Nataliya Zhukova

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Nataliya Zhukova

Dr

 https://orcid.org/0000-0002-3221-2396
20102023

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  • 2023

    Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities

    Sun, C. X., Daniel, P., Bradshaw, G., Shi, H., Loi, M., Chew, N., Parackal, S., Tsui, V., Liang, Y., Koptyra, M., Adjumain, S., Sun, C., Chong, W. C., Fernando, D., Drinkwater, C., Tourchi, M., Habarakada, D., Sooraj, D., Carvalho, D., Storm, P. B., & 36 othersBaubet, V., Sayles, L. C., Fernandez, E., Nguyen, T., Pörksen, M., Doan, A., Crombie, D. E., Panday, M., Zhukova, N., Dun, M. D., Ludlow, L. E., Day, B., Stringer, B. W., Neeman, N., Rubens, J. A., Raabe, E. H., Vinci, M., Tyrrell, V., Fletcher, J. I., Ekert, P. G., Dumevska, B., Ziegler, D. S., Tsoli, M., Syed Sulaiman, N. F., Loh, A. H. P., Low, S. Y. Y., Sweet-Cordero, E. A., Monje, M., Resnick, A., Jones, C., Downie, P., Williams, B., Rosenbluh, J., Gough, D., Cain, J. E. & Firestein, R., 10 Apr 2023, In: Cancer Cell. 41, 4, p. 660-677.e7 26 p.

    Research output: Contribution to journal › Article › Research › peer-review

    4 Citations (Scopus)
  • 2019

    Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

    Guerreiro Stucklin, A. S., Ryall, S., Fukuoka, K., Zapotocky, M., Lassaletta, A., Li, C., Bridge, T., Kim, B., Arnoldo, A., Kowalski, P. E., Zhong, Y., Johnson, M., Li, C., Ramani, A. K., Siddaway, R., Nobre, L. F., de Antonellis, P., Dunham, C., Cheng, S., Boué, D. R., & 42 othersFinlay, J. L., Coven, S. L., de Prada, I., Perez-Somarriba, M., Faria, C. C., Grotzer, M. A., Rushing, E., Sumerauer, D., Zamecnik, J., Krskova, L., Garcia Ariza, M., Cruz, O., Morales La Madrid, A., Solano, P., Terashima, K., Nakano, Y., Ichimura, K., Nagane, M., Sakamoto, H., Gil-da-Costa, M. J., Silva, R., Johnston, D. L., Michaud, J., Wilson, B., van Landeghem, F. K. H., Oviedo, A., McNeely, P. D., Crooks, B., Fried, I., Zhukova, N., Hansford, J. R., Nageswararao, A., Garzia, L., Shago, M., Brudno, M., Irwin, M. S., Bartels, U., Ramaswamy, V., Bouffet, E., Taylor, M. D., Tabori, U. & Hawkins, C., 1 Dec 2019, In: Nature Communications. 10, 1, 13 p., 4343.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    File
    178 Citations (Scopus)

  • Functional repair assay for the diagnosis of constitutional mismatch repair deficiency from non-neoplastic tissue

    Shuen, A. Y., Lanni, S., Panigrahi, G. B., Edwards, M., Yu, L., Campbell, B. B., Mandel, A., Zhang, C., Zhukova, N., Alharbi, M., Bernstein, M., Bowers, D. C., Carroll, S., Cole, K. A., Constantini, S., Crooks, B., Dvir, R., Farah, R., Hijiya, N., George, B., & 34 othersLaetsch, T. W., Larouche, V., Lindhorst, S., Luiten, R. C., Magimairajan, V., Mason, G., Mason, W., Mordechai, O., Mushtaq, N., Nicholas, G., Oren, M., Palma, L., Pedroza, L. A., Ramdas, J., Samuel, D., Schneider, K. W., Seeley, A., Semotiuk, K., Shamvil, A., Sumerauer, D., Toledano, H., Tomboc, P., Wierman, M., Damme, A. V., Lee, Y. Y., Zapotocky, M., Bouffet, E., Durno, C., Aronson, M., Gallinger, S., Foulkes, W. D., Malkin, D., Tabori, U. & Pearson, C. E., 1 Jan 2019, In: Journal of Clinical Oncology. 37, 6, p. 461-470 10 p.

    Research output: Contribution to journal › Article › Research › peer-review

    22 Citations (Scopus)

  • Ongoing issues with the management of children with Constitutional Mismatch Repair Deficiency syndrome

    Farah, R. A., Maalouf, F., Chahine, N. A., Farhat, H., Campbell, B., Zhukova, N., Durno, C., Aronson, M., Hawkins, C., Bouffet, E. & Tabori, U., Aug 2019, In: European Journal of Medical Genetics. 62, 8, 4 p., 103706.

