Research Output per year
Personal profile
Research interests
Nicholas is a synthetic organic chemist who’s work focuses on the design and synthesis of molecules that have applications within the areas of drug discovery and life sciences. Nicholas’ research interests include:
- Anti-microbial therapies that enhance macrophage killing of M. tuberculosis and other bacteria.
- Anti-retroviral therapies for HIV, including inhibitors of reverse transcriptase and integrase.
- Bromodomain and kinase inhibitors for the treatment of inflammatory diseases.
- The detection of proteases in inflammatory diseases using activity based probes and the development of protease inhibitors.
- Lanthanide complexes for in situ determination of protein structure.
- Ligands for GPCRs, including the adenosine receptors, adrenergic receptors and protease activated receptors.
Keywords
- Tuberculosis
- HIV
- Inflammation
- Medicinal Chemistry
- Structure-Based Drug Design
- Fragment Based Drug Design
- Drug Delivery
- Hit-to-lead
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Research Output 2001 2018
- 18 Article
8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase
Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D. 6 Feb 2018 In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.Research output: Contribution to journal › Article › Research › peer-review
Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages
Sadek, M., Barzegar Amiri Olia, M., Nowell, C. J., Barlow, N., Schiesser, C. H., Nicholson, S. E. & Norton, R. S. 15 Oct 2017 In : Bioorganic & Medicinal Chemistry. 25, 20, p. 5743–5748 6 p.Research output: Contribution to journal › Article › Research › peer-review
Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation
Edgington-Mitchell, L. E., Barlow, N., Aurelio, L., Samha, A., Szabo, M., Graham, B. & Bunnett, N. 15 Jan 2017 In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 254-260 7 p.Research output: Contribution to journal › Article › Research › peer-review
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
Jensen, D. D. , Lieu, T. , Halls, M. L. , Veldhuis, N. A. , Imlach, W. L. , Mai, Q. N. , Poole, D. P. , Quach, T. , Aurelio, L. , Conner, J. , Klein Herenbrink, C. , Barlow, N. , Simpson, J. S. , Scanlon, M. J. , Graham, B. , McCluskey, A. , Robinson, P. J. , Escriou, V. , Nassini, R. , Materazzi, S. & 6 others 31 May 2017 In : Science Translational Medicine. 9, 392, 15 p., aal3447Research output: Contribution to journal › Article › Research › peer-review
Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2
Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., McLean, P., Lohman, R. J., Fairlie, D. P. & Bunnett, N. W. 1 Sep 2016 In : British Journal of Pharmacology. 173, 18, p. 2752-2765 14 p.Research output: Contribution to journal › Article › Research › peer-review