Projects per year
Personal profile
Biography
Dr Nicole Mifsud is Group Leader of the Clinical Immunology Laboratory in the Department of Biochemistry & Molecular Biology and Biomedicine Discovery Institute, Monash University. She graduated with a PhD in Immunology in 2005 at the University of Melbourne, with a particular focus in transplantation immunology. Dr Mifsud completed her first postdoctoral training in T cell immunology examining immunogenic epitopes in influenza and melanoma at the Ludwig Institute for Cancer Research (Melbourne). Her second postdoctoral position reignited her passion for clinical research in transplantation immunology in the Department of Medicine, Monash University/Alfred Hospital. Dr Mifsud’s research program explores T cell-mediated immune responses. The exquisite specificity of TCR/peptide/HLA complex interactions are critical for immune reactivity involved in pathogenic control and clearance, but are also pertinent to many human disorders (i.e. autoimmunity, allergy, cancer) and therapies for end-stage disease (i.e. transplantation). However, TCR cross-reactivity is known to drive inappropriate T cell responses that contribute to human disease susceptibility and allograft rejection in transplantation. Understanding the intrinsic nature of T cells to be cross-reactive and their impact in human disease is of critical importance to provide translatable outcomes for clinical management of individual patients (personalised medicine), as well as providing a mechanistic framework for the development of immunotherapeutics.
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Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Immunology, PhD, Assessing the allogeneic T cell response in transplantation, University of Melbourne
Award Date: 1 Mar 2005
Immunology, Honours (H1), Assessing the allogeneic T cell response in transplantation. , University of Melbourne
Award Date: 31 Dec 2000
Biological Sciences, Bachelor Degree, La Trobe University
Award Date: 31 Dec 1992
Research area keywords
- HLA
- transplantation
- immunology
- T cells
- alloreactivity
- cross-reactivity
- Viral immunity
- autoimmunity
- drug allergy
Collaborations and top research areas from the last five years
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Non-canonical antigen sources for cross-strain protective influenza immunity
Illing, P. (Primary Chief Investigator (PCI)), Braun, A. (Chief Investigator (CI)), Lahoud, M. (Associate Investigator (AI)), O'Keeffe, M. (Associate Investigator (AI)), Kedzierska, K. (Associate Investigator (AI)), Purcell, A. (Associate Investigator (AI)) & Mifsud, N. (Associate Investigator (AI))
1/01/24 → 31/12/27
Project: Research
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Identification of alloreactive T cell targets on human transplantable tissues.
Mifsud, N. (Primary Chief Investigator (PCI)), Purcell, A. (Chief Investigator (CI)) & Sharland, A. (Chief Investigator (CI))
1/07/23 → 31/12/24
Project: Research
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Opening the black box - studies of the major histocompatibility complex class I immunopeptidome in allorecognition and transplant tolerance induction
Sharland, A. (Primary Chief Investigator (PCI)) & Mifsud, N. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/24
Project: Research
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School of Biomedical Sciences (SOBS) Travel Grant
Mifsud, N. (Primary Chief Investigator (PCI))
Monash University – Internal School Contribution, Monash University – Internal Department Contribution
26/04/15 → 30/04/15
Project: Other
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The role of cross-reactive T cells in severe lung disease following viral respiratory infections
Purcell, A. (Primary Chief Investigator (PCI)), Kotsimbos, T. (Chief Investigator (CI)) & Mifsud, N. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/18
Project: Research
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CD8+ T-cell responses towards conserved influenza B virus epitopes across anatomical sites and age
