Projects per year
Personal profile
Biography
Nathan completed his PhD in mid-2009 at the University of Birmingham, UK, studying immune evasion by Epstein-Barr Virus. Thereafter, he joined the group of Tony Purcell at the University of Melbourne, transitioning to Monash University in 2012. Nathan's research is focused on understanding how different aspects of the MHC antigen processing pathway impact upon T cell immunity to pathogens and tumors, with a specific emphasis on how the abundance of MHC-peptides play a role in driving the magnitude and efficacy of T cell responses. In conjunction with this work, Dr Croft is engaged in mapping the peptide repertoires of healthy and pathogen-infected cell lines, as well as cells and tissues of tumor origin. Together this work strives to develop novel bioinformatics and data repositories that will model and predict the generation of peptide epitopes and their potential immunogenicity.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Immunology, PhD, University of Birmingham
Award Date: 15 Jun 2009
Research area keywords
- Immunology
- Proteomics
- Peptidomics
- Immunopeptidomics
- Mass spectrometry
- Systems immunology
- Bioinformatics
- Infection and immunity
- Antigen presentation
Network
Projects
- 1 Finished
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Recognition of virus-infected cells by T cells
Tscharke, D. C., La Gruta, N., Purcell, A. & Croft, N.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/19
Project: Research
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Immunolyser: A web-based computational pipeline for analysing and mining immunopeptidomic data
Munday, P. R., Fehring, J., Revote, J., Pandey, K., Shahbazy, M., Scull, K. E., Ramarathinam, S. H., Faridi, P., Croft, N. P., Braun, A., Li, C. & Purcell, A. W., Jan 2023, In: Computational and Structural Biotechnology Journal. 21, p. 1678-1687 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Anthem: a user customised tool for fast and accurate prediction of binding between peptides and HLA class I molecules
Mei, S., Li, F., Xiang, D., Ayala, R., Faridi, P., Webb, G. I., Illing, P. T., Rossjohn, J., Akutsu, T., Croft, N. P., Purcell, A. W. & Song, J., Sep 2021, In: Briefings in Bioinformatics. 22, 5, p. 1-16 16 p., bbaa415.Research output: Contribution to journal › Article › Research › peer-review
17 Citations (Scopus) -
IFNγ Modulates the Immunopeptidome of Triple Negative Breast Cancer Cells by Enhancing and Diversifying Antigen Processing and Presentation
Goncalves, G., Mullan, K. A., Duscharla, D., Ayala, R., Croft, N. P., Faridi, P. & Purcell, A. W., 22 Apr 2021, In: Frontiers in Immunology. 12, 13 p., 645770.Research output: Contribution to journal › Article › Research › peer-review
Open Access15 Citations (Scopus) -
Kinetics of Abacavir-Induced Remodelling of the Major Histocompatibility Complex Class I Peptide Repertoire
Illing, P. T., van Hateren, A., Darley, R., Croft, N. P., Mifsud, N. A., King, S., Kostenko, L., Bharadwaj, M., McCluskey, J., Elliott, T. & Purcell, A. W., 19 May 2021, In: Frontiers in Immunology. 12, 19 p., 672737.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Resourcing, annotating, and analysing synthetic peptides of SARS-CoV-2 for immunopeptidomics and other immunological studies
Li, C., Revote, J., Ramarathinam, S. H., Chung, S. Z., Croft, N. P., Scull, K. E., Huang, Z., Ayala, R., Braun, A., Mifsud, N. A., Illing, P. T., Faridi, P. & Purcell, A. W., Sep 2021, In: Proteomics. 21, 17-18, 11 p., e2100036.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)
Activities
- 1 Membership of industry collaboration/ network
-
Biochemistry & Molecular Biology (Organisational unit)
Anthony Purcell (Member), Steve Quenette (Member), Craig Paul Bonnington (Member), Stephen Tate (Member), Nick Koletsas (Member) & Nathan Paul Croft (Member)
1 Apr 2018 → 31 Dec 2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network