Personal profile

Research interests

Nicholas is a synthetic organic chemist who’s work focuses on the design and synthesis of molecules that have applications within the areas of drug discovery and life sciences. Nicholas’ research interests include:

  • Anti-microbial therapies that enhance macrophage killing of M. tuberculosis and other bacteria.
  • Anti-retroviral therapies for HIV, including inhibitors of reverse transcriptase and integrase.
  • Bromodomain and kinase inhibitors for the treatment of inflammatory diseases.
  • The detection of proteases in inflammatory diseases using activity based probes and the development of protease inhibitors.
  • Lanthanide complexes for in situ determination of protein structure.
  • Ligands for GPCRs, including the adenosine receptors, adrenergic receptors and protease activated receptors.

Keywords

  • Tuberculosis
  • HIV
  • Inflammation
  • Medicinal Chemistry
  • Structure-Based Drug Design
  • Fragment Based Drug Design
  • Drug Delivery
  • Hit-to-lead

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Research Output 2001 2018

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D. 6 Feb 2018 In : Chemistry-A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journalArticle

Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages

Sadek, M., Barzegar Amiri Olia, M., Nowell, C. J., Barlow, N., Schiesser, C. H., Nicholson, S. E. & Norton, R. S. 15 Oct 2017 In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5743–5748 6 p.

Research output: Contribution to journalArticle

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation

Edgington-Mitchell, L. E., Barlow, N., Aurelio, L., Samha, A., Szabo, M., Graham, B. & Bunnett, N. 15 Jan 2017 In : Bioorganic & Medicinal Chemistry Letters. 27, 2, p. 254-260 7 p.

Research output: Contribution to journalArticle

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D. , Lieu, T. , Halls, M. L. , Veldhuis, N. A. , Imlach, W. L. , Mai, Q. N. , Poole, D. P. , Quach, T. , Aurelio, L. , Conner, J. , Klein Herenbrink, C. , Barlow, N. , Simpson, J. S. , Scanlon, M. J. , Graham, B. , McCluskey, A. , Robinson, P. J. , Escriou, V. , Nassini, R. , Materazzi, S. & 6 others Geppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W. 31 May 2017 In : Science Translational Medicine. 9, 392, 15 p., aal3447

Research output: Contribution to journalArticle

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W. 1 Sep 2016 In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.

Research output: Contribution to journalArticle