If you made any changes in Pure these will be visible here soon.

Research Output 2007 2019

  • 32 Article
  • 2 Chapter (Book)
  • 2 Review Article
  • 1 Comment / Debate
2007

A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates

Hislop, A. D., Ressing, M. E., Van Leeuwen, D., Pudney, V. A., Horst, D., Koppers-Lalic, D., Croft, N. P., Neefjes, J. J., Rickinson, A. B. & Wiertz, E. J. H. J., 6 Aug 2007, In : Journal of Experimental Medicine. 204, 8, p. 1863-1873 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2009

An HLA-A2-restricted T-Cell epitope mapped to the BNLF2a immune evasion protein of epstein-barr virus that inhibits TAP

Bell, M. J., Abbott, R. J. M., Croft, N. P., Hislop, A. D. & Burrows, S. R., Mar 2009, In : Journal of Virology. 83, 6, p. 2783-2788 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation

Horst, D., Van Leeuwen, D., Croft, N. P., Garstka, M. A., Hislop, A. D., Kremmer, E., Rickinson, A. B., Wiertz, E. J. H. J. & Ressing, M. E., 15 Feb 2009, In : Journal of Immunology. 182, 4, p. 2313-2324 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Stage-specific inhibition of MHC class I presentation by the epstein-barr virus BNLF2a protein during virus lytic cycle

Croft, N. P., Shannon-Lowe, C., Bell, A. I., Horst, D., Kremmer, E., Ressing, M. E., Wiertz, E. J. H. J., Middeldorp, J. M., Rowe, M., Rickinson, A. B. & Hislop, A. D., Jun 2009, In : PLoS Pathogens. 5, 6, e1000490.

Research output: Contribution to journalArticleResearchpeer-review

2010

Enhancing tumor vaccines: Catalyzing MHC class II peptide exchange

Croft, N. P. & Purcell, A. W., Feb 2010, In : Expert Review of Vaccines. 9, 2, p. 129-132 4 p.

Research output: Contribution to journalComment / DebateResearchpeer-review

Epitope discovery and their use in peptide based vaccines

Dudek, N. L., Perlmutter, P., Aguilar, M. I., Croft, N. & Purcell, A. W., 2010, In : Current Pharmaceutical Design. 16, 28, p. 3149 - 3157 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring

Tan, C. T., Croft, N. P., Dudek, N. L., Williamson, N. A. & Purcell, A. W., 2011, In : Proteomics. 11, 11, p. 2336 - 2340 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptidomimetics: modifying peptides in the pursuit of better vaccines

Croft, N. P. & Purcell, A. W., 2011, In : Expert Review of Vaccines. 10, 2, p. 211 - 226 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Constitutive and inflammatory immunopeptidome of pancreatic beta-cells

Dudek, N. L., Tan, C. T., Gorasia, D. G., Croft, N. P., Illing, P. T. & Purcell, A. W., 2012, In : Diabetes. 61, 11, p. 3018 - 3025 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Tracking protein aggregation and mislocalization in cells with flow cytometry

Ramdzan, Y. M., Polling, S., Chia, C. P. Z., Ng, I. H. W., Ormsby, A. R., Croft, N. P., Purcell, A. W., Bogoyevitch, M. A., Ng, D. CH., Gleeson, P. A. & Hatters, D. M., 2012, In : Nature Methods. 9, 5, p. 467 - 470 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

HLA peptide length preferences control CD8+ T cell responses

Rist, M. J., Theodossis, A., Croft, N. P., Neller, M. A., Welland, A. D., Chen, Z., Sullivan, L. C., Burrows, J. M., Miles, J. J., Brennan, R. M., Gras, S., Khanna, R., Brooks, A., McCluskey, J., Purcell, A. W., Rossjohn, J. & Burrows, S. R., 2013, In : Journal of Immunology. 191, 2, p. 561-571 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Kinetics of antigen expression and epitope presentation during virus infection

