20012018
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Research Output 2001 2018

2018

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages

Sadek, M., Barzegar Amiri Olia, M., Nowell, C. J., Barlow, N., Schiesser, C. H., Nicholson, S. E. & Norton, R. S., 15 Oct 2017, In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5743–5748 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation

Edgington-Mitchell, L. E., Barlow, N., Aurelio, L., Samha, A., Szabo, M., Graham, B. & Bunnett, N., 15 Jan 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 254-260 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 othersGeppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

2016

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W., 1 Sep 2016, In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Barlow, N., Nasser, Y., Zhao, P., Sharma, N., Guerrero-Alba, R., Edgington-Mitchell, L. E., Lieu, T., Veldhuis, N. A., Poole, D. P., Conner, J. W., Lindstrom, E., Craig, A. W., Graham, B., Vanner, S. J. & Bunnett, N. W., 2015, In : Neurogastroenterology and Motility. 27, 11, p. 1675-1680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

Brewer, K. D., Bacaj, T., Cavalli, A., Camilloni, C., Swarbrick, J. D., Liu, J., Zhou, A., Zhou, P., Barlow, N., Xu, J., Seven, A. B., Prinslow, E. A., Voleti, R., Haussinger, D., Bonvin, A. M. J. J., Tomchick, D. R., Vendruscolo, M., Graham, B., Sudhof, T. C. & Rizo, J., 2015, In : Nature Structural and Molecular Biology. 22, 7, p. 555 - 564 10 p.

Research output: Contribution to journalArticleResearchpeer-review

File

Neutrophil elastase activates protease-activated receptor-2 (PAR2) and transient receptor potential vanilloid 4 (TRPV4) to cause inflammation and pain

Zhao, P., Lieu, T. M., Barlow, N., Sostegni, S., Haerteis, S., Korbmacher, C., Liedtke, W., Jimenez-Vargas, N. N., Vanner, S. & Bunnett, N. W., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13875 - 13887 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4

Zhao, P., Lieu, T. M., Barlow, N., Metcalf, M., Veldhuis, N. A., Jensen, D. D., Kocan, M., Sostegni, S., Haerteis, S., Baraznenok, V. A., Henderson, I., Lindstrom, E., Guerrero-Alba, R., Valdez-Morales, E., Liedtke, W., McIntyre, P., Vanner, S., Korbmacher, C. & Bunnett, N. W., 2014, In : Journal of Biological Chemistry. 289, 39, p. 27215 - 27234 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhanced cytotoxicity through conjugation of a "clickable" luminescent Re(I) complex to a cell-penetrating lipopeptide

Leonidova, A., Pierroz, V., Adams, L. A., Barlow, N., Ferrari, S., Graham, B. & Gasser, G. A., 2014, In : A C S Medicinal Chemistry Letters. 5, 7, p. 809 - 814 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Dennis, M., Chhabra, S., Wang, Z-C., Debono, A. J., Dolezal, O., Newman, J., Pitcher, N. P., Rahmani, R. S., Cleary, B., Barlow, N., Hattarki, M., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 2014, In : Journal of Medicinal Chemistry. 57, 22, p. 9612 - 9626 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Effect of linker length and composition on heterobivalent ligand-mediated receptor cross-talk between the A1 adenosine and beta2 adrenergic receptors

Barlow, N., Baker, S. P. & Scammells, P. J., 2013, In : ChemMedChem. 8, 12, p. 2036 - 2046 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK

Chhabra, S., Barlow, N., Dolezal, O., Hattarki, M., Newman, J., Peat, T., Graham, B. & Swarbrick, J. D., 2013, In : PLoS ONE. 8, 4, 15 p., e59535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Lanthanide tags for site-specific ligation to an unnatural amino acid and generation of pseudocontact shifts in proteins

Loh, C. T., Ozawa, K., Tuck, K. L., Barlow, N., Huber, T., Otting, G. & Graham, B., 2013, In : Bioconjugate Chemistry. 24, 2, p. 260 - 268 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Facile, divergent route to bis-Zn(II)dipicolylamine type chemosensors for pyrophosphate

Pathberiya, L. G., Barlow, N., Nguyen, T. B. T., Graham, B. & Tuck, K. L., 2012, In : Tetrahedron. 68, 46, p. 9435 - 9439 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra

Graham, B., Loh, C., Swarbrick, J., Ung, P., Shin, J., Yagi, H., Jia, X., Chhabra, S., Barlow, N., Pintacuda, G., Huber, T. & Otting, G., 2011, In : Bioconjugate Chemistry. 22, 10, p. 2118 - 2125 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Partly-PEGylated poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers

Kaminskas, L. M., Wu, Z., Barlow, N., Krippner, G. Y., Boyd, B. J. & Porter, C. J. H., 2009, In : Journal of Pharmaceutical Sciences. 98, 10, p. 3871 - 3875 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

Capturing the imagination with Green Chemistry...and explosions, froth, color, phase changes and lollies

Clarke, M., Barlow, N., Patti, A. & Scott, J. L., 2001, In : Australian Journal of Education in Chemistry. 57, p. 25-31 7 p.

Research output: Contribution to journalArticleResearch