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1996 …2024

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Personal profile


Dr Nicole Mifsud is Group Leader of the Clinical Immunology Laboratory in the Department of Biochemistry & Molecular Biology and Biomedicine Discovery Institute, Monash University. She graduated with a PhD in Immunology in 2005 at the University of Melbourne, with a particular focus in transplantation immunology. Dr Mifsud completed her first postdoctoral training in T cell immunology examining immunogenic epitopes in influenza and melanoma at the Ludwig Institute for Cancer Research (Melbourne). Her second postdoctoral position reignited her passion for clinical research in transplantation immunology in the Department of Medicine, Monash University/Alfred Hospital. Dr Mifsud’s research program explores T cell-mediated immune responses. The exquisite specificity of TCR/peptide/HLA complex interactions are critical for immune reactivity involved in pathogenic control and clearance, but are also pertinent to many human disorders (i.e. autoimmunity, allergy, cancer) and therapies for end-stage disease (i.e. transplantation). However, TCR cross-reactivity is known to drive inappropriate T cell responses that contribute to human disease susceptibility and allograft rejection in transplantation. Understanding the intrinsic nature of T cells to be cross-reactive and their impact in human disease is of critical importance to provide translatable outcomes for clinical management of individual patients (personalised medicine), as well as providing a mechanistic framework for the development of immunotherapeutics.

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Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Immunology, PhD, Assessing the allogeneic T cell response in transplantation, University of Melbourne

Award Date: 1 Mar 2005

Immunology, Honours (H1), Assessing the allogeneic T cell response in transplantation. , University of Melbourne

Award Date: 31 Dec 2000

Biological Sciences, Bachelor Degree, La Trobe University

Award Date: 31 Dec 1992

Research area keywords

  • HLA
  • transplantation
  • immunology
  • T cells
  • alloreactivity
  • cross-reactivity
  • Viral immunity
  • autoimmunity
  • drug allergy

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or