Projects per year
Personal profile
Biography
Nicole is a a post-doctoral research fellow in the Centre for Innate Immunity and Infectious Diseases at Hudson Institute of Medical Research (formerly Monash Institute of Medical Research), Clayton. She has 39 publications in total, 10 of which are first author and 3 senior author publications. Nicole has contributed to work published in a number of high impact journals including Science, Nature, Nature Immunology, Nature Medicine, Blood and Journal of Immunology. Nicole is a Chief Investigator on an ARC Discovery Project grant (2021-2023) and on NHMRC Project Grant (2017-2021), NHRMC New Investigator Award (2014-2016) and an Associate Investigator on international grants (including the Bill and Melinda Gates Foundation) worth almost $1.5 million (AUD).
Nicole's research focuses on examining the structure and function of the type I interferons with the view to understanding how this relationship relates to normal interferon signalling and how we may abrogate interferon signals when they are detrimental to health.
Nicole is currently a team leader of a research sub-group which produces recombinant proteins, three different subtypes of mouse and human type I interferons that are used by collaborators locally, nationally and world-wide, and are also used in protein structure-function studies and crystallography projects.
Since, and including her PhD studies, the research projects that Nicole has worked on have all had a common thread, focusing on the investigation of protein-protein interactions with the view to the development of improved immunotherapeutics. Nicole has a continued interest in this field.
Community service
2012 Science in Schools Program, Kananook Primary School, Seaford, Victoria.
2013 Science in Schools Program, Kananook Primary School, Seaford, Victoria.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biotechnology, PhD
Award Date: 31 Oct 2002
Biotechnology, Masters
Award Date: 31 Dec 1994
Research area keywords
- Type I Interferons
- Protein-Protein Interactions
- Cytokine Signaling
- Cytokne Signaling
Network
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Deciphering novel cross-talk between innate cytokine receptors
O'Keeffe, M., De Weerd, N. & Hertzog, P.
Australian Research Council (ARC)
30/06/21 → 30/06/24
Project: Research
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Evaluation of IL-6 cytokine subfamily antagonists for the treatment of inflammatory arthritis
Jazayeri, J., Carroll, G. & De Weerd, N.
1/01/04 → 31/12/05
Project: Research
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Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML
Salmon, J. M., Todorovski, I., Stanley, K. L., Bruedigam, C., Kearney, C. J., Martelotto, L. G., Rossello, F., Semple, T., Arnau, G. M., Zethoven, M., Bots, M., Bjelosevic, S., Cluse, L. A., Fraser, P. J., Litalien, V., Vidacs, E., McArthur, K., Matthews, A. Y., Gressier, E., De Weerd, N. A., & 15 others , Jun 2022, In: Cancer Discovery. 12, 6, p. 1560-1579 20 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization
Ming-Chin Lee, K., Achuthan, A. A., De Souza, D. P., Lupancu, T. J., Binger, K. J., Lee, M. K. S., Xu, Y., McConville, M. J., de Weerd, N. A., Dragoljevic, D., Hertzog, P. J., Murphy, A. J., Hamilton, J. A. & Fleetwood, A. J., 19 Apr 2022, In: Cell Reports. 39, 3, 11 p., 110719.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Structural integrity with functional plasticity: what type I IFN receptor polymorphisms reveal
de Weerd, N. A., Vivian, J. P., Lim, S. S., Huang, S. U-S. & Hertzog, P. J., Sep 2020, In: Journal of Leukocyte Biology. 108, 3, p. 909-924 16 p.Research output: Contribution to journal › Review Article › Research › peer-review
7 Citations (Scopus) -
A structural "star" in interferon gamma signaling
Hertzog, P. J. & de Weerd, N. A., 1 May 2019, In: Immunology and Cell Biology. 97, 5, p. 442-444 3 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access1 Citation (Scopus) -
Properties and functions of the novel type I interferon epsilon
Marks, Z. R. C., Campbell, N., deWeerd, N. A., Lim, S. S., Gearing, L. J., Bourke, N. M. & Hertzog, P. J., 1 Jun 2019, In: Seminars in Immunology. 43, 9 p., 101328.Research output: Contribution to journal › Review Article › Research › peer-review
19 Citations (Scopus)