Menon, T. (Leading Author), Illing, P. T. (Leading Author), Chaurasia, P. (Leading Author), McQuilten, H. A., Shepherd, C., Rowntree, L. C., Petersen, J., Littler, D. R., Khuu, G., Huang, Z., Allen, L. F., Rockman, S., Crowe, J., Flanagan, K. L., Wakim, L. M., Nguyen, T. H. O., Mifsud, N. A., Rossjohn, J. (Leading Author), Purcell, A. W. (Leading Author) & van de Sandt, C. E. (Leading Author) & 1 others, , 29 Apr 2024, In: Nature Communications. 15, 1, 21 p., 3387.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes
Braun, A., Rowntree, L. C., Huang, Z., Pandey, K., Thuesen, N., Li, C., Petersen, J., Littler, D. R., Raji, S., Nguyen, T. H. O., Jappe Lange, E., Persson, G., Schantz Klausen, M., Kringelum, J., Chung, S., Croft, N. P., Faridi, P., Ayala, R., Rossjohn, J. & Illing, P. T. & 6 others, , Dec 2024, In: Nature Communications. 15, 1, 12 p., 7547.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
A combined immunopeptidomics, proteomics, and cell surface proteomics approach to identify immunotherapy targets for diffuse intrinsic pontine glioma
Pandey, K., Wang, S. S., Mifsud, N. A., Faridi, P., Davenport, A. J., Webb, A. I., Sandow, J. J., Ayala, R., Monje, M., Cross, R. S., Ramarathinam, S. H., Jenkins, M. R. & Purcell, A. W., 11 Aug 2023, In: Frontiers in Oncology. 13, 17 p., 1192448.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Are Induced/altered Self-peptide Antigens Responsible for De Novo Autoreactivity in Transplantation?
Sharland, A. F., Hill, A. E., Son, E. T., Scull, K. E., Mifsud, N. A. & Purcell, A. W., 1 Jun 2023, In: Transplantation. 107, 6, p. 1232-1236 5 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access1 Citation (Scopus) -
Endogenous H3.3K27M derived peptide restricted to HLA-A∗02:01 is insufficient for immune-targeting in diffuse midline glioma
Wang, S. S., Pandey, K., Watson, K. A., Abbott, R. C., Mifsud, N. A., Gracey, F. M., Ramarathinam, S. H., Cross, R. S., Purcell, A. W. & Jenkins, M. R., 21 Sept 2023, In: Molecular Therapy - Oncolytics. 30, p. 167-180 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus)
Prizes
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Australasian Society for Immunology (ASI) Postdoctoral Travel Grant
Mifsud, Nicole (Recipient), 2010
Prize: Prize (including medals and awards)
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Best Oral Presentation Award: Australian and South East Asian Tissue Typing Association Conference
Mifsud, Nicole (Recipient), 2002
Prize: Prize (including medals and awards)
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Best Oral Presentation Award: Australian and South East Asian Tissue Typing Association Conference
Mifsud, Nicole (Recipient), 2001
Prize: Prize (including medals and awards)
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Central Clinical School Travel Grant
Mifsud, N. (Recipient), 2013
Prize: Prize (including medals and awards)
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NHMRC Peter Doherty Training Fellowship
Mifsud, Nicole (Recipient), 2007
Prize: Competitive Fellowships
Activities
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Frontiers in Immunology (Journal)
Nicole Mifsud (Guest editor)
2019 → 2021Activity: Publication peer-review and editorial work types › Editorial responsibility
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Frontiers in Immunology (Journal)
Nicole Mifsud (Guest editor)
2019 → …Activity: Publication peer-review and editorial work types › Editorial responsibility
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Australian and New Zealand Society for Immunology: Women Speakers
Nicole Mifsud (Member)
2018 → …Activity: External Academic Engagement › Professional association or peak discipline body
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Monash Partners Academic Health Science Centre (Infection and Inflammation Theme)
Nicole Mifsud (Member)
2018 → …Activity: External Academic Engagement › Committees and working groups
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HLA (Journal)
Nicole Mifsud (Editorial board member)
2017 → …Activity: Publication peer-review and editorial work types › Editorial responsibility
Press/Media
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The Margaret Pratt Foundation - Charity Luncheon
31/12/09
1 Media contribution
Press/Media: Public Engagement Activities