20032022
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Research Output 2003 2019

2019

Agonist-dependent development of delta opioid receptor tolerance in the colon

DiCello, J. J., Saito, A., Rajasekhar, P., Sebastian, B. W., McQuade, R. M., Gondin, A. B., Veldhuis, N. A., Canals, M., Carbone, S. E. & Poole, D. P., Aug 2019, In : Cellular and Molecular Life Sciences. 76, 15, p. 3033–3050 18 p.

Research output: Contribution to journalArticleResearchpeer-review

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Ramirez Garcia, P. D., Retamal, J. S., Shenoy, P., Imlach, W., Sykes, M., Truong, N., Constandil, L., Pelissier, T., Nowell, C. J., Khor, S. Y., Layani, L. M., Lumb, C., Poole, D. P., Lieu, T., Stewart, G. D., Mai, Q. N., Jensen, D. D., Latorre, R., Scheff, N. N., Schmidt, B. L. & 5 others, Quinn, J. F., Whittaker, M. R., Veldhuis, N. A., Davis, T. P. & Bunnett, N. W., Dec 2019, In : Nature Nanotechnology. 14, p. 1150-1159 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Development of a Shape-Controlled H2S Delivery System Using Epoxide-Functional Nanoparticles

Yu, S. H., Esser, L., Khor, S. Y., Senyschyn, D., Veldhuis, N. A., Whittaker, M. R., Ercole, F., Davis, T. P. & Quinn, J. F., 2019, In : Journal of Polymer Science, Part A: Polymer Chemistry. 57, 18, p. 1982–1993 12 p.

Research output: Contribution to journalArticleResearchpeer-review

G-Protein–Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Canals, M., Poole, D. P., Veldhuis, N. A., Schmidt, B. L. & Bunnett, N. W., 1 May 2019, In : Gastroenterology. 156, 6, p. 1600-1616 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain

Retamal, J. S., Ramírez-García, P. D., Shenoy, P. A., Poole, D. P. & Veldhuis, N. A., 12 Nov 2019, In : Frontiers in Molecular Neuroscience. 12, p. 1-10 10 p., 273.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Mu and Delta Opioid Receptors are Co-expressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon

Di Cello, J., Carbone, S., Saito, A., Rajasekhar, P., Ceredig, R. A., Pham, V., Valant, C., Christopoulos, A., Veldhuis, N. A., Canals, M., Massotte, D. & Poole, D. P., 20 Nov 2019, (Accepted/In press) In : Cellular and Molecular Gastroenterology and Hepatology. 47 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Rapid Assessment of Nanoparticle Extravasation in a Microfluidic Tumor Model

Vu, N. M., Rajasekhar, P., Poole, D. P., Khor, S. Y., Truong Phuoc, N., Nowell, C., Quinn, J. F., Whittaker, M., Veldhuis, N. & Davis, T. P., 29 Mar 2019, In : ACS Applied Nano Materials. 2, 4, p. 1844-1856 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018
9 Citations (Scopus)

A Novel Ultra-Stable, Monomeric Green Fluorescent Protein for Direct Volumetric Imaging of Whole Organs Using CLARITY

Scott, D. J., Gunn, N. J., Yong, K. J., Wimmer, V. C., Veldhuis, N. A., Challis, L. M., Haidar, M., Petrou, S., Bathgate, R. A. D. & Griffin, M. D. W., 1 Dec 2018, In : Scientific Reports. 8, 1, 15 p., 667.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Inflammation-associated changes in DOR expression and function in the mouse colon

Dicello, J. J., Saito, A., Rajasekhar, P., Eriksson, E. M., McQuade, R., Nowell, C., Sebastian, B., Fichna, J., Veldhuis, N. A., Canals, M., Bunnett, N., Carbone, S. E. & Poole, D. P., 1 Oct 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 315, 4, p. G544-G559 39 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Yu, S. H., Patra, M., Ferrari, S., Ramirez Garcia, P., Veldhuis, N. A., Kaminskas, L. M., Graham, B., Quinn, J. F., Whittaker, M. R., Gasser, G. & Davis, T. P., 29 Oct 2018, In : Journal of Materials Chemistry B. 6, 47, p. 7805-7810 6 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 others, Scheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017
38 Citations (Scopus)