Croft, N. P., Smith, S. A., Wong, Y. C., Tan, C. T., Dudek, N. L., Flesch, I. E. A., Lin, L. C. W., Tscharke, D. C. & Purcell, A. W., 2013, In : PLoS Pathogens. 9, 1 (Art. ID: :e1003129), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Novel tumor derived peptides in vaccines

Purcell, A. W., Croft, N. P. & Dudek, N. L., 2013, Handbook of Biologically Active Peptides. Kastin, A. J. (ed.). 2nd ed. USA: Elsevier, p. 580 - 589 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2014

A comprehensive analysis of constitutive naturally processed and presented HLA-C*04:01 (Cw4)-specific peptides

Schittenhelm, R. B., Dudek, N. L., Croft, N. P., Ramarathinam, S. & Purcell, A. W., 2014, In : Tissue Antigens. 83, 3, p. 174 - 179 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of novel disease-specific and membrane-associated candidate markers in a mouse model of multiple sclerosis

Dagley, L. F., Croft, N. P., Isserlin, R., Olsen, J. B., Fong, V., Emili, A. & Purcell, A. W., 2014, In : Molecular & Cellular Proteomics. 13, 1, p. 679 - 700 22 p.

Research output: Contribution to journalArticleResearchpeer-review

mRNA Structural constraints on EBNA1 synthesis impact on in vivo antigen presentation and early priming of CD8+ T cells

Tellam, J., Zhong, J., Lekieffre, L., Bhat, P., Martinez, M., Croft, N. P., Kaplan, W., Tellam, R. L. & Khanna, R., 1 Oct 2014, In : PLoS Pathogens. 10, 10, 13 p., e1004423.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes

Trujillo, J. A., Gras, S., Twist, K-A., Croft, N. P., Channappanavar, R., Rossjohn, J., Purcell, A. W. & Perlman, S., 2014, In : Journal of Immunology. 192, 11, p. 5245 - 5256 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The cellular redox environment alters antigen presentation

Trujillo, J. A., Croft, N. P., Dudek, N. L., Channappanavar, R., Theodossis, A., Webb, A. I., Dunstone, M. A., Illing, P. TT., Butler, N. S., Fett, C., Tscharke, D. C., Rossjohn, J., Perlman, S. & Purcell, A. W., 2014, In : Journal of Biological Chemistry. 289, 40, p. 27979 - 27991 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

A comprehensive analysis of peptides presented by HLA-A1

Giam, K. L., Ayala-Perez, R., Illing, P. T. T., Schittenhelm, R. B., Croft, N. P., Purcell, A. W. & Dudek, N. L., 2015, In : Tissue Antigens. 85, 6, p. 492 - 496 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantifying epitope presentation using mass spectrometry

Croft, N. P., Purcell, A. W. & Tscharke, D. C., 2015, In : Molecular Immunology. 68, 2 - Part A, p. 77 - 80 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Simultaneous quantification of viral antigen expression kinetics using data-independent (DIA) mass spectrometry

Croft, N. P., de Verteuil, D. A., Smith, S. A., Wong, Y. C., Schittenhelm, R. B., Tscharke, D. C. & Purcell, A. W., 2015, In : Molecular & Cellular Proteomics. 14, 5, p. 1361 - 1372 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Sizing up the key determinants of the CD8 T cell response

Tscharke, D. C., Croft, N. P., Doherty, P. C. & La Gruta, N. L., 2015, In : Nature Reviews Immunology. 15, 11, p. 705 - 716 12 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell cross-reactivity between a highly immunogenic EBV epitope and a self-peptide naturally presented by HLA-B*18:01+ cells

Rist, M. J., Hibbert, K. M., Croft, N. P., Smith, C., Neller, M. A., Burrows, J. M., Miles, J. J., Purcell, A. W., Rossjohn, J., Gras, S. & Burrows, S. R., 2015, In : Journal of Immunology. 194, 10, p. 4668 - 4675 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

