Projects per year
Personal profile
Research interests
Nicholas is a synthetic organic chemist who’s work focuses on the design and synthesis of molecules that have applications within the areas of drug discovery and life sciences.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Organic chemistry
- Peptide Chemistry
- Medicinal Chemistry
- Structure-Based Drug Design
- Fragment Based Drug Design
- Drug Delivery
- Hit-to-lead
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Finished
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Lead optimisation of novel inhibitors of IRAP for the treatment of fibrosis in diabetes-induced renal and cardiovascular disease
Gaspari, T., Chai, S., Widdop, R., Thompson, P., Nielsen, K., Perez, S., Dear, A., Yun, B., Pfleger, K. & Barlow, N.
1/10/21 → 30/11/23
Project: Research
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Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach
Mansouri, M., Rumrill, S., Dawson, S., Johnson, A., Pinson, J. A., Gunzburg, M. J., Latham, C. F., Barlow, N., Mbogo, G. W., Ellenberg, P., Headey, S. J., Sluis-Cremer, N., Tyssen, D., Bauman, J. D., Ruiz, F. X., Arnold, E., Chalmers, D. K. & Tachedjian, G., Apr 2023, In: Molecules. 28, 7, 26 p., 3103.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Targeting Melanocortin Receptors Using SNAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates
Yue, W. K., Zhang, T., Shandre Mugan, R., Barlow, N., Chalmers, D. K., Pouton, C. W. & Thompson, P. E., 21 Feb 2023, In: Journal of Medicinal Chemistry. 66, 5, p. 3273-3283 11 p.Research output: Contribution to journal › Article › Research › peer-review
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Enhanced nitric oxide production by macrophages treated with a cell-penetrating peptide conjugate
Rahman, A., Matthews, M. A., Nowell, C. J., Chalmers, D. K., Thompson, P. E., Nicholson, S. E., Barlow, N. & Norton, R. S., Jun 2022, In: Bioorganic Chemistry. 123, 9 p., 105763.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Granzyme K initiates IL-6 and IL-8 release from epithelial cells by activating protease-activated receptor 2
Kaiserman, D., Zhao, P., Rowe, C. L., Leong, A., Barlow, N., Joeckel, L. T., Hitchen, C., Stewart, S. E., Hollenberg, M. D., Bunnett, N., Suhrbier, A. & Bird, P. I., Jul 2022, In: PLoS ONE. 17, 7, 16 p., e0270584.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Membrane Permeating Macrocycles: Design Guidelines from Machine Learning
Williams-Noonan, B. J., Speer, M. N., Le, T. C., Sadek, M. M., Thompson, P. E., Norton, R. S., Yuriev, E., Barlow, N., Chalmers, D. K. & Yarovsky, I., 30 Sept 2022, In: Journal of Chemical Information and Modeling. 62, 19, p. 4605–4619 15 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus)