Projects per year
Personal profile
Research interests
Nicholas is a synthetic organic chemist who’s work focuses on the design and synthesis of molecules that have applications within the areas of drug discovery and life sciences.
Research area keywords
- Organic chemistry
- Peptide Chemistry
- Medicinal Chemistry
- Structure-Based Drug Design
- Fragment Based Drug Design
- Drug Delivery
- Hit-to-lead
Network
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Projects
- 1 Active
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Lead optimisation of novel inhibitors of IRAP for the treatment of fibrosis in diabetes-induced renal and cardiovascular disease
Gaspari, T., Chai, S., Widdop, R., Thompson, P., Nielsen, K., Perez, S., Dear, A., Yun, B., Pfleger, K. & Barlow, N.
1/10/21 → 30/11/23
Project: Research
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Assessing the cellular toxicity of peptide inhibitors of intracellular protein-protein interactions by microinjection
Babu Reddiar, S., Al-Wassiti, H., Pouton, C. W., Nowell, C. J., Matthews, M. A., Rahman, A., Barlow, N. & Norton, R. S., 1 Jan 2021, In: Bioorganic & Medicinal Chemistry. 29, 8 p., 115906.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Improving Membrane Permeation in the Beyond Rule-of-Five Space by Using Prodrugs to Mask Hydrogen Bond Donors
Barlow, N., Chalmers, D. K., Williams-Noonan, B. J., Thompson, P. E. & Norton, R. S., 21 Aug 2020, In: ACS Chemical Biology. 15, 8, p. 2070-2078 9 p.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus) -
IRAP Inhibitors: M1-Aminopeptidase Family Inspiration
Barlow, N. & Thompson, P. E., 25 Sep 2020, In: Frontiers in Pharmacology. 11, 8 p., 585930.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access3 Citations (Scopus) -
Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP)
Barlow, N., Vanga, S. R., Sävmarker, J., Sandström, A., Burns, P., Hallberg, A., Åqvist, J., Gutiérrez-De-Terán, H., Hallberg, M., Larhed, M., Chai, S. Y. & Thompson, P. E., Feb 2020, In: RSC Medicinal Chemistry. 11, 2, p. 234-244 11 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus) -
8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase
Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In: Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.Research output: Contribution to journal › Article › Research › peer-review
13 Citations (Scopus)