    Research output: Contribution to journal › Letter › Other › peer-review

    5 Citations (Scopus)

  • Use of bevacizumab as a single agent or in adjunct with traditional chemotherapy regimens in children with unresectable or progressive low-grade glioma

    Zhukova, N., Rajagopal, R., Lam, A., Coleman, L., Shipman, P., Walwyn, T., Williams, M., Sullivan, M., Campbell, M., Bhatia, K., Gottardo, N. G. & Hansford, J. R., Jan 2019, In: Cancer Medicine. 8, 1, p. 40-50 11 p.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    File
    33 Citations (Scopus)
  • 2017

    Therapeutic and prognostic implications of BRAF V600E in pediatric low-grade gliomas

    Lassaletta, A., Zapotocky, M., Mistry, M., Ramaswamy, V., Honnorat, M., Krishnatry, R., Stucklin, A. G., Zhukova, N., Arnoldo, A., Ryall, S., Ling, C., McKeown, T., Loukides, J., Cruz, O., De Torres, C., Ho, C. Y., Packer, R. J., Tatevossian, R., Qaddoumi, I., Harreld, J. H., & 48 othersDalton, J. D., Mulcahy-Levy, J., Foreman, N., Karajannis, M. A., Wang, S., Snuderl, M., Rao, A. N., Giannini, C., Kieran, M., Ligon, K. L., Garre, M. L., Nozza, P., Mascelli, S., Raso, A., Mueller, S., Nicolaides, T., Silva, K., Perbet, R., Vasiljevic, A., Conter, C. F., Frappaz, D., Leary, S., Crane, C., Chan, A., Ng, H. K., Shi, Z. F., Mao, Y., Finch, E., Eisenstat, D., Wilson, B., Carret, A. S., Hauser, P., Sumerauer, D., Krskova, L., Larouche, V., Fleming, A., Zelcer, S., Jabado, N., Rutka, J. T., Dirks, P., Taylor, M. D., Chen, S., Bartels, U., Huang, A., Ellison, D. W., Bouffet, E., Hawkins, C. & Tabori, U., 1 Sept 2017, In: Journal of Clinical Oncology. 35, 25, p. 2934-2941 8 p.

    Research output: Contribution to journal › Article › Research › peer-review

    201 Citations (Scopus)
  • 2016

    Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study

    Krishnatry, R., Zhukova, N., Guerreiro Stucklin, A. S., Pole, J. D., Mistry, M., Fried, I., Ramaswamy, V., Bartels, U., Huang, A., Laperriere, N., Dirks, P., Nathan, P. C., Greenberg, M., Malkin, D., Hawkins, C., Bandopadhayay, P., Kieran, M. W., Manley, P. E., Bouffet, E. & Tabori, U., 15 Apr 2016, In: Cancer. 122, 8, p. 1261-1269 9 p.

    Research output: Contribution to journal › Article › Research › peer-review

    93 Citations (Scopus)

  • Immune checkpoint inhibition for hypermutant glioblastoma multiforme resulting from germline biallelic mismatch repair deficiency

    Bouffet, E., Larouche, V., Campbell, B. B., Merico, D., De Borja, R., Aronson, M., Durn, C., Krueger, J., Cabric, V., Ramaswamy, V., Zhukova, N., Mason, G., Farah, R., Afzal, S., Yalon, M., Rechavi, G., Magimairajan, V., Walsh, M. F., Constantini, S., Dvir, R., & 22 othersElhasid, R., Reddy, A., Osborn, M., Sullivan, M., Hansford, J., Dodgshun, A., Klauber-Demore, N., Peterson, L., Patel, S., Lindhorst, S., Atkinson, J., Cohen, Z., Laframboise, R., Dirks, P., Taylor, M., Malkin, D., Albrecht, S., Dudley, R. W. R., Jabado, N., Hawkins, C. E., Shlien, A. & Tabori, U., 1 Jul 2016, In: Journal of Clinical Oncology. 34, 19, p. 2206-2211 6 p.

