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Research Output 2003 2019

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2019

Agonist-dependent development of delta opioid receptor tolerance in the colon

DiCello, J. J., Saito, A., Rajasekhar, P., Sebastian, B. W., McQuade, R. M., Gondin, A. B., Veldhuis, N. A., Canals, M., Carbone, S. E. & Poole, D. P., Aug 2019, In : Cellular and Molecular Life Sciences. 76, 15, p. 3033–3050 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of a shape-controlled H 2 S delivery system using epoxide-functional nanoparticles

Yu, S. H., Esser, L., Khor, S. Y., Senyschyn, D., Veldhuis, N. A., Whittaker, M. R., Ercole, F., Davis, T. P. & Quinn, J. F., 23 Apr 2019, (Accepted/In press) In : Journal of Polymer Science, Part A: Polymer Chemistry. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

G protein-coupled receptor trafficking and signaling: new insights into the enteric nervous system

Carbone, S. E., Veldhuis, N. A., Gondin, A. B. & Poole, D. P., 1 Apr 2019, In : American journal of physiology. Gastrointestinal and liver physiology. 316, 4, p. G446-G452 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

A Novel Ultra-Stable, Monomeric Green Fluorescent Protein for Direct Volumetric Imaging of Whole Organs Using CLARITY

Scott, D. J., Gunn, N. J., Yong, K. J., Wimmer, V. C., Veldhuis, N. A., Challis, L. M., Haidar, M., Petrou, S., Bathgate, R. A. D. & Griffin, M. D. W., 1 Dec 2018, In : Scientific Reports. 8, 1, 15 p., 667.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inflammation-associated changes in DOR expression and function in the mouse colon

Dicello, J. J., Saito, A., Rajasekhar, P., Eriksson, E. M., McQuade, R., Nowell, C., Sebastian, B., Fichna, J., Veldhuis, N. A., Canals, M., Bunnett, N., Carbone, S. E. & Poole, D. P., 1 Oct 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 315, 4, p. G544-G559 39 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Yu, S. H., Patra, M., Ferrari, S., Ramirez Garcia, P., Veldhuis, N. A., Kaminskas, L. M., Graham, B., Quinn, J. F., Whittaker, M. R., Gasser, G. & Davis, T. P., 29 Oct 2018, In : Journal of Materials Chemistry B. 6, 47, p. 7805-7810 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 othersScheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Yarwood, R. E., Imlach, W. L., Lieu, T., Veldhuis, N. A., Jensen, D. D., Herenbrink, C. K., Aurelio, L., Cai, Z., Christie, M. J., Poole, D. P., Porter, C. J. H., McLean, P., Hicks, G. A., Geppetti, P., Halls, M. L., Canals, M. & Bunnett, N. W., 14 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 46, p. 12309-12314 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 othersGeppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

Polymers with acyl-protected perthiol chain termini as convenient building blocks for doubly responsive H2S-donating nanoparticles

Yu, S. H., Ercole, F., Veldhuis, N. A., Whittaker, M. R., Davis, T. P. & Quinn, J. F., 7 Nov 2017, In : Polymer Chemistry. 8, 41, p. 6362-6367 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Barlow, N., Nasser, Y., Zhao, P., Sharma, N., Guerrero-Alba, R., Edgington-Mitchell, L. E., Lieu, T., Veldhuis, N. A., Poole, D. P., Conner, J. W., Lindstrom, E., Craig, A. W., Graham, B., Vanner, S. J. & Bunnett, N. W., 2015, In : Neurogastroenterology and Motility. 27, 11, p. 1675-1680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

G protein-coupled receptors: dynamic machines for signaling pain and itch

Geppetti, P., Veldhuis, N. A., Lieu, T. & Bunnett, N. W., 2015, In : Neuron. 88, 4, p. 635-649 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

Poole, D. P., Lieu, T. M., Pelayo, J-C., Eriksson, E. M. Y., Veldhuis, N. A. & Bunnett, N. W., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 4, p. G248-G259 12 p.

Research output: Contribution to journalArticleResearchpeer-review

P2Y1 receptor activation of the TRPV4 ion channel enhances purinergic signaling in satellite glial cells

Rajasekhar, P., Poole, D. P., Liedtke, W., Bunnett, N. W. & Veldhuis, N. A., 2015, In : Journal of Biological Chemistry. 290, 48, p. 29051-29062 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantification and potential functions of endogenous agonists of transient receptor potential channels in patients with irritable bowel syndrome

Cenac, N., Bautzova, T., Le Faouder, P., Veldhuis, N. A., Poole, D. P., Rolland, C., Bertrand, J., Liedtke, W., Dubourdeau, M., Bertrand-Michel, J., Zecchi, L., Stanghellini, V., Bunnett, N. W., Barbara, G. & Vergnolle, N., 2015, In : Gastroenterology. 149, 2, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation

Veldhuis, N. A., Poole, D. P., Grace, M., McIntyre, P. & Bunnett, N. W., 2015, In : Pharmacological Reviews. 67, 1, p. 36 - 73 38 p.

