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Structure and function of interferons and their receptors


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Personal profile


Nicole is a  a post-doctoral research fellow in the Centre for Innate Immunity and Infectious Diseases at Hudson Institute of Medical Research (formerly Monash Institute of Medical Research), Clayton. She has 39 publications in total, 10 of which are first author and 3 senior author publications. Nicole has contributed to work published in a number of high impact journals including Science, Nature, Nature Immunology, Nature Medicine, Blood and Journal of Immunology. Nicole is a Chief Investigator on an ARC Discovery Project grant (2021-2023) and on NHMRC Project Grant (2017-2021), NHRMC New Investigator Award (2014-2016) and an Associate Investigator on international grants (including the Bill and Melinda Gates Foundation) worth almost $1.5 million (AUD).

Nicole's research focuses on examining the structure and function of the type I interferons with the view to understanding how this relationship relates to normal interferon signalling and how we may abrogate interferon signals when they are detrimental to health.

Nicole is currently a team leader of a research sub-group which produces recombinant proteins, three different subtypes of mouse and human type I interferons that are used by collaborators locally, nationally and world-wide, and are also used in protein structure-function studies and crystallography projects.

Since, and including her PhD studies, the research projects that Nicole has worked on have all had a common thread, focusing on the investigation of protein-protein interactions with the view to the development of improved immunotherapeutics. Nicole has a continued interest in this field.

Community service

2012 Science in Schools Program, Kananook Primary School, Seaford, Victoria.

2013  Science in Schools Program, Kananook Primary School, Seaford, Victoria.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Biotechnology, PhD

Award Date: 31 Oct 2002

Biotechnology, Masters

Award Date: 31 Dec 1994

Research area keywords

  • Type I Interferons
  • Protein-Protein Interactions
  • Cytokine Signaling
  • Cytokne Signaling


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