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Research Output 2004 2018

2018

A novel role for Lyl1 in primitive erythropoiesis

Chiu, S. K., Saw, J. M. Y., Huang, Y., Sonderegger, S. E., Wong, N. C. L., Powell, D. R., Beck, D., Pimanda, J., Tremblay, C. & Curtis, D. J., 11 Oct 2018, In : Development. 145, 19, 9 p., dev162990.

Research output: Contribution to journalArticleResearchpeer-review

Early-Life Formation of the Microbial and Immunological Environment of the Human Airways

Pattaroni, C., Watzenboeck, M. L., Schneidegger, S., Kieser, S., Wong, N. C., Bernasconi, E., Pernot, J., Mercier, L., Knapp, S., Nicod, L. P., Marsland, C. P., Roth-Kleiner, M. & Marsland, B. J., 12 Dec 2018, In : Cell Host and Microbe. 24, 6, p. 857-865.e4 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Profiling DNA methylation differences between inbred mouse strains on the Illumina Human Infinium MethylationEPIC microarray

Gujar, H., Liang, J. W., Wong, N. C. & Mozhui, K., 1 Mar 2018, In : PLoS ONE. 13, 3, 18 p., 0193496.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Tremblay, C., Saw, J., Chiu, S. K., Wong, N. C., Tsyganov, K., Ghotb, S., Graham, A. N., Yan, F., Guirguis, A., Sonderegger, S., Lee, N., Kalitsis, P., Reynolds, J., Ting, S., Powell, D., Jane, S. & Curtis, D., 1 Dec 2018, In : Nature Communications. 9, 1, 13 p., 3535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection

Muscat, A. M., Wong, N. C., Drummond, K. J., Algar, E. M., Khasraw, M., Verhaak, R., Field, K., Rosenthal, M. A. & Ashley, D. M., 1 Jan 2018, In : Oncotarget. 9, 8, p. 7844-7858 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Genome-scale methylation assessment did not identify prognostic biomarkers in oral tongue carcinomas

Lim, A. M., Wong, N. C., Pidsley, R., Zotenko, E., Corry, J., Dobrovic, A., Clark, S. J., Rischin, D. & Solomon, B., 18 Jul 2016, In : Clinical Epigenetics. 8, 1, 12 p., 74.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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MethPat: A tool for the analysis and visualisation of complex methylation patterns obtained by massively parallel sequencing

Wong, N. C., Pope, B. J., Candiloro, I. L., Korbie, D., Trau, M., Wong, S. Q., Mikeska, T., Zhang, X., Pitman, M., Eggers, S., Doyle, S. R. & Dobrovic, A., 24 Feb 2016, In : BMC Bioinformatics. 17, 1, 14 p., 98.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Exemplary multiplex bisulfite amplicon data used to demonstrate the utility of Methpat

Wong, N. C., Pope, B. J., Candiloro, I., Korbie, D., Trau, M., Wong, S. Q., Mikeska, T., Bryce, B. J., Thompson, E. W., Eggers, S., Doyle, S. R. & Dobrovic, A., 1 Jan 2015, In : GigaScience. 4, 1, 8 p., 55.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Paediatric leukaemia DNA methylation profiling using MBD enrichment and SOLiD sequencing on archival bone marrow smears

Wong, N. C. L., Meredith, G. D., Marnellos, G., Dudas, M., Parkinson-Bates, M., Halemba, M. S., Chatterton, Z., Maksimovic, J., Ashley, D. M., Mechinaud, F., Craig, J. M. & Saffery, R., 18 Mar 2015, In : GigaScience. 4, 1, 6 p., 11.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma

Do, H., Wong, N. C., Murone, C., John, T., Solomon, B., Mitchell, P. L. & Dobrovic, A., 26 Feb 2014, In : Scientific Reports. 4, 8 p., 4186.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Atypical Spitzoid neoplasms: A review of potential markers of biological behavior including sentinel node biopsy

