Projects per year
Personal profile
Biography
Nathan completed his PhD in mid-2009 at the University of Birmingham, UK, studying immune evasion by Epstein-Barr Virus. Thereafter, he joined the group of Tony Purcell at the University of Melbourne, transitioning to Monash University in 2012. Nathan's research is focused on understanding how different aspects of the MHC antigen processing pathway impact upon T cell immunity to pathogens and tumors, with a specific emphasis on how the abundance of MHC-peptides play a role in driving the magnitude and efficacy of T cell responses. In conjunction with this work, Dr Croft is engaged in mapping the peptide repertoires of healthy and pathogen-infected cell lines, as well as cells and tissues of tumor origin. Together this work strives to develop novel bioinformatics and data repositories that will model and predict the generation of peptide epitopes and their potential immunogenicity.
Education/Academic qualification
Immunology, PhD, University of Birmingham
Research area keywords
- Immunology
- Proteomics
- Peptidomics
- Immunopeptidomics
- Mass spectrometry
- Systems immunology
- Bioinformatics
- Infection and immunity
- Antigen presentation
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2015 2023
- 2 Active
Unravelling the role of type I Interferon family in human infectious and inflammatory diseases
Hertzog, P., Casanova, J., Netea, M. G., Turner, S., Creek, D., Gearing, J., Croft, N., Forster, S. & Polo, J.
National Health & Medical Research Council (NHMRC)
1/01/19 → 31/12/23
Project: Research
Recognition of virus-infected cells by T cells
Tscharke, D., La Gruta, N., Purcell, A. & Croft, N.
National Health & Medical Research Council (NHMRC)
1/01/15 → 31/12/19
Project: Research
Research Output 2007 2019
A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction
Mei, S., Li, F., Leier, A., Marquez-Lago, T. T., Giam, K., Croft, N. P., Akutsu, T., Smith, A. I., Li, J., Rossjohn, J., Purcell, A. W. & Song, J., 14 Jun 2019, (Accepted/In press) In : Briefings in Bioinformatics. 17 p., bbz051.Research output: Contribution to journal › Review Article › Research › peer-review
Most viral peptides displayed by class I MHC on infected cells are immunogenic
Croft, N. P., Smith, S. A., Pickering, J., Sidney, J., Peters, B., Faridi, P., Witney, M. J., Sebastian, P., Flesch, I. E. A., Heading, S. L., Sette, A., La Gruta, N. L., Purcell, A. W. & Tscharke, D. C., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3112-3117 6 p.Research output: Contribution to journal › Article › Research › peer-review
Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses
Wu, T., Guan, J., Handel, A., Tscharke, D. C., Sidney, J., Sette, A., Wakim, L. M., Sng, X. Y. X., Thomas, P. G., Croft, N. P., Purcell, A. W. & La Gruta, N. L., 28 Jun 2019, In : Nature Communications. 10, 1, 14 p., 2846.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Response to Comment on "A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands"
Faridi, P., Li, C., Ramarathinam, S. H., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Croft, N. P. & Purcell, A. W., 16 Aug 2019, In : Science Immunology. 4, 38, 4 p., eaaw8457.Research output: Contribution to journal › Article › Other › peer-review
Open Access
A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands
Faridi, P., Li, C., Ramarathinam, S. H., Vivian, J. P., Illing, P. T., Mifsud, N. A., Ayala, R., Song, J., Gearing, L. J., Hertzog, P. J., Ternette, N., Rossjohn, J., Croft, N. P. & Purcell, A. W., 12 Oct 2018, In : Science Immunology. 3, 28, 12 p., eaar3947.Research output: Contribution to journal › Article › Research › peer-review
Activities 2018 2018
- 1 Membership of industry collaboration/ network
Biochemistry & Molecular Biology (Organisational unit)
Anthony Purcell (Member), Steve Quenette (Member), Craig Paul Bonnington (Member), Stephen Tate (Member), Nick Koletsas (Member), Nathan Paul Croft (Member)1 Apr 2018 → 31 Dec 2020
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network