Nadia Rosenthal

Professor

20062019
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Research Output 2007 2019

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2019

Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease

Wilmanns, J. C., Pandey, R., Hon, O., Chandran, A., Schilling, J. M., Forte, E., Wu, Q., Cagnone, G., Bais, P., Philip, V., Coleman, D., Kocalis, H., Archer, S. K., Pearson, J. T., Ramialison, M., Heineke, J., Patel, H. H., Rosenthal, N. A., Furtado, M. B. & Costa, M. W., Feb 2019, In : Molecular Metabolism. 20, p. 102-114 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function

Padrón-Barthe, L., Villalba-Orero, M., Gómez-Salinero, J. M., Acín-Pérez, R., Cogliati, S., López-Olañeta, M., Ortiz-Sánchez, P., Bonzón-Kulichenko, E., Vázquez, J., García-Pavía, P., Rosenthal, N., Enríquez, J. A. & Lara-Pezzi, E., 13 Feb 2018, In : Journal of the American College of Cardiology. 71, 6, p. 654-667 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

Skelly, D. A., Squiers, G. T., McLellan, M. A., Bolisetty, M. T., Robson, P., Rosenthal, N. A. & Pinto, A. R., 16 Jan 2018, In : Cell Reports. 22, 3, p. 600-610 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

A guardian of the heartbeat

Rosenthal, N., 6 Jul 2017, In : New England Journal of Medicine. 377, 1, p. 84-86 3 p.

Research output: Contribution to journalArticleResearchpeer-review

An atypical role for the myeloid receptor Mincle in central nervous system injury

Arumugam, T. V., Manzanero, S., Furtado, M., Biggins, P. J., Hsieh, Y. H., Gelderblom, M., MacDonald, K. P. A., Salimova, E., Li, Y. I., Korn, O., Dewar, D., Macrae, I. M., Ashman, R. B., Tang, S-C., Rosenthal, N. A., Ruitenberg, M. J., Magnus, T. & Wells, C. A., 1 Jun 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 6, p. 2098-2111 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cardiac regeneration: All work and no repair?

Kennedy-Lydon, T. M. & Rosenthal, N., 29 Mar 2017, In : Science Translational Medicine. 9, 383, 5 p., eaad9019.

Research output: Contribution to journalArticleOtherpeer-review

Congenital valvular defects associated with deleterious mutations in the PLD1 gene

Ta-Shma, A., Zhang, K., Salimova, E., Zernecke, A., Sieiro-Mosti, D., Stegner, D., Furtado, M., Shaag, A., Perles, Z., Nieswandt, B., Rein, A. J. J. T., Rosenthal, N., Neiman, A. M. & Elpeleg, O., 1 Apr 2017, In : Journal of Medical Genetics. 54, 4, p. 278-286 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cre-loxP-Mediated Recombination: General Principles and Experimental Considerations

McLellan, M. A., Rosenthal, N. A. & Pinto, A. R., 2 Mar 2017, In : Current Protocols in Mouse Biology. 7, 1, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling

Furtado, M. B., Wilmanns, J. C., Chandran, A., Perera, J., Hon, O., Biben, C., Willow, T. J., Nim, H. T., Kaur, G., Simonds, S., Wu, Q., Willians, D., Salimova, E., Plachta, N., Denegre, J. M., Murray, S. A., Fatkin, D., Cowley, M., Pearson, J. T., Kaye, D. & 4 othersRamialison, M., Harvey, R. P., Rosenthal, N. A. & Costa, M. W., 23 Mar 2017, In : JCI Insight. 2, 6, p. e88271 18 p., e88271.

Research output: Contribution to journalArticleResearch

Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease

Hasham, M. G., Baxan, N., Stuckey, D. J., Branca, J., Perkins, B., Dent, O., Duffy, T., Hameed, T. S., Stella, S. E., Bellahcene, M., Schneider, M. D., Harding, S. E., Rosenthal, N. & Sattler, S., 1 Mar 2017, In : Disease Models and Mechanisms. 10, 3, p. 259-270 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels

Furtado, M. B., Wilmanns, J., Chandran, A., Tonta, M. A., Biben, C., Eichenlaub, M. P., Coleman, H. A., Berger, S., Bouveret, R., Singh, R., Harvey, R. P., Ramialison, M. S. M., Pearson, J. T., Parkington, H. C., Rosenthal, N. A. & Da Costa, M. W., 2016, In : Differentiation. 91, 1-3, p. 29 - 41 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Genome wide conditional mouse knockout resources

