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Research Output

2019

Downregulation of MHC Class I Expression by Influenza A and B Viruses

Koutsakos, M., McWilliam, H. E. G., Aktepe, T. E., Fritzlar, S., Illing, P. T., Mifsud, N. A., Purcell, A. W., Rockman, S., Reading, P. C., Vivian, J. P., Rossjohn, J., Brooks, A. G., Mackenzie, J. M., Mintern, J. D., Villadangos, J. A., Nguyen, T. H. O. & Kedzierska, K., 29 May 2019, In : Frontiers in Immunology. 10, 12 p., 1158.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

HLA-associated antiepileptic drug-induced cutaneous adverse reactions

Mullan, K. A., Anderson, A., Illing, P. T., Kwan, P., Purcell, A. W. & Mifsud, N. A., Jun 2019, In : HLA. 93, 6, p. 417-435 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

Human CD8 + T cell cross-reactivity across influenza A, B and C viruses

Koutsakos, M., Illing, P. T., Nguyen, T. H. O., Mifsud, N. A., Crawford, J. C., Rizzetto, S., Eltahla, A. A., Clemens, E. B., Sant, S., Chua, B. Y., Wong, C. Y., Allen, E. K., Teng, D., Dash, P., Boyd, D. F., Grzelak, L., Zeng, W., Hurt, A. C., Barr, I., Rockman, S. & 17 others, Jackson, D. C., Kotsimbos, T. C., Cheng, A. C., Richards, M., Westall, G. P., Loudovaris, T., Mannering, S. I., Elliott, M., Tangye, S. G., Wakim, L. M., Rossjohn, J., Vijaykrishna, D., Luciani, F., Thomas, P. G., Gras, S., Purcell, A. W. & Kedzierska, K., 18 Feb 2019, In : Nature Immunology. 20, p. 613-625 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)
Open Access
3 Citations (Scopus)
2018

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Faridi, P., Li, C., Ramarathinam, S. H., Vivian, J. P., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Hertzog, P. J., Ternette, N., Rossjohn, J., Croft, N. P. & Purcell, A. W., 12 Oct 2018, In : Science Immunology. 3, 28, 12 p., eaar3947.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Illing, P. T., Pymm, P., Croft, N. P., Hilton, H. G., Jojic, V., Han, A. S., Mendoza, J. L., Mifsud, N. A., Dudek, N. L., McCluskey, J., Parham, P., Rossjohn, J., Vivian, J. P. & Purcell, A. W., 8 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4693.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Identification of native and posttranslationally modified HLA-B*57:01- restricted HIV envelope derived epitopes using immunoproteomics

Ramarathinam, S. H., Gras, S., Alcantara, S., Yeung, A. W. S., Mifsud, N. A., Sonza, S., Illing, P., Glaros, E. N., Center, R. J., Thomas, S. R., Kent, S. J., Ternette, N., Purcell, D. F. J., Rossjohn, J. & Purcell, A. W., Jun 2018, In : Proteomics. 18, 12, 11 p., 1700253.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Inability to detect cross-reactive memory T cells challenges the frequency of heterologous immunity among common viruses

Rowntree, L. C., Nguyen, T. H. O., Halim, H., Purcell, A. W., Rossjohn, J., Gras, S., Kotsimbos, T. C. & Mifsud, N. A., 15 Jun 2018, In : Journal of Immunology. 200, 12, p. 3993-4003 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2017

Maintenance of the EBV-specific CD8+ TCRαβ repertoire in immunosuppressed lung transplant recipients

Nguyen, T. HO., Bird, N. L., Grant, E. J., Miles, J. J., Thomas, P. G., Kotsimbos, T. C., Mifsud, N. A. & Kedzierska, K., Jan 2017, In : Immunology and Cell Biology. 95, 1, p. 77-86 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)
2016

Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions

Illing, P. T., Mifsud, N. A. & Purcell, A. W., Oct 2016, In : Current Opinion in Immunology. 42, p. 31-40 10 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

21 Citations (Scopus)
4 Citations (Scopus)

HLA and Drug Hypersensitivity

Illing, P. T., Mifsud, N. A., Vivian, J. P. & Purcell, A. W., 27 Apr 2016, Molecular Immunology. Academic Press, Vol. 2. p. 310-317 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2015

Dendritic cell-mediated phagocytosis but not immune activation is enhanced by plasmin

Borg, R., Samson, A. L., Au, A. E-L., Scholzen, A., Fuchsberger, M., Kong, Y. Y., Freeman, R., Mifsud, N. A., Plebanski, M. & Medcalf, R. L., 2015, In : PLoS ONE. 10, 7 , 19 p., e0131216.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

