Projects per year
Personal profile
Biography
Professor Nicole La Gruta is head of the T cell development and function laboratory in the Department of Biochemistry and Molecular Biology at Monash University. She completed postdoctoral studies at St Jude Children’s Research Hospital, in Memphis, Tennessee, before returning to Melbourne in 2002 as part of Prof Peter Doherty’s laboratory at the University of Melbourne. Nicole was appointed at Monash University in 2016 where she undertakes a comprehensive program of research to elucidate the key determinants of robust T cell immunity in the context of virus infection and autoimmune disease. She also has a keen interest in understanding the molecular basis of T cell dysfunction in the elderly. It is hoped that a better understanding of the drivers of optimal and dysfunctional T cell responses will inform the targeted design and application of T cell-based vaccines and therapeutics.
Research interests
My laboratory investigates the determinants of effective T cell responses, T cell ageing, and T cell mediated autoimmunity
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Affiliate member, University of Melbourne
2016 → …
Research area keywords
- T cells
- Ageing
- T cell receptors
- immunodominance hierarchy
Collaborations and top research areas from the last five years
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The Role of Lck/CD8 Association in Negatively Regulating T cell Activation
9/06/23 → 8/06/26
Project: Research
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Structure-based antigen design as a novel strategy for precision mRNA vaccines
Quast, I., Buckle, A., La Gruta, N., Hill, D. & Beilharz, T.
15/05/23 → 15/05/25
Project: Research
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Gatekeepers of optimal T cell immune function in health and aging-related decline
1/01/23 → 31/12/27
Project: Research
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Analysis of adjuvanting compounds for elicitation of T cell responses
11/12/20 → 30/04/21
Project: Research
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Helminth Infection−Induced Increase in Virtual Memory CD8 T Cells Is Transient, Driven by IL-15, and Absent in Aged Mice
Hussain, T., Nguyen, A., Daunt, C., Thiele, D., Pang, E. S., Li, J., Zaini, A., O’Keeffe, M., Zaph, C., Harris, N. L., Quinn, K. M. & La Gruta, N. L., 1 Feb 2023, In: Journal of Immunology. 210, 3, p. 297-309 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
TCR_Explore: A novel webtool for T cell receptor repertoire analysis
Mullan, K. A., Zhang, J. B., Jones, C. M., Goh, S. J. R., Revote, J., Illing, P. T., Purcell, A. W., La Gruta, N. L., Li, C. & Mifsud, N. A., Jan 2023, In: Computational and Structural Biotechnology Journal. 21, p. 1272-1282 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Thanks for the memories: Low-avidity T cells shine against escape variants
Zareie, P. & La Gruta, N. L., 13 Jun 2023, In: Immunity. 56, 6, p. 1160-1162 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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A subset of immune-system T cells branded as seeds for type 1 diabetes
Turner, S. J. & La Gruta, N. L., Jan 2022, In: Nature. 602, 7895, p. 35-36 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
2 Citations (Scopus) -
Checkpoint inhibitor immunotherapy diminishes oocyte number and quality in mice
Winship, A., Alesi, L. R., Sant, S., Stringer, J., Cantavenera, A., Hegarty, T. S., Lliberos Requesens, C., Liew, S. H. J., Sarma, U., Griffiths, M., Zerafa, N., Fox, S. B., Brown, E., Caramia, F., Zareie, P., La Gruta, N., Phillips, K. A., Strasser, A., Loi, S. & Hutt, K., Aug 2022, In: Nature Cancer. 3, 8, p. 1-13 13 p.Research output: Contribution to journal › Article › Research › peer-review
16 Citations (Scopus)