Personal profile

Biography

The brain is a remarkably dynamic organ that is continually reorganising and adapting its structure and function. These rapid and long term changes give rise to our thoughts, govern how we perceive our environment and allow us to either retain information in our mind for brief periods or to store information over many years. Even subtle disruptions in the mechanisms governing brain dynamics can have devastating effects on social and cognitive functioning and possibly underlie mental illnesses such as schizophrenia. As such, understanding the functional importance of the mechanisms responsible for dynamic brain organisation is a key focus of neuroscience research.

One method particularly suited to studying the dynamic brain is transcranial magnetic stimulation (TMS), a non-invasive method of stimulating cortical brain regions in living humans. TMS is a versatile technique which can be used to probe specific excitatory and inhibitory cortical circuits, to map connectivity between brain regions and to temporarily alter brain function by inducing neuroplasticity (i.e. transiently reorganising brain circuits). The ability of TMS to alter brain activity makes it a powerful tool to causally investigate the role of specific brain mechanisms, regions and networks in function and behaviour.

My research concentrates on combining TMS with neuroimaging techniques (EEG, MRI) to understand the role of excitatory/inhibitory mechanisms, brain organisation (oscillations, connectivity) and plasticity in healthy and unhealthy brain function. My specific interests include: understanding the brain mechanisms responsible for short and long term memory; developing concurrent TMS-EEG methods to non-invasively study cortical network properties; investigating whether abnormal excitation/inhibition, connectivity and plasticity contribute to cognitive deficits in mental illnesses such as schizophrenia; understanding how dynamic changes in brain organisation (i.e. oscillations, connectivity) give rise to improved or reduced behavioural performance (i.e. learning).

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Keywords

  • Transcranial magnetic stimulation
  • neuroimaging
  • schizophrenia
  • memory
  • plasticity

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Research Output 2008 2018

ARTIST: A fully automated artifact rejection algorithm for single-pulse TMS-EEG data

Wu, W., Keller, C. J., Rogasch, N. C., Longwell, P., Shpigel, E., Rolle, C. E. & Etkin, A. 1 Apr 2018 In : Human Brain Mapping. 39, 4, p. 1607-1625 19 p.

Research output: Contribution to journalArticle

Biophysical modeling of neural plasticity induced by transcranial magnetic stimulation

Wilson, M. T., Fulcher, B. D., Fung, P. K., Robinson, P. A., Fornito, A. & Rogasch, N. C. 1 Jun 2018 In : Clinical Neurophysiology. 129, 6, p. 1230-1241 12 p.

Research output: Contribution to journalReview Article

Cortical inhibition assessed using paired-pulse TMS-EEG is increased in older adults

Opie, G. M., Sidhu, S. K., Rogasch, N. C., Ridding, M. C. & Semmler, J. G. May 2018 In : Brain Stimulation. 11, 3, p. 545-557 13 p.

Research output: Contribution to journalArticle

GABA concentration in sensorimotor cortex following high-intensity exercise and relationship to lactate levels

Coxon, J. P., Cash, R. F. H., Hendrikse, J. J., Rogasch, N. C., Stavrinos, E., Suo, C. & Yücel, M. 15 Feb 2018 In : Journal of Physiology. 596, 4, p. 691-702 12 p.

Research output: Contribution to journalArticle