Projects per year
Personal profile
Biography
Prof. Huntington is the head of the Cancer Immunotherapy Laboratory at the Biomedicine Discovery Institute at Monash University, Australia. He is an international leader on natural killer (NK) cell biology with notable contributions to: regulatory mechanisms of IL-15 signalling in NK cells, identification of human and murine NK cell differentiation pathways, novel xenograft models to study human haematopoiesis and identification of multiple checkpoint in NK cell activation and tumour immunity. Prof. Huntington leads a research program aimed at deciphering the regulatory networks that control NK cell immunity and a drug discovery program using cutting-edge in vivo screens for novel checkpoints in NK cell activation for targeting in cancer immunotherapy. Prof. Huntington is President of MIN (Melbourne Immunotherapy Network), serves as project director for several pharmaceutical collaborative research programs at The Walter and Eliza Hall Institute and is a co-founder and chief scientific officer of oNKo-Innate Pty Ltd
Education/Academic qualification
PhD, University of Melbourne
2002 → 2006
External positions
Laboratory Head (Level D), The Walter and Eliza Hall Institute of Medical Research (WEHI)
2017 → 2018Laboratory Head (Level C), The Walter and Eliza Hall Institute of Medical Research (WEHI)
2013 → 2017Honorary Fellow (Level C), University of Melbourne
2013 → 2017Senior Research Fellow (Level B), The Walter and Eliza Hall Institute of Medical Research (WEHI)
2011 → 2012Human Frontiers Long-Term Fellow, Institut Pasteur (Pasteur Institute)
2008 → 2011RG Menzies Scholar & CJ Martin Fellow, Institut Pasteur (Pasteur Institute)
2007 → 2012CCV Sydney Parker Smith Postdoctoral Cancer Research Fellow, The Walter and Eliza Hall Institute of Medical Research (WEHI)
2006 → 2007
Network
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Projects 2019 2022
- 7 Active
Effective melanoma immunity by targeting novel checkpoints NK cell activation
1/08/19 → 14/05/20
Project: Research
Identification of CIS as a potent checkpoint in NK cell-mediated tumour immunity
Huntington, N., Smyth, M. J., Vivier, E. & Nicholson, S. E.
National Health & Medical Research Council (NHMRC)
1/06/19 → 31/12/20
Project: Research
Identification of E-protein complexes controlling natural killer cell fate and tumour immunity
Huntington, N., Corcoran, L. M., Vivier, E. & Nicholson, S. E.
National Health & Medical Research Council (NHMRC)
1/02/19 → 31/12/19
Project: Research
Inhibiting Bcl-2 and NK cells improves stem cell transplant outcomes in Acute Myeloid Leukaemia
Ritchie, D. & Huntington, N.
29/01/19 → 31/12/20
Project: Research
Research Output 2003 2019
1
Citation
(Scopus)
A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients
Cursons, J., Souza-Fonseca-Guimaraes, F., Foroutan, M., Anderson, A., Hollande, F., Hediyeh-Zadeh, S., Behren, A., Huntington, N. D. & Davis, M. J., Jul 2019, In : Cancer Immunology Research. 7, 7, p. 1162-1174 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Author Correction: Tissue-resident memory CD8+ T cells promote melanoma–immune equilibrium in skin (Nature, (2019), 565, 7739, (366-371), 10.1038/s41586-018-0812-9)
Park, S. L., Buzzai, A., Rautela, J., Hor, J. L., Hochheiser, K., Effern, M., McBain, N., Wagner, T., Edwards, J., McConville, R., Wilmott, J. S., Scolyer, R. A., Tüting, T., Palendira, U., Gyorki, D., Mueller, S. N., Huntington, N. D., Bedoui, S., Hölzel, M., Mackay, L. K. & 2 others, , 28 Feb 2019, In : Nature. 566, 7745, p. E10 1 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access
6
Citations
(Scopus)
Bone marrow transplantation generates T cell-dependent control of myeloma in mice
Vuckovic, S., Minnie, S. A., Smith, D., Gartlan, K. H., Watkins, T. S., Markey, K. A., Mukhopadhyay, P., Guillerey, C., Kuns, R. D., Locke, K. R., Pritchard, A. L., Johansson, P. A., Varelias, A., Zhang, P., Huntington, N. D., Waddell, N., Chesi, M., Miles, J. J., Smyth, M. J. & Hill, G. R., 2 Jan 2019, In : Journal of Clinical Investigation. 129, 1, p. 106-121 16 p., CI98888.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
2
Citations
(Scopus)
Context-Dependent Role for T-bet in T Follicular Helper Differentiation and Germinal Center Function following Viral Infection
Sheikh, A. A., Cooper, L., Feng, M., Souza-Fonseca-Guimaraes, F., Lafouresse, F., Duckworth, B. C., Huntington, N. D., Moon, J. J., Pellegrini, M., Nutt, S. L., Belz, G. T., Good-Jacobson, K. L. & Groom, J. R., 13 Aug 2019, In : Cell Reports. 28, 7, p. 1758-1772 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Cytotoxic T Lymphocytes and Natural Killer Cells
Nutt, S. L. & Huntington, N. D., 2019, Clinical Immunology: Principles and Practice. Rich, R. R., Fleisher, T. A., Shearer, W. T., Schroeder, H. W., Frew, A. J. & Weyand, C. M. (eds.). 5th ed. Sweden: Elsevier, p. 247-259 13 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
Prizes
11th Meeting of the Society for Natural Immunity Travel Scholarship
Nicholas Huntington (Recipient), 2008
Prize: Other distinction
1st High Commendation for the Victorian Premier’s Award
Nicholas Huntington (Recipient), 2006
Prize: Prize (including medals and awards)
2012 Travel Award for Society of Natural Immunity 2012 Meeting
Nicholas Huntington (Recipient), 2012
Prize: Prize (including medals and awards)
Australian Museum Eureka Prize Finalist - UNSW Prize for Scientific Research
Nicholas Huntington (Recipient), 2016
Prize: Prize (including medals and awards)
Cancer Council Victoria Postdoctoral Fellowship
Nicholas Huntington (Recipient), 2006
Prize: Competitive Fellowships