Research Output per year
Personal profile
Research interests
Nicholas is a synthetic organic chemist who’s work focuses on the design and synthesis of molecules that have applications within the areas of drug discovery and life sciences. Nicholas’ research interests include:
- Anti-microbial therapies that enhance macrophage killing of M. tuberculosis and other bacteria.
- Anti-retroviral therapies for HIV, including inhibitors of reverse transcriptase and integrase.
- Bromodomain and kinase inhibitors for the treatment of inflammatory diseases.
- The detection of proteases in inflammatory diseases using activity based probes and the development of protease inhibitors.
- Lanthanide complexes for in situ determination of protein structure.
- Ligands for GPCRs, including the adenosine receptors, adrenergic receptors and protease activated receptors.
Keywords
- Tuberculosis
- HIV
- Inflammation
- Medicinal Chemistry
- Structure-Based Drug Design
- Fragment Based Drug Design
- Drug Delivery
- Hit-to-lead
Network
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Research Output 2001 2018
- 19 Article
8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase
Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.Research output: Contribution to journal › Article › Research › peer-review
A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent
Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.Research output: Contribution to journal › Article › Research › peer-review
Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages
Sadek, M., Barzegar Amiri Olia, M., Nowell, C. J., Barlow, N., Schiesser, C. H., Nicholson, S. E. & Norton, R. S., 15 Oct 2017, In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5743–5748 6 p.Research output: Contribution to journal › Article › Research › peer-review
Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation
Edgington-Mitchell, L. E., Barlow, N., Aurelio, L., Samha, A., Szabo, M., Graham, B. & Bunnett, N., 15 Jan 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 254-260 7 p.Research output: Contribution to journal › Article › Research › peer-review
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 others, 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.Research output: Contribution to journal › Article › Research › peer-review