• Cnr Wellington and Blackburn Rds, 23 Innovation Walk

    3800 Clayton

    Australia

Accepting PhD Students

20042019
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Research Output 2004 2019

2019

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

Yang, S. N. Y., Atkinson, S. C., Fraser, J. E., Wang, C., Maher, B., Roman, N., Forwood, J. K., Wagstaff, K. M., Borg, N. A. & Jans, D. A., 24 Mar 2019, In : Cells. 8, 3, 15 p., 281.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

Integrating Experiment and Theory to Understand TCR-pMHC Dynamics

Buckle, A. M. & Borg, N. A., 7 Dec 2018, In : Frontiers in Immunology. 9, 10 p., 2898.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Previously hidden dynamics at the TCR-peptide-MHC interface revealed

Fodor, J., Riley, B. T., Borg, N. A. & Buckle, A. M., 15 Jun 2018, In : Journal of Immunology. 200, 12, p. 4134-4145 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization

Huang, C., Lewis, C., Borg, N. A., Canals, M., Diep, H., Drummond, G. R., Goode, R. J., Schittenhelm, R. B., Vinh, A., Zhu, M., Kemp-Harper, B., Kleifeld, O. & Stone, M. J., 6 Apr 2018, In : Journal of Proteome Research. 17, 4, p. 1485-1499 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus v

Atkinson, S. C., Audsley, M. D., Lieu, K. G., Marsh, G. A., Thomas, D. R., Heaton, S. M., Paxman, J. J., Wagstaff, K. M., Buckle, A. M., Moseley, G. W., Jans, D. A. & Borg, N. A., 10 Jan 2018, In : Scientific Reports. 8, 1, 17 p., 358.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Structural Capacitance in Protein Evolution and Human Diseases

Li, C., Clark, L. V. T., Zhang, R., Porebski, B. T., McCoey, J. M., Borg, N. A., Webb, G. I., Kass, I., Buckle, M., Song, J., Woolfson, A. & Buckle, A. M., 14 Sep 2018, In : Journal of Molecular Biology. 430, 18, p. 3200-3217 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Ubiquitin in cell-cycle regulation and dysregulation in cancer

Borg, N. A. & Dixit, V. M., Mar 2017, In : Annual Review of Cancer Biology. 1, p. 59-77 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2016

Brinp1-/- mice exhibit autism-like behaviour, altered memory, hyperactivity and increased parvalbumin-positive cortical interneuron density

Berkowicz, S. R., Featherby, T. J., Qu, Z., Giousoh, A., Borg, N. A., Heng, J. I., Whisstock, J. C. & Bird, P. I., 31 Mar 2016, In : Molecular Autism. 7, 22, 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Smoothing a rugged protein folding landscape by sequence-based redesign

Porebski, B. T., Keleher, S., Hollins, J. J., Nickson, A. A., Marijanovic, E. M., Borg, N. A., Costa, M. G. S., Pearce, M. A., Dai, W., Zhu, L., Irving, J. A., Hoke, D. E., Kass, I., Whisstock, J. C., Bottomley, S. P., Webb, G. I., McGowan, S. & Buckle, A. M., 26 Sep 2016, In : Scientific Reports. 6, 14 p., 33958.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Ubiquitin in the activation and attenuation of innate antiviral immunity

Heaton, S. M., Borg, N. A. & Dixit, V. M., 11 Jan 2016, In : Journal of Experimental Medicine. 213, 1, p. 1-13 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Ubiquitin Signaling to NF-κB

Borg, N. A. & Dixit, V. M., 27 Apr 2016, Encyclopedia of Immunobiology. Ratcliffe, M. J. H. (ed.). Academic Press, Vol. 3. p. 51-64 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2015

The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope

Atkinson, S. C., Armistead, J. S., Mathias, D. K., Sandeu, M. M., Tao, D., Borhani-Dizaji, N., Tarimo, B. B., Morlais, I., Dinglasan, R. R. & Borg, N. A., 2015, In : Nature Structural and Molecular Biology. 22, 7, p. 532 - 539 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Antibodies to a single, conserved epitope in Anopheles APN1 inhibit universal transmission of Plasmodium falciparum and Plasmodium vivax malaria