A Systems Approach to Understand Antigen Presentation and the Immune Response

Dudek, N. L., Croft, N. P., Schittenhelm, R. B., Ramarathinam, S. H. & Purcell, A. W., 2016, Proteomics in Systems Biology : Methods and Protocols. Reinders, J. (ed.). USA: Springer, p. 189 - 210 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Characterization of the antigen processing machinery and endogenous peptide presentation of a Bat MHC class I molecule

Wynne, J. W., Woon, A. P., Dudek, N. L., Croft, N. P., Ng, J. H. J., Baker, M. L., Wang, L-F. & Purcell, A. W., 1 Jun 2016, In : Journal of Immunology. 196, 11, p. 4468-4476 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family

Heinz, E., Stubenrauch, C. J., Grinter, R., Croft, N. P., Purcell, A. W., Strugnell, R. A., Dougan, G. & Lithgow, T., 13 Jun 2016, In : Genome Biology and Evolution. 8, 6, p. 1690-1705 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Immunology by numbers: Quantitation of antigen presentation completes the quantitative milieu of systems immunology!

Purcell, A. W., Croft, N. P. & Tscharke, D. C., Jun 2016, In : Current Opinion in Immunology. 40, p. 88-95 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The primary immune response to Vaccinia virus vaccination includes cells with a distinct cytotoxic effector CD4 T-cell phenotype

PHIIDO Study Group, 17 Oct 2016, In : Vaccine. 34, 44, p. 5251-5261 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands

Faridi, P., Li, C., Ramarathinam, S. H., Vivian, J. P., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Hertzog, P. J., Ternette, N., Rossjohn, J., Croft, N. P. & Purcell, A. W., 12 Oct 2018, In : Science Immunology. 3, 28, 12 p., eaar3947.

Research output: Contribution to journalArticleResearchpeer-review

Employing proteomics in the study of antigen presentation: an update

Ramarathinam, S. H., Croft, N. P., Illing, P. T., Faridi, P. & Purcell, A. W., 13 Aug 2018, In : Expert Review of Proteomics. 15, 8, p. 637-645 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome

Illing, P. T., Pymm, P., Croft, N. P., Hilton, H. G., Jojic, V., Han, A. S., Mendoza, J. L., Mifsud, N. A., Dudek, N. L., McCluskey, J., Parham, P., Rossjohn, J., Vivian, J. P. & Purcell, A. W., 8 Nov 2018, In : Nature Communications. 9, 1, 13 p., 4693.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

In Immunopeptidomics We Need a Sniper Instead of a Shotgun

Faridi, P., Purcell, A. W. & Croft, N. P., 1 Jun 2018, In : Proteomics. 18, 12, 4 p., 1700464.

Research output: Contribution to journalArticleOtherpeer-review

Isolation of T cell receptors targeting recurrent neoantigens in hematological malignancies

Tubb, V. M., Schrikkema, D. S., Croft, N. P., Purcell, A. W., Linnemann, C., Freriks, M. R., Chen, F., Long, H. M., Lee, S. P. & Bendle, G. M., 13 Jul 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 14 p., 70.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The use of CRISPR/Cas9 gene editing to confirm congenic contaminations in host-pathogen interaction studies

Ferrand, J., Croft, N. P., Pépin, G., Diener, K. R., Wu, D., Mangan, N. E., Pedersen, J., Behlke, M. A., Hayball, J. D., Purcell, A. W., Ferrero, R. L. & Gantier, M. P., 19 Mar 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 10 p., 87.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2019

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Croft, N. P., Smith, S. A., Pickering, J., Sidney, J., Peters, B., Faridi, P., Witney, M. J., Sebastian, P., Flesch, I. E. A., Heading, S. L., Sette, A., La Gruta, N. L., Purcell, A. W. & Tscharke, D. C., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3112-3117 6 p.

Research output: Contribution to journalArticleResearchpeer-review