Accepting PhD Students

PhD projects

A range of projects are available to students broadly investigating the role of lymphatics in disease and drug delivery to lymphatics to treat disease. This includes formulation, drug delivery, lymph and plasma pharmacokinetic analysis, immunology and metabolism focusses.

20052020

Research output per year

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Research Output

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Article
2020

Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans

Trevaskis, N. L., Lee, G., Escott, A., Phang, K. L., Hong, J., Cao, E., Katneni, K., Charman, S. A., Han, S., Charman, W. N., Phillips, A. R. J., Windsor, J. A. & Porter, C. J. H., 21 May 2020, In : Frontiers in Physiology. 11, 11 p., 458.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)
1 Citation (Scopus)

Sex-specific adipose tissue imprinting of regulatory T cells

Vasanthakumar, A., Chisanga, D., Blume, J., Gloury, R., Britt, K., Henstridge, D. C., Zhan, Y., Torres, S. V., Liene, S., Collins, N., Cao, E., Sidwell, T., Li, C., Spallanzani, R. G., Liao, Y., Beavis, P. A., Gebhardt, T., Trevaskis, N., Nutt, S. L., Zajac, J. D. & 5 others, Davey, R. A., Febbraio, M. A., Mathis, D., Shi, W. & Kallies, A., 26 Mar 2020, In : Nature. 579, 7800, p. 581–585+ 29 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Targeting immune cells within lymph nodes

Porter, C. J. H. & Trevaskis, N. L., Jun 2020, In : Nature Nanotechnology. 15, 6, p. 423-425 3 p.

Research output: Contribution to journalArticleOtherpeer-review

2019

Lymphatic Uptake of Liposomes after Intraperitoneal Administration Primarily Occurs via the Diaphragmatic Lymphatics and is Dependent on Liposome Surface Properties

Lee, G., Han, S., Inocencio, I., Cao, E., Hong, J., Phillips, A. R. J., Windsor, J. A., Porter, C. J. H. & Trevaskis, N. L., 2 Dec 2019, In : Molecular Pharmaceutics. 16, 12, p. 4987-4999 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Promoting intestinal lymphatic transport targets a liver-X receptor (LXR) agonist (WAY-252,623) to lymphocytes and enhances immunomodulation

Cao, E., Lindgren, A., Martinsson, S., Hu, L., Lindfors, L., Sigfridsson, K., Skantze, U., Michaëlsson, E., Trevaskis, N. L. & Porter, C. J. H., 28 Feb 2019, In : Journal of Controlled Release. 296, p. 29-39 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group

Koziolek, M., Alcaro, S., Augustijns, P., Basit, A. W., Grimm, M., Hens, B., Hoad, C. L., Jedamzik, P., Madla, C. M., Maliepaard, M., Marciani, L., Maruca, A., Parrott, N., Pávek, P., Porter, C. J. H., Reppas, C., van Riet-Nales, D., Rubbens, J., Statelova, M., Trevaskis, N. L. & 4 others, Valentová, K., Vertzoni, M., Čepo, D. V. & Corsetti, M., 15 Jun 2019, In : European Journal of Pharmaceutical Sciences. 134, p. 31-59 29 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
29 Citations (Scopus)
2018

Distribution of therapeutic proteins into thoracic lymph after intravenous administration is protein size-dependent and primarily occurs within the liver and mesentery

Yadav, P., McLeod, V. M., Nowell, C. J., Selby, L. I., Johnston, A. P. R., Kaminskas, L. M. & Trevaskis, N. L., 28 Feb 2018, In : Journal of Controlled Release. 272, p. 17-28 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2017

Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623

McEvoy, C. L., Trevaskis, N. L., Feeney, O. M., Edwards, G. A., Perlman, M. E., Ambler, C. M. & Porter, C. J. H., 4 Dec 2017, In : Molecular Pharmaceutics. 14, 12, p. 4525-4538 14 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2016

50 years of oral lipid-based formulations: provenance, progress and future perspectives

Feeney, O. M., Crum, M. F., McEvoy, C., Trevaskis, N., Williams, H., Pouton, C., Charman, W. N., Bergstrom, C. & Porter, C. J. H., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 167-194 27 p.