    Research output: Contribution to journal › Article › Research › peer-review

    513 Citations (Scopus)
  • 2015

    BRAF mutation and CDKN2A deletion define a clinically distinct subgroup of childhood secondary high-grade glioma

    Mistry, M., Zhukova, N., Merico, D., Rakopoulos, P., Krishnatry, R., Shago, M., Stavropoulos, J., Alon, N., Pole, J. D., Ray, P. N., Navickiene, V., Mangerel, J., Remke, M., Buczkowicz, P., Ramaswamy, V., Stucklin, A. G., Li, M., Young, E. J., Zhang, C., Castelo-Branco, P., & 14 othersBakry, D., Laughlin, S., Shlien, A., Chan, J., Ligon, K. L., Rutka, J. T., Dirks, P. B., Taylor, M. D., Greenberg, M., Malkin, D., Huang, A., Bouffet, E., Hawkins, C. E. & Tabori, U., 20 Mar 2015, In: Journal of Clinical Oncology. 33, 9, p. 1015-1022 8 p.

    Research output: Contribution to journal › Article › Research › peer-review

    180 Citations (Scopus)
  • 2014

    Favorable survival and metabolic outcome for children with diencephalic syndrome using a radiation-sparing approach

    Kilday, J. P., Bartels, U., Huang, A., Barron, M., Shago, M., Mistry, M., Zhukova, N., Laperriere, N., Dirks, P., Hawkins, C., Bouffet, E. & Tabori, U., 1 Jan 2014, In: Journal of Neuro-Oncology. 116, 1, p. 195-204 10 p.

    Research output: Contribution to journal › Article › Research › peer-review

    22 Citations (Scopus)

  • WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

    Zhukova, N., Ramaswamy, V., Remke, M., Martin, D. C., Castelo-Branco, P., Zhang, C. H., Fraser, M., Tse, K., Poon, R., Shih, D. J. H., Baskin, B., Ray, P. N., Bouffet, E., Dirks, P., von Bueren, A. O., Pfaff, E., Korshunov, A., Jones, D. T. W., Northcott, P. A., Kool, M., & 40 othersPugh, T. J., Pomeroy, S. L., Cho, Y. J., Pietsch, T., Gessi, M., Rutkowski, S., Bognár, L., Cho, B. K., Eberhart, C. G., Conter, C. F., Fouladi, M., French, P. J., Grajkowska, W. A., Gupta, N., Hauser, P., Jabado, N., Vasiljevic, A., Jung, S., Kim, S. K., Klekner, A., Kumabe, T., Lach, B., Leonard, J. R., Liau, L. M., Massimi, L., Pollack, I. F., Ra, Y. S., Rubin, J. B., Van Meir, E. G., Wang, K. C., Weiss, W. A., Zitterbart, K., Bristow, R. G., Alman, B., Hawkins, C. E., Malkin, D., Clifford, S. C., Pfister, S. M., Taylor, M. D. & Tabori, U., 27 Jan 2014, In: Acta Neuropathologica Communications. 2, 1, 12 p., 174.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    File
    35 Citations (Scopus)
  • 2013

    Methylation of the TERT promoter and risk stratification of childhood brain tumours: An integrative genomic and molecular study

    Castelo-Branco, P., Choufani, S., Mack, S., Gallagher, D., Zhang, C., Lipman, T., Zhukova, N., Walker, E. J., Martin, D., Merino, D., Wasserman, J. D., Elizabeth, C., Alon, N., Zhang, L., Hovestadt, V., Kool, M., Jones, D. T. W., Zadeh, G., Croul, S., Hawkins, C., & 9 othersHitzler, J., Wang, J. C. Y., Baruchel, S., Dirks, P. B., Malkin, D., Pfister, S., Taylor, M. D., Weksberg, R. & Tabori, U., 1 May 2013, In: The Lancet Oncology. 14, 6, p. 534-542 9 p.

    Research output: Contribution to journal › Article › Research › peer-review

    195 Citations (Scopus)

  • Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

    Zhukova, N., Ramaswamy, V., Remke, M., Pfaff, E., Shih, D. J. H., Martin, D. C., Castelo-Branco, P., Baskin, B., Ray, P. N., Bouffet, E., Von Bueren, A. O., Jones, D. T. W., Northcott, P. A., Kool, M., Sturm, D., Pugh, T. J., Pomeroy, S. L., Cho, Y. J., Pietsch, T., Gessi, M., & 41 othersRutkowski, S., Bognar, L., Klekner, A., Cho, B. K., Kim, S. K., Wang, K. C., Eberhart, C. G., Fevre-Montange, M., Fouladi, M., French, P. J., Kros, M., Grajkowska, W. A., Gupta, N., Weiss, W. A., Hauser, P., Jabado, N., Jouvet, A., Jung, S., Kumabe, T., Lach, B., Leonard, J. R., Rubin, J. B., Liau, L. M., Massimi, L., Pollack, I. F., Ra, Y. S., Van Meir, E. G., Zitterbart, K., Schüller, U., Hill, R. M., Lindsey, J. C., Schwalbe, E. C., Bailey, S., Ellison, D. W., Hawkins, C., Malkin, D., Clifford, S. C., Korshunov, A., Pfister, S., Taylor, M. D. & Tabori, U., 10 Aug 2013, In: Journal of Clinical Oncology. 31, 23, p. 2927-2935 9 p.