Armistead, J. S., Morlais, I., Mathias, D. K., Jardim, J. G., Joy, J., Fridman, A., Finnefrock, A. C., Bagchi, A., Plebanski, M., Scorpio, D. G., Churcher, T. S., Borg, N., Sattabongkot, J. & Dinglasan, R. R., 2014, In : Infection and Immunity. 82, 2, p. 818 - 829 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Understanding the structural dynamics of TCR-pMHC complex interactions

Kass, I., Buckle, A. M. & Borg, N. A., 2014, In : Trends in Immunology. 35, 12, p. 604 - 612 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

A small molecule glycosaminoglycan mimetic blocks Plasmodium invasion of the mosquito midgut

Mathias, D. K., Pastrana-Mena, R., Ranucci, E., Tao, D., Ferruti, P., Ortega, C., Staples, G. O., Zaia, J., Takashima, E., Tsuboi, T., Borg, N., Verotta, L. & Dinglasan, R. R., 2013, In : PLoS Pathogens. 9, 11, 14 p., e1003757.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Mitochondrially localised MUL1 is a novel modulator of antiviral signaling

Jenkins, K. A., Khoo, J. J., Sadler, A. J., Piganis, R. A. R., Wang, D., Borg, N., Hjerrild, K., Gould, J. A., Thomas, B., Nagley, P., Hertzog, P. J. & Mansell, A. S., 2013, In : Immunology and Cell Biology. 91, 4, p. 321 - 330 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Epitope flexibility and dynamic footprint revealed by molecular dynamics of a pMHC-TCR complex

Reboul, C., Meyer, G. R., Porebski, B., Borg, N. A. & Buckle, A. M., 2012, In : PLoS Computational Biology. 8, 3 (Art. ID: e1002404), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2009

The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes

Paxman, J. J., Borg, N., Horne, H. J., Thompson, P., Chin, K. Y., Sharma, P., Simpson, J. S., Wielens, J., Piek, S., Kahler, C. M., Sakellaris, H., Pearce, M. C., Bottomley, S. P., Rossjohn, J. & Scanlon, M., 2009, In : Journal of Biological Chemistry. 284, 26, p. 17835 - 17845 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR

Wun, K. S., Borg, N., Kjer-Nielsen, L., Beddoe, T. C., Koh, R., Richardson, S. K., Thakur, M., Howell, A. R., Scott-Browne, J. P., Gapin, L., Godfrey, D. I., McCluskey, J. & Rossjohn, J., 2008, In : Journal of Experimental Medicine. 205, 4, p. 939 - 949 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease

Henderson, K., Tye-Din, J. A., Reid, H. H., Chen, Z., Borg, N., Beissbarth, T., Tatham, A., Mannering, S. I., Purcell, A. W., Dudek, N. L., van Heel, D. A., McCluskey, J., Rossjohn, J. & Anderson, R. P., 2007, In : Immunity. 27, 1, p. 23 - 34 12 p.

Research output: Contribution to journalArticleResearchpeer-review

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

Tynan, F. E., Reid, H. H., Kjer-Nielsen, L., Miles, J. J., Wilce, M. C. J., Kostenko, L., Borg, N., Williamson, N. A., Beddoe, T. C., Purcell, A. W., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2007, In : Nature Immunology. 8, 3, p. 268 - 276 9 p.

Research output: Contribution to journalArticleResearchpeer-review

CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor

Borg, N., Wun, K. S., Kjer-Nielsen, L., Wilce, M. C. J., Pellicci, D. G., Koh, R., Besra, G. S., Bharadwaj, M., Godfrey, D. I., McCluskey, J. & Rossjohn, J., 2007, In : Nature. 448, 7149, p. 44 - 49 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Germline-encoded recognition of diverse glycolipids by natural killer T cells

Scott-Browne, J. P., Matsuda, J. L., Mallevaey, T., White, J., Borg, N., McCluskey, J., Rossjohn, J., Kappler, J., Marrack, P. & Gapin, L., 2007, In : Nature Immunology. 8, 10, p. 1105 - 1113 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural insight into natural killer T cell receptor recognition of CD1d

Borg, N., Kjer-Nielsen, L., McCluskey, J. & Rossjohn, J., 2007, In : Advances in Experimental Medicine and Biology. 598, p. 20 - 34 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease

Henderson, K., Reid, H. H., Borg, N., Broughton, S. E., Huyton, T., Anderson, R. P., McCluskey, J. & Rossjohn, J., 2007, In : Acta Crystallographica. Section F: Structural Biology Communications. 63, 12, p. 1021 - 1025 5 p.

