Projects per year
Personal profile
Biography
Dr Nicole Mifsud is Group Leader of the Clinical Immunology Laboratory in the Department of Biochemistry & Molecular Biology and Biomedicine Discovery Institute, Monash University. She graduated with a PhD in Immunology in 2005 at the University of Melbourne, with a particular focus in transplantation immunology. Dr Mifsud completed her first postdoctoral training in T cell immunology examining immunogenic epitopes in influenza and melanoma at the Ludwig Institute for Cancer Research (Melbourne). Her second postdoctoral position reignited her passion for clinical research in transplantation immunology in the Department of Medicine, Monash University/Alfred Hospital. Dr Mifsud’s research program explores T cell-mediated immune responses. The exquisite specificity of TCR/peptide/HLA complex interactions are critical for immune reactivity involved in pathogenic control and clearance, but are also pertinent to many human disorders (i.e. autoimmunity, allergy, cancer) and therapies for end-stage disease (i.e. transplantation). However, TCR cross-reactivity is known to drive inappropriate T cell responses that contribute to human disease susceptibility and allograft rejection in transplantation. Understanding the intrinsic nature of T cells to be cross-reactive and their impact in human disease is of critical importance to provide translatable outcomes for clinical management of individual patients (personalised medicine), as well as providing a mechanistic framework for the development of immunotherapeutics.
Related Links:
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Immunology, PhD, University of Melbourne
Award Date: 1 Mar 2005
Immunology, Honours (H1), University of Melbourne
Award Date: 31 Dec 2000
Biological Sciences, Bachelor Degree, La Trobe University
Award Date: 31 Dec 1992
Research area keywords
- HLA
- transplantation
- immunology
- T cells
- alloreactivity
- cross-reactivity
- Viral immunity
- autoimmunity
- drug allergy
Network
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Cross-reactive T cells mediate allograft rejection in transplantation.
Kotsimbos, T., Mifsud, N. & Tait, B. D.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/09 → 31/12/11
Project: Research
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TCR_Explore: A novel webtool for T cell receptor repertoire analysis
Mullan, K. A., Zhang, J. B., Jones, C. M., Goh, S. J. R., Revote, J., Illing, P. T., Purcell, A. W., La Gruta, N. L., Li, C. & Mifsud, N. A., Jan 2023, In: Computational and Structural Biotechnology Journal. 21, p. 1272-1282 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Editorial: The Immunology of Adverse Drug Reactions
Illing, P. T., Mifsud, N. A., Ardern-Jones, M. R. & Trubiano, J., 18 Feb 2022, In: Frontiers in Immunology. 13, 3 p., 863414.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access -
HLA-A∗11:01-restricted CD8+ T cell immunity against influenza A and influenza B viruses in Indigenous and non-Indigenous people
Habel, J. R., Nguyen, A. T., Rowntree, L. C., Szeto, C., Mifsud, N. A., Clemens, E. B., Loh, L., Chen, W., Rockman, S., Nelson, J., Davies, J., Miller, A., Tong, S. Y. C., Rossjohn, J., Gras, S., Purcell, A. W., Hensen, L., Kedzierska, K. & Illing, P. T., Mar 2022, In: PLoS Pathogens. 18, 3, 28 p., e1010337.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Understanding the Role of HLA Class I Molecules in the Immune Response to Influenza Infection and Rational Design of a Peptide-Based Vaccine
Muraduzzaman, A. K. M., Illing, P. T., Mifsud, N. A. & Purcell, A. W., 21 Nov 2022, In: Viruses. 14, 11, 18 p., 2578.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access -
Broad-based influenza-specific cd8+ t cell response without the typical immunodominance hierarchy and its potential implication
Huang, M., Xu, R., Triffon, C., Mifsud, N. & Chen, W., Jun 2021, In: Viruses. 13, 6, 17 p., 1080.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)
Prizes
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Australasian Society for Immunology (ASI) Postdoctoral Travel Grant
Mifsud, Nicole (Recipient), 2010
Prize: Prize (including medals and awards)
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Best Oral Presentation Award: Australian and South East Asian Tissue Typing Association Conference
Mifsud, Nicole (Recipient), 2001
Prize: Prize (including medals and awards)
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Best Oral Presentation Award: Australian and South East Asian Tissue Typing Association Conference
Mifsud, Nicole (Recipient), 2002
Prize: Prize (including medals and awards)
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Central Clinical School Travel Grant
Mifsud, Nicole (Recipient), 2013
Prize: Prize (including medals and awards)
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NHMRC Peter Doherty Training Fellowship
Mifsud, Nicole (Recipient), 2007
Prize: Competitive Fellowships
Activities
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Frontiers in Immunology (Journal)
Nicole Mifsud (Guest editor)
2019 → 2021Activity: Publication peer-review and editorial work types › Editorial responsibility
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Frontiers in Immunology (Journal)
Nicole Mifsud (Guest editor)
2019 → …Activity: Publication peer-review and editorial work types › Editorial responsibility
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Monash Partners Academic Health Science Centre (Infection and Inflammation Theme)
Nicole Mifsud (Member)
2018 → …Activity: External Academic Engagement › Committees and working groups
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Australian and New Zealand Society for Immunology: Women Speakers
Nicole Mifsud (Member)
2018 → …Activity: External Academic Engagement › Professional association or peak discipline body
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HLA (Journal)
Nicole Mifsud (Editorial board member)
2017 → …Activity: Publication peer-review and editorial work types › Editorial responsibility
Press/Media
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The Margaret Pratt Foundation - Charity Luncheon
31/12/09
1 Media contribution
Press/Media: Public Engagement Activities