Kaloff, C., Anastassiadis, K., Ayadi, A., Baldock, R., Beig, J., Birling, M. C., Bradley, A., Brown, S. D. M., Bürger, A., Bushell, W., Chiani, F., Collins, F. S., Doe, B., Eppig, J. T., Finnell, R. H., Fletcher, J. C., Flicek, P., El Fray, M., Friedel, R. H., Gambadoro, A. & 46 othersGates, H., Hansen, J., Herault, Y., Hicks, G., Hörlein, A., Hrabé de Angelis, M., Iyer, V. J., de Jong, P. J., Koscielny, G., Kühn, R., Liu, P., Lloyd, K. C. K., Lopez, R. G., Marschall, J. S., Martínez, S., McKerlie, C., Meehan, T., von Melchner, H., Moore, M., Murray, S. A., Nagy, A., Nutter, L. M. J., Pavlovic, G., Pombero, A., Prosser, H., Ramirez-Solis, R., Ringwald, M., Rosen, B., Rosenthal, N., Rossant, J., Ruiz Noppinger, P., Ryder, E., Skarnes, W. C., Schick, J., Schnütgen, F., Schofield, P. E., Seisenberger, C., Selloum, M., Smedley, D. P., Simpson, E. M., Stewart, A. F., Teboul, L., Tocchini Valentini, G. P., Valenzuela, D. M., West, A. P. & Wurst, W., 2016, In : Drug Discovery Today: Disease Models. 20, p. 3-12 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Revisiting Cardiac Cellular Composition

Pinto, A. R., Ilinykh, A., Ivey, M. J., Kuwabara, J. T., D'Antoni, M. L., Debuque, R., Chandran, A., Wang, L., Arora, K., Rosenthal, N. & Tallquist, M. D., 2016, In : Circulation Research. 118, 3, p. 400-409 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The neonate versus adult mammalian immune system in cardiac repair and regeneration

Sattler, S. & Rosenthal, N., 1 Jul 2016, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1863, 7, p. 1813-1821 9 p.

Research output: Contribution to journalArticleResearchpeer-review

View from the heart: Cardiac fibroblasts in development, scarring and regeneration

Furtado, M. B., Nim, H. T., Boyd, S. E. & Rosenthal, N. A., 1 Feb 2016, In : Development. 143, 3, p. 387-397 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Cardiac regeneration: epicardial mediated repair

Kennedy-Lydon, T. M. & Rosenthal, N. A., 2015, In : Proceedings of the Royal Society B: Biological Sciences. 282, 1821, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cardiac-restricted IGF-1Ea overexpression reduces the early accumulation of inflammatory myeloid cells and mediates expression of extracellular matrix remodelling genes after myocardial infarction

Gallego-Colon, E., Sampson, R. D., Sattler, S., Schneider, M. D., Rosenthal, N. A. & Tonkin, J., 2015, In : Mediators of Inflammation. 2015, 10 p., 484357.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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CARFMAP: a curated pathway map of cardiac fibroblasts

Nim, H. T., Furtado, M. B., Costa, M. W., Kitano, H., Rosenthal, N. A. & Boyd, S. E., 2015, In : PLoS ONE. 10, 12, 16 p., e0143274.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Monocyte/macrophage-derived IGF-1 orchestrates murine skeletal muscle regeneration and modulates autocrine polarization

Tonkin, J., Temmerman, L., Sampson, R. D., Gallego-Colon, E., Barberi, L., Bilbao, D., Schneider, M. D., Musaro, A. & Rosenthal, N. A., 2015, In : Molecular Therapy. 23, 7, p. 1189 - 1200 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Utilising the resources of the International Knockout Mouse Consortium: the Australian experience

Cotton, L. M., Meilak, M., Templeton, T., Gonzalez, J., Nenci, A., Cooney, M. A., Truman, D., Rodda, F., Lynas, A., Viney, E. M., Rosenthal, N. A., Bianco, D. M., O'Bryan, M. K. & Smyth, I. M., 2015, In : Mammalian Genome. 26, 3-4, p. 142 - 158 17 p.

