Projects per year
Personal profile
Biography
Nicole is a a post-doctoral research fellow in the Centre for Innate Immunity and Infectious Diseases at Hudson Institute of Medical Research, Clayton. She has 46 publications in total, 11 of which are first author and 5 senior author publications. Nicole has contributed to work published in a number of high impact journals including Science, Nature, Nature Immunology, Nature Medicine, Blood and Journal of Immunology. Nicole is currently a Chief Investigator on two NHMRC Ideas Grants (2026-2029 and 2026-2030) and has previously held an ARC Discovery Project grant (2021-2023), NHRMC New Investigator Award (2014-2016) and on NHMRC Project Grant (2017-2021), and as an Associate Investigator on international grants (including the Bill and Melinda Gates Foundation).
Nicole's research focuses on examining the structure and function of the type I interferons and how they cross-talk with type III interferons, with the view to understanding how this relationship relates to normal interferon signalling and how we may abrogate interferon signals when they are detrimental to health.
Nicole is currently a team leader of a research sub-group which produces recombinant forms of mouse and human interferons and their receptors which are used by collaborators locally, nationally and world-wide, and are also used in protein structure-function studies.
Since, and including her PhD studies, the research projects that Nicole has worked on have all had a common thread, focusing on the investigation of protein-protein interactions with the view to the development of improved immunotherapeutics. Nicole has a continued interest in this field.
Community service
2012 Science in Schools Program, Kananook Primary School, Seaford, Victoria.
2013 Science in Schools Program, Kananook Primary School, Seaford, Victoria.
Education/Academic qualification
Biotechnology, PhD, Biotechnology of grass pollen allergens for improved hay fever immunotherapy
Award Date: 31 Oct 2002
Biotechnology, Masters, Isolation and characterisation of a cytochrome P450 genomic clone and expression of homologous genes in Arabidopsis
Award Date: 31 Dec 1994
Research area keywords
- Type I Interferons
- Protein-Protein Interactions
- Cytokine Signaling
- Cytokne Signaling
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
-
SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
-
Novel interferon treatment to mitigate serious viral infections
De Weerd, N. (Primary Chief Investigator (PCI)), O'Keeffe, M. (Chief Investigator (CI)), Hertzog, P. (Chief Investigator (CI)), Bardin, P. (Chief Investigator (CI)), Thomas, B. (Chief Investigator (CI)), Garama, D. (Chief Investigator (CI)), Leong, P. (Chief Investigator (CI)), Werder, R. B. (Associate Investigator (AI)), MacDonald, M. I. (Associate Investigator (AI)), Bourke, J. (Associate Investigator (AI)), Illing, P. (Associate Investigator (AI)) & Gough, D. (Associate Investigator (AI))
1/01/26 → 31/12/29
Project: Research
-
Identification and Selective targeting of proinflammatory effects of interferons
Hertzog, P. (Primary Chief Investigator (PCI)), De Weerd, N. (Chief Investigator (CI)), Sivaraman, H. (Chief Investigator (CI)), Hofer, M. (Associate Investigator (AI)), Gearing, J. (Associate Investigator (AI)), Morand, E. (Associate Investigator (AI)) & Casanova, J.-L. (Associate Investigator (AI))
1/01/26 → 31/12/30
Project: Research
-
Deciphering novel cross-talk between innate cytokine receptors
O'Keeffe, M. (Primary Chief Investigator (PCI)), De Weerd, N. (Chief Investigator (CI)) & Hertzog, P. (Chief Investigator (CI))
ARC - Australian Research Council
30/06/21 → 30/06/24
Project: Research
-
Characterization of a novel IFNbeta signaling axis mediated via IFNAR1
De Weerd, N. (Primary Chief Investigator (PCI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/14 → 31/12/16
Project: Research
-
Evaluation of IL-6 cytokine subfamily antagonists for the treatment of inflammatory arthritis
Jazayeri, J. (Primary Chief Investigator (PCI)), Carroll, G. (Chief Investigator (CI)) & De Weerd, N. (Chief Investigator (CI))
1/01/04 → 31/12/05
Project: Research
-
A STAT3–STING–IFN axis controls the metastatic spread of small cell lung cancer
Guanizo, A. C., Luong, Q., Jayasekara, W. S. N., de Geus, E. D., Inampudi, C., Xue, V. S., Chen, J., de Weerd, N. A., Matthews, A. Y., Gantier, M. P., Balic, J. J., Arulananda, S., Garama, D. J., Hertzog, P. J., Ganju, V., Watkins, D. N., Cain, J. E. & Gough, D. J., Dec 2024, In: Nature Immunology. 25, 12, p. 2259-2269 11 p.Research output: Contribution to journal › Article › Research › peer-review
24 Link opens in a new tab Citations (Scopus) -
Epithelially Restricted Interferon Epsilon Protects Against Colitis
de Geus, E. D., Volaric, J. S., Matthews, A. Y., Mangan, N. E., Chang, J., Ooi, J. D., de Weerd, N. A., Giles, E. M. & Hertzog, P. J., 2024, In: Cellular and Molecular Gastroenterology and Hepatology. 17, 2, p. 267-278 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Link opens in a new tab Citations (Scopus) -
Interferon-epsilon is a novel regulator of NK cell responses in the uterus
Mayall, J. R., Horvat, J. C., Mangan, N. E., Chevalier, A., McCarthy, H., Hampsey, D., Donovan, C., Brown, A. C., Matthews, A. Y., de Weerd, N. A., de Geus, E. D., Starkey, M. R., Kim, R. Y., Daly, K., Goggins, B. J., Keely, S., Maltby, S., Baldwin, R., Foster, P. S. & Boyle, M. J. & 4 others, , 15 Feb 2024, In: EMBO Molecular Medicine. 16, 2, p. 267-293 27 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Link opens in a new tab Citations (Scopus) -
Characterization of Monoclonal Antibodies to Measure Cell Surface Protein Levels of Human Interferon-Lambda Receptor 1
de Weerd, N. A., Ogungbola, O., Liu, X., Matthews, A. Y., Ismail, A., Vivian, J. P., Lim, S. S., Tyrrell, D. L., Putcha, N., Skawinski, M., Dickensheets, H., Lavoie, T. B., Donnelly, R. P., Hertzog, P. J. & Santer, D. M., Sept 2023, In: Journal of Interferon and Cytokine Research. 43, 9, p. 403-413 11 p.Research output: Contribution to journal › Article › Research › peer-review
5 Link opens in a new tab Citations (Scopus) -
Interferon-ε is a tumour suppressor and restricts ovarian cancer
Marks, Z. R. C., Campbell, N. K., Mangan, N. E., Vandenberg, C. J., Gearing, L. J., Matthews, A. Y., Gould, J. A., Tate, M. D., Wray-McCann, G., Ying, L., Rosli, S., Brockwell, N., Parker, B. S., Lim, S. S., Bilandzic, M., Christie, E. L., Stephens, A. N., de Geus, E., Wakefield, M. J. & Ho, G. Y. & 8 others, , 16 Aug 2023, In: Nature. 620, 7976, p. 1063-1070+ 30 p.Research output: Contribution to journal › Article › Research › peer-review
59 Link opens in a new tab Citations (Scopus)