20082019
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Personal profile

Biography

The brain is a remarkably dynamic organ that is continually reorganising and adapting its structure and function. These rapid and long term changes give rise to our thoughts, govern how we perceive our environment and allow us to either retain information in our mind for brief periods or to store information over many years. Even subtle disruptions in the mechanisms governing brain dynamics can have devastating effects on social and cognitive functioning and possibly underlie mental illnesses such as schizophrenia. As such, understanding the functional importance of the mechanisms responsible for dynamic brain organisation is a key focus of neuroscience research.

One method particularly suited to studying the dynamic brain is transcranial magnetic stimulation (TMS), a non-invasive method of stimulating cortical brain regions in living humans. TMS is a versatile technique which can be used to probe specific excitatory and inhibitory cortical circuits, to map connectivity between brain regions and to temporarily alter brain function by inducing neuroplasticity (i.e. transiently reorganising brain circuits). The ability of TMS to alter brain activity makes it a powerful tool to causally investigate the role of specific brain mechanisms, regions and networks in function and behaviour.

My research concentrates on combining TMS with neuroimaging techniques (EEG, MRI) to understand the role of excitatory/inhibitory mechanisms, brain organisation (oscillations, connectivity) and plasticity in healthy and unhealthy brain function. My specific interests include: understanding the brain mechanisms responsible for short and long term memory; developing concurrent TMS-EEG methods to non-invasively study cortical network properties; investigating whether abnormal excitation/inhibition, connectivity and plasticity contribute to cognitive deficits in mental illnesses such as schizophrenia; understanding how dynamic changes in brain organisation (i.e. oscillations, connectivity) give rise to improved or reduced behavioural performance (i.e. learning).

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Research area keywords

  • Transcranial magnetic stimulation
  • neuroimaging
  • schizophrenia
  • memory
  • plasticity

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Projects 2014 2018

Research Output 2008 2019

Clinical utility and prospective of TMS–EEG

Tremblay, S., Rogasch, N. C., Premoli, I., Blumberger, D. M., Casarotto, S., Chen, R., Di Lazzaro, V., Farzan, F., Ferrarelli, F., Fitzgerald, P. B., Hui, J., Ilmoniemi, R. J., Kimiskidis, V. K., Kugiumtzis, D., Lioumis, P., Pascual-Leone, A., Pellicciari, M. C., Rajji, T., Thut, G., Zomorrodi, R. & 2 others, Ziemann, U. & Daskalakis, Z. J., May 2019, In : Clinical Neurophysiology. 130, 5, p. 802-844 43 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Differentiating responders and non-responders to rTMS treatment for depression after one week using resting EEG connectivity measures

Bailey, NW., Hoy, KE., Rogasch, NC., Thomson, RH., McQueen, S., Elliot, D., Sullivan, CM., Fulcher, BD., Daskalakis, ZJ. & Fitzgerald, PB., 1 Jan 2019, In : Journal of Affective Disorders. 242, p. 68-79 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Impact of concurrent task performance on transcranial direct current stimulation (tDCS)-Induced changes in cortical physiology and working memory

Hill, A. T., Rogasch, N. C., Fitzgerald, P. B. & Hoy, K. E., 1 Apr 2019, In : Cortex. 113, p. 37-57 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Mindfulness Meditators Do Not Show Differences in Electrophysiological Measures of Error Processing

Bailey, N. W., Raj, K., Freedman, G., Fitzgibbon, B., Rogasch, N. C., Van Dam, N. T. & Fitzgerald, P. B., 15 Jul 2019, In : Mindfulness. 10, 7, p. 1360-1380 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Mindfulness meditators show altered distributions of early and late neural activity markers of attention in a response inhibition task

Bailey, N., Freedman, G., Raj, K., Sullivan, C., Rogasch, N., Chung, S., Hoy, K., Chambers, R., Hassed, C., Van Dam, N., Koenig, T. & Fitzgerald, P., 6 Aug 2019, In : PLoS ONE. 14, 8, 25 p., e0203096.

Research output: Contribution to journalArticleResearchpeer-review

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