Research output: Contribution to journalArticleOther

2006

A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition

Kjer-Nielsen, L., Borg, N. A., Pellicci, D. G., Beddoe, T. C., Kostenko, L., Clements, C. S., Williamson, N. A., Smyth, M. J., Besra, G. S., Reid, H. H., Bharadwaj, M., Godfrey, D. I., Rossjohn, J. & McCluskey, J., 2006, In : Journal of Experimental Medicine. 203, 3, p. 661 - 673 13 p.

Research output: Contribution to journalArticleResearchpeer-review

TCRalpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope

Miles, J. J., Borg, N. A., Brennan, R. M., Tynan, F. E., Kjer-Nielsen, L., Silins, S. L., Bell, M. J., Burrows, J. M., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2006, In : Journal of Immunology. 177, 10, p. 6804 - 6814 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

A super-bulged epitope and single amino acid polymorphism identify critical features for T cell recognition

McCluskey, J. (ed.), Tynan, F. E., Burrows, S. R., Tait, B. (ed.), Holdsworth, R. (ed.), Buckle, A. M., Christiansen, F. (ed.), Clements, C. S., Borg, N., Beddoe, T. C., Whisstock, J. C., Wilce, M. C. J., Silins, S. L., Burrows, J. M., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W. & Rossjohn, J., 2005, p. 571 - 571. 1 p.

Research output: Contribution to conferenceAbstractOther

CTL recognition of a bulged viral peptide involves biased TCR selection

Miles, J. J., Elhassen, D., Borg, N. A., Silins, S. L., Tynan, F. E., Burrows, J. M., Purcell, A. W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S. R. & McCluskey, J., 2005, In : Journal of Immunology. 175, 6, p. 3826 - 3834 9 p.

Research output: Contribution to journalArticleResearchpeer-review

High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I: implications for T-Cell receptor engagement and T-cell immunodominance

Tynan, F. E., Borg, N., Miles, J. J., Beddoe, T. C., Elhassen, D., Silins, S. L., van Zuylen, W. JM., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J., Burrows, S. R. & Rossjohn, J., 2005, In : Journal of Biological Chemistry. 280, 25, p. 23900 - 23909 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Predicting the human T cell receptor choice before viral infection; Facts learnt from primary infection

Miles, J. J., McCluskey, J. (ed.), Tait, B. (ed.), Borg, N., Holdsworth, R. (ed.), Tynan, F. E., Kjer-Nielsen, L., Christiansen, F. (ed.), Elhassen, D., Silins, S. L., Burrows, J. M., Brennan, R. M., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2005, p. 493 - 493. 1 p.

Research output: Contribution to conferenceAbstractOther

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Tynan, F. E., Burrows, S. R., Buckle, A. M., Clements, C. S., Borg, N. A., Miles, J. J., Beddoe, T. C., Whisstock, J. C., Wilce, M. C. J., Silins, S. L., Burrows, J. M., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 11, p. 1114 - 1122 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The CDR3 regions of an Immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

Borg, N. A., Ely, L. K., Beddoe, T. C., Macdonald, W. A., Reid, H. H., Clements, C. S., Purcell, A. W., Kjer-Nielsen, L., Miles, J. J., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 2, p. 171 - 180 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

Tynan, F. E., Elhassen, D., Purcell, A. W., Burrows, J. M., Borg, N. A., Miles, J. J., Williamson, N. A., Green, K. J., Tellam, J., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1249 - 1260 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III

Lawrence, M. C., Borg, N. A., Streltsov, V. A., Pilling, P. A., Epa, V. C., Varghese, J. N., McKimm-Breschkin, J. L. & Colman, P. M., 30 Jan 2004, In : Journal of Molecular Biology. 335, 5, p. 1343-1357 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The structure of H-2Kb and Kbm8 complexed to a herpes simplex virus determinant: Evidence for a conformational switch that governs T cell repertoire selection and viral resistance

Webb, A. I., Borg, N. A., Dunstone, M. A., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Carbone, F. R., Bottomley, S. P., Aguilar, M. I., Purcell, A. W. & Rossjohn, J., 2004, In : Journal of Immunology. 173, 1, p. 402 - 409 8 p.

Research output: Contribution to journalArticleResearchpeer-review