Research output: Contribution to journalArticleResearchpeer-review

VISIONET: intuitive visualisation of overlapping transcription factor networks, with applications in cardiogenic gene discovery

Nim, H. T., Furtado, M. B., Da Costa, M., Rosenthal, N. A., Kitano, H. & Boyd, S. E., 2015, In : BMC Bioinformatics. 16, 1 (Art. No: 141), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

Age-related changes in tissue macrophages precede cardiac functional impairment

Pinto, R. I. A., Godwin, J. W., Chandran, A., Hersey, L. K., Ilinykh, A., Debuque, R., Wang, L. & Rosenthal, N. A., 2014, In : Aging Clinical and Experimental Research. 6, 5, p. 399 - 413 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair

Furtado, M. B., Da Costa, M., Pranoto, E. M. A., Salimova, E., Pinto, R. I. A., Lam, N. T., Park, A., Snider, P., Chandran, A., Harvey, R. P., Boyd, R. L., Conway, S., Pearson, J. T., Kaye, D. M. & Rosenthal, N. A., 2014, In : Circulation Research. 114, 9, p. 1422 - 1434 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Extracellular matrix considerations for scar-free repair and regeneration: Insights from regenerative diversity among vertebrates

Godwin, J. W., Kuraitis, D. & Rosenthal, N. A., 2014, In : International Journal of Biochemistry and Cell Biology. 56, p. 47 - 55 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice

Johannesson, B., Sattler, S., Semenova, E., Pastore, S., Kennedy-Lydon, T. M., Sampson, R. D., Schneider, M. D., Rosenthal, N. A. & Bilbao, D., 2014, In : Disease Models and Mechanisms. 7, 8, p. 977 - 985 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease

Bilbao, D., Luciani Silverman, L., Johannesson, B., Piszczek, A. & Rosenthal, N. A., 2014, In : EMBO Molecular Medicine. 6, 11, p. 1423 - 1435 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Intramyocardial cell delivery: Observations in murine hearts

Poggioli, T., Sarathchandra, P., Rosenthal, N. & Santini, M. P., 24 Jan 2014, In : Journal of Visualized Experiments. 83, e51064.

Research output: Contribution to journalArticleOtherpeer-review

Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation

Pinto, R. I. A., Godwin, J. W. & Rosenthal, N. A., 2014, In : Stem Cell Research. 13, 3 (Part B), p. 705 - 714 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Microarray profiling to analyse adult cardiac fibroblast identity

Furtado, M. B., Nim, H. T., Gould, J. A., Costa, M. W., Rosenthal, N. A. & Boyd, S. E., 2014, In : Genomics Data. 2, p. 345 - 350 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Preparing the ground for tissue regeneration: from mechanism to therapy

Forbes, S. J. & Rosenthal, N. A., 2014, In : Nature Medicine. 20, 8, p. 857 - 869 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Progressive replacement of embryo-derived cardiac macrophages with age

Molawi, K., Wolf, Y., Kandalla, P. K., Favret, J., Hagemeyer, N., Frenzel, K., Pinto, R. I. A., Klapproth, K., Henri, S., Malissen, B., Rodewald, H-R., Rosenthal, N. A., Bajenoff, M., Prinz, M., Jung, S. & Sieweke, M. H., 2014, In : Journal of Experimental Medicine. 211, 11, p. 2151 - 2158 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Scar-free wound healing and regeneration in amphibians: immunological influences on regenerative success

Godwin, J. W. & Rosenthal, N. A., 2014, In : Differentiation. 87, 1-2, p. 66 - 75 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice

Carnevali, L., Graiani, G., Rossi, S., Banchaabouchi, M. A., Macchi, E., Quaini, F., Rosenthal, N. A. & Sgoifo, A., 2014, In : PLoS ONE. 9, 4 (Art. No.: e95499), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction

Zarrinpashneh, E., Poggioli, T., Sarathchandra, P., Lexow, J., Monassier, L., Terracciano, C., Lang, F., Damilano, F., Zhou, J. Q., Rosenzweig, A., Rosenthal, N. A. & Santini, M. P., 2013, In : PLoS ONE. 8, 11, 13 p., e80268.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver

Lexow, J., Poggioli, T., Sarathchandra, P., Santini, M. P. & Rosenthal, N. A., 2013, In : Disease Models and Mechanisms. 6, 6, p. 1470 - 1476 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy

Da Costa, M., Guo, G., Wolstein, O., Vale, M., Castro, M. L., Wang, L., Otway, R., Riek, P., Cochrane, N., Furtado, M. B., Semsarian, C., Weintraub, R., Yeoh, T., Hayward, C. S., Keogh, A., Macdonald, P., Feneley, M. P., Graham, R. M., Seidman, J. G., Seidman, C. E. & 3 othersRosenthal, N. A., Fatkin, D. & Harvey, R. P., 2013, In : Circulation: Cardiovascular Genetics. 6, 3, p. 238 - 247 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Isolation and analysis of single cells from the mouse heart

Pinto, R. I. A., Chandran, A., Rosenthal, N. A. & Godwin, J. W., 2013, In : Journal of Immunological Methods. 393, 1-2, p. 74 - 80 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Macrophages are required for adult salamander limb regeneration

Godwin, J. W., Pinto, R. I. A. & Rosenthal, N. A., 2013, In : Proceedings of the National Academy of Sciences. 110, 23, p. 9415 - 9420 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile

Pinto, A. R., Paolicelli, R., Salimova, E., Gospocic, J., Slonimsky, E., Bilbao-Cortes, D., Godwin, J. W. & Rosenthal, N. A., 2012, In : PLoS ONE. 7, 5, 11 p., e36814.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Beyond knockouts: cre resources for conditional mutagenesis

Murray, S. A., Eppig, J., Smedley, D., Simpson, E. M. & Rosenthal, N. A., 2012, In : Mammalian Genome. 23, 9-10, p. 587 - 599 13 p.

Research output: Contribution to journalArticleResearchpeer-review

CreZOO--the European virtual repository of Cre and other targeted conditional driver strains

Chandras, C., Zouberakis, M., Salimova, E., Smedley, D., Rosenthal, N. A. & Aidinis, V., 2012, In : Database: the Journal of Biological Databases and Curation. 2012, bas029, p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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E-peptides control bioavailability of IGF-1

Hede, M., Salimova, E., Piszczek, A., Perlas, E., Winn, N., Nastasi, T. & Rosenthal, N. A., 2012, In : PLoS ONE. 7, 12, 11 p., e51152.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Follistatin-like 3 mediates paracrine fibroblast activation by cardiomyocytes

Panse, K. D., Felkin, L. E., Lopez-Olaneta, M. M., Gomez-Salinero, J. M., Villalba, M., Munoz, L., Nakamura, K., Shimano, M., Walsh, K., Barton, P. JR., Rosenthal, N. A. & Lara-Pezzi, E., 2012, In : Journal of Cardiovascular Translational Research. 5, 6, p. 814 - 826 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia

Prele, C., Reichelt, M., Mutsaers, S., Davies, M., Delbridge, L., Headrick, J., Rosenthal, N., Bogoyevitch, M. & Grounds, M., 2012, In : Cardiovascular Pathology. 21, 1, p. 17 - 27 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction

Tourvon, M., Escoubet, B., Mericskay, M., Angelini, A., Lamotte, L., Santini, M. P., Rosenthal, N. A., Daegelen, D., Tuil, D. & Decaux, J-F., 2012, In : Disease Models and Mechanisms. 5, 4, p. 481 - 491 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart

Vinciguerra, M., Santini, M. P., Martinez, C., Pazienza, V., Claycomb, W. C., Giuliani, A. & Rosenthal, N. A., 2012, In : Aging Cell. 11, 1, p. 139 - 149 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Myocardial regenerative properties of macrophage populations and stem cells

Santini, M. P. & Rosenthal, N. A., 2012, In : Journal of Cardiovascular Translational Research. 5, 5, p. 700 - 712 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Nerve growth factor stimulates cardiac regeneration via cardiomyocyte proliferation in experimental heart failure

Lam, N. T-W., Currie, P. D., Lieschke, G. J., Rosenthal, N. A. & Kaye, D. M., 2012, In : PLoS ONE. 7, 12 (Art. ID: e53210), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Proximal tubule overexpression of a locally acting IGF isoform, Igf-1Ea, increases inflammation after ischemic injury

Rae, F. K., Suhaimi, N., Li, J., Nastasi, T., Slonimsky, E., Rosenthal, N. & Little, M. H., Feb 2012, In : Growth Hormone and IGF Research. 22, 1, p. 6-16 11 p.

Research output: Contribution to journalArticleResearchpeer-review