If you made any changes in Pure these will be visible here soon.

Personal profile


Nathan completed his PhD in mid-2009 at the University of Birmingham, UK, studying immune evasion by Epstein-Barr Virus. Thereafter, he joined the group of Tony Purcell at the University of Melbourne, transitioning to Monash University in 2012. Nathan's research is focused on understanding how different aspects of the MHC antigen processing pathway impact upon T cell immunity to pathogens and tumors, with a specific emphasis on how the abundance of MHC-peptides play a role in driving the magnitude and efficacy of T cell responses. In conjunction with this work, Dr Croft is engaged in mapping the peptide repertoires of healthy and pathogen-infected cell lines, as well as cells and tissues of tumor origin. Together this work strives to develop novel bioinformatics and data repositories that will model and predict the generation of peptide epitopes and their potential immunogenicity. 

Education/Academic qualification

Immunology, PhD, University of Birmingham

Research area keywords

  • Immunology
  • Proteomics
  • Peptidomics
  • Immunopeptidomics
  • Mass spectrometry
  • Systems immunology
  • Bioinformatics
  • Infection and immunity
  • Antigen presentation

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2015 2023

Research Output 2007 2020

  • 34 Article
  • 3 Review Article
  • 2 Chapter (Book)
  • 1 Comment / Debate
1 Citation (Scopus)

T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease

Petersen, J., Ciacchi, L., Tran, M. T., Loh, K. L., Kooy-Winkelaar, Y., Croft, N. P., Hardy, M. Y., Chen, Z., McCluskey, J., Anderson, R. P., Purcell, A. W., Tye-Din, J. A., Koning, F., Reid, H. H. & Rossjohn, J., Jan 2020, In : Nature Structural and Molecular Biology. 27, p. 49-61 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction

Mei, S., Li, F., Leier, A., Marquez-Lago, T. T., Giam, K., Croft, N. P., Akutsu, T., Smith, A. I., Li, J., Rossjohn, J., Purcell, A. W. & Song, J., 14 Jun 2019, (Accepted/In press) In : Briefings in Bioinformatics. 17 p., bbz051.

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)

Most viral peptides displayed by class I MHC on infected cells are immunogenic

Croft, N. P., Smith, S. A., Pickering, J., Sidney, J., Peters, B., Faridi, P., Witney, M. J., Sebastian, P., Flesch, I. E. A., Heading, S. L., Sette, A., La Gruta, N. L., Purcell, A. W. & Tscharke, D. C., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3112-3117 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses

Wu, T., Guan, J., Handel, A., Tscharke, D. C., Sidney, J., Sette, A., Wakim, L. M., Sng, X. Y. X., Thomas, P. G., Croft, N. P., Purcell, A. W. & La Gruta, N. L., 28 Jun 2019, In : Nature Communications. 10, 1, 14 p., 2846.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)
Open Access

Activities 2018 2018

  • 1 Membership of industry collaboration/ network

Biochemistry & Molecular Biology (Organisational unit)

Anthony Purcell (Member), Steve Quenette (Member), Craig Paul Bonnington (Member), Stephen Tate (Member), Nick Koletsas (Member), Nathan Paul Croft (Member)
1 Apr 201831 Dec 2020

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of industry collaboration/ network