Projects per year
Personal profile
Biography
Professor Nicole La Gruta is head of the T cell development and function laboratory in the Department of Biochemistry and Molecular Biology at Monash University. She completed postdoctoral studies at St Jude Children’s Research Hospital, in Memphis, Tennessee, before returning to Melbourne in 2002 as part of Prof Peter Doherty’s laboratory at the University of Melbourne. Nicole was appointed at Monash University in 2016 where she undertakes a comprehensive program of research to elucidate the key determinants of robust T cell immunity in the context of virus infection and autoimmune disease. She also has a keen interest in understanding the molecular basis of T cell dysfunction in the elderly. It is hoped that a better understanding of the drivers of optimal and dysfunctional T cell responses will inform the targeted design and application of T cell-based vaccines and therapeutics.
Research interests
My laboratory investigates the determinants of effective T cell responses, T cell ageing, and T cell mediated autoimmunity
External positions
Affiliate member, The University of Melbourne
2016 → …Keywords
- T cells
- Ageing
- T cell receptors
- immunodominance hierarchy
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2012 2021
A molecular investigation into the naive T cell repertoire
La Gruta, N. L., Gras, S. & Miles, J.
1/03/17 → 31/12/19
Project: Research
Limiting the impact of influenza
Turner, S. J., La Gruta, N. L., Chen, W., Kedzierska, K., Jackson, D., Brown, L. E. & Doherty, P. C.
1/01/15 → 31/12/19
Project: Research
Research Output 1998 2018
Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells
Quinn, K. M., Fox, A., Harland, K. L., Russ, B. E., Li, J., Nguyen, T. H. O., Loh, L., Olshanksy, M., Naeem, H., Tsyganov, K., Wiede, F., Webster, R., Blyth, C., Sng, X. Y. X., Tiganis, T., Powell, D., Doherty, P. C., Turner, S. J., Kedzierska, K. & La Gruta, N. L. 19 Jun 2018 In : Cell Reports. 23, 12, p. 3512-3524 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease
Wang, Z. , Zhu, L. , Nguyen, T. H. O. , Wan, Y. , Sant, S. , Quiñones-Parra, S. M. , Crawford, J. C. , Eltahla, A. A. , Rizzetto, S. , Bull, R. A. , Qiu, C. , Koutsakos, M. , Clemens, E. B. , Loh, L. , Chen, T. , Liu, L. , Cao, P. , Ren, Y. , Kedzierski, L. , Kotsimbos, T. & 10 others 26 Feb 2018 In : Nature Communications. 9, 1, 12 p., 824Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Understanding the drivers of MHC restriction of T cell receptors
La Gruta, N. L., Gras, S., Daley, S. R., Thomas, P. G. & Rossjohn, J. 10 Apr 2018 (Accepted/In press) In : Nature Reviews Immunology. 12 p.Research output: Contribution to journal › Article › Research › peer-review
CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin
Overgaard, N. H., Cruz, J. L., Bridge, J. A., Nel, H. J., Frazer, I. H., La Gruta, N. L., Blumenthal, A., Steptoe, R. J. & Wells, J. W. 1 Sep 2017 In : Journal of Leukocyte Biology. 102, 3, p. 837-844 8 p.Research output: Contribution to journal › Article › Research › peer-review
Corrigendum to ‘‘Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host’’ [J.Theor. Biol. 413 (2017) 34–49] (S0022519316303629)(10.1016/j.jtbi.2016.11.008)
Yan, A. W. C., Cao, P., Heffernan, J. M., McVernon, J., Quinn, K. M., La Gruta, N. L., Laurie, K. L. & McCaw, J. M. 21 Apr 2017 In : Journal of Theoretical Biology. 419, p. 394 1 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review