Projects per year
Personal profile
Biography
Professor Nicole La Gruta is head of the T cell development and function laboratory in the Department of Biochemistry and Molecular Biology at Monash University. She completed postdoctoral studies at St Jude Children’s Research Hospital, in Memphis, Tennessee, before returning to Melbourne in 2002 as part of Prof Peter Doherty’s laboratory at the University of Melbourne. Nicole was appointed at Monash University in 2016 where she undertakes a comprehensive program of research to elucidate the key determinants of robust T cell immunity in the context of virus infection and autoimmune disease. She also has a keen interest in understanding the molecular basis of T cell dysfunction in the elderly. It is hoped that a better understanding of the drivers of optimal and dysfunctional T cell responses will inform the targeted design and application of T cell-based vaccines and therapeutics.
Research interests
My laboratory investigates the determinants of effective T cell responses, T cell ageing, and T cell mediated autoimmunity
External positions
Affiliate member, University of Melbourne
2016 → …Research area keywords
- T cells
- Ageing
- T cell receptors
- immunodominance hierarchy
Network
Projects
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Exceptions Prove the Rule: How Antigen Recognition Drives T cell Activation
1/01/20 → 31/12/22
Project: Research
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Limiting the impact of influenza
Turner, S., La Gruta, N., Chen, W., Kedzierska, K., Jackson, D., Brown, L. E. & Doherty, P. C.
1/01/15 → 31/12/19
Project: Research
Research output
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A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice
Valencia-Hernandez, A. M., Ng, W. Y., Ghazanfari, N., Ghilas, S., de Menezes, M. N., Holz, L. E., Huang, C., English, K., Naung, M., Tan, P. S., Tullett, K. M., Steiner, T. M., Enders, M. H., Beattie, L., Chua, Y. C., Jones, C. M., Cozijnsen, A., Mollard, V., Cai, Y., Bowen, D. G. & 15 others, , 10 Jun 2020, In : Cell Host & Microbe. 27, 6, p. 950-962 13 p.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
Metabolic characteristics of CD8+ T cell subsets in young and aged individuals are not predictive of functionality
Quinn, K. M., Hussain, T., Kraus, F., Formosa, L. E., Lam, W. K., Dagley, M. J., Saunders, E. C., Assmus, L. M., Wynne-Jones, E., Loh, L., van de Sandt, C. E., Cooper, L., Good-Jacobson, K. L., Kedzierska, K., Mackay, L. K., McConville, M. J., Ramm, G., Ryan, M. T. & La Gruta, N. L., 5 Jun 2020, In : Nature Communications. 11, 1, 13 p., 2857.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile4 Citations (Scopus) -
MHC restriction: Where are we now?
Zareie, P., Farenc, C. & La Gruta, N. L., Apr 2020, In : Viral Immunology. 33, 3, p. 179-187 9 p.Research output: Contribution to journal › Article › Other › peer-review
Open AccessFile1 Citation (Scopus) -
Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility
Wirasinha, R. C., Davies, A. R., Srivastava, M., Sheridan, J. M., Sng, X. Y. X., Delmonte, O. M., Dobbs, K., Loh, K. L., Miosge, L. A., Lee, C. E., Chand, R., Chan, A., Yap, J. Y., Keller, M. D., Chen, K., Rossjohn, J., La Gruta, N. L., Vinuesa, C. G., Reid, H. H., Lionakis, M. S. & 5 others, , 27 Oct 2020, In : Journal of Experimental Medicine. 218, 2, 19 p., e20200476.Research output: Contribution to journal › Article › Research › peer-review
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Overlapping Peptides Elicit Distinct CD8+ T Cell Responses following Influenza A Virus Infection
Assmus, L. M., Guan, J., Wu, T., Farenc, C., Sng, X. Y. X., Zareie, P., Nguyen, A., Nguyen, A. T., Tscharke, D. C., Thomas, P. G., Rossjohn, J., Gras, S., Croft, N. P., Purcell, A. W. & La Gruta, N. L., 1 Oct 2020, In : Journal of Immunology. 205, 7, p. 1731-1742 12 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)