Nigel Jones

Assoc Professor

Accepting PhD Students

19982022

Research output per year

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Research Output

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Article
2020
1 Citation (Scopus)

The genetic ablation of tau improves long-term, but not short-term, functional outcomes after experimental traumatic brain injury in mice

Tan, X. L., Zheng, P., Wright, D. K., Sun, M., Brady, R. D., Liu, S., McDonald, S. J., Mychasiuk, R., Cenap, S., Jones, N. C., O’Brien, T. J. & Shultz, S. R., 2020, In : Brain Injury. 34, 1, p. 131–139 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Cognitive deficits in a rat model of temporal lobe epilepsy using touchscreen-based translational tools

Carron, S., Dezsi, G., Ozturk, E., Nithianantharajah, J. & Jones, N. C., Aug 2019, In : Epilepsia. 60, 8, p. 1650-1660 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy

Casillas-Espinosa, P. M., Shultz, S. R., Braine, E. L., Jones, N. C., Snutch, T. P., Powell, K. L. & O'Brien, T. J., Nov 2019, In : Progress in Neurobiology. 182, 11 p., 101677.

Research output: Contribution to journalArticleResearchpeer-review

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Santana-Gomez, C., Andrade, P., Hudson, M. R., Paananen, T., Ciszek, R., Smith, G., Ali, I., Rundle, B. K., Ndode-Ekane, X. E., Casillas-Espinosa, P. M., Immonen, R., Puhakka, N., Jones, N., Brady, R. D., Perucca, P., Shultz, S. R., Pitkänen, A., O'Brien, T. J. & Staba, R., Oct 2019, In : Epilepsy Research. 156, 8 p., 106110.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Kamnaksh, A., Puhakka, N., Ali, I., Smith, G., Aniceto, R., McCullough, J., Das Gupta, S., Ndode-Ekane, X. E., Brady, R., Casillas-Espinosa, P., Hudson, M., Santana-Gomez, C., Immonen, R., Abreu, P. A. D., Jones, N., Shultz, S., Staba, R. J., O'Brien, T. J., Agoston, D. & Pitkänen, A., 1 Jan 2019, In : Epilepsy Research. 149, p. 92-101 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Casillas-Espinosa, P. M., Andrade, P., Santana-Gomez, C., Paananen, T., Smith, G., Ali, I., Ciszek, R., Ndode-Ekane, X. E., Brady, R. D., Tohka, J., Hudson, M. R., Perucca, P., Braine, E. L., Immonen, R., Puhakka, N., Shultz, S. R., Jones, N. C., Staba, R. J., Pitkänen, A. & O'Brien, T. J., Oct 2019, In : Epilepsy Research. 156, 10 p., 106131.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

High-Frequency Neuronal Oscillatory Abnormalities in the Phospholipase C-β1 Knockout Mouse Model of Schizophrenia

Hudson, M. R., Hannan, A. J., O'Brien, T. J. & Jones, N. C., 1 Mar 2019, In : International Journal of Neuropsychopharmacology. 22, 3, p. 221-231 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Raloxifene recovers effects of prenatal immune activation on cognitive task-induced gamma power

Schroeder, A., Nakamura, J. P., Hudson, M., Jones, N. C., Du, X., Sundram, S. & Hill, R. A., 1 Dec 2019, In : Psychoneuroendocrinology. 110, 12 p., 104448.

Research output: Contribution to journalArticleResearchpeer-review

Selective serotonin reuptake inhibitors and risk of epilepsy after traumatic brain injury – A population based cohort study

Christensen, J., Pedersen, H. S., Fenger-Grøn, M., Fann, J. R., Jones, N. C. & Vestergaard, M., 19 Jul 2019, In : PLoS ONE. 14, 7, 16 p., e0219137.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring

Sivathamboo, S., Farrand, S., Chen, Z., White, E. J., Pattichis, A. A., Hollis, C., Carino, J., Roberts, C. J., Minogue, T., Jones, N. C., Yerra, R., French, C., Perucca, P., Kwan, P., Velakoulis, D., O'Brien, T. J. & Goldin, J., 15 Jan 2019, In : Neurology. 92, 3, p. e194-e204 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma

Luwor, R., Morokoff, A. P., Amiridis, S., D’Abaco, G., Paradiso, L., Stylli, S. S., Nguyen, H. P. T., Tarleton, M., Young, K. A., O’Brien, T. J., Robinson, P. J., Chircop, M., McCluskey, A. & Jones, N. C., 16 Mar 2019, In : Cancer Investigation. 37, 3, p. 144-155 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Webster, K. M., Shultz, S. R., Ozturk, E., Dill, L. K., Sun, M., Casillas-Espinosa, P., Jones, N. C., Crack, P. J., O'Brien, T. J. & Semple, B. D., 1 Oct 2019, In : Experimental Neurology. 320, 14 p., 112979.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The maternal immune activation model uncovers a role for the Arx gene in GABAergic dysfunction in schizophrenia

Nakamura, J. P., Schroeder, A., Hudson, M., Jones, N., Gillespie, B., Du, X., Notaras, M., Swaminathan, V., Reay, W. R., Atkins, J. R., Green, M. J., Carr, V. J., Cairns, M. J., Sundram, S. & Hill, R. A., Oct 2019, In : Brain, Behavior, and Immunity. 81, p. 161-171 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The mGluR2/3 agonist LY379268 reverses NMDA receptor antagonist effects on cortical gamma oscillations and phase coherence, but not working memory impairments, in mice

Sokolenko, E., Hudson, M. R., Nithianantharajah, J. & Jones, N. C., 1 Dec 2019, In : Journal of Psychopharmacology. 33, 12, p. 1588-1599 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2018

A companion to the preclinical common data elements on neurobehavioral comorbidities of epilepsy: a report of the TASK3 behavior working group of the ILAE/AES Joint Translational Task Force

Mazarati, A., Jones, N., Galanopoulou, A. S., Harte‐Hargrove, L. C., Kalynchuk, L. E., Lenck‐Santini, PP., Medel‐Matus, JS., Nehlig, A., de la Prida, L. M., Sarkisova, K. & Veliskova, J., 1 Nov 2018, In : Epilepsia Open. 3, p. 24-52 29 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
6 Citations (Scopus)

Brain-derived neurotrophic factor haploinsufficiency impairs high-frequency cortical oscillations in mice

Jones, N. C., Hudson, M., Foreman, J., Rind, G., Hill, R., Manning, E. E. & van den Buuse, M., Oct 2018, In : European Journal of Neuroscience. 48, 8, p. 2816-2825 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Chronic fluoxetine treatment accelerates kindling epileptogenesis in mice independently of 5-HT2A receptors

Li, C., Silva, J., Ozturk, E., Dezsi, G., O'Brien, T. J., Renoir, T. & Jones, N. C., 1 Jul 2018, In : Epilepsia. 59, 7, p. e114-e119 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Somatic GNAQ mutation in the forme fruste of Sturge-Weber syndrome

Hildebrand, M. S., Harvey, S. A., Malone, S., Damiano, J. A., Do, H., Ye, Z., McQuillan, L., Maixner, W. J., Kalnins, R., Nolan, B., Wood, M., Ozturk, E., Jones, N., Gillies, G., Pope, K., Lockhart, P. J., Dobrovic, A., Leventer, R. J., Scheffer, I. E. & Berkovic, S. F., 1 Jun 2018, In : Neurology: Genetics. 4, 3, 5 p., e236.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)
2017

Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice

Liu, S., Shen, Y., Shultz, S. R., Nguyen, A., Hovens, C., Adlard, P. A., Bush, A. I., Chan, J., Kwan, P., O'Brien, T. J. & Jones, N. C., 1 Sep 2017, In : Epilepsia. 58, 9, p. e136-e141 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Disease-Modifying Effects of Neural Regeneration Peptide 2945 in the GAERS Model of Absence Epilepsy

Dezsi, G., Sieg, F., Thomas, M., O’Brien, T. J., van der Hart, M. & Jones, N. C., 1 Jul 2017, In : Neurochemical Research. 42, 7, p. 2055-2064 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Estradiol and raloxifene modulate hippocampal gamma oscillations during a spatial memory task

Schroeder, A., Hudson, M., Du, X., Wu, Y. W. C., Nakamura, J., van den Buuse, M., Jones, N. C. & Hill, R., 1 Apr 2017, In : Psychoneuroendocrinology. 78, p. 85-92 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Evaluating whole genome sequence data from the genetic absence epilepsy rat from strasbourg and its related non-epileptic strain

Casillas-Espinosa, P. M., Powell, K. L., Zhu, M., Campbell, C. R., Maia, J. M., Ren, Z., Jones, N. C., O'Brien, T. J. & Petrovski, S., 1 Jul 2017, In : PLoS ONE. 12, 7, 14 p., e0179924.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Extensive phenotyping of two ARX polyalanine expansion mutation mouse models that span clinical spectrum of intellectual disability and epilepsy

Jackson, M. R., Lee, K., Mattiske, T., Jaehne, E. J., Ozturk, E., Baune, B. T., O'Brien, T. J., Jones, N. & Shoubridge, C., 1 Sep 2017, In : Neurobiology of Disease. 105, p. 245-256 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Local NMDA receptor hypofunction evokes generalized effects on gamma and high-frequency oscillations and behavior

