Projects per year
Personal profile
Biography
Prof. Huntington is the head of the Cancer Immunotherapy Laboratory at the Biomedicine Discovery Institute at Monash University, Australia. He is an international leader on natural killer (NK) cell biology with notable contributions to: regulatory mechanisms of IL-15 signalling in NK cells, identification of human and murine NK cell differentiation pathways, novel xenograft models to study human haematopoiesis and identification of multiple checkpoint in NK cell activation and tumour immunity. Prof. Huntington leads a research program aimed at deciphering the regulatory networks that control NK cell immunity and a drug discovery program using cutting-edge in vivo screens for novel checkpoints in NK cell activation for targeting in cancer immunotherapy. Prof. Huntington is President of MIN (Melbourne Immunotherapy Network), serves as project director for several pharmaceutical collaborative research programs at The Walter and Eliza Hall Institute and is a co-founder and chief scientific officer of oNKo-Innate Pty Ltd
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, A quantitative analysis of signalling mutations on B and NK cell effector functions, University of Melbourne
2002 → 2006
External positions
Laboratory Head (Level D), Walter and Eliza Hall Institute of Medical Research (WEHI)
2017 → 2018
Honorary Fellow (Level C), University of Melbourne
2013 → 2017
Laboratory Head (Level C), Walter and Eliza Hall Institute of Medical Research (WEHI)
2013 → 2017
Senior Research Fellow (Level B), Walter and Eliza Hall Institute of Medical Research (WEHI)
2011 → 2012
Human Frontiers Long-Term Fellow, Institut Pasteur (Pasteur Institute)
2008 → 2011
RG Menzies Scholar & CJ Martin Fellow, Institut Pasteur (Pasteur Institute)
2007 → 2012
CCV Sydney Parker Smith Postdoctoral Cancer Research Fellow, Walter and Eliza Hall Institute of Medical Research (WEHI)
2006 → 2007
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Natural Killer Cell Cancer Immunotherapy
Huntington, N. (Primary Chief Investigator (PCI))
1/01/21 → 31/12/25
Project: Research
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FLEX immunotherapeutics – a new class of anticancer biologics
Dickins, R. (Primary Chief Investigator (PCI)), Huntington, N. (Chief Investigator (CI)), Oxley, E. (Chief Investigator (CI)) & Kershaw, N. (Chief Investigator (CI))
31/07/22 → 30/11/24
Project: Research
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Melanoma_TP53: Targeting MDM Pathway to Enhance Cancer Immunotherapy Response Rates
Huntington, N. (Primary Chief Investigator (PCI)), Foroutan, M. (Chief Investigator (CI)) & Scheer, S. (Chief Investigator (CI))
1/01/22 → 31/12/24
Project: Research
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Defining the role of natural killer cells in the radiotherapy treatment response of metastatic prostate cancer
Molania, R. (Primary Chief Investigator (PCI)), Foroutan, M. (Chief Investigator (CI)), Sandhu, S. K. (Chief Investigator (CI)), Huntington, N. (Chief Investigator (CI)) & Cursons, J. (Chief Investigator (CI))
4/01/21 → 3/01/24
Project: Research
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Next Generation Cell Therapies for Cancer
Tiganis, T. (Primary Chief Investigator (PCI)), Huntington, N. (Chief Investigator (CI)), Darcy, P. (Associate Investigator (AI)), Zhang, Z.-Y. (Associate Investigator (AI)), Cursons, J. (Associate Investigator (AI)) & Vivier, É. (Associate Investigator (AI))
1/12/19 → 31/12/23
Project: Research
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Author Correction: CIS is a potent checkpoint in NK cell–mediated tumor immunity (Nature Immunology, (2016), 17, 7, (816-824), 10.1038/ni.3470)
Delconte, R. B., Kolesnik, T. B., Dagley, L. F., Rautela, J., Shi, W., Putz, E. M., Stannard, K., Zhang, J. G., Teh, C., Firth, M., Ushiki, T., Andoniou, C. E., Degli-Esposti, M. A., Sharp, P. P., Sanvitale, C. E., Infusini, G., Liau, N. P. D., Linossi, E. M., Burns, C. J. & Carotta, S. & 12 others, , Feb 2024, In: Nature Immunology. 25, 2, p. 371-372 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
CD45 limits early Natural Killer cell development
Meza Guzman, L. G., Hyland, C. D., Bidgood, G. M., Leong, E., Shen, Z., Goh, W., Rautela, J., Vince, J. E., Nicholson, S. E. & Huntington, N. D., Jan 2024, In: Immunology and Cell Biology. 102, 1, p. 58-70 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Correction to: Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells (Nature Immunology, (2017), 18, 9, (1004-1015), 10.1038/ni.3800)
Gao, Y., Souza-Fonseca-Guimaraes, F., Bald, T., Ng, S. S., Young, A., Ngiow, S. F., Rautela, J., Straube, J., Waddell, N., Blake, S. J., Yan, J., Bartholin, L., Lee, J. S., Vivier, E., Takeda, K., Messaoudene, M., Zitvogel, L., Teng, M. W. L., Belz, G. T. & Engwerda, C. R. & 4 others, , May 2024, In: Nature Immunology. 25, 5, p. 925-926 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development
Goh, W., Sudholz, H., Foroutan, M., Scheer, S., Pfefferle, A., Delconte, R. B., Meng, X., Shen, Z., Hennessey, R., Kong, I. Y., Schuster, I. S., Andoniou, C. E., Davis, M. J., Hediyeh-Zadeh, S., Souza-Fonseca-Guimaraes, F., Parish, I. A., Beavis, P., Thiele, D., Chopin, M. & Degli-Esposti, M. A. & 5 others, , 2024, In: Nature Immunology. 25, 25 p.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
Interferon-epsilon is a novel regulator of NK cell responses in the uterus
Mayall, J. R., Horvat, J. C., Mangan, N. E., Chevalier, A., McCarthy, H., Hampsey, D., Donovan, C., Brown, A. C., Matthews, A. Y., de Weerd, N. A., de Geus, E. D., Starkey, M. R., Kim, R. Y., Daly, K., Goggins, B. J., Keely, S., Maltby, S., Baldwin, R., Foster, P. S. & Boyle, M. J. & 4 others, , 15 Feb 2024, In: EMBO Molecular Medicine. 16, 2, p. 267-293 27 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus)
Prizes
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11th Meeting of the Society for Natural Immunity Travel Scholarship
Huntington, Nicholas (Recipient), 2008
Prize: Other distinction
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1st High Commendation for the Victorian Premier’s Award
Huntington, Nicholas (Recipient), 2006
Prize: Prize (including medals and awards)
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2012 Travel Award for Society of Natural Immunity 2012 Meeting
Huntington, Nicholas (Recipient), 2012
Prize: Prize (including medals and awards)
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Australian Museum Eureka Prize Finalist - UNSW Prize for Scientific Research
Huntington, Nicholas (Recipient), 2016
Prize: Prize (including medals and awards)
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Cancer Council Victoria Postdoctoral Fellowship
Huntington, Nicholas (Recipient), 2006
Prize: Competitive Fellowships