Research output: Contribution to journalArticleResearchpeer-review

154 Citations (Scopus)

A new in vitro lipid digestion - in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations

Crum, M., Trevaskis, N., Williams, H. D., Pouton, C. W. & Porter, C. J., 2016, In : Pharmaceutical Research. 33, 4, p. 970-982 13 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)
Open Access
File
6 Citations (Scopus)

Glyceride-mimetic prodrugs incorporating self-immolative spacers promote lymphatic transport, avoid first-pass metabolism, and enhance oral bioavailability

Hu, L., Quach, T., Han, S., Lim, S. F., Yadav, P., Senyschyn, D., Trevaskis, N. L., Simpson, J. S. & Porter, C. J. H., 2016, In : Angewandte Chemie - International Edition. 55, 44, p. 13700 –13705 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Lymphatic transport and lymphocyte targeting of a triglyceride mimetic prodrug is enhanced in a large animal model: studies in greyhound dogs

Han, S., Hu, L., Gracia, G., Quach, T., Simpson, J. S., Edwards, G. A., Trevaskis, N. L. & Porter, C. J. H., 3 Oct 2016, In : Molecular Pharmaceutics. 13, 10, p. 3351-3361 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Single intravenous dose of novel flurbiprofen-loaded proniosome formulations provides prolonged systemic exposure and anti-inflammatory effect

Verma, P., Prajapati, S. K., Yadav, R., Senyschyn, D., Shea, P. R. & Trevaskis, N. L., 7 Nov 2016, In : Molecular Pharmaceutics. 13, 11, p. 3688-3699 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2015

From sewer to saviour-targeting the lymphatic system to promote drug exposure and activity

Trevaskis, N., Kaminskas, L. M. & Porter, C. J., 2015, In : Nature Reviews Drug Discovery. 14, 11, p. 781 - 803 23 p.

Research output: Contribution to journalArticleResearchpeer-review

190 Citations (Scopus)

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats

Kaminskas, L. M., McLeod, V. M., Ascher, D. B., Ryan, G., Jones, S. A., Haynes, J. M., Trevaskis, N., Chan, L. J., Sloan, E. K., Finnin, B. A. L., Williamson, M. M., Velkov, T., Williams, E. D., Kelly, B., Owen, D. J. & Porter, C. J., 2015, In : Molecular Pharmaceutics. 12, 2, p. 432 - 443 12 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug

Han, S., Hu, L., Quach, T., Simpson, J. S., Trevaskis, N. & Porter, C. J., 2015, In : Pharmaceutical Research. 32, 5, p. 1830-1844 15 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
2014

In vitro-in vivo evaluation of lipid based formulations of the CETP inhibitors CP-529,414 (torcetrapib) and CP-532,623

McEvoy, C. L., Trevaskis, N., Edwards, G. A., Perlman, M. E., Ambler, C. M., Mack, M. C., Brockhurst, B. & Porter, C. J., 2014, In : European Journal of Pharmaceutics and Biopharmaceutics. 88, 3, p. 973 - 985 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Targeted delivery of a model immunomodulator to the lymphatic system: Comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies

Han, S., Quach, T., Hu, L., Wahab, A., Charman, W. N., Stella, V. J., Trevaskis, N., Simpson, J. S. & Porter, C. J., 2014, In : Journal of Controlled Release. 177, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)
2013

A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport

Trevaskis, N., Caliph, S. M., Nguyen, G., Tso, P., Charman, W. N. & Porter, C. J., 2013, In : Pharmaceutical Research. 30, 12, p. 3254 - 3270 17 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation

Yeap, Y. Y., Trevaskis, N., Quach, T., Tso, P., Charman, W. N. & Porter, C. J., 2013, In : Molecular Pharmaceutics. 10, 5, p. 1874 - 1889 16 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)
34 Citations (Scopus)

Lipid-based formulations and drug supersaturation: Harnessing the unique benefits of the lipid digestion/absorption pathway

Williams, H. D., Trevaskis, N., Yeap, Y. Y., Anby, M. U., Pouton, C. W. & Porter, C. J., 2013, In : Pharmaceutical Research. 30, 12, p. 2976 - 2992 17 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

Strategies to address low drug solubility in discovery and development

Williams, H. D., Trevaskis, N., Charman, S. A., Shanker, R., Charman, W. N., Pouton, C. W. & Porter, C. J., 2013, In : Pharmacological Reviews. 65, 1, p. 315 - 499 185 p.