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Yarwood, R. E., Imlach, W. L., Lieu, T., Veldhuis, N. A., Jensen, D. D., Herenbrink, C. K., Aurelio, L., Cai, Z., Christie, M. J., Poole, D. P., Porter, C. J. H., McLean, P., Hicks, G. A., Geppetti, P., Halls, M. L., Canals, M. & Bunnett, N. W., 14 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 46, p. 12309-12314 6 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 others, Geppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Polymers with acyl-protected perthiol chain termini as convenient building blocks for doubly responsive H2S-donating nanoparticles

Yu, S. H., Ercole, F., Veldhuis, N. A., Whittaker, M. R., Davis, T. P. & Quinn, J. F., 7 Nov 2017, In : Polymer Chemistry. 8, 41, p. 6362-6367 6 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Role of Nonneuronal TRPV4 Signaling in Inflammatory Processes

Rajasekhar, P., Poole, D. P. & Veldhuis, N. A., 2017, Ion Channels DownUnder. Geraghty, D. P. & Rash, L. D. (eds.). Cambridge MA USA: Academic Press, Vol. 79. p. 117-139 23 p. (Advances in Pharmacology; vol. 79). (Advances in Pharmacology).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2015
2 Citations (Scopus)

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Barlow, N., Nasser, Y., Zhao, P., Sharma, N., Guerrero-Alba, R., Edgington-Mitchell, L. E., Lieu, T., Veldhuis, N. A., Poole, D. P., Conner, J. W., Lindstrom, E., Craig, A. W., Graham, B., Vanner, S. J. & Bunnett, N. W., 2015, In : Neurogastroenterology and Motility. 27, 11, p. 1675-1680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

G protein-coupled receptors: dynamic machines for signaling pain and itch

Geppetti, P., Veldhuis, N. A., Lieu, T. & Bunnett, N. W., 2015, In : Neuron. 88, 4, p. 635-649 15 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

Poole, D. P., Lieu, T. M., Pelayo, J-C., Eriksson, E. M. Y., Veldhuis, N. A. & Bunnett, N. W., 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 4, p. G248-G259 12 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

P2Y1 receptor activation of the TRPV4 ion channel enhances purinergic signaling in satellite glial cells

Rajasekhar, P., Poole, D. P., Liedtke, W., Bunnett, N. W. & Veldhuis, N. A., 2015, In : Journal of Biological Chemistry. 290, 48, p. 29051-29062 12 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Quantification and potential functions of endogenous agonists of transient receptor potential channels in patients with irritable bowel syndrome

Cenac, N., Bautzova, T., Le Faouder, P., Veldhuis, N. A., Poole, D. P., Rolland, C., Bertrand, J., Liedtke, W., Dubourdeau, M., Bertrand-Michel, J., Zecchi, L., Stanghellini, V., Bunnett, N. W., Barbara, G. & Vergnolle, N., 2015, In : Gastroenterology. 149, 2, p. 433-444 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Targeting of transient receptor potential channels in digestive disease

Poole, D. P., Lieu, T., Veldhuis, N. A., Rajasekhar, P. & Bunnett, N. W., 2015, TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use. Szallasi, A. (ed.). London UK: Elsevier, p. 385-403 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

55 Citations (Scopus)

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation

Veldhuis, N. A., Poole, D. P., Grace, M., McIntyre, P. & Bunnett, N. W., 2015, In : Pharmacological Reviews. 67, 1, p. 36 - 73 38 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

Fichna, J., Poole, D. P., Veldhuis, N., MacEachern, S. J., Saur, D., Zakrzewski, P. K., Cygankiewicz, A. I., Mokrowiecka, A., Malecka-Panas, E., Krajewska, W. M., Liedtke, W., Steinhoff, M. S., Timmermans, J-P., Bunnett, N. W., Sharkey, K. A. & Storr, M. A., 2015, In : Journal of Molecular Medicine. 93, 12, p. 1297-1309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
26 Citations (Scopus)

Activation of mu opioid receptors sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via beta-arrestin-2-mediated cross-talk