Lee, J., Hudson, M. R., O'Brien, T. J., Nithianantharajah, J. & Jones, N. C., 1 Sep 2017, In : Neuroscience. 358, p. 124-136 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Sensitive quantitative detection of somatic mosaic mutation in “double cortex” syndrome

Damiano, J. A., Do, H., Ozturk, E., Burgess, R., Kalnins, R., Jones, N. C., Dobrovic, A., Berkovic, S. F. & Hildebrand, M. S., 1 Dec 2017, In : Epileptic Disorders. 19, 4, p. 450-455 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states

Barry, G., Briggs, J. A., Hwang, D. W., Nayler, S. P., Fortuna, P. R. J., Jonkhout, N., Dachet, F., Maag, J. L. V., Mestdagh, P., Singh, E. M., Avesson, L., Kaczorowski, D. C., Ozturk, E., Jones, N. C., Vetter, I., Arriola-Martinez, L., Hu, J., Franco, G. R., Warn, V. M., Gong, A. & 10 others, Dinger, M. E., Rigo, F., Lipovich, L., Morris, M. J., O'Brien, T. J., Lee, D. S., Loeb, J. A., Blackshaw, S., Mattick, J. S. & Wolvetang, E. J., 5 Jan 2017, In : Scientific Reports. 7, 11 p., 40127.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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35 Citations (Scopus)

The N -Methyl d -Aspartate Glutamate Receptor Antagonist Ketamine Disrupts the Functional State of the Corticothalamic Pathway

Anderson, P. M., Jones, N. C., O'Brien, T. J. & Pinault, D., 1 Jun 2017, In : Cerebral Cortex. 27, 6, p. 3172-3185 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)
2016

Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype

Minter, M. R., Moore, Z., Zhang, M., Brody, K. M., Jones, N. C., Shultz, S. R., Taylor, J. M. & Crack, P. J., 11 Jul 2016, In : Acta neuropathologica communications. 4, 1, 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Environmental enrichment delays limbic epileptogenesis and restricts pathologic synaptic plasticity

Yang, M., Ozturk, E., Salzberg, M. R., Rees, S., Morris, M., O'Brien, T. J. & Jones, N. C., 1 Mar 2016, In : Epilepsia. 57, 3, p. 484-494 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety

Dezsi, G., Ozturk, E., Salzberg, M. R., Morris, M., O'Brien, T. J. & Jones, N. C., 1 Sep 2016, In : Neurobiology of Disease. 93, p. 129-136 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Mutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy

Hildebrand, M. S., Griffin, N. G., Damiano, J. A., Cops, E. J., Burgess, R., Ozturk, E., Jones, N. C., Leventer, R. J., Freeman, J. L., Harvey, A. S., Sadleir, L. G., Scheffer, I. E., Major, H., Darbro, B. W., Allen, A. S., Goldstein, D. B., Kerrigan, J. F., Berkovic, S. F. & Heinzen, E. L., 4 Aug 2016, In : American Journal of Human Genetics. 99, 2, p. 423-429 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Neurological Dysfunction in Early Maturity of a Model for Niemann–Pick C1 Carrier Status

Hung, Y. H., Walterfang, M., Churilov, L., Bray, L., Jacobson, L. H., Barnham, K. J., Jones, N. C., O’Brien, T. J., Velakoulis, D. & Bush, A. I., 1 Jul 2016, In : Neurotherapeutics. 13, 3, p. 614-622 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Reversal of evoked gamma oscillation deficits is predictive of antipsychotic activity with a unique profile for clozapine

Hudson, M. R., Rind, G., O'Brien, T. J. & Jones, N. C., 19 Apr 2016, In : Translational Psychiatry. 6, 9 p., e784.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau

Liu, S. J., Zheng, P., Wright, D. K., Dezsi, G., Braine, E., Nguyen, T., Corcoran, N. M., Johnston, L. A., Hovens, C. M., Mayo, J. N., Hudson, M., Shultz, S. R., Jones, N. C. & O'Brien, T. J., 1 Jul 2016, In : Brain. 139, 7, p. 1919-1938 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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46 Citations (Scopus)
2015

A mouse model of Alzheimer's disease displays increased susceptibility to kindling and seizure-associated death

Chan, J., Jones, N. C., Bush, A. I., O'Brien, T. J. & Kwan, P., 1 Jun 2015, In : Epilepsia. 56, 6, p. e73-e77 5 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Memory impairment in rats after desflurane anesthesia is age and dose dependent

Callaway, J. K., Jones, N. C., Royse, A. G. & Royse, C. F., 2015, In : Journal of Alzheimer's Disease. 44, 3, p. 995-1005 11 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Neuregulin 1 expression and electrophysiological abnormalities in the Neuregulin 1 transmembrane domain heterozygous mutant mouse