Research output: Contribution to journalArticleResearchpeer-review

757 Citations (Scopus)

The impact of lymphatic transport on the systemic disposition of lipophilic drugs

Caliph, S. M., Cao, E., Bulitta, J. B., Hu, L., Han, S., Porter, C. J. & Trevaskis, N., 2013, In : Journal of Pharmaceutical Sciences. 102, 7, p. 2395 - 2408 14 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The potential for drug supersaturation during intestinal processing of lipid-based formulations may be enhanced for basic drugs

Yeap, Y. Y., Trevaskis, N. & Porter, C. J., 2013, In : Molecular Pharmaceutics. 10, 7, p. 2601 - 2615 15 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
2011
6 Citations (Scopus)

Correction to "targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?"

Trevaskis, N. L., Charman, W. N. & Porter, C. J. H., 5 Dec 2011, In : Molecular Pharmaceutics. 8, 6, p. 2484 1 p.

Research output: Contribution to journalArticleOtherpeer-review

5 Citations (Scopus)

Fatty acid binding proteins: potential chaperones of cytosolic drug transport in the enterocyte?

Trevaskis, N., Nguyen, G., Scanlon, M. & Porter, C., 2011, In : Pharmaceutical Research. 28, 9, p. 2176 - 2190 15 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2010

Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?

Trevaskis, N., Charman, W. & Porter, C., 2010, In : Molecular Pharmaceutics. 7, 6, p. 2297 - 2309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623)

Trevaskis, N., McEvoy, C. L., McIntosh, M. P., Edwards, G. A., Shanker, R., Charman, W. N. & Porter, C. J., 2010, In : Pharmaceutical Research. 27, p. 878 - 893 16 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)
2009

Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism

Trevaskis, N., Shackleford, D., Charman, W. N., Edwards, G. A., Gardin, A., Appel-Dingemanse, S., Kretz, O., Galli, B. & Porter, C. J., 2009, In : Pharmaceutical Research. 26, 6, p. 1486 - 1495 10 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)
2008

Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update

Trevaskis, N., Charman, W. N. & Porter, C. J., 2008, In : Advanced Drug Delivery Reviews. 60, 6, p. 702 - 716 15 p.

Research output: Contribution to journalArticleResearchpeer-review

261 Citations (Scopus)
2007

Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

Porter, C. J., Trevaskis, N. & Charman, W. N., 2007, In : Nature Reviews Drug Discovery. 6, 14, p. 231 - 248 18 p.

Research output: Contribution to journalArticleResearchpeer-review

1165 Citations (Scopus)
2006

An acute and coincident increase in FABP expression and lymphatic lipid and drug transport occurs during intestinal infusion of lipid-based drug formulations to rats

Trevaskis, N. L., Lo, C. M., Ma, L. Y., Tso, P., Irving, H. R., Porter, C. J. H. & Charman, W. N., 2006, In : Pharmaceutical Research. 23, 8, p. 1786 - 1796 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat

Trevaskis, N., Porter, C. J. H. & Charman, W. N., 2006, In : Drug Metabolism and Disposition. 34, 5, p. 729 - 733 5 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport

Trevaskis, N., Porter, C. J. H. & Charman, W. N., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 316, 2, p. 881 - 891 11 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Tissue uptake of DDT is independent of chylomicron metabolism

Trevaskis, N. L., Tso, P., Rider, T., Charman, W. N., Porter, C. J. H. & Jandacek, R., 2006, In : Archives of Toxicology. 80, 4, p. 196 - 200 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2005

Bile increases intestinal lymphatic drug transport in the fasted rat

Trevaskis, N., Porter, C. J. H. & Charman, W. N., 2005, In : Pharmaceutical Research. 22, 11, p. 1863 - 1870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)