McCormack, C. J., Conyers, R. K., Scolyer, R. A., Kirkwood, J., Speakman, D., Wong, N., Kelly, J. W. & Henderson, M. A., 1 Oct 2014, In : Melanoma Research. 24, 5, p. 437-447 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetic deregulation in pediatric acute lymphoblastic leukemia

Chatterton, Z., Morenos, L., Mechinaud, F., Ashley, D. M., Craig, J. M., Sexton-Oates, A., Halemba, M. S., Parkinson-Bates, M., Ng, J., Morrison, D., Carroll, W. L., Saffery, R. & Wong, N. C., 6 Jan 2014, In : Epigenetics. 9, 3, p. 459-467 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1

Morenos, L., Chatterton, Z., Ng, J. L., Halemba, M. S., Parkinson-Bates, M., Mechinaud, F., Elwood, N., Saffery, R. & Wong, N. C., 24 May 2014, In : Molecular Cancer. 13, 1, 11 p., 123.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome

Lim, A. M., Candiloro, I. L. M., Wong, N., Collins, M., Do, H., Takano, E. A., Angel, C., Young, R. J., Corry, J., Wiesenfeld, D., Kleid, S., Sigston, E., Lyons, B., Rischin, D., Solomon, B. & Dobrovic, A., 1 Jan 2014, In : Clinical Epigenetics. 6, 1, 16 p., 22.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array

Naeem, H., Wong, N. C., Chatterton, Z., Hong, M. K. H., Pedersen, J. S., Corcoran, N. M., Hovens, C. M. & Macintyre, G., 2014, In : BMC Genomics. 15, 1 (Art. ID: 51), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Stability of gene expression and epigenetic profiles highlights the utility of patient-derived paediatric acute lymphoblastic leukaemia xenografts for investigating molecular mechanisms of drug resistance

Wong, N. C., Bhadri, V. A., Maksimovic, J., Parkinson-Bates, M., Ng, J., Craig, J. M., Saffery, R. & Lock, R. B., 1 Jun 2014, In : BMC Genomics. 15, 1, 13 p., 416.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Validation of DNA methylation biomarkers for diagnosis of acute lymphoblastic leukemia

Chatterton, Z., Burke, D., Emslie, K. R., Craig, J. M., Ng, J., Ashley, D. M., Mechinaud, F., Saffery, R. & Wong, N. C., 2014, In : Clinical Chemistry. 60, 7, p. 995-1003 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Condensin i associates with structural and gene regulatory regions in vertebrate chromosomes

Kim, J. H., Zhang, T., Wong, N. C., Davidson, N., Maksimovic, J., Oshlack, A., Earnshaw, W. C., Kalitsis, P. & Hudson, D. F., 14 Oct 2013, In : Nature Communications. 4, 14 p., 2537.

Research output: Contribution to journalArticleResearchpeer-review

Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA

Wong, N. C., Ng, J., Hall, N. E., Lunke, S., Salmanidis, M., Brumatti, G., Ekert, P. G., Craig, J. M. & Saffery, R., 1 Jul 2013, In : Genomics. 102, 1, p. 38-46 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The use of DNA from archival dried blood spots with the Infinium HumanMethylation450 array

Joo, J. H. E., Wong, E. M., Baglietto, L., Jung, C-H., Tsimiklis, H., Park, D. J., Wong, N. C., English, D. R., Hopper, J. L., Severi, G., Giles, G. G. & Southey, M. C., 15 Mar 2013, In : BMC Biotechnology. 13, 23.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

A distinct DNA methylation signature defines pediatric pre-B cell acute lymphoblastic leukemia

Wong, N. C., Ashley, D., Chatterton, Z., Parkinson-Bates, M., Ng, H. K., Halemba, M. S., Kowalczyk, A., Bedo, J., Wang, Q. J., Bell, K. M., Algar, E., Craig, J. M. & Saffery, R., 1 Jan 2012, In : Epigenetics. 7, 6, p. 535-541 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Evaluation of microrna expression in patient bone marrow aspirate slides

