Projects per year
Personal profile
Biography
Nathan completed his PhD in mid-2009 at the University of Birmingham, UK, studying immune evasion by Epstein-Barr Virus. Thereafter, he joined the group of Tony Purcell at the University of Melbourne, transitioning to Monash University in 2012. Nathan's research is focused on understanding how different aspects of the MHC antigen processing pathway impact upon T cell immunity to pathogens and tumors, with a specific emphasis on how the abundance of MHC-peptides play a role in driving the magnitude and efficacy of T cell responses. In conjunction with this work, Dr Croft is engaged in mapping the peptide repertoires of healthy and pathogen-infected cell lines, as well as cells and tissues of tumor origin. Together this work strives to develop novel bioinformatics and data repositories that will model and predict the generation of peptide epitopes and their potential immunogenicity.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Immunology, PhD, Immune Evasion By Epstein-Barr Virus -- Studies on BNLF2a, University of Birmingham
Award Date: 15 Jun 2009
Research area keywords
- Immunology
- Proteomics
- Peptidomics
- Immunopeptidomics
- Mass spectrometry
- Systems immunology
- Bioinformatics
- Infection and immunity
- Antigen presentation
Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Recognition of virus-infected cells by T cells
Tscharke, D. C. (Primary Chief Investigator (PCI)), La Gruta, N. (Chief Investigator (CI)), Purcell, A. (Chief Investigator (CI)) & Croft, N. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/19
Project: Research
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Mapping the immunopeptidome of seven SARS-CoV-2 antigens across common HLA haplotypes
Braun, A., Rowntree, L. C., Huang, Z., Pandey, K., Thuesen, N., Li, C., Petersen, J., Littler, D. R., Raji, S., Nguyen, T. H. O., Jappe Lange, E., Persson, G., Schantz Klausen, M., Kringelum, J., Chung, S., Croft, N. P., Faridi, P., Ayala, R., Rossjohn, J. & Illing, P. T. & 6 others, , Dec 2024, In: Nature Communications. 15, 1, 12 p., 7547.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
MHCpLogics: an interactive machine learning-based tool for unsupervised data visualization and cluster analysis of immunopeptidomes
Shahbazy, M., Ramarathinam, S. H., Li, C., Illing, P. T., Faridi, P. (Leading Author), Croft, N. P. & Purcell, A. W., 1 Mar 2024, In: Briefings in Bioinformatics. 25, 2, 17 p., bbae087.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Benchmarking Bioinformatics Pipelines in Data-Independent Acquisition Mass Spectrometry for Immunopeptidomics
Shahbazy, M., Ramarathinam, S. H., Illing, P. T., Jappe, E. C., Faridi, P., Croft, N. P. & Purcell, A. W., Apr 2023, In: Molecular & Cellular Proteomics. 22, 4, 14 p., 100515.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus) -
Immunolyser: A web-based computational pipeline for analysing and mining immunopeptidomic data
Munday, P. R., Fehring, J., Revote, J., Pandey, K., Shahbazy, M., Scull, K. E., Ramarathinam, S. H., Faridi, P., Croft, N. P., Braun, A., Li, C. & Purcell, A. W., Jan 2023, In: Computational and Structural Biotechnology Journal. 21, p. 1678-1687 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Profound N-glycan remodelling accompanies MHC-II immunopeptide presentation
Goodson, H., Kawahara, R., Chatterjee, S., Goncalves, G., Fehring, J., Purcell, A. W., Croft, N. P. & Thaysen-Andersen, M., 2023, In: Frontiers in Immunology. 14, p. 1-10 10 p., 1258518.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus)
Activities
- 1 Membership of industry collaboration/ network
-
Biochemistry & Molecular Biology (Organisational unit)
Purcell, A. (Member), Quenette, S. (Member), Bonnington, C. P. (Member), Tate, S. (Member), Koletsas, N. (Member) & Croft, N. P. (Member)
1 Apr 2018 → 31 Dec 2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network