20142020

Research output per year

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Personal profile

Biography

Dr. Neelam Shah is a Postdoctoral Research Fellow at Monash University Biomedicine Discovery Institute. Dr. Neelam’s research is focused on RNA biology and innate immunity and utilizes a broad range of research techniques including protein biochemistry, molecular biology and structural biology to understand the RNA-proteins interactions and the regulation of viral RNA translation.

Dr. Shah completed a BSc (Hons) at Hazara University, Pakistan and was awarded the university gold medal for the highest distinction achieved. After her Master’s degree in biochemistry from Quaid-i-Azam University, Pakistan, she was awarded with Monash Graduate Scholarship and Faculty Postgraduate Research International Scholarship to commence a PhD at Monash University under the supervision of A/Prof. Jackie Wilce and Prof. Matthew Wilce. Dr. Neelam’s PhD research project involved biophysical analyses of the interactions of human antiviral protein RIG-I with short viral RNA mimics to understand antiviral innate immune signaling pathway. This work resulted in a high impact first author publication and three travel awards. Dr. Neelam has presented her work at several national and international conferences and meetings, where, her work has been well received.

In 2018, she started working as a postdoctoral researcher in A/Prof. Jackie Wilce’s lab. Her current research focuses on investigating the mechanism of viral RNA replication and translation initiation within the host cell using different biophysical and structural tools.

 

Education/Academic qualification

Biochemistry, PhD, Monash University

Award Date: 1 Aug 2018

Research area keywords

  • Innate Immunity
  • RNA Biology
  • RNA-Protein Interactions
  • Structural Biology
  • Biophysical Approaches
  • Antiviral Signalling

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Research Output

Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain

García-Palmero, I., Shah, N., Ali, N. A., Daly, R. J., Wilce, J. A. & Villalobo, A., 15 Jul 2020, In : Archives of Biochemistry and Biophysics. 687, 8 p., 108386.

Research output: Contribution to journalArticleResearchpeer-review

Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis

Shah, N., Beckham, S. A., Wilce, J. A. & Wilce, M. C. J., 6 Apr 2018, In : Nucleic Acids Research. 46, 6, p. 3169-3186 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Extracellular Vesicles and Matrix Remodeling Enzymes: The Emerging Roles in Extracellular Matrix Remodeling, Progression of Diseases and Tissue Repair

Nawaz, M., Shah, N., Zanetti, B. R., Maugeri, M., Silvestre, R. N., Fatima, F., Neder, L. & Valadi, H., Oct 2018, In : Cells. 7, 10, 26 p., 167.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Genetic analysis of consanguineous families presenting with congenital ocular defects

Ullah, E., Nadeem Saqib, M. A., Sajid, S., Shah, N., Zubair, M., Khan, M. A., Ahmed, I., Ali, G., Dutta, A. K., Danda, S., Lao, R., Ling-Fung Tang, P., Kwok, P. Y., Ansar, M. & Slavotinek, A., 1 May 2016, In : Experimental Eye Research. 146, p. 163-171 9 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The emerging role of extracellular vesicles as biomarkers for urogenital cancers

Nawaz, M., Camussi, G., Valadi, H., Nazarenko, I., Ekström, K., Wang, X., Principe, S., Shah, N., Ashraf, N. M., Fatima, F., Neder, L. & Kislinger, T., Dec 2014, In : Nature Reviews Urology. 11, 12, p. 688-701 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

142 Citations (Scopus)