Exhaled breath condensate pepsin: potential noninvasive test for gastroesophageal reflux in COPD and bronchiectasis

Lee, A., Button, B., Denehy, L., Roberts, S. K., Bamford, T. L., Mu, F-T., Mifsud, N. A., Stirling, R. G. & Wilson, J. W., 2015, In : Respiratory care. 60, 2, p. 244-250 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology

Hardy, C. L., King, S. J., Mifsud, N. A., Hedger, M. P., Phillips, D. J., Mackay, F., de Kretser, D. M., Wilson, J. W., Rolland, J. M. & O'Hehir, R. E., Jul 2015, In : Immunology and Cell Biology. 93, 6, p. 567-574 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

The oral iron chelator deferasirox inhibits NF-kappaB mediated gene expression without impacting on proximal activation: implications for myelodysplasia and aplastic anaemia

Banerjee, A., Mifsud, N. A., Bird, R. J., Forsyth, C. J., Szer, J., Tam, C., Kellner, S. V., Grigg, A. P., Motum, P., Bentley, M., Opat, S. & Grigoriadis, G., 2015, In : British Journal of Haematology. 168, 4, p. 576 - 582 7 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The presence of HLA-E-Restricted, CMV-Specific CD8+ T Cells in the blood of lung transplant recipients correlates with chronic allograft rejection

Sullivan, L. C., Westall, G. P., Widjaja, J. M. L., Mifsud, N. A., Nguyen, T. H. O., Meehan, A. C., Kotsimbos, T. C. & Brooks, A. G., 24 Aug 2015, In : PLoS ONE. 10, 8, 11 p., e0135972.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)
2014

Recognition of distinct cross-reactive virus-specific CD8+ T cells reveals a unique TCR signature in a clinical setting

Nguyen, T. H. O., Rowntree, L., Pellicci, D. G., Bird, N. L., Handel, A., Kjer-Nielsen, L., Kedzierska, K., Kotsimbos, A. T. C. & Mifsud, N. A., 2014, In : Journal of Immunology. 192, 11, p. 5039 - 5049 11 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Safety, feasibility, and effect of remote ischemic conditioning in patients undergoing lung transplantation

Lin, E., Snell, G. I., Levvey, B., Mifsud, N. A., Paul, M., Buckland, M., Gooi, J., Marasco, S., Sharland, A. F. & Myles, P. S., 2014, In : Journal of Heart and Lung Transplantation. 33, 11, p. 1139 - 1148 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2013

Clara cells and injury post lung transplantation: An evolving story (Letter)

Bourdin, A., Mifsud, N. A., Chanez, B., Snell, G. I. & Kotsimbos, A. T. C., 2013, In : American Journal of Transplantation. 13, 5, p. 1370 - 1370 1 p.

Research output: Contribution to journalLetterOther

1 Citation (Scopus)

Cross-reactive anti-viral T cells increase prior to an episode of viral reactivation post human lung transplantation

Nguyen, T. H. O., Westall, G. P., Bull, T. E., Meehan, A. C., Mifsud, N. A. & Kotsimbos, A. T. C., 2013, In : PLoS ONE. 8, 2, 12 p., e56042.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Endogenous-peptide-dependent alloreactivity: new scientific insights and clinical implications

D'Orsogna, L. J., Nguyen, T. H. O., Claas, F. HJ., Witt, C. S. & Mifsud, N. A., 2013, In : Tissue Antigens. 81, 6, p. 399 - 407 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Human leucocyte antigen-defined microchimerism early post-transplant does not predict for stable lung allograft function

Rowntree, L., Bayliss, J., Nguyen, T. H. O., Kotsimbos, A. T. C. & Mifsud, N. A., 2013, In : Clinical and Experimental Immunology. 172, 3, p. 483 - 489 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition

Meehan, A. C., Mifsud, N. A., Nguyen, T. H. O., Levvey, B., Snell, G. I., Kotsimbos, A. T. C. & Westall, G. P., 2013, In : PLoS ONE. 8, 3, 10 p., e60144.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)
2012

A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen

Zhao, R. Y., Mifsud, N. A., Xiao, K., Chan, K-F., Oveissi, S., Jackson, H., Dimopoulos, N., Guillaume, P., Knights, A. J., Lowen, T., Robson, N. C., Russell, S. E., Scotet, E., Davis, I., Maraskovsky, E., Cebon, J., Luescher, I. F. & Chen, W., 2012, In : PLoS ONE. 7, 9, 12 p., e44707.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Detection and characterisation of Alloreactive T cells

Bharadwaj, M., Mifsud, N. A. & McCluskey, J., 2012, Immunogenetics: Methods and Applications in Clinical Practice. Christiansen, F. T. (ed.). London: Humana Press, p. 309 - 337 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