Long, L. E., Anderson, P., Frank, E., Shaw, A., Liu, S., Huang, X. F., Pinault, D., Karl, T., O'Brien, T. J., Weickert, C. S. & Jones, N. C., 19 May 2015, In : PLoS ONE. 10, 5, e0124114.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Schultz, S. R., Wright, D. K., Zheng, P., Stuchbery, R., Liu, S-J., Sashindranath, M., Medcalf, R. L., Johnston, L. A., Hovens, C. M., Jones, N. C. & O'Brien, T. J., 2015, In : Brain. 138, 5, p. 1297 - 1313 17 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)
2014

Chronic administration of antipsychotics attenuates ongoing and ketamine-induced increases in cortical γ oscillations

Anderson, P. M., Pinault, D., O'Brien, T. J. & Jones, N. C., 29 Nov 2014, In : International Journal of Neuropsychopharmacology. 17, 11, p. 1895-1904 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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25 Citations (Scopus)

Chronic antidepressant treatment accelerates kindling epileptogenesis in rats

Cardamone, L., Salzberg, M. R., Koe, A. S., Ozturk, E., O'Brien, T. J. & Jones, N. C., 2014, In : Neurobiology of Disease. 63, p. 194-200 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Early life maternal separation stress augmentation of limbic epileptogenesis: The role of corticosterone and HPA axis programming

Koe, A. S., Salzberg, M. R., Morris, M. J., O'Brien, T. J. & Jones, N. C., 2014, In : Psychoneuroendocrinology. 42, p. 124-133 10 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Effects of aberrant gamma frequency oscillations on prepulse inhibition

Jones, N. C., Anderson, P., Rind, G., Sullivan, C., Van Den Buuse, M. & O'Brien, T. J., 2014, In : International Journal of Neuropsychopharmacology. 17, 10, p. 1671-1681 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Granulocyte-macrophage colony-stimulating factor is neuroprotective in experimental traumatic brain injury

Shultz, S. R., Tan, X. L., Wright, D. K., Liu, S. J., Semple, B. D., Johnston, L., Jones, N. C., Cook, A. D., Hamilton, J. A. & O'Brien, T. J., 15 May 2014, In : Journal of Neurotrauma. 31, 10, p. 976-983 8 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

HCN channelopathy and cardiac electrophysiologic dysfunction in genetic and acquired rat epilepsy models

Powell, K. L., Jones, N. C., Kennard, J. T., Ng, C., Urmaliya, V., Lau, S., Tran, A., Zheng, T., Ozturk, E., Dezsi, G., Megatia, I., Delbridge, L. M. D., Pinault, D., Reid, C. A., White, P. J. & O'Brien, T. J., 2014, In : Epilepsia. 55, 4, p. 609 - 620 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Seizure expression, behavior, and brain morphology differences in colonies of Genetic Absence Epilepsy Rats from Strasbourg

Powell, K. L., Tang, H., Ng, C., Guillemain, I., Dieuset, G., Dezsi, G., Çarçak, N., Onat, F., Martin, B., O'Brien, T. J., Depaulis, A. & Jones, N. C., 1 Dec 2014, In : Epilepsia. 55, 12, p. 1959-1968 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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32 Citations (Scopus)

The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy

Çarçak, N., Zheng, T., Ali, I., Abdullah, A., French, C., Powell, K. L., Jones, N. C., Van Raay, L., Rind, G., Onat, F. & O'Brien, T. J., 2014, In : Epilepsia. 55, 5, p. 654-665 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)
2013

Axon initial segment structural plasticity in animal models of genetic and acquired epilepsy

Harty, R. C., Kim, T. H., Thomas, E. A., Cardamone, L., Jones, N. C., Petrou, S. & Wimmer, V. C., Aug 2013, In : Epilepsy Research. 105, 3, p. 272-279 8 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Can structural or functional changes following traumatic brain injury in the rat predict epileptic outcome?

Shultz, S. R., Cardamone, L., Liu, Y. R., Edward Hogan, R., MacCotta, L., Wright, D. K., Zheng, P., Koe, A., Gregoire, M. C., Williams, J. P., Hicks, R. J., Jones, N. C., Myers, D. E., O'Brien, T. J. & Bouilleret, V., Jul 2013, In : Epilepsia. 54, 7, p. 1240-1250 11 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

DNA Methylation Mediates Persistent Epileptiform Activity In Vitro and In Vivo

Machnes, Z. M., Huang, T. C. T., Chang, P. K. Y., Gill, R., Reist, N., Dezsi, G., Ozturk, E., Charron, F., O'Brien, T. J., Jones, N. C., McKinney, R. A. & Szyf, M., 2 Oct 2013, In : PLoS ONE. 8, 10, e76299.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
33 Citations (Scopus)