Projects per year
Personal profile
Biography
Prof. Huntington is the head of the Cancer Immunotherapy Laboratory at the Biomedicine Discovery Institute at Monash University, Australia. He is an international leader on natural killer (NK) cell biology with notable contributions to: regulatory mechanisms of IL-15 signalling in NK cells, identification of human and murine NK cell differentiation pathways, novel xenograft models to study human haematopoiesis and identification of multiple checkpoint in NK cell activation and tumour immunity. Prof. Huntington leads a research program aimed at deciphering the regulatory networks that control NK cell immunity and a drug discovery program using cutting-edge in vivo screens for novel checkpoints in NK cell activation for targeting in cancer immunotherapy. Prof. Huntington is President of MIN (Melbourne Immunotherapy Network), serves as project director for several pharmaceutical collaborative research programs at The Walter and Eliza Hall Institute and is a co-founder and chief scientific officer of oNKo-Innate Pty Ltd
Education/Academic qualification
PhD, A quantitative analysis of signalling mutations on B and NK cell effector functions, University of Melbourne
2002 → 2006
External positions
Laboratory Head (Level D), Walter and Eliza Hall Institute of Medical Research (WEHI)
2017 → 2018
Honorary Fellow (Level C), University of Melbourne
2013 → 2017
Laboratory Head (Level C), Walter and Eliza Hall Institute of Medical Research (WEHI)
2013 → 2017
Senior Research Fellow (Level B), Walter and Eliza Hall Institute of Medical Research (WEHI)
2011 → 2012
Human Frontiers Long-Term Fellow, Institut Pasteur (Pasteur Institute)
2008 → 2011
RG Menzies Scholar & CJ Martin Fellow, Institut Pasteur (Pasteur Institute)
2007 → 2012
CCV Sydney Parker Smith Postdoctoral Cancer Research Fellow, Walter and Eliza Hall Institute of Medical Research (WEHI)
2006 → 2007
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Projects
- 13 Finished
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FLEX immunotherapeutics – a new class of anticancer biologics
Dickins, R. (Primary Chief Investigator (PCI)), Huntington, N. (Chief Investigator (CI)), Oxley, E. (Chief Investigator (CI)) & Kershaw, N. (Chief Investigator (CI))
31/07/22 → 30/11/24
Project: Research
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Melanoma_TP53: Targeting MDM Pathway to Enhance Cancer Immunotherapy Response Rates
Huntington, N. (Primary Chief Investigator (PCI)), Foroutan, M. (Chief Investigator (CI)) & Scheer, S. (Chief Investigator (CI))
1/01/22 → 31/12/24
Project: Research
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Defining the role of natural killer cells in the radiotherapy treatment response of metastatic prostate cancer
Molania, R. (Primary Chief Investigator (PCI)), Foroutan, M. (Chief Investigator (CI)), Sandhu, S. (Chief Investigator (CI)), Huntington, N. (Chief Investigator (CI)) & Cursons, J. (Chief Investigator (CI))
4/01/21 → 3/01/24
Project: Research
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Natural Killer Cell Cancer Immunotherapy
Huntington, N. (Primary Chief Investigator (PCI))
1/01/21 → 31/12/25
Project: Research
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Next Generation Cell Therapies for Cancer
Tiganis, T. (Primary Chief Investigator (PCI)), Huntington, N. (Chief Investigator (CI)), Darcy, P. (Associate Investigator (AI)), Zhang, Z.-Y. (Associate Investigator (AI)), Cursons, J. (Associate Investigator (AI)) & Vivier, É. (Associate Investigator (AI))
1/12/19 → 31/12/23
Project: Research
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Adjusting the scope of natural killer cells in cancer therapy
Shen, Z., Meng, X., Rautela, J., Chopin, M. & Huntington, N. D., Jul 2025, In: Cellular & Molecular Immunology. 22, 7, p. 699-711 13 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access23 Link opens in a new tab Citations (Scopus) -
Lymph-node-derived stem-like but not tumor-tissue-resident CD8+ T cells fuel anticancer immunity
Wijesinghe, S. K. M., Rausch, L., Gabriel, S. S., Galletti, G., De Luca, M., Qin, L., Wen, L., Tsui, C., Man, K., Heyden, L., Mason, T., Newland, L. D., Kueh, A., Liao, Y., Chisanga, D., Swatler, J., Voulaz, E., Marulli, G., Errico, V. & Losurdo, A. & 10 others, , Aug 2025, In: Nature Immunology. 26, 8, p. 1367-1383 17 p.Research output: Contribution to journal › Article › Research › peer-review
32 Link opens in a new tab Citations (Scopus) -
Author Correction: CIS is a potent checkpoint in NK cell–mediated tumor immunity (Nature Immunology, (2016), 17, 7, (816-824), 10.1038/ni.3470)
Delconte, R. B., Kolesnik, T. B., Dagley, L. F., Rautela, J., Shi, W., Putz, E. M., Stannard, K., Zhang, J. G., Teh, C., Firth, M., Ushiki, T., Andoniou, C. E., Degli-Esposti, M. A., Sharp, P. P., Sanvitale, C. E., Infusini, G., Liau, N. P. D., Linossi, E. M., Burns, C. J. & Carotta, S. & 12 others, , Feb 2024, In: Nature Immunology. 25, 2, p. 371-372 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
CD45 limits early Natural Killer cell development
Meza Guzman, L. G., Hyland, C. D., Bidgood, G. M., Leong, E., Shen, Z., Goh, W., Rautela, J., Vince, J. E., Nicholson, S. E. & Huntington, N. D., Jan 2024, In: Immunology and Cell Biology. 102, 1, p. 58-70 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Link opens in a new tab Citations (Scopus) -
Context-restricted PD-(L)1 checkpoint agonism by CTLA4-Ig therapies inhibits T cell activity
Oxley, E. P. (Leading Author), Kershaw, N. J. (Leading Author), Louis, C., Goodall, K. J., Garwood, M. M., Jee Ho, S. M., Voo, V. T. F., Park, H. Y., Iaria, J., Wong, L. L. L., Lebenbaum, A. G., Wiranata, S., Pang, E. S., Edwards, E. S. J., D'Silva, D. B., Hansen, J., van Zelm, M. C., O'Keeffe, M., Hogarth, P. M. & Haynes, N. M. & 3 others, , 22 Oct 2024, In: Cell Reports. 43, 10, 20 p., 114834.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Link opens in a new tab Citations (Scopus)
Prizes
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11th Meeting of the Society for Natural Immunity Travel Scholarship
Huntington, N. (Recipient), 2008
Prize: Other distinction
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1st High Commendation for the Victorian Premier’s Award
Huntington, N. (Recipient), 2006
Prize: Prize (including medals and awards)
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2012 Travel Award for Society of Natural Immunity 2012 Meeting
Huntington, N. (Recipient), 2012
Prize: Prize (including medals and awards)
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2025 Dr. John Raftos AM Medal
Huntington, N. (Recipient), 30 Nov 2027
Prize: Prize (including medals and awards)
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Australian Museum Eureka Prize Finalist - UNSW Prize for Scientific Research
Huntington, N. (Recipient), 2016
Prize: Prize (including medals and awards)