Rowan, M. P., Bierbower, S. M., Eskander, M. A., Szteyn, K., Por, E. D., Gomez, R., Veldhuis, N. A., Bunnett, N. W. & Jeske, N. A., 2014, In : PLoS ONE. 9, 4, 12 p., e93688.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
76 Citations (Scopus)

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4

Zhao, P., Lieu, T. M., Barlow, N., Metcalf, M., Veldhuis, N. A., Jensen, D. D., Kocan, M., Sostegni, S., Haerteis, S., Baraznenok, V. A., Henderson, I., Lindstrom, E., Guerrero-Alba, R., Valdez-Morales, E., Liedtke, W., McIntyre, P., Vanner, S., Korbmacher, C. & Bunnett, N. W., 2014, In : Journal of Biological Chemistry. 289, 39, p. 27215 - 27234 20 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon

Pelayo, J-C., Veldhuis, N. A., Eriksson, E. M., Bunnett, N. W. & Poole, D. P., 2014, In : Cell and Tissue Research. 356, 2, p. 319 - 332 14 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

Grace, M., Lieu, T. M., Darby, B., Abogadie, F. C., Veldhuis, N. A., Bunnett, N. W. & McIntyre, P., 2014, In : British Journal of Pharmacology. 171, 16, p. 3881 - 3894 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
80 Citations (Scopus)

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling

Poole, D. P., Amadesi, S., Veldhuis, N. A., Abogadie, F. C., Lieu, T. M., Darby, W., Liedtke, W., Lew, M. J., McIntyre, P. B. & Bunnett, N. W., 2013, In : Journal of Biological Chemistry. 288, 8, p. 5790 - 5802 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
32 Citations (Scopus)

N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor

Veldhuis, N. A., Lew, M. J., Abogadie, F. C., Poole, D. P., Jennings, E. A., Ivanusic, J. J., Eilers, H., Bunnett, N. W. & McIntyre, P. B., 2012, In : Journal of Biological Chemistry. 287, 28, p. 21765 - 21772 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
54 Citations (Scopus)

Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function

Gibbs, G., Orta, G., Reddy, T., Koppers, A., Martinez-Lopez, P., de la Vega-Beltran, J., Lo, J. C., Veldhuis, N., Jamsai, D., McIntyre, P. B., Darszon, A. & O'Bryan, M., 2011, In : Proceedings of the National Academy of Sciences. 108, 17, p. 7034 - 7039 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

In silico modeling of the Menkes copper-translocating P-type ATPase 3rd metal binding domain predicts that phosphorylation regulates copper-binding

Veldhuis, N. A., Kuiper, M. J., Dobson, R. C. J., Pearson, R. B. & Camakaris, J., Jun 2011, In : BioMetals. 24, 3, p. 477-487 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
15 Citations (Scopus)

Conservation of copper-transporting P(IB)-type ATPase function

Southon, A., Palstra, N., Veldhuis, N., Gaeth, A., Robin, C., Burke, R. & Camakaris, J., 2010, In : BioMetals. 23, 4, p. 681 - 694 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
46 Citations (Scopus)

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase

Veldhuis, N. A., Valova, V. A., Gaeth, A. P., Palstra, N., Hannan, K. M., Michell, B. J., Kelly, L. E., Jennings, I., Kemp, B. E., Pearson, R. B., Robinson, P. J. & Camakaris, J., 2009, In : International Journal of Biochemistry and Cell Biology. 41, 12, p. 2403 - 2412 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

The multi-layered regulation of copper translocating P-type ATPases

Veldhuis, N. A., Gaeth, A. P., Pearson, R. B., Gabriel, K. & Camakaris, J., 2009, In : BioMetals. 22, 1, p. 177 - 190 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
22 Citations (Scopus)

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase

Voskoboinik, I., Fernando, R., Veldhuis, N., Hannan, K. M., Marmy-Conus, N., Pearson, R. B. & Camakaris, J., 28 Mar 2003, In : Biochemical and Biophysical Research Communications. 303, 1, p. 337-342 6 p.

Research output: Contribution to journalArticleResearchpeer-review