Morenos, L., Saffery, R., Mechinaud, F., Ashley, D., Elwood, N. J., Craig, J. M. & Wong, N. C., 13 Aug 2012, In : PLoS ONE. 7, 8, e42951.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

FXN methylation predicts expression and clinical outcome in Friedreich ataxia

Evans-Galea, M. V., Carrodus, N., Rowley, S. M., Corben, L. A., Tai, G., Saffery, R., Galati, J. C., Wong, N. C., Craig, J. M., Lynch, D. R., Regner, S. R., Brocht, A. F. D., Perlman, S. L., Bushara, K. O., Gomez, C. M., Wilmot, G. R., Li, L., Varley, E., Delatycki, M. B. & Sarsero, J. P., 2012, In : Annals of Neurology. 71, 4, p. 487 - 497 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Genome-scale DNA methylation analyses of cancer in children

Wong, N. C. & Ashley, D. M., 1 Jan 2012, Epigenomics: From Chromatin Biology to Therapeutics. Cambridge University Press, p. 338-346 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Normal DNA methylation dynamics in DICER1-deficient mouse embryonic stem cells

Ip, J., Canham, P., Choo, A., Inaba, Y., Jacobs, S. A., Kalitsis, P., Mattiske, D., Ng, J., Saffery, R., Wong, N. C., Wong, L. & Mann, J. R., 2012, In : PLoS Genetics. 8, 9, 13 p., e1002919.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Specific-site methylation of tumour suppressor ANKRD11 in breast cancer

Lim, S. P., Wong, N. C., Suetani, R. J., Ho, K., Ng, J. L., Neilsen, P. M., Gill, P. G., Kumar, R. & Callen, D. F., 1 Nov 2012, In : European Journal of Cancer. 48, 17, p. 3300-3309 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Evidence of increased DNA methylation of the androgen receptor gene in occipital hair follicles from men with androgenetic alopecia

Cobb, J. E., Wong, N. C., Yip, L. W., Martinick, J., Bosnich, R., Sinclair, R. D., Craig, J. M., Saffery, R., Harrap, S. B. & Ellis, J. A., 1 Jul 2011, In : British Journal of Dermatology. 165, 1, p. 210-213 4 p.

Research output: Contribution to journalLetterOtherpeer-review

Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies

Hogan, L. E., Meyer, J. A., Yang, J., Wang, J., Wong, N., Yang, W., Condos, G., Hunger, S. P., Raetz, E., Saffery, R., Relling, M. V., Bhojwani, D., Morrison, D. J. & Carroll, W. L., 10 Nov 2011, In : Blood. 118, 19, p. 5218-5226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigating the potential role of genetic and epigenetic variation of DNA methyltransferase genes in hyperplastic polyposis syndrome

Drini, M., Wong, N. C., Scott, H. S., Craig, J. M., Dobrovic, A., Hewitt, C. A., Dow, C., Young, J. P., Jenkins, M. A., Saffery, R. & Macrae, F. A., 25 Feb 2011, In : PLoS ONE. 6, 2, 8 p., e16831.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Wide-ranging DNA methylation differences of primary trophoblast cell populations and derived cell lines: Implications and opportunities for understanding trophoblast function

Novakovic, B., Gordon, L., Wong, N., Moffett, A., Manuelpillai, U., Craig, J., Sharkey, A. & Saffery, R., 2011, In : Molecular Human Reproduction. 17, 6, p. 344 - 353 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

A Phase II trial of primary temozolomide in patients with grade III oligodendroglial brain tumors

Gan, H. K., Rosenthal, M. A., Dowling, A. J., Kalnins, R., Algar, E., Wong, N., Benson, A., Woods, A. M. & Cher, L., May 2010, In : Neuro-Oncology. 12, 5, p. 500-507 8 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia

