Projects per year
Personal profile
Research interests
I am a Research Fellow with expertise in peptide chemistry and small molecule drug discovery. I manage a drug discovery group at Monash University and my teamwork in both translational and fundamental research. I have particular interest in drug targets that includes peptidases, proteases and GPCRs. I currently oversee programs in diabetes research that investigate the role of the melanocortin receptors in glucose control.
My research also focuses on the discovery of new chemical tools to enable investigations intracellular signaling during disease progression. My team has developed and demonstrated new technologies for providing cell membrane permeability to chemical tools and bioactive peptides.
Over the last 5 years my drug discovery team have brought 3 new peptide drug candidates to a preclinical development stage and overseen successful commercialization through the establishment of start-up companies for each candidate.
Research area keywords
- Organic chemistry
- Peptide Chemistry
- Medicinal Chemistry
- Structure-Based Drug Design
- Fragment Based Drug Design
- Drug Delivery
- Hit-to-lead
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Lead optimisation of novel inhibitors of IRAP for the treatment of fibrosis in diabetes-induced renal and cardiovascular disease
Gaspari, T. (Primary Chief Investigator (PCI)), Chai, S. (Chief Investigator (CI)), Widdop, R. (Chief Investigator (CI)), Thompson, P. (Chief Investigator (CI)), Nielsen, K. (Chief Investigator (CI)), Perez, S. (Partner Investigator (PI)), Dear, A. (Chief Investigator (CI)), Yun, B. (Chief Investigator (CI)), Pfleger, K. (Chief Investigator (CI)) & Barlow, N. (Chief Investigator (CI))
1/10/21 → 30/11/23
Project: Research
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Inhibition of IRAP Enhances the Expression of Pro-Cognitive Markers Drebrin and MAP2 in Rat Primary Neuronal Cells
Stam, F., Bjurling, S., Nylander, E., Håkansson, E. O., Barlow, N., Gising, J., Larhed, M., Odell, L. R., Grönbladh, A. & Hallberg, M., Nov 2024, In: International Journal of Molecular Sciences. 25, 22, 12016.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Link opens in a new tab Citations (Scopus) -
Insulin Regulated Aminopeptidase (IRAP) Inhibition – A Novel Treatment for Diabetes-Induced Cardiovascular Disease
Hollands, C., Ferens, D. M., Salimova, E., Thompson, P., Barlow, N., Velagic, A., Ritchie, R. H., Chai, S. Y., Widdop, R. E. & Gaspari, T., Aug 2024, In: Heart Lung and Circulation. 33, S4, p. S480 1 p., 770.Research output: Contribution to journal › Meeting Abstract
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Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach
Mansouri, M., Rumrill, S., Dawson, S., Johnson, A., Pinson, J. A., Gunzburg, M. J., Latham, C. F., Barlow, N., Mbogo, G. W., Ellenberg, P., Headey, S. J., Sluis-Cremer, N., Tyssen, D., Bauman, J. D., Ruiz, F. X., Arnold, E., Chalmers, D. K. & Tachedjian, G., Apr 2023, In: Molecules. 28, 7, 26 p., 3103.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
Targeting Melanocortin Receptors Using SNAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates
Yue, W. K., Zhang, T., Shandre Mugan, R., Barlow, N., Chalmers, D. K., Pouton, C. W. & Thompson, P. E., 21 Feb 2023, In: Journal of Medicinal Chemistry. 66, 5, p. 3273-3283 11 p.Research output: Contribution to journal › Article › Research › peer-review
2 Link opens in a new tab Citations (Scopus) -
Enhanced nitric oxide production by macrophages treated with a cell-penetrating peptide conjugate
Rahman, A., Matthews, M. A., Nowell, C. J., Chalmers, D. K., Thompson, P. E., Nicholson, S. E., Barlow, N. & Norton, R. S., Jun 2022, In: Bioorganic Chemistry. 123, 9 p., 105763.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile9 Link opens in a new tab Citations (Scopus)