    Research output: Contribution to journal › Article › Research › peer-review

    346 Citations (Scopus)

  • TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

    Remke, M., Ramaswamy, V., Peacock, J., Shih, D. J. H., Koelsche, C., Northcott, P. A., Hill, N., Cavalli, F. M. G., Kool, M., Wang, X., Mack, S. C., Barszczyk, M., Morrissy, A. S., Wu, X., Agnihotri, S., Luu, B., Jones, D. T. W., Garzia, L., Dubuc, A. M., Zhukova, N., & 63 othersVanner, R., Kros, J. M., French, P. J., Van Meir, E. G., Vibhakar, R., Zitterbart, K., Chan, J. A., Bognár, L., Klekner, A., Lach, B., Jung, S., Saad, A. G., Liau, L. M., Albrecht, S., Zollo, M., Cooper, M. K., Thompson, R. C., Delattre, O. O., Bourdeaut, F., Doz, F. F., Garami, M., Hauser, P., Carlotti, C. G., Van Meter, T. E., Massimi, L., Fults, D., Pomeroy, S. L., Kumabe, T., Ra, Y. S., Leonard, J. R., Elbabaa, S. K., Mora, J., Rubin, J. B., Cho, Y. J., McLendon, R. E., Bigner, D. D., Eberhart, C. G., Fouladi, M., Wechsler-Reya, R. J., Faria, C. C., Croul, S. E., Huang, A., Bouffet, E., Hawkins, C. E., Dirks, P. B., Weiss, W. A., Schüller, U., Pollack, I. F., Rutkowski, S., Meyronet, D., Jouvet, A., Fèvre-Montange, M., Jabado, N., Perek-Polnik, M., Grajkowska, W. A., Kim, S. K., Rutka, J. T., Malkin, D., Tabori, U., Pfister, S. M., Korshunov, A., Von Deimling, A. & Taylor, M. D., 31 Oct 2013, In: Acta Neuropathologica. 126, 6, p. 917-929 13 p.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    129 Citations (Scopus)

  • Williams-Beuren syndrome and burkitt leukemia

    Zhukova, N. & Naqvi, A., 1 Jan 2013, In: Journal of Pediatric Hematology/Oncology. 35, 1, p. e30-e32 3 p.

    Research output: Contribution to journal › Article › Other › peer-review

    13 Citations (Scopus)
  • 2012

    Monoallelic expression determines oncogenic progression and outcome in benign and malignant brain tumors

    Walker, E. J., Zhang, C., Castelo-Branco, P., Hawkins, C., Wilson, W., Zhukova, N., Alon, N., Novokmet, A., Baskin, B., Ray, P., Knobbe, C., Dirks, P., Taylor, M. D., Croul, S., Malkin, D. & Tabori, U., 1 Feb 2012, In: Cancer Research. 72, 3, p. 636-644 9 p.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    43 Citations (Scopus)
  • 2010

    A common molecular mechanism underlies two phenotypically distinct 17p13.1 microdeletion syndromes

    Shlien, A., Baskin, B., Achatz, M. I. W., Stavropoulos, D. J., Nichols, K. E., Hudgins, L., Morel, C. F., Adam, M. P., Zhukova, N., Rotin, L., Novokmet, A., Druker, H., Shago, M., Ray, P. N., Hainaut, P. & Malkin, D., 12 Nov 2010, In: American Journal of Human Genetics. 87, 5, p. 631-642 12 p.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    36 Citations (Scopus)

  • TP53 alterations determine clinical subgroups and survival of patients with choroid plexus tumors

    Tabori, U., Shlien, A., Baskin, B., Levitt, S., Ray, P., Alon, N., Hawkins, C., Bouffet, E., Pienkowska, M., Lafay-Cousin, L., Gozali, A., Zhukova, N., Shane, L., Gonzalez, I., Finlay, J. & Malkin, D., 20 Apr 2010, In: Journal of Clinical Oncology. 28, 12, p. 1995-2001 7 p.

    Research output: Contribution to journal › Article › Research › peer-review

    148 Citations (Scopus)