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Personal profile


Natalie's research merges the fields of Immunology, Stem Cells and Cancer Biology. Her initial research focused on the relatively unexplored stromal cells of the Thymus which are essential for T cell production and Immunity. Natalie pioneered methods pertaining to the isolation and characterization of these technically-challenging and rare stromal cell subsets, resulting in methodologies that are still cited today. She developed novel, 3D in vitro culture systems which led to the identification of rare, multipotential stem cells within the thymus organ, resulting in the first published report of in vitro-verified progenitor/stem cells from the adult thymus (Cell Reports, 2014). Currently Natalie is applying these stromal techniques in the field of Prostate Cancer, where she aims to develop much needed in vitro model systems to allow the recreation and exploration of human Prostate Cancer cells in vitro.

Research interests

Development of preclinical, patient-specific in vitro models of Prostate Cancer. Human Prostate cancer cell-lines have been used for decades in the preclinical evaluation of new therapies. Mostly, these simple 2D models have failed to fulfil the promise of new drugs, and do not progess past clinical trials. Our fundamental hypothesis is that current models do not reflect the complexity of prostatic tumours. Prostate cancer cells are dependent on their surrounding microenvironment, which consists of multiple cell-types including extracelular matrix and vasculature. Engineering of the microenvironment using multiple, primary human cells is a novel approach to develop a patient-specific in vitro model system.

Monash teaching commitment

Tutor- Immunology 3031

Guest Lecturer Immunology 3031/41

Community service

Natalie is an active member of the Prostate Cancer Support Group network. Here we liase with local support groups to organize talks, visits and tours of the laboratory with members of the public and those affected by prostate cancer. This is a vital interaction with research scientists and clinicians to help teach the public about the importance of university level research and how we utilize the human prostate cancer specimans as the initial stage of translational medicine.


  • Immunology
  • Prostate Cancer
  • In vitro model systems
  • adult thymus
  • thymic epithelial cells
  • enzymatic digestion
  • collagenase
  • flow cytometry

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2007 2020

Research Output 2006 2019

Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target

Lee, R. S., Zhang, L., Berger, A., Lawrence, M. G., Song, J., Niranjan, B., Davies, R. G., Lister, N. L., Sandhu, S. K., Rubin, M. A., Risbridger, G. P., Taylor, R. A., Rickman, D. S., Horvath, L. G. & Daly, R. J., 1 Apr 2019, In : Neoplasia (United States). 21, 4, p. 389-400 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment

Nguyen, E. V., Pereira, B. A., Lawrence, M. G., Ma, X., Rebello, R. J., Chan, H., Niranjan, B., Wu, Y., Ellem, S., Guan, X., Wu, J., Skhinas, J. N., Cox, T. R., Risbridger, G. P., Taylor, R. A., Lister, N. L. & Daly, R. J., 1 Jul 2019, In : Molecular and Cellular Proteomics. 18, 7, p. 1410-1427 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

Watt, M. J., Clark, A. K., Selth, L. A., Haynes, V. R., Lister, N., Rebello, R., Porter, L. H., Niranjan, B., Whitby, S. T., Lo, J., Huang, C., Schittenhelm, R. B., Anderson, K. E., Furic, L., Wijayaratne, P. R., Matzaris, M., Montgomery, M. K., Papargiris, M., Norden, S., Febbraio, M. & 4 othersRisbridger, G. P., Frydenberg, M., Nomura, D. K. & Taylor, R. A., 6 Feb 2019, In : Science Translational Medicine. 11, 478, 12 p., eaau5758.

Research output: Contribution to journalArticleResearchpeer-review

Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro

Pereira, B. A., Lister, N. L., Hashimoto, K., Teng, L., Flandes-Iparraguirre, M., Eder, A., Sanchez-Herrero, A., Niranjan, B., Melbourne Urological Research Alliance (MURAL), Frydenberg, M., Papargiris, M. M., Lawrence, M. G., Taylor, R. A., Hutmacher, D. W., Ellem, S. J., Risbridger, G. P. & De-Juan-Pardo, E. M., 1 Mar 2019, In : Biomaterials. 197, p. 72-85 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Lawrence, M. G., Obinata, D., Sandhu, S., Selth, L. A., Wong, S. Q., Porter, L. H., Lister, N., Pook, D., Pezaro, C. J., Goode, D. L., Rebello, R. J., Clark, A. K., Papargiris, M., Van Gramberg, J., Hanson, A. R., Banks, P., Wang, H., Niranjan, B., Keerthikumar, S., Hedwards, S. & 32 othersHuglo, A., Yang, R., Henzler, C., Li, Y., Lopez-Campos, F., Castro, E., Toivanen, R., Azad, A., Bolton, D., Goad, J., Grummet, J., Harewood, L., Kourambas, J., Lawrentschuk, N., Moon, D., Murphy, D. G., Sengupta, S., Snow, R., Thorne, H., Mitchell, C., Pedersen, J., Clouston, D., Norden, S., Ryan, A., Dehm, S. M., Tilley, W. D., Pearson, R. B., Hannan, R. D., Frydenberg, M., Furic, L., Taylor, R. A. & Risbridger, G. P., 1 Nov 2018, In : European Urology. 74, 5, p. 562-572 11 p.

Research output: Contribution to journalArticleResearchpeer-review


Australian Postgraduate Award

Natalie Lister (Recipient), 2007

Prize: Prize (including medals and awards)

Australian Stem Cell Centre PhD Scholarship

Natalie Lister (Recipient), 2007

Prize: Prize (including medals and awards)

Monash Departmental Scholarship

Natalie Lister (Recipient), 2006

Prize: Prize (including medals and awards)

Monash Graduate Scholarship

Natalie Lister (Recipient), 2005

Prize: Prize (including medals and awards)