Nathan is an adjunct Senior Research Fellow with the Monash Addiction Research Centre (MARC) as well as with the Ambulance Victoria Centre for Reseach and Evaluation. Nathan has a diverse background that includes being a pharmacologist and toxicologist, as well as being an experienced clinician and academic.

Nathan has a particular research, teaching and clinical specialisation that centres around pharmacotherapy and clinical toxicology in critical care medicine as well as acute opioid toxicity, fatal and non-fatal heroin overdose and opioid dependence. Nathan research in this field has focused on improving clinical outcomes and translational research through the use of large and complex datasets as well as data linkage, collaborative research that informs best-practice clinical care, evaluating the impact of public health interventions to reduce opioid-related deaths, and the development of clinical practice guidelines.

Nathan is currently completing a number of research projects related to complex acute drug toxicity presentations in the out-of-hospital environment, adverse fatal outcomes related to opioid toxicity and the development of evidence-based clinical practice guidelines.