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Personal profile


Nicole is a researcher with 29 publications in total, 9 of which are first author and 3 senior author publications. Nicole has contributed to work published in a number of high impact journals including Science, Nature Immunology, Nature Medicine, Blood and Journal of Immunology. Nicole is a recipient of an NHMRC New Investigator grant (2014-2016) and a post-doctoral research fellow in the Centre for Innate Immunity and Infectious Diseases at Hudson Institute of Medical Research (formerly Monash Institute of Medical Research), Clayton. Nicole is working to elucidate structural and mechanistic characteristics of type I interferon receptor signalling, which lead to a significant publication in Nature Immunology in 2013. 

Since, and including her PhD studies, the research projects that Nicole has worked on have all had a common thread, focusing on the investigation of protein-protein interactions with the view to the development of improved immunotherapeutics. Nicole has a continued interest in this field.

Community service

2012 Science in Schools Program, Kananook Primary School, Seaford, Victoria.

2013  Science in Schools Program, Kananook Primary School, Seaford, Victoria.

Research area keywords

  • Type I Interferons
  • Protein-Protein Interactions
  • Cytokine Signaling
  • Cytokne Signaling

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Research Output

  • 25 Article
  • 2 Encyclopaedia / Dictionary Entry
  • 2 Review Article
  • 1 Short Survey

A structural "star" in interferon gamma signaling

Hertzog, P. J. & de Weerd, N. A., 1 May 2019, In : Immunology and Cell Biology. 97, 5, p. 442-444 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
1 Citation (Scopus)

Properties and functions of the novel type I interferon epsilon

Marks, Z. R. C., Campbell, N., deWeerd, N. A., Lim, S. S., Gearing, L. J., Bourke, N. M. & Hertzog, P. J., 1 Jun 2019, In : Seminars in Immunology. 43, 9 p., 101328.

Research output: Contribution to journalReview ArticleResearchpeer-review

A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans

Zhang, G., Deweerd, N. A., Stifter, S. A., Liu, L., Zhou, B., Wang, W., Zhou, Y., Ying, B., Hu, X., Matthews, A. Y., Ellis, M., Triccas, J. A., Hertzog, P. J., Britton, W. J., Chen, X. & Feng, C. G., 1 Dec 2018, In : Nature Communications. 9, 1, 9 p., 85.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
11 Citations (Scopus)

Defining the distinct, intrinsic properties of the novel type i interferon, IFNϵ

Stifter, S. A., Matthews, A. Y., Mangan, N. E., Fung, K. Y., Drew, A., Tate, M. D., Soares Da Costa, T. P., Hampsey, D., Mayall, J., Hansbro, P. M., Minambres, A. G., Eid, S. G., Mak, J., Scoble, J., Lovrecz, G., DeWeerd, N. A. & Hertzog, P. J., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 9, p. 3168-3179 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling

de Weerd, N. A., Matthews, A. Y., Pattie, P. R., Bourke, N. M., Lim, S. S., Vivian, J. P., Rossjohn, J. & Hertzog, P. J., 5 May 2017, In : Journal of Biological Chemistry. 292, 18, p. 7554-7565 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)