Projects per year
Personal profile
Biography
Our research takes inspiration from the various mechanisms that Nature has developed to produce, modify, and transport biomolecules in specific cells throughout evolution. Using a multidisciplinary approach, we aim to develop new therapeutics, with a focus on oligonucleotides and peptide-based treatments.
Oligonucleotides and peptides have complex chemistry, with various reactive functional groups that make developing new chemistry tools for their selective modification and efficient delivery into specific cells challenging. Our research recognizes these challenges and aims to create new chemistry tools that are selective, quantitative, and bio-compatible, to enable the development of efficient drug delivery methods for these biomolecules. In short, our research focuses on developing new chemistry tools for the selective modification of oligonucleotides and peptides, to facilitate their efficient drug delivery into specific cells.
Research interests
Nucleic acids, which include DNA, RNA, and other oligonucleotides, are truly remarkable and complex molecules that are essential for life. Nucleic acids play a crucial role in storing, transmitting, and expressing genetic information in all living organisms. Their astonishing ability to recognize and bind to specific complementary nucleic acids sequences, and self-assemble into complex three-dimensional structures, has led to the development of novel applications beyond their traditional biological roles.
At the Patil Lab, we focus on utilizing these unique properties to design and develop cutting-edge therapeutics, biosensors, and biochemical tools. By exploiting the molecular recognition and self-assembly properties of nucleic acids, we can generate functional architectures that enable us to study and manipulate cellular processes.
We're particularly interested in exploring how we can use both synthetic and natural oligonucleotides in combination with other biomolecules to create new tools for various applications. These applications include detecting diseases, developing new and innovative treatments, reviving existing therapeutics and studying fundamental biological processes at the molecular level.
By combining oligonucleotides with other biomolecules, we can create novel architectures and systems that can detect and respond to specific targets with high sensitivity and precision. These new tools and techniques have the potential to revolutionize the way we study and treat diseases and advance our understanding of the fundamental workings of biology.
1) Peptide Nucleic Acids (PNAs) as antisense antibiotics
2) Backbone-modified antisense oligonucleotides
3) Lipopeptide-based antibiotic drug development
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary Fellow
26 Aug 2017 → 1 Jan 2018
Research area keywords
- Peptide Chemistry
- Oligonucleotides
- Organic chemistry
- Medicinal Chemistry
- Pharmacology
- Pharmacy
- Drug Development
- Drug Delivery
- Drug Design
Network
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Integrating AI, Big Data and Smart Drug Design against 'Superbugs'
Song, J., Li, J., Patil, N., Schmidt, D. & Thompson, P.
1/01/20 → 31/12/23
Project: Research
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Targeting pan-drug resistant (PDR) Gram-negative pathogens with novel anti-sense drug technology
1/01/19 → 31/12/22
Project: Research
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Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity
Patil, N. A., Ma, W., Jiang, X., He, X., Yu, H. H., Wickremasinghe, H., Wang, J., Thompson, P. E., Velkov, T., Roberts, K. D. & Li, J., 6 Feb 2023, In: Journal of Medicinal Chemistry. 66, 4, p. 2865–2876 12 p.Research output: Contribution to journal › Article › Research › peer-review
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An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates
Patil, N. A., Thombare, V. J., Li, R., He, X., Lu, J., Yu, H. H., Wickremasinghe, H., Pamulapati, K., Azad, M. A. K., Velkov, T., Roberts, K. D. & Li, J., 15 Mar 2022, In: Frontiers in Chemistry. 10, 10 p., 843163.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
An Intelligent Strategy with All-Atom Molecular Dynamics Simulations for the Design of Lipopeptides against Multidrug-Resistant Pseudomonas aeruginosa
Jiang, X., Han, M., Tran, K., Patil, N. A., Ma, W., Roberts, K. D., Xiao, M., Sommer, B., Schreiber, F., Wang, L., Velkov, T. & Li, J., 28 Jul 2022, In: Journal of Medicinal Chemistry. 65, 14, p. 10001-10013 13 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens
Roberts, K. D., Zhu, Y., Azad, M. A. K., Han, M. L., Wang, J., Wang, L., Yu, H. H., Horne, A. S., Pinson, J. A., Rudd, D., Voelcker, N. H., Patil, N. A., Zhao, J., Jiang, X., Lu, J., Chen, K., Lomovskaya, O., Hecker, S. J., Thompson, P. E., Nation, R. L., & 4 others , 2022, In: Nature Communications. 13, 1, 15 p., 1625.Research output: Contribution to journal › Article › Research › peer-review
Open Access22 Citations (Scopus) -
Conjugation approaches for peptide-mediated delivery of oligonucleotides therapeutics
Patil, N. A., 2022, In: Australian Journal of Chemistry. 75, 2, p. 24-33 10 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus)
Prizes
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Albert Shimmins Postgraduate Writing Up Award
Patil, Nitin (Recipient), 15 Jul 2016
Prize: Prize (including medals and awards)
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American Peptide Symposium Student Travel Award
Patil, Nitin (Recipient), 2015
Prize: Prize (including medals and awards)
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Best Research Article Award
Patil, Nitin (Recipient), 24 May 2017
Prize: Prize (including medals and awards)
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Bridging Postdoctoral Research Fellow
Patil, Nitin (Recipient), 1 Feb 2018
Prize: Competitive Fellowships
Activities
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Bioorganic Chemistry (Journal)
Nitin Patil (Peer reviewer)
2019 → …Activity: Publication peer-review and editorial work types › Peer review responsibility
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Organic Letters (Journal)
Nitin Patil (Peer reviewer)
1 Dec 2019 → …Activity: Publication peer-review and editorial work types › Peer review responsibility
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Communications Biology (Journal)
Nitin Patil (Peer reviewer)
1 Dec 2019 → …Activity: Publication peer-review and editorial work types › Peer review responsibility
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MNHS Graduate Research Mentoring Program
Nitin Patil (Mentor)
2019 → …Activity: Other Teaching Engagements and non-HDR Supervisions › Mentor/ Internship supervision
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Opportunities to reduce drug resistance and the role of international collaboration in AMR
Nitin Patil (Contributor)
31 Jan 2019Activity: Community Talks, Presentations, Exhibitions and Events › Public lecture/debate/seminar
Press/Media
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Monash BDI researchers secure six NHMRC Fellowships
15/08/18
1 item of Media coverage
Press/Media: Article/Feature