Chatterton, Z., Morenos, L., Saffery, R., Craig, J. M., Ashley, D. & Wong, N. C., Oct 2010, In : Epigenomics. 2, 5, p. 697-708 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

DNA methylation-mediated down-regulation of DNA methyltransferase-1 (DNMT1) is coincident with, but not essential for, global hypomethylation in human placenta

Novakovic, B., Wong, N., Sibson, M., Ng, H., Morley, R., Manuelpillai, U., Down, T., Rakyan, V., Beck, S., Hiendleder, S., Roberts, C., Craig, J. & Saffery, R., 2010, In : Journal of Biological Chemistry. 285, 13, p. 9583 - 9593 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition

Bachmann, P. S., Piazza, R. G., Janes, M. E., Wong, N. C., Davies, C., Mogavero, A., Bhadri, V. A., Szymanska, B., Geninson, G., Magistroni, V., Cazzaniga, G., Biondi, A., Miranda-Saavedra, D., Göttgens, B., Saffery, R., Craig, J. M., Marshall, G. M., Gambacorti-Passerini, C., Pimanda, J. E. & Lock, R. B., 21 Oct 2010, In : Blood. 116, 16, p. 3013-3022 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice

Zajac, M. S., Pang, T. Y. C., Wong, N., Weinrich, B., Leang, L. S. K., Craig, J. M., Saffery, R. & Hannan, A. J., 1 May 2010, In : Hippocampus. 20, 5, p. 621-636 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

A case-sibling assessment of the association between skin pigmentation and other vitamin d-related factors and type 1 diabetes mellitus

Ponsonby, A. L., Cameron, F., Saffery, R., Pezic, A., Wong, N., Craig, J., Ellis, J. & Dwyer, T., 1 Sep 2009, In : Photochemistry and Photobiology. 85, 5, p. 1267-1270 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Archived Guthrie blood spots as a novel source for quantitative DNA methylation analysis

Wong, N. C., Morley, R., Saffery, R. & Craig, J. M., 1 Oct 2008, In : BioTechniques. 45, 4, p. 423-430 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylation of the adenomatous polyposis coli (APC) gene in human placenta and hypermethylation in choriocarcinoma cells

Wong, N. C., Novakovic, B., Weinrich, B., Dewi, C., Andronikos, R., Sibson, M., Macrae, F., Morley, R., Pertile, M. D., Craig, J. M. & Saffery, R., 8 Sep 2008, In : Cancer Letters. 268, 1, p. 56-62 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Specific tumour-associated methylation in normal human term placenta and first-trimester cytotrophoblasts

Novakovic, B., Rakyan, V., Ng, H. K., Manuelpillai, U. C., Dewi, C., Wong, N. C-L., Morley, R., Down, T., Beck, S., Craig, J. M. & Saffery, R., 2008, In : Molecular Human Reproduction. 14, 9, p. 547 - 554 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation

Wong, N. C., Wong, L. H., Quach, J. M., Canham, P., Craig, J. M., Song, J. Z., Clark, S. J. & Choo, K. H. A., Feb 2006, In : PLoS Genetics. 2, 2, p. 172-186 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

BAC-based PCR fragment microarray: High-resolution detection of chromosomal deletion and duplication breakpoints

Ren, H., Francis, W., Boys, A., Chueh, A. C., Wong, N., La, P., Wong, L. H., Ryan, J., Slater, H. R. & Choo, K. H. A., May 2005, In : Human Mutation. 25, 5, p. 476-482 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromere

Chueh, A. C., Wong, L. H., Wong, N. & Choo, K. H. A., 1 Jan 2005, In : Human Molecular Genetics. 14, 1, p. 85-93 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Effects of scaffold/matrix alteration on centromeric function and gene expression

Sumer, H., Saffery, R., Wong, N., Craig, J. M. & Choo, K. H. A., 2004, In : Journal of Biological Chemistry. 279, 36, p. 37631 - 37639 9 p.

Research output: Contribution to journalArticleResearchpeer-review