1 Citation (Scopus)

Donor clara cell secretory protein polymorphism is a risk factor for bronchiolitis obliterans syndrome after lung transplantation

Bourdin, A., Mifsud, N. A., Chanez, B., McLean, C. A., Chanez, P., Snell, G. I. & Kotsimbos, A. T. C., 2012, In : Transplantation. 94, 6, p. 652 - 658 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2011

High levels of mannose-binding lectin are associated with poor outcomes after lung transplantation

Carroll, K. E., Dean, M. M., Heatley, S. L., Meehan, A. C., Mifsud, N., Kotsimbos, T. C., Snell, G. I. & Westall, G. P., 2011, In : Transplantation. 91, 9, p. 1044-1049 6 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
2010

Cross-presentation of HCMV chimeric protein enables generation and measurement of polyclonal T cells

Nguyen, T. H. O., Sullivan, L. C., Kotsimbos, T. C., Schwarer, A. P. & Mifsud, N. A., 2010, In : Immunology and Cell Biology. 88, 6, p. 676 - 684 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Influenza a infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7-and type I IFN-dependent fashion

Wei, J., Waithman, J., Lata, R., Mifsud, N., Cebon, J., Kay, T., Smyth, M., Sadler, A. & Chen, W., 2010, In : Journal of Immunology. 185, 10, p. 6013 - 6022 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Natural killer cell activation in the lung allograft early posttransplantation

Meehan, A. C., Sullivan, L. C., Mifsud, N. A., Brooks, A. G., Snell, G. I., Kotsimbos, T. C. & Westall, G. P., 2010, In : Transplantation. 89, p. 756 - 763 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipients

Mifsud, N. A., Nguyen, T. H. O., Tait, B. D. & Kotsimbos, A., 2010, In : Transplantation. 90, 12, p. 1439 - 1449 11 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Respiratory epithelium: an unlikely reservoir for latent human polyomavirus infection but a likely portal of entry.

Keating, D., Michaelides, A., Mifsud, N., Bowden, S. & Kotsimbos, A., 2010, In : Transplantation. 89, 5, p. 634 - 635 2 p.

Research output: Contribution to journalLetterOther

1 Citation (Scopus)
2009

Differential dynamics of donor DC and non-DC peripheral blood mononuclear cell microchimerism in lung transplantation

Van der Meulen, J. D., Mifsud, N. A., Abud, D., Paul, E., Varney, M., Lewin, S. R., Cameron, P. U. & Kotsimbos, T. C., 2009, In : Clinical Immunology. 133, 2, p. 179 - 183 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Pepsin, a measure of pulmonary microaspiration in COPD and bronchiectasis

Lee, A., Herbert, R. (ed.), Button, B., Denehy, L., Roberts, S., Bamford, T. L., Mifsud, N. A., Mu, F-T., Stirling, R. G. & Wilson, J. W., 2009, p. 13 - 13. 1 p.

Research output: Contribution to conferenceAbstract

2008

Cell-mediated rejection results in allograft loss after liver cell transplantation

Allen, K. J., Mifsud, N. A., Williamson, R., Bertolino, P. & Hardikar, W., 2008, In : Liver Transplantation. 14, 5, p. 688 - 694 7 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity

Chessman, D., Kostenko, L., Lethborg, T., Purcell, A. W., Williamson, N. A., Chen, Z., Kjer-Nielsen, L., Mifsud, N. A., Tait, B. D., Holdsworth, R., Almeida, C. A., Nolan, D., Macdonald, W. A., Archbold, J. K., Kellerher, A. D., Marriott, D., Mallal, S., Bharadwaj, M., Rossjohn, J. & McCluskey, J., 2008, In : Immunity. 28, 6, p. 822 - 832 11 p.

Research output: Contribution to journalArticleResearchpeer-review

238 Citations (Scopus)

Human Leukocyte Antigen Class I-Restricted Activation of CD8+ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity (DOI: 10.1016/j.immuni.2008.04.020)

Chessman, D., Kostenko, L., Lethborg, T., Purcell, A. W., Williamson, N. A., Chen, Z., Kjer-Nielsen, L., Mifsud, N. A., Tait, B. D., Holdsworth, R., Almeida, C. A., Nolan, D., Macdonald, W. A., Archbold, J. K., Kellerher, A. D., Marriott, D., Mallal, S., Bharadwaj, M., Rossjohn, J. & McCluskey, J., 18 Jul 2008, In : Immunity. 29, 1, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Immunodominance hierarchies and gender bias in direct Tcd8-cell alloreactivity

