y., Lu, J., Han, M-L., Jiang, X., Azad, M. A. K., Patil, N. A., Lin, Y-W., Zhao, J., Hu, Y., Yu, H. H., Chen, K., Boyce, J. D., Dunstan, R. A., Lithgow, T., Barlow, C. K., Li, W., Schneider-Futschik, E. K., Wang, J., Gong, B., Sommer, B. & 6 others, , 8 Jun 2020, (Accepted/In press) In : Advanced Science. 13 p., 2000704.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides
Patil, N. A., Karas, J. A., Wade, J. D., Hossain, M. A. & Tailhades, J., 26 Jun 2019, In : Chemistry - A European Journal. 25, 36, p. 8599-8603 5 p.Research output: Contribution to journal › Article › Research › peer-review
1
Citation
(Scopus)
The Adsorption of Amyloidogenic Peptides to Functionalized Surfaces Is Biased by Charge and Hydrophilicity
John, T., Greene, G. W., Patil, N. A., Dealey, T. J. A., Hossain, M. A., Abel, B. & Martin, L. L., 12 Nov 2019, In : Langmuir. 35, 45, p. 14522-14531 10 p.Research output: Contribution to journal › Article › Research › peer-review
2
Citations
(Scopus)
The Kinetics of Amyloid Fibrillar Aggregation of Uperin 3.5 Is Directed by the Peptide's Secondary Structure
John, T., Dealey, T. J. A., Gray, N. P., Patil, N. A., Hossain, M. A., Abel, B., Carver, J. A., Hong, Y. & Martin, L. L., 6 Aug 2019, In : Biochemistry. 58, 35, p. 3656-3668 13 p.Research output: Contribution to journal › Article › Research › peer-review
2
Citations
(Scopus)
Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates
Patil, N. A., Karas, J. A., Turner, B. J. & Shabanpoor, F., 20 Mar 2019, In : Bioconjugate Chemistry. 30, 3, p. 793-799 7 p.Research output: Contribution to journal › Article › Research › peer-review
2
Citations
(Scopus)
Prizes
Albert Shimmins Postgraduate Writing Up Award
Patil, Nitin (Recipient), 15 Jul 2016
Prize: Prize (including medals and awards)
American Peptide Symposium Student Travel Award
Patil, Nitin (Recipient), 2015
Prize: Prize (including medals and awards)
Best Research Article Award
Patil, Nitin (Recipient), 24 May 2017
Prize: Prize (including medals and awards)
Bridging Postdoctoral Research Fellow
Patil, Nitin (Recipient), 1 Feb 2018
Prize: Competitive Fellowships
Activities
MNHS Graduate Research Mentoring Program
Nitin Patil (Mentor)
2019 → …
Activity: Other Teaching Engagements and non-HDR Supervisions › Mentor/ Internship supervision
Organic Letters (Journal)
Nitin Patil (Peer reviewer)
1 Dec 2019 → …
Activity: Publication peer-review and editorial work types › Peer review responsibility
Bioorganic Chemistry (Journal)
Nitin Patil (Peer reviewer)
2019 → …
Activity: Publication peer-review and editorial work types › Peer review responsibility
Opportunities to reduce drug resistance and the role of international collaboration in AMR
Nitin Patil (Contributor)
31 Jan 2019
Activity: Community Talks, Presentations, Exhibitions and Events › Public lecture/debate/seminar
Communications Biology (Journal)
Nitin Patil (Peer reviewer)
1 Dec 2019 → …
Activity: Publication peer-review and editorial work types › Peer review responsibility
Press / Media
Monash BDI researchers secure six NHMRC Fellowships
15/08/18
1 item of Media coverage
Press/Media: Article/Feature