Projects per year
Personal profile
Biography
Research interests
We investigate how the organisms most commonly inhabiting the intestine of people living in developing countries, the microbiota and helminth parasites, interact with the host immune system.
Our ongoing projects fall into two main categories, The first investigates how we can prevent the damage inflicted by intestinal helminth infection (nutrient malabsorption, growth retardation, anemia), whilst the second investigates the well described link between intestinal helminth infection and protection against so called 'western' diseases such as allergy, inflammatory bowel disease, autoimmunity and obesity (metabolic syndrome).
Project One: Investigating how cells associated with the type 2 immune system function to promote health and limit helminth infection.
Approximately one third of the worlds population, mainly children living in improvised conditions, live with intestinal helminth infection which can cause growth retardation, school absenteeism and cognitive impairment trapping communities in poverty. This project specifically investigates the impact of cells associated with type two immunity (alternatively activated macrophages, eosinophils, ILC2s, Th2 cells) on protecting the infected individuals with the ultimate goal of improving our understanding of these complex parasites and developing vaccines. Our work aims to:
i) intestinal function during healthily states and following helminth infection,
ii) parasite viability and ability to establish infection,
iii) wound healing in response to tissue damage caused by helminths.
Project Two: Investigating how helminth interactions with our gut microbiota influences disease.
Much excitement has surrounded the finding that the gut microbiome can determine our health status, leading to calls for the development of microbial-based interventions for various disease states including allergy, inflammatory bowel disease and Metabolic Syndrome. Current approaches for developing such interventions involves studies in which investigators attempt to link microbial populations to disease by comparing healthy and diseased individuals living within westernized societies. Yet even healthy individuals living in westernized countries harbor a “dysbiotic” microbiota that is lacking in complexity as compared to the microbiota found in individuals living in developing countries. This has been hypothesized to result from modern diets that are low in fiber, and high in fats and sugar. We have recently published a seminal paper providing evidence that helminth infection also promotes the existence of a healthy microbiota and that this microbiota can provide protection against allergic diseases in animal models. Thus we hypothesize that a helminth-altered microbiota likely represents the “natural” or “ancient” microbiota that humans evolved with over millennia. We are now actively engaged in determining:
i) how helminth infection alters gut microbial communities
ii) whether helminth altered gut microbial communities can prevent other western diseases, including Metabolic syndrome.
These studies are expected to lead to the identification of novel microbial-based therapeutics for a wide range of inflammatory disorders.
Supervision interests
We are currently seeking motivated and talented honors and PhD students
Research area keywords
- Intestinal Immunology
- Helminth infection
- Microbiome
- type 2 immunity
Network
Projects
-
Mechanisms of diet induced inflammatory diseases: an interplay between fat and fibre?
1/09/15 → 31/08/17
Project: Research
-
The use of dietary fermentable fiber for the prevention of allergic disease.
1/01/15 → 31/12/16
Project: Research
-
Antibody-mediated protective immunity and wound healing during helminth infection.
1/10/14 → 30/09/17
Project: Research
-
Role of antibodies in protective immunity against helminth parasites
1/10/14 → 30/09/17
Project: Research
Research output
-
Microbial metabolism of l-tyrosine protects against allergic airway inflammation
Wypych, T. P., Pattaroni, C., Perdijk, O., Yap, C., Trompette, A., Anderson, D., Creek, D. J., Harris, N. L. & Marsland, B. J., 25 Jan 2021, In : Nature Immunology. 24 p.Research output: Contribution to journal › Article › Research › peer-review
-
Microbiome-induced antigen-presenting cell recruitment coordinates skin and lung allergic inflammation
Ubags, N. D., Trompette, A., Pernot, J., Nibbering, B., Wong, N. C., Pattaroni, C., Rapin, A., Nicod, L. P., Harris, N. L. & Marsland, B. J., 1 Mar 2021, In : Journal of Allergy and Clinical Immunology. 147, 3, p. 1049-1062.e7 21 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products
de los Reyes Jiménez, M., Lechner, A., Alessandrini, F., Bohnacker, S., Schindela, S., Trompette, A., Haimerl, P., Thomas, D., Henkel, F., Mourão, A., Geerlof, A., da Costa, C. P., Chaker, A. M., Brüne, B., Nüsing, R., Jakobsson, P. J., Nockher, W. A., Feige, M. J., Haslbeck, M., Ohnmacht, C. & 5 others, , 22 Apr 2020, In : Science Translational Medicine. 12, 540, 14 p., eaay0605.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps
Bouchery, T., Moyat, M., Sotillo, J., Silverstein, S., Volpe, B., Coakley, G., Tsourouktsoglou, T-D., Becker, L., Shah, K., Kulagin, M., Guiet, R., Camberis, M., Schmidt, A., Seitz, A., Giacomin, P., Le Gros, G., Papayannopoulos, V., Loukas, A. & Harris, N. L., 12 Feb 2020, In : Cell Host & Microbe. 27, 2, p. 277-289.e6 19 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Immune serum–activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae
Coakley, G., Volpe, B., Bouchery, T., Shah, K., Butler, A., Geldhof, P., Hatherill, M., Horsnell, W. G. C., Esser-von Bieren, J. & Harris, N. L., 1 May 2020, (Accepted/In press) In : Parasite Immunology. 12 p.Research output: Contribution to journal › Review Article › Research › peer-review
5 Citations (Scopus)