Projects per year
Personal profile
Biography
Dr. Ng Chen Seng currently serves as a Principal Investigator, Lecturer, and Institutional Biosafety Committee (IBC) Biosafety Officer in the Division of Medical Biosciences, School of Science, at Monash University Malaysia. He earned his Bachelor of Science in Biotechnology from Universiti Malaysia Sabah in 2008 and subsequently completed both his Master’s and Doctorate degrees in Viral Immunology at Kyoto University, Japan. His doctoral training was under the mentorship of Professor Takashi Fujita, a renowned scientist recognized for discovering IRF—the interferon regulatory factor family—and RIG-I, the cytoplasmic sensor for viral RNA.
Prior to joining Monash University, Dr. Ng conducted postdoctoral research at the University of California, Los Angeles (UCLA) under Professor Alexander Hoffmann, as well as at the University of British Columbia. Despite having completed his formal academic training and professional appointments, Dr. Ng continues to pursue lifelong learning. He recently obtained an Advanced Certification in Cell Biology from the Massachusetts Institute of Technology (MIT) and a MicroBachelors in Neuroscience from Harvard University.
Dr. Ng has authored numerous peer-reviewed publications in high-impact international journals, including iScience (Cell Press), Cell Death and Differentiation (Nature Publishing Group), Communication Biology (Nature), Autophagy, Journal of Virology, and PLOS Pathogens, among others. Notably, he identified interferon signaling as a key molecular signature in SOD1-linked amyotrophic lateral sclerosis (ALS), a debilitating neurodegenerative disease. This discovery holds promise as a novel diagnostic marker or therapeutic target. His recent work also elucidates species-specific differences in Type I and Type II interferon responses between humans and mice, offering a compelling explanation for the historical failure of Type I interferon therapies in clinical trials during the 1980s.
In recognition of his contributions to neuroscience and viral immunology, Dr. Ng was recently honored with the IBRO Rising Star Award by the International Brain Research Organization (IBRO). His current research leverages artificial intelligence and machine learning to unravel the complex molecular mechanisms underlying ALS.
Research interests
Dr. Ng's laboratory has a broad interest in the application of cutting-edge ideas and technology to the study of disease-relavant models. Major directions include innate immunity, virology, cell death, autophagy, signal transduction, and neuro-inflammation. Clinical issues of interest include autoimmune diseases, infection and inflammation.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Viral Immunology , Doctor of Philosophy in Life Sciences, Kyoto University
Viral Immunology , Master of Science in Life Sciences, Kyoto University
Research area keywords
- Innate and Adaptive Immunity
- Amyotrophic Lateral Sclerosis
- Pathogen recognition receptors
- Virology
Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Neuro-innate immune hit perspective of neurotrophic viral infection
Chen Seng, N. (Primary Chief Investigator (PCI))
1/10/23 → 31/12/24
Project: Research
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Integrated transcriptomic profiling reveals a STING-mediated Type II Interferon signature in SOD1-mutant amyotrophic lateral sclerosis models
Hiew, J. Y., Lim, Y. S., Liu, H. & Ng, C. S., 2 Mar 2025, In: Communications Biology. 8, 1, 347.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Linker Design for the Antibody Drug Conjugates: A Comprehensive Review
Lei, Y., Zheng, M., Chen, P., Seng Ng, C., Peng Loh, T. & Liu, H., 2025, (Accepted/In press) In: ChemMedChem. 22 p., 2500262.Research output: Contribution to journal › Review Article › Research › peer-review
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Phytochemical-based nanosystems: recent advances and emerging application in antiviral photodynamic therapy
Loo, Y. S., Yusoh, N. A., Lim, W. F., Ng, C. S., Zahid, N. I., Mat Azmi, I. D., Madheswaran, T. & Lee, T. Y., 2025, In: Nanomedicine. 20, 4, p. 401-416 16 p.Research output: Contribution to journal › Review Article › Research › peer-review
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Shaping the future of antiviral Treatment: Spotlight on Nucleobase-Containing drugs and their revolutionary impact
Wong, X. K., Ng, C. S. & Yeong, K. Y., Mar 2024, In: Bioorganic Chemistry. 144, 46 p., 107150.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Cannabis: The new antiviral hero?
Choo, W. S. & Ng, C. S., 20 Mar 2023, The Microbiologist.Research output: Contribution to specialist publication › Editorial › Other
Open Access
Prizes
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Excellent Educator Award for Semester 1, 2023
Chen Seng, N. (Recipient), 8 May 2023
Prize: Other distinction
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Excellent Educator Award for Semester 2, 2024
Chen Seng, N. (Recipient), 29 Aug 2024
Prize: Other distinction
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Heart Lung Innovation Research Institute Safety Award
Chen Seng, N. (Recipient), 15 May 2020
Prize: Prize (including medals and awards)
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Japanese Government (Monbukagakusho: MEXT) Fellowship for Postgraduate Research Study
Ng, C. S. (Recipient), 1 Oct 2011
Prize: Competitive Fellowships
Activities
- 16 Contribution to conference
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The 3rd Heart Lung Innovation Trainee Research Day
Ng, C. S. (Speaker)
6 Aug 2019Activity: Participating in or organising an event types › Contribution to conference
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Centre for Heart Lung Innovation Seminar Talk Series
Ng, C. S. (Invited speaker)
10 May 2019Activity: Participating in or organising an event types › Contribution to conference
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Immunology, Inflammation, Infection, and Transplantation (I3T) Research in Progress (R.I.P) Seminar Talk
Ng, C. S. (Speaker)
8 Aug 2018Activity: Participating in or organising an event types › Contribution to conference
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The 6th Annual Meeting of the International Cytokine & Interferon Society
Ng, C. S. (Session chair)
27 Oct 2018 → 30 Oct 2018Activity: Participating in or organising an event types › Contribution to conference
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La Jolla Immunology Conference
Ng, C. S. (Speaker)
16 Oct 2018 → 18 Oct 2018Activity: Participating in or organising an event types › Contribution to conference
Press/Media
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Your Source for Life Sciences in Vancouver (Publications of the Week)
25/02/20
1 item of Media coverage
Press/Media: Profile/Interview