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PhD projects

Structure and function of interferons and their receptors.<br/>Investigation of IFNs as treatment for viral infections.

1999 …2026

Research activity per year

Personal profile

Biography

Nicole is a  a post-doctoral research fellow in the Centre for Innate Immunity and Infectious Diseases at Hudson Institute of Medical Research, Clayton. She has 46 publications in total, 11 of which are first author and 5 senior author publications. Nicole has contributed to work published in a number of high impact journals including Science, Nature, Nature Immunology, Nature Medicine, Blood and Journal of Immunology. Nicole is currently a Chief Investigator on two NHMRC Ideas Grants (2026-2029 and 2026-2030) and has previously held an ARC Discovery Project grant (2021-2023), NHRMC New Investigator Award (2014-2016) and on NHMRC Project Grant (2017-2021), and as an Associate Investigator on international grants (including the Bill and Melinda Gates Foundation). 

Nicole's research focuses on examining the structure and function of the type I interferons and how they cross-talk with type III interferons, with the view to understanding how this relationship relates to normal interferon signalling and how we may abrogate interferon signals when they are detrimental to health.

Nicole is currently a team leader of a research sub-group which produces recombinant forms of mouse and human interferons and their receptors which are used by collaborators locally, nationally and world-wide, and are also used in protein structure-function studies.

Since, and including her PhD studies, the research projects that Nicole has worked on have all had a common thread, focusing on the investigation of protein-protein interactions with the view to the development of improved immunotherapeutics. Nicole has a continued interest in this field.

Community service

2012 Science in Schools Program, Kananook Primary School, Seaford, Victoria.

2013  Science in Schools Program, Kananook Primary School, Seaford, Victoria.

Education/Academic qualification

Biotechnology, PhD, Biotechnology of grass pollen allergens for improved hay fever immunotherapy

Award Date: 31 Oct 2002

Biotechnology, Masters, Isolation and characterisation of a cytochrome P450 genomic clone and expression of homologous genes in Arabidopsis

Award Date: 31 Dec 1994

Research area keywords

  • Type I Interferons
  • Protein-Protein Interactions
  • Cytokine Signaling
  • Cytokne Signaling

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or