Projects per year
Personal profile
Biography
Nathan completed his PhD in mid-2009 at the University of Birmingham, UK, studying immune evasion by Epstein-Barr Virus. Thereafter, he joined the group of Tony Purcell at the University of Melbourne, transitioning to Monash University in 2012. Nathan's research is focused on understanding how different aspects of the MHC antigen processing pathway impact upon T cell immunity to pathogens and tumors, with a specific emphasis on how the abundance of MHC-peptides play a role in driving the magnitude and efficacy of T cell responses. In conjunction with this work, Dr Croft is engaged in mapping the peptide repertoires of healthy and pathogen-infected cell lines, as well as cells and tissues of tumor origin. Together this work strives to develop novel bioinformatics and data repositories that will model and predict the generation of peptide epitopes and their potential immunogenicity.
Education/Academic qualification
Immunology, PhD, University of Birmingham
Award Date: 15 Jun 2009
Research area keywords
- Immunology
- Proteomics
- Peptidomics
- Immunopeptidomics
- Mass spectrometry
- Systems immunology
- Bioinformatics
- Infection and immunity
- Antigen presentation
Network
Projects
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Unravelling the role of type I Interferon family in human infectious and inflammatory diseases
Hertzog, P., Casanova, J., Netea, M. G., Turner, S., Creek, D., Gearing, J., Croft, N., Forster, S. & Polo, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/19 → 31/12/23
Project: Research
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Recognition of virus-infected cells by T cells
Tscharke, D. C., La Gruta, N., Purcell, A. & Croft, N.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/19
Project: Research
Research output
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A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction
Mei, S., Li, F., Leier, A., Marquez-Lago, T. T., Giam, K., Croft, N. P., Akutsu, T., Smith, A. I., Li, J., Rossjohn, J., Purcell, A. W. & Song, J., Jul 2020, In : Briefings in Bioinformatics. 21, 4, p. 1119-1135 17 p., bbz051.Research output: Contribution to journal › Review Article › Research › peer-review
17 Citations (Scopus) -
Benchmarking predictions of MHC class I restricted T cell epitopes in a comprehensively studied model system
Paul, S., Croft, N. P., Purcell, A. W., Tscharke, D. C., Sette, A., Nielsen, M. & Peters, B., 26 May 2020, In : PLoS Computational Biology. 16, 5, 18 p., e1007757.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile7 Citations (Scopus) -
Immunopeptidomic Analysis Reveals That Deamidated HLA-bound Peptides Arise Predominantly from Deglycosylated Precursors
Mei, S., Ayala, R., Ramarathinam, S. H., Illing, P. T., Faridi, P., Song, J., Purcell, A. W. & Croft, N. P., 1 Jul 2020, In : Molecular & Cellular Proteomics. 19, 7, p. 1236-1247 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Overlapping Peptides Elicit Distinct CD8+ T Cell Responses following Influenza A Virus Infection
Assmus, L. M., Guan, J., Wu, T., Farenc, C., Sng, X. Y. X., Zareie, P., Nguyen, A., Nguyen, A. T., Tscharke, D. C., Thomas, P. G., Rossjohn, J., Gras, S., Croft, N. P., Purcell, A. W. & La Gruta, N. L., 1 Oct 2020, In : Journal of Immunology. 205, 7, p. 1731-1742 12 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Peptide Presentation to T Cells: Solving the Immunogenic Puzzle: Systems Immunology Profiling of Antigen Presentation for Prediction of CD8+ T Cell Immunogenicity
Croft, N. P., Mar 2020, In : BioEssays. 42, 3, 9 p., 1900200.Research output: Contribution to journal › Review Article › Research › peer-review
1 Citation (Scopus)
Activities
- 1 Membership of industry collaboration/ network
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Biochemistry & Molecular Biology (Organisational unit)
Anthony Purcell (Member), Steve Quenette (Member), Craig Paul Bonnington (Member), Stephen Tate (Member), Nick Koletsas (Member) & Nathan Paul Croft (Member)
1 Apr 2018 → 31 Dec 2020Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network