Projects per year
Personal profile
Biography
Nicole is a researcher with 29 publications in total, 9 of which are first author and 3 senior author publications. Nicole has contributed to work published in a number of high impact journals including Science, Nature Immunology, Nature Medicine, Blood and Journal of Immunology. Nicole is a recipient of an NHMRC New Investigator grant (2014-2016) and a post-doctoral research fellow in the Centre for Innate Immunity and Infectious Diseases at Hudson Institute of Medical Research (formerly Monash Institute of Medical Research), Clayton. Nicole is working to elucidate structural and mechanistic characteristics of type I interferon receptor signalling, which lead to a significant publication in Nature Immunology in 2013.
Since, and including her PhD studies, the research projects that Nicole has worked on have all had a common thread, focusing on the investigation of protein-protein interactions with the view to the development of improved immunotherapeutics. Nicole has a continued interest in this field.
Community service
2012 Science in Schools Program, Kananook Primary School, Seaford, Victoria.
2013 Science in Schools Program, Kananook Primary School, Seaford, Victoria.
Keywords
- Type I Interferons
- Protein-Protein Interactions
- Cytokine Signaling
- Cytokne Signaling
Network
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Projects 2004 2016
- 2 Finished
Characterization of a novel IFNbeta signaling axis mediated via IFNAR1
National Health & Medical Research Council (NHMRC)
1/01/14 → 31/12/16
Project: Research
Evaluation of IL-6 cytokine subfamily antagonists for the treatment of inflammatory arthritis
Jazayeri, J., Carroll, G. & De Weerd, N.
1/01/04 → 31/12/05
Project: Research
Research Output 1999 2019
A structural "star" in interferon gamma signaling
Hertzog, P. J. & de Weerd, N. A., 1 May 2019, In : Immunology and Cell Biology. 97, 5, p. 442-444 3 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access
A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans
Zhang, G., Deweerd, N. A., Stifter, S. A., Liu, L., Zhou, B., Wang, W., Zhou, Y., Ying, B., Hu, X., Matthews, A. Y., Ellis, M., Triccas, J. A., Hertzog, P. J., Britton, W. J., Chen, X. & Feng, C. G., 1 Dec 2018, In : Nature Communications. 9, 1, 9 p., 85.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Defining the distinct, intrinsic properties of the novel type i interferon, IFNϵ
Stifter, S. A., Matthews, A. Y., Mangan, N. E., Fung, K. Y., Drew, A., Tate, M. D., Soares Da Costa, T. P., Hampsey, D., Mayall, J., Hansbro, P. M., Minambres, A. G., Eid, S. G., Mak, J., Scoble, J., Lovrecz, G., DeWeerd, N. A. & Hertzog, P. J., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 9, p. 3168-3179 12 p.Research output: Contribution to journal › Article › Research › peer-review
A hot spot on interferon α/β receptor subunit 1 (IFNAR1) underpins its interaction with interferon-β and dictates signaling
de Weerd, N. A., Matthews, A. Y., Pattie, P. R., Bourke, N. M., Lim, S. S., Vivian, J. P., Rossjohn, J. & Hertzog, P. J., 5 May 2017, In : Journal of Biological Chemistry. 292, 18, p. 7554-7565 13 p.Research output: Contribution to journal › Article › Research › peer-review
Auto-phosphorylation represses protein kinase R activity
Wang, D., De Weerd, N. A., Willard, B., Polekhina, G., Williams, B. R. G. & Sadler, A. J., 10 Mar 2017, In : Scientific Reports. 7, 15 p., 44340.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File