• Dandenong Road, Building 76, 19 Innovation Walk

    3800 Clayton

    Australia

19982021
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Personal profile

Biography

Professor Nicole La Gruta is head of the T cell development and function laboratory in the Department of Biochemistry and Molecular Biology at Monash University. She completed postdoctoral studies at St Jude Children’s Research Hospital, in Memphis, Tennessee, before returning to Melbourne in 2002 as part of Prof Peter Doherty’s laboratory at the University of Melbourne. Nicole was appointed at Monash University in 2016 where she undertakes a comprehensive program of research to elucidate the key determinants of robust T cell immunity in the context of virus infection and autoimmune disease. She also has a keen interest in understanding the molecular basis of T cell dysfunction in the elderly. It is hoped that a better understanding of the drivers of optimal and dysfunctional T cell responses will inform the targeted design and application of T cell-based vaccines and therapeutics.

Research interests

My laboratory investigates the determinants of effective T cell responses, T cell ageing, and T cell mediated autoimmunity

External positions

Affiliate member, The University of Melbourne

2016 → …

Keywords

  • T cells
  • Ageing
  • T cell receptors
  • immunodominance hierarchy

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Projects 2012 2021

Research Output 1998 2018

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

Quinn, K. M., Fox, A., Harland, K. L., Russ, B. E., Li, J., Nguyen, T. H. O., Loh, L., Olshanksy, M., Naeem, H., Tsyganov, K., Wiede, F., Webster, R., Blyth, C., Sng, X. Y. X., Tiganis, T., Powell, D., Doherty, P. C., Turner, S. J., Kedzierska, K. & La Gruta, N. L. 19 Jun 2018 In : Cell Reports. 23, 12, p. 3512-3524 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

Wang, Z. , Zhu, L. , Nguyen, T. H. O. , Wan, Y. , Sant, S. , Quiñones-Parra, S. M. , Crawford, J. C. , Eltahla, A. A. , Rizzetto, S. , Bull, R. A. , Qiu, C. , Koutsakos, M. , Clemens, E. B. , Loh, L. , Chen, T. , Liu, L. , Cao, P. , Ren, Y. , Kedzierski, L. , Kotsimbos, T. & 10 others McCaw, J. M., La Gruta, N. L., Turner, S. J., Cheng, A. C., Luciani, F., Zhang, X., Doherty, P. C., Thomas, P. G., Xu, J. & Kedzierska, K. 26 Feb 2018 In : Nature Communications. 9, 1, 12 p., 824

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Understanding the drivers of MHC restriction of T cell receptors

La Gruta, N. L., Gras, S., Daley, S. R., Thomas, P. G. & Rossjohn, J. 10 Apr 2018 (Accepted/In press) In : Nature Reviews Immunology. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin

Overgaard, N. H., Cruz, J. L., Bridge, J. A., Nel, H. J., Frazer, I. H., La Gruta, N. L., Blumenthal, A., Steptoe, R. J. & Wells, J. W. 1 Sep 2017 In : Journal of Leukocyte Biology. 102, 3, p. 837-844 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Corrigendum to ‘‘Modelling cross-reactivity and memory in the cellular adaptive immune response to influenza infection in the host’’ [J.Theor. Biol. 413 (2017) 34–49] (S0022519316303629)(10.1016/j.jtbi.2016.11.008)

Yan, A. W. C., Cao, P., Heffernan, J. M., McVernon, J., Quinn, K. M., La Gruta, N. L., Laurie, K. L. & McCaw, J. M. 21 Apr 2017 In : Journal of Theoretical Biology. 419, p. 394 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review