Projects per year
Personal profile
Biography
Prof. Huntington is the head of the Cancer Immunotherapy Laboratory at the Biomedicine Discovery Institute at Monash University, Australia. He is an international leader on natural killer (NK) cell biology with notable contributions to: regulatory mechanisms of IL-15 signalling in NK cells, identification of human and murine NK cell differentiation pathways, novel xenograft models to study human haematopoiesis and identification of multiple checkpoint in NK cell activation and tumour immunity. Prof. Huntington leads a research program aimed at deciphering the regulatory networks that control NK cell immunity and a drug discovery program using cutting-edge in vivo screens for novel checkpoints in NK cell activation for targeting in cancer immunotherapy. Prof. Huntington is President of MIN (Melbourne Immunotherapy Network), serves as project director for several pharmaceutical collaborative research programs at The Walter and Eliza Hall Institute and is a co-founder and chief scientific officer of oNKo-Innate Pty Ltd
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, University of Melbourne
2002 → 2006
External positions
Laboratory Head (Level D), Walter and Eliza Hall Institute of Medical Research (WEHI)
2017 → 2018
Honorary Fellow (Level C), University of Melbourne
2013 → 2017
Laboratory Head (Level C), Walter and Eliza Hall Institute of Medical Research (WEHI)
2013 → 2017
Senior Research Fellow (Level B), Walter and Eliza Hall Institute of Medical Research (WEHI)
2011 → 2012
Human Frontiers Long-Term Fellow, Institut Pasteur (Pasteur Institute)
2008 → 2011
RG Menzies Scholar & CJ Martin Fellow, Institut Pasteur (Pasteur Institute)
2007 → 2012
CCV Sydney Parker Smith Postdoctoral Cancer Research Fellow, Walter and Eliza Hall Institute of Medical Research (WEHI)
2006 → 2007
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Melanoma_TP53: Targeting MDM Pathway to Enhance Cancer Immunotherapy Response Rates
Huntington, N., Foroutan, M. & Scheer, S.
1/01/22 → 31/12/24
Project: Research
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Defining the role of natural killer cells in the radiotherapy treatment response of metastatic prostate cancer
Foroutan, M., Sandhu, S., Huntington, N. & Cursons, J.
4/01/21 → 3/01/24
Project: Research
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Next Generation Cell Therapies for Cancer
Tiganis, T., Huntington, N., Darcy, P., Zhang, Z., Cursons, J. & Vivier, E.
1/12/19 → 31/12/23
Project: Research
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FLEX immunotherapeutics – a new class of anticancer biologics
Dickins, R., Huntington, N., Oxley, E. & Kershaw, N. J.
Project: Research
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CIS controls the functional polarization of GM-CSF-derived macrophages
Zhang, S., Rautela, J., Bediaga, N. G., Kolesnik, T. B., You, Y., Nie, J., Dagley, L. F., Bedo, J., Wang, H., Sun, L., Sutherland, R., Surgenor, E., Iannarella, N., Allan, R., Souza-Fonseca-Guimaraes, F., Xie, Y., Wang, Q., Zhang, Y., Xu, Y., Nutt, S. L., & 5 others, Jan 2023, In: Cellular & Molecular Immunology. 20, 1, p. 65–79 15 p.Research output: Contribution to journal › Article › Research › peer-review
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Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy
Poh, A. R., Love, C. G., Chisanga, D., Steer, J. H., Baloyan, D., Chopin, M., Nutt, S., Rautela, J., Huntington, N. D., Etemadi, N., O’Brien, M., O’Keefe, R., Ellies, L. G., Macri, C., Mintern, J. D., Whitehead, L., Gangadhara, G., Boon, L., Chand, A. L., Lowell, C. A., & 3 others, 24 Jun 2022, In: Science Advances. 8, 25, 13 p., eabl7882.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia
Carrington, E. M., Louis, C., Kratina, T., Hancock, M., Keenan, C. R., Iannarella, N., Allan, R. S., Wardak, A. Z., Czabotar, P. E., Herold, M. J., Schenk, R. L., White, C. A., D'Silva, D., Yang, Y., Wong, W., Wong, H., Bryant, V. L., Huntington, N. D., Rautela, J., Sutherland, R. M., & 6 others, 8 Jun 2021, In: Blood Advances. 5, 11, p. 2550-2562 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
MAIT cells regulate NK cell-mediated tumor immunity
Petley, E. V., Koay, H. F., Henderson, M. A., Sek, K., Todd, K. L., Keam, S. P., Lai, J., House, I. G., Li, J., Zethoven, M., Chen, A. X. Y., Oliver, A. J., Michie, J., Freeman, A. J., Giuffrida, L., Chan, J. D., Pizzolla, A., Mak, J. Y. W., McCulloch, T. R., Souza-Fonseca-Guimaraes, F., & 11 others, 6 Aug 2021, In: Nature Communications. 12, 1, 15 p., 4746.Research output: Contribution to journal › Article › Research › peer-review
Open Access24 Citations (Scopus) -
Mesenchymal stromal cell apoptosis is required for their therapeutic function
Pang, S. H. M., D’Rozario, J., Mendonca, S., Bhuvan, T., Payne, N. L., Zheng, D., Hisana, A., Wallis, G., Barugahare, A., Powell, D., Rautela, J., Huntington, N. D., Dewson, G., Huang, D. C. S., Gray, D. H. D. & Heng, T. S. P., 11 Nov 2021, In: Nature Communications. 12, 1, 19 p., 6495.Research output: Contribution to journal › Article › Research › peer-review
Open Access45 Citations (Scopus)
Prizes
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11th Meeting of the Society for Natural Immunity Travel Scholarship
Huntington, Nicholas (Recipient), 2008
Prize: Other distinction
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1st High Commendation for the Victorian Premier’s Award
Huntington, Nicholas (Recipient), 2006
Prize: Prize (including medals and awards)
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2012 Travel Award for Society of Natural Immunity 2012 Meeting
Huntington, Nicholas (Recipient), 2012
Prize: Prize (including medals and awards)
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Australian Museum Eureka Prize Finalist - UNSW Prize for Scientific Research
Huntington, Nicholas (Recipient), 2016
Prize: Prize (including medals and awards)
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Cancer Council Victoria Postdoctoral Fellowship
Huntington, Nicholas (Recipient), 2006
Prize: Competitive Fellowships