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Personal profile


Prof. Huntington is the head of the Cancer Immunotherapy Laboratory at the Biomedicine Discovery Institute at Monash University, Australia. He is an international leader on natural killer (NK) cell biology with notable contributions to: regulatory mechanisms of IL-15 signalling in NK cells, identification of human and murine NK cell differentiation pathways, novel xenograft models to study human haematopoiesis and identification of multiple checkpoint in NK cell activation and tumour immunity. Prof. Huntington leads a research program aimed at deciphering the regulatory networks that control NK cell immunity and a drug discovery program using cutting-edge in vivo screens for novel checkpoints in NK cell activation for targeting in cancer immunotherapy. Prof. Huntington is President of MIN (Melbourne Immunotherapy Network), serves as project director for several pharmaceutical collaborative research programs at The Walter and Eliza Hall Institute and is a co-founder and chief scientific officer of oNKo-Innate Pty Ltd

Education/Academic qualification

PhD, University of Melbourne


External positions

Laboratory Head (Level D), The Walter and Eliza Hall Institute of Medical Research (WEHI)


Laboratory Head (Level C), The Walter and Eliza Hall Institute of Medical Research (WEHI)


Honorary Fellow (Level C), University of Melbourne


Senior Research Fellow (Level B), The Walter and Eliza Hall Institute of Medical Research (WEHI)


Human Frontiers Long-Term Fellow, Institut Pasteur (Pasteur Institute)


RG Menzies Scholar & CJ Martin Fellow, Institut Pasteur (Pasteur Institute)


CCV Sydney Parker Smith Postdoctoral Cancer Research Fellow, The Walter and Eliza Hall Institute of Medical Research (WEHI)


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Projects 2019 2023

Research Output 2003 2019

6 Citations (Scopus)

A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients

Cursons, J., Souza-Fonseca-Guimaraes, F., Foroutan, M., Anderson, A., Hollande, F., Hediyeh-Zadeh, S., Behren, A., Huntington, N. D. & Davis, M. J., Jul 2019, In : Cancer Immunology Research. 7, 7, p. 1162-1174 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Author Correction: Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin (Nature, (2019), 565, 7739, (366-371), 10.1038/s41586-018-0812-9)

Park, S. L., Buzzai, A., Rautela, J., Hor, J. L., Hochheiser, K., Effern, M., McBain, N., Wagner, T., Edwards, J., McConville, R., Wilmott, J. S., Scolyer, R. A., Tüting, T., Palendira, U., Gyorki, D., Mueller, S. N., Huntington, N. D., Bedoui, S., Hölzel, M., Mackay, L. K. & 2 others, Waithman, J. & Gebhardt, T., 28 Feb 2019, In : Nature. 566, 7745, p. E10 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
7 Citations (Scopus)

Bone marrow transplantation generates T cell-dependent control of myeloma in mice

Vuckovic, S., Minnie, S. A., Smith, D., Gartlan, K. H., Watkins, T. S., Markey, K. A., Mukhopadhyay, P., Guillerey, C., Kuns, R. D., Locke, K. R., Pritchard, A. L., Johansson, P. A., Varelias, A., Zhang, P., Huntington, N. D., Waddell, N., Chesi, M., Miles, J. J., Smyth, M. J. & Hill, G. R., 2 Jan 2019, In : Journal of Clinical Investigation. 129, 1, p. 106-121 16 p., CI98888.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection

Sheikh, A. A., Cooper, L., Feng, M., Souza-Fonseca-Guimaraes, F., Lafouresse, F., Duckworth, B. C., Huntington, N. D., Moon, J. J., Pellegrini, M., Nutt, S. L., Belz, G. T., Good-Jacobson, K. L. & Groom, J. R., 13 Aug 2019, In : Cell Reports. 28, 7, p. 1758-1772 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Cytotoxic T Lymphocytes and Natural Killer Cells

Nutt, S. L. & Huntington, N. D., 2019, Clinical Immunology: Principles and Practice. Rich, R. R., Fleisher, T. A., Shearer, W. T., Schroeder, H. W., Frew, A. J. & Weyand, C. M. (eds.). 5th ed. Sweden: Elsevier, p. 247-259 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review