Mifsud, N. A., Purcell, A. W., Chen, W. W., Holdsworth, R., Tait, B. D. & McCluskey, J., 2008, In : American Journal of Transplantation. 8, 1, p. 121 - 132 12 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
69 Citations (Scopus)

Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity

Nguyen, T. H. O., Mifsud, N. A., Stewart, L. A., Rose, M. J., Etto, T. L., Williamson, N. A., Purcell, A. W., Kotsimbos, T. C. & Schwarer, A., 2008, In : Protein Expression and Purification. 61, 1, p. 22 - 30 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2006

Striking immunodominance hierarchy of naturally occurring CD8+ and CD4+ T cell responses to tumor antigen NY-ESO-1

Jackson, H., Dimopoulos, N., Mifsud, N. A., Tai, T. Y., Chen, Q., Svobodova, S., Browning, J., Luescher, I., Stockert, L., Old, L. J., Davis, I. D., Cebon, J. & Chen, W., 15 May 2006, In : Journal of Immunology. 176, 10, p. 5908-5917 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
2004

Crystal structure of the human T cell receptor CD3 heterodimer complexed to the therapeutic mAb OKT3

Kjer-Nielsen, L., Dunstone, M. A., Kostenko, L., Ely, L. K., Beddoe, T. C., Mifsud, N. A., Purcell, A. W., Brooks, A. G., McCluskey, J. & Rossjohn, J., 2004, In : Proceedings of the National Academy of Sciences. 101, 20, p. 7675 - 7680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)

Immunodominant CD4+ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant

Chen, Q., Jackson, H., Parente, P., Luke, T., Rizkalla, M., Tai, T. Y., Zhu, H. C., Mifsud, N. A., Dimopoulos, N., Masterman, K. A., Hopkins, W., Goldie, H., Maraskovsky, E., Green, S., Miloradovic, L., McCluskey, J., Old, L. J., Davis, I. D., Cebon, J. & Chen, W., 22 Jun 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 25, p. 9363-9368 6 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

Zernich, D., Purcell, A. W., Macdonald, W. A., Kjer-Nielsen, L., Ely, L. K., Laham, N., Crockford, T., Mifsud, N. A., Bharadwaj, M., Chang, L., Tait, B. D., Holdsworth, R., Brooks, A. G., Bottomley, S. P., Beddoe, T. C., Peh, C. A., Rossjohn, J. & McCluskey, J., 2004, In : The Journal of Experimental Medicine. 200, 1, p. 13 - 24 12 p.

Research output: Contribution to journalArticleResearchpeer-review

116 Citations (Scopus)
2003

A naturally selected dimorphism within the HLA-B44 supertype alters Class I structure, peptide repertoire, and T cell recognition

Macdonald, W. A., Purcell, A. W., Mifsud, N. A., Ely, L. K., Williams, D. S., Chang, L., Gorman, J. J., Clements, C. S., Kjer-Nielsen, L., Koelle, D. M., Burrows, S. R., Tait, B. D., Holdsworth, R., Brooks, A. G., Lovrecz, G. O., Lu, L., Rossjohn, J. & McCluskey, J., 2003, In : The Journal of Experimental Medicine. 198, 5, p. 679 - 691 13 p.

Research output: Contribution to journalArticleResearchpeer-review

156 Citations (Scopus)

Dissecting the role of peptides in the immune response: Theory, practice and the application to vaccine design

Purcell, A. W., Zeng, W., Mifsud, N. A., Ely, L. K., Macdonald, W. A. & Jackson, D. C., 1 May 2003, In : Journal of Peptide Science. 9, 5, p. 255-281 27 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

46 Citations (Scopus)
2000

A novel cis-AB variant allele arising from a nucleotide substitution A796C in the B transferase gene [1]

Mifsud, N. A., Watt, J. M., Condon, J. A., Haddad, A. P. & Sparrow, R. L., 2000, In : Transfusion. 40, 10, p. 1276-1277 2 p.

Research output: Contribution to journalLetterOtherpeer-review

31 Citations (Scopus)
1999

Serologic and molecular investigations of a chimera

Mifsud, N. A., Haddad, A. P., Hart, C. F., Holdsworth, R., Condon, J. A., Swain, M. & Sparrow, R. L., 1999, In : Immunohematology. 15, 3, p. 100-104 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
1997

Use of the polymerase chain reaction-sequence specific oligonucleotide technique for the detection of the K1/K2 polymorphism of the Kell blood group system [4]

Mifsud, N. A., Haddad, A. P., Sparrow, R. L. & Condon, J. A., 1997, In : Blood. 89, 12, p. 4662-4663 2 p.

Research output: Contribution to journalLetterOtherpeer-review

4 Citations (Scopus)