Research output: Contribution to journalArticleResearchpeer-review

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

Fichna, J., Poole, D. P., Veldhuis, N., MacEachern, S. J., Saur, D., Zakrzewski, P. K., Cygankiewicz, A. I., Mokrowiecka, A., Malecka-Panas, E., Krajewska, W. M., Liedtke, W., Steinhoff, M. S., Timmermans, J-P., Bunnett, N. W., Sharkey, K. A. & Storr, M. A., 2015, In : Journal of Molecular Medicine. 93, 12, p. 1297-1309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Activation of mu opioid receptors sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via beta-arrestin-2-mediated cross-talk

Rowan, M. P., Bierbower, S. M., Eskander, M. A., Szteyn, K., Por, E. D., Gomez, R., Veldhuis, N. A., Bunnett, N. W. & Jeske, N. A., 2014, In : PLoS ONE. 9, 4, 12 p., e93688.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4

Zhao, P., Lieu, T. M., Barlow, N., Metcalf, M., Veldhuis, N. A., Jensen, D. D., Kocan, M., Sostegni, S., Haerteis, S., Baraznenok, V. A., Henderson, I., Lindstrom, E., Guerrero-Alba, R., Valdez-Morales, E., Liedtke, W., McIntyre, P., Vanner, S., Korbmacher, C. & Bunnett, N. W., 2014, In : Journal of Biological Chemistry. 289, 39, p. 27215 - 27234 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon

Pelayo, J-C., Veldhuis, N. A., Eriksson, E. M., Bunnett, N. W. & Poole, D. P., 2014, In : Cell and Tissue Research. 356, 2, p. 319 - 332 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

Grace, M., Lieu, T. M., Darby, B., Abogadie, F. C., Veldhuis, N. A., Bunnett, N. W. & McIntyre, P., 2014, In : British Journal of Pharmacology. 171, 16, p. 3881 - 3894 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling

Poole, D. P., Amadesi, S., Veldhuis, N. A., Abogadie, F. C., Lieu, T. M., Darby, W., Liedtke, W., Lew, M. J., McIntyre, P. B. & Bunnett, N. W., 2013, In : Journal of Biological Chemistry. 288, 8, p. 5790 - 5802 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor

Veldhuis, N. A., Lew, M. J., Abogadie, F. C., Poole, D. P., Jennings, E. A., Ivanusic, J. J., Eilers, H., Bunnett, N. W. & McIntyre, P. B., 2012, In : Journal of Biological Chemistry. 287, 28, p. 21765 - 21772 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function

Gibbs, G., Orta, G., Reddy, T., Koppers, A., Martinez-Lopez, P., de la Vega-Beltran, J., Lo, J. C., Veldhuis, N., Jamsai, D., McIntyre, P. B., Darszon, A. & O'Bryan, M., 2011, In : Proceedings of the National Academy of Sciences. 108, 17, p. 7034 - 7039 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding

Veldhuis, N. A., Kuiper, M. J., Dobson, R. C. J., Pearson, R. B. & Camakaris, J., Jun 2011, In : BioMetals. 24, 3, p. 477-487 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Conservation of copper-transporting P(IB)-type ATPase function

Southon, A., Palstra, N., Veldhuis, N., Gaeth, A., Robin, C., Burke, R. & Camakaris, J., 2010, In : BioMetals. 23, 4, p. 681 - 694 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase

Veldhuis, N. A., Valova, V. A., Gaeth, A. P., Palstra, N., Hannan, K. M., Michell, B. J., Kelly, L. E., Jennings, I., Kemp, B. E., Pearson, R. B., Robinson, P. J. & Camakaris, J., 2009, In : International Journal of Biochemistry and Cell Biology. 41, 12, p. 2403 - 2412 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The multi-layered regulation of copper translocating P-type ATPases

Veldhuis, N. A., Gaeth, A. P., Pearson, R. B., Gabriel, K. & Camakaris, J., 2009, In : BioMetals. 22, 1, p. 177 - 190 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase

Voskoboinik, I., Fernando, R., Veldhuis, N., Hannan, K. M., Marmy-Conus, N., Pearson, R. B. & Camakaris, J., 28 Mar 2003, In : Biochemical and Biophysical Research Communications. 303, 1, p. 337-342 6 p.

Research output: Contribution to journalArticleResearchpeer-review