Accepting PhD Students

PhD projects

A range of projects are available to students broadly investigating the role of lymphatics in disease and drug delivery to lymphatics to treat disease. This includes formulation, drug delivery, lymph and plasma pharmacokinetic analysis, immunology and metabolism focusses.

20052020

Research output per year

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Personal profile

Biography

Position

Head of Lymphatic Biology and Drug Delivery Laboratory, Monash Institute of Pharmaceutical Sciences

Senior Lecturer, Faculty of Pharmacy and Pharmaceutical Sciences

Research interests
Dr Trevaskis’ research group is focussed on the role of lymphatics in immune-metabolic disease and drug delivery to the lymphatics to treat these diseases.
The lymphatic system has physiological functions in dietary fat absorption, immune response and fluid balance. Importantly, the lymphatic system has recently been found to play important roles in a range of diseases including immune and inflammatory diseases, cancers and metabolic disease. Dr Trevaskis’ research group is particularly focussed on understanding the mechanisms by which lymphatic dysfunction contributes to diseases such as arthritis, pancreatitis, neuroinflammation, atherosclerosis, obesity and type 2 diabetes. Her group is also advancing the design of drug delivery systems to target the lymphatics and treat these diseases including orally administered lipid prodrugs and parenterally administered nano-systems such as liposomes, lipoprotein mimetics and polymer systems.


Research publications
Dr Trevaskis has published >47 research papers (>3900 cites, H index 21, FWCI 2.7 in 2020) including in top journals Nature (2020), Nature Nano (2020), Angewandte Chemie (2016) and Journal of Controlled Release (x3 front covers).

She has contributed to highly cited invited reviews on lipid based and lymphatic drug delivery including in Nature Reviews Drug Discovery, Advanced Drug Delivery Reviews x3 and Pharmacological Reviews.


Patents
Dr Trevaskis is an inventor on over 18 PCT for oral lipid prodrugs to target lymphatics granted in 2015-2019. The patents were licensed to Puretech Health in 2017 and further sub-licensed to Boehringer Ingelheim.


Prizes
Dr Trevaskis received the MIPS Future Research Leader Award (2018), AK McIntyre prize from the Australian Physiological Society (2015), Mollie Holman Doctoral Medal for thesis excellence (2006) and Gold Medal for top BPharm student (2001) at Monash University.


Research team supervision
Dr Trevaskis’ research group currently includes 2 post-doctoral fellows, 7 PhD, 1 masters and 2 honours students. She has supervised 13 student completions (8 PhD, 5 Honours). Her PhD students have received major international awards including two Lipid-Based Drug Delivery student awards from the American Association of Pharmaceutical Scientists and an Oral Drug Delivery award from the Controlled Release Society. All have secured employment in industry or academia.


Professional involvement
Dr Trevaskis is a member of Australian Physiological Society (AuPS) council and led the local organizing committee for their annual meeting in 2017. She co-led the organizing committee for the Australasian Pharmaceutical Science Association (APSA) annual meeting in 2019. Dr Trevaskis also organized annual Melbourne Lymphatic Symposiums in 2016-2019.
She is a scientific advisor for the Journal of Pharmaceutical Science and was a top reviewer in 2017. 

Within Monash, Dr Trevaskis currently serves as a category B member on the MIPS animal ethics committee. She is lead of the Her Research Matters Established Leader Program which aims to foster the development of women in science at Monash. She also sits on Faculty Education Committees.


Invited presentations
Dr Trevaskis presented invited symposiums at the Gordon Research Conference on Lymphatics (2020), Australasian Vascular Biology Meeting (2019), Australian Neuro-Gastrointestinal Motility Association (2017), FIP world congress (2015) and Australian Physiological Society meeting (2013).

Monash teaching commitment

Unit coordinator of PHR1022 How Medicines Work 2, Master of Pharmacy 

Lecturer in Pharmacokinetics and Drug Delivery in PHR1022 How Medicines Work 2, Master of Pharmacy 

Lecturer in Drug Delivery and Formulation in PHR2021 How Medicines Work 3, Master of Pharmacy

Lecturer in Pharmacokinetics adn Drug Delivery in PHR1011 Bridge to Practice 1, Master of Pharmacy

Lecturer in Drug Delivery and Formulation in PHR1101 Bridge to Practice 2, Master of Pharmacy

Supervisor for Bachelor of Pharmacy and Pharmaceutical Science student lab placements

Supervisor for Honours Degree in Pharmaceutical Science

Supervisor for Enhanced Doctoral Training Program in Pharmaceutical Sciences

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Projects

Noxopharm 2019 studies

Trevaskis, N.

15/04/1915/04/20

Project: Other

Noxopharm 2018 studies

Trevaskis, N.

19/12/1731/12/18

Project: Research

Noxopharm lymph uptake idronoxil studies 2

Trevaskis, N.

3/01/1731/05/17

Project: Research

Research Output

Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans

Trevaskis, N. L., Lee, G., Escott, A., Phang, K. L., Hong, J., Cao, E., Katneni, K., Charman, S. A., Han, S., Charman, W. N., Phillips, A. R. J., Windsor, J. A. & Porter, C. J. H., 21 May 2020, In : Frontiers in Physiology. 11, 11 p., 458.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Sex-specific adipose tissue imprinting of regulatory T cells

Vasanthakumar, A., Chisanga, D., Blume, J., Gloury, R., Britt, K., Henstridge, D. C., Zhan, Y., Torres, S. V., Liene, S., Collins, N., Cao, E., Sidwell, T., Li, C., Spallanzani, R. G., Liao, Y., Beavis, P. A., Gebhardt, T., Trevaskis, N., Nutt, S. L., Zajac, J. D. & 5 others, Davey, R. A., Febbraio, M. A., Mathis, D., Shi, W. & Kallies, A., 26 Mar 2020, In : Nature. 579, 7800, p. 581–585+ 29 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Targeting immune cells within lymph nodes

Porter, C. J. H. & Trevaskis, N. L., Jun 2020, In : Nature Nanotechnology. 15, 6, p. 423-425 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Lymphatic Uptake of Liposomes after Intraperitoneal Administration Primarily Occurs via the Diaphragmatic Lymphatics and is Dependent on Liposome Surface Properties

Lee, G., Han, S., Inocencio, I., Cao, E., Hong, J., Phillips, A. R. J., Windsor, J. A., Porter, C. J. H. & Trevaskis, N. L., 2 Dec 2019, In : Molecular Pharmaceutics. 16, 12, p. 4987-4999 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Activities

  • 1 Submissions to industry or govt committees, commissions and inquiries

Drug Delivery, Disposition and Dynamics

Natalie Trevaskis (Member)

30 Nov 2011

Activity: External Academic EngagementSubmissions to industry or govt committees, commissions and inquiries