Projects per year
Personal profile
Biography
Professor Nicole La Gruta is head of the T cell development and function laboratory in the Department of Biochemistry and Molecular Biology at Monash University. She completed postdoctoral studies at St Jude Children’s Research Hospital, in Memphis, Tennessee, before returning to Melbourne in 2002 as part of Prof Peter Doherty’s laboratory at the University of Melbourne. Nicole was appointed at Monash University in 2016 where she undertakes a comprehensive program of research to elucidate the key determinants of robust T cell immunity in the context of virus infection and autoimmune disease. She also has a keen interest in understanding the molecular basis of T cell dysfunction in the elderly. It is hoped that a better understanding of the drivers of optimal and dysfunctional T cell responses will inform the targeted design and application of T cell-based vaccines and therapeutics.
Research interests
My laboratory investigates the determinants of effective T cell responses, T cell ageing, and T cell mediated autoimmunity
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Affiliate member, University of Melbourne
2016 → …
Research area keywords
- T cells
- Ageing
- T cell receptors
- immunodominance hierarchy
Network
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Exceptions Prove the Rule: How Antigen Recognition Drives T cell Activation
1/01/20 → 31/12/22
Project: Research
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Analysis of adjuvanting compounds for elicitation of T cell responses
11/12/20 → 30/04/21
Project: Research
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Limiting the impact of influenza
Turner, S., La Gruta, N., Chen, W., Kedzierska, K., Jackson, D., Brown, L. E. & Doherty, P. C.
1/01/15 → 31/12/19
Project: Research
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A subset of immune-system T cells branded as seeds for type 1 diabetes
Turner, S. J. & La Gruta, N. L., Jan 2022, In: Nature. 602, 7895, p. 35-36 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
1 Citation (Scopus) -
Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infection
Di Pietro, A., Polmear, J., Cooper, L., Damelang, T., Hussain, T., Hailes, L., O’Donnell, K., Udupa, V., Mi, T., Preston, S., Shtewe, A., Hershberg, U., Turner, S. J., La Gruta, N. L., Chung, A. W., Tarlinton, D. M., Scharer, C. D. & Good-Jacobson, K. L., Jan 2022, In: Nature Immunology. 23, 1, p. 86-98 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling
Zareie, P., Szeto, C., Farenc, C., Gunasinghe, S. D., Kolawole, E. M., Nguyen, A., Blyth, C., Sng, X. Y. X., Li, J., Jones, C. M., Fulcher, A. J., Jacobs, J. R., Wei, Q., Wojciech, L., Petersen, J., Gascoigne, N. R. J., Evavold, B. D., Gaus, K., Gras, S., Rossjohn, J. & 1 others, , 4 Jun 2021, In: Science. 372, 6546, 14 p., eabe9124.Research output: Contribution to journal › Article › Research › peer-review
7 Citations (Scopus) -
Evaluation of inflammation and follicle depletion during ovarian ageing in mice
Lliberos, C., Liew, S. H., Zareie, P., La Gruta, N. L., Mansell, A. & Hutt, K., 11 Jan 2021, In: Scientific Reports. 11, 1, 15 p., 278.Research output: Contribution to journal › Article › Research › peer-review
Open Access14 Citations (Scopus) -
Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients
Nguyen, T. H. O., Koutsakos, M., van de Sandt, C. E., Crawford, J. C., Loh, L., Sant, S., Grzelak, L., Allen, E. K., Brahm, T., Clemens, E. B., Auladell, M., Hensen, L., Wang, Z., Nüssing, S., Jia, X., Günther, P., Wheatley, A. K., Kent, S. J., Aban, M., Deng, Y. M. & 16 others, , Dec 2021, In: Nature Communications. 12, 1, 17 p., 2691.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus)