20062019

Research output per year

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Research Output

2019

Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease

Wilmanns, J. C., Pandey, R., Hon, O., Chandran, A., Schilling, J. M., Forte, E., Wu, Q., Cagnone, G., Bais, P., Philip, V., Coleman, D., Kocalis, H., Archer, S. K., Pearson, J. T., Ramialison, M., Heineke, J., Patel, H. H., Rosenthal, N. A., Furtado, M. B. & Costa, M. W., Feb 2019, In : Molecular Metabolism. 20, p. 102-114 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Variable outcomes of human heart attack recapitulated in genetically diverse mice

Salimova, E., Nowak, K. J., Estrada, A. C., Furtado, M. B., McNamara, E., Nguyen, Q., Balmer, L., Preuss, C., Holmes, J. W., Ramialison, M., Morahan, G. & Rosenthal, N. A., 4 Mar 2019, In : npj Regenerative Medicine. 4, 15 p., 5.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

Activation of Serine One-Carbon Metabolism by Calcineurin Aβ1 Reduces Myocardial Hypertrophy and Improves Ventricular Function

Padrón-Barthe, L., Villalba-Orero, M., Gómez-Salinero, J. M., Acín-Pérez, R., Cogliati, S., López-Olañeta, M., Ortiz-Sánchez, P., Bonzón-Kulichenko, E., Vázquez, J., García-Pavía, P., Rosenthal, N., Enríquez, J. A. & Lara-Pezzi, E., 13 Feb 2018, In : Journal of the American College of Cardiology. 71, 6, p. 654-667 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

Skelly, D. A., Squiers, G. T., McLellan, M. A., Bolisetty, M. T., Robson, P., Rosenthal, N. A. & Pinto, A. R., 16 Jan 2018, In : Cell Reports. 22, 3, p. 600-610 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
85 Citations (Scopus)
2017

An atypical role for the myeloid receptor Mincle in central nervous system injury

Arumugam, T. V., Manzanero, S., Furtado, M., Biggins, P. J., Hsieh, Y. H., Gelderblom, M., MacDonald, K. P. A., Salimova, E., Li, Y. I., Korn, O., Dewar, D., Macrae, I. M., Ashman, R. B., Tang, S-C., Rosenthal, N. A., Ruitenberg, M. J., Magnus, T. & Wells, C. A., 1 Jun 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 6, p. 2098-2111 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
28 Citations (Scopus)

Cardiac regeneration: All work and no repair?

Kennedy-Lydon, T. M. & Rosenthal, N., 29 Mar 2017, In : Science Translational Medicine. 9, 383, 5 p., eaad9019.

Research output: Contribution to journalArticleOtherpeer-review

7 Citations (Scopus)

Chasing the recipe for a pro-regenerative immune system

Godwin, J. W., Pinto, A. R. & Rosenthal, N. A., 1 Jan 2017, In : Seminars in Cell and Developmental Biology. 61, p. 71-79 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

38 Citations (Scopus)

Congenital valvular defects associated with deleterious mutations in the PLD1 gene

Ta-Shma, A., Zhang, K., Salimova, E., Zernecke, A., Sieiro-Mosti, D., Stegner, D., Furtado, M., Shaag, A., Perles, Z., Nieswandt, B., Rein, A. J. J. T., Rosenthal, N., Neiman, A. M. & Elpeleg, O., 1 Apr 2017, In : Journal of Medical Genetics. 54, 4, p. 278-286 9 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Cre-loxP-Mediated Recombination: General Principles and Experimental Considerations

McLellan, M. A., Rosenthal, N. A. & Pinto, A. R., 2 Mar 2017, In : Current Protocols in Mouse Biology. 7, 1, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Of mice and CRISPR: The post-CRISPR future of the mouse as a model system for the human condition

Liu, E. T., Bolcun-Filas, E., Grass, D. S., Lutz, C., Murray, S., Shultz, L. & Rosenthal, N., 1 Feb 2017, In : EMBO Reports. 18, 2, p. 187-193 7 p.

Research output: Contribution to journalComment / DebateResearchpeer-review

Open Access
File
15 Citations (Scopus)

Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling

Furtado, M. B., Wilmanns, J. C., Chandran, A., Perera, J., Hon, O., Biben, C., Willow, T. J., Nim, H. T., Kaur, G., Simonds, S., Wu, Q., Willians, D., Salimova, E., Plachta, N., Denegre, J. M., Murray, S. A., Fatkin, D., Cowley, M., Pearson, J. T., Kaye, D. & 4 others, Ramialison, M., Harvey, R. P., Rosenthal, N. A. & Costa, M. W., 23 Mar 2017, In : JCI Insight. 2, 6, p. e88271 18 p., e88271.

Research output: Contribution to journalArticleResearch

5 Citations (Scopus)
2016

A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels

Furtado, M. B., Wilmanns, J., Chandran, A., Tonta, M. A., Biben, C., Eichenlaub, M. P., Coleman, H. A., Berger, S., Bouveret, R., Singh, R., Harvey, R. P., Ramialison, M. S. M., Pearson, J. T., Parkington, H. C., Rosenthal, N. A. & Da Costa, M. W., 2016, In : Differentiation. 91, 1-3, p. 29 - 41 13 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Genome wide conditional mouse knockout resources

Kaloff, C., Anastassiadis, K., Ayadi, A., Baldock, R., Beig, J., Birling, M. C., Bradley, A., Brown, S. D. M., Bürger, A., Bushell, W., Chiani, F., Collins, F. S., Doe, B., Eppig, J. T., Finnell, R. H., Fletcher, J. C., Flicek, P., El Fray, M., Friedel, R. H., Gambadoro, A. & 46 others, Gates, H., Hansen, J., Herault, Y., Hicks, G., Hörlein, A., Hrabé de Angelis, M., Iyer, V. J., de Jong, P. J., Koscielny, G., Kühn, R., Liu, P., Lloyd, K. C. K., Lopez, R. G., Marschall, J. S., Martínez, S., McKerlie, C., Meehan, T., von Melchner, H., Moore, M., Murray, S. A., Nagy, A., Nutter, L. M. J., Pavlovic, G., Pombero, A., Prosser, H., Ramirez-Solis, R., Ringwald, M., Rosen, B., Rosenthal, N., Rossant, J., Ruiz Noppinger, P., Ryder, E., Skarnes, W. C., Schick, J., Schnütgen, F., Schofield, P. E., Seisenberger, C., Selloum, M., Smedley, D. P., Simpson, E. M., Stewart, A. F., Teboul, L., Tocchini Valentini, G. P., Valenzuela, D. M., West, A. P. & Wurst, W., 2016, In : Drug Discovery Today: Disease Models. 20, p. 3-12 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Revisiting Cardiac Cellular Composition

Pinto, A. R., Ilinykh, A., Ivey, M. J., Kuwabara, J. T., D'Antoni, M. L., Debuque, R., Chandran, A., Wang, L., Arora, K., Rosenthal, N. & Tallquist, M. D., 2016, In : Circulation Research. 118, 3, p. 400-409 10 p.

Research output: Contribution to journalArticleResearchpeer-review

349 Citations (Scopus)

The cardiac fibroblast: Origin, identity and role in homeostasis and disease

Furtado, M. B., Costa, M. W. & Rosenthal, N. A., 1 Sep 2016, In : Differentiation. 92, 3, p. 93-101 9 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

15 Citations (Scopus)

View from the heart: Cardiac fibroblasts in development, scarring and regeneration

Furtado, M. B., Nim, H. T., Boyd, S. E. & Rosenthal, N. A., 1 Feb 2016, In : Development (Cambridge). 143, 3, p. 387-397 11 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)
2015

Cardiac regeneration: epicardial mediated repair

Kennedy-Lydon, T. M. & Rosenthal, N. A., 2015, In : Proceedings of the Royal Society B: Biological Sciences. 282, 1821, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
17 Citations (Scopus)

Cardiac-restricted IGF-1Ea overexpression reduces the early accumulation of inflammatory myeloid cells and mediates expression of extracellular matrix remodelling genes after myocardial infarction

Gallego-Colon, E., Sampson, R. D., Sattler, S., Schneider, M. D., Rosenthal, N. A. & Tonkin, J., 2015, In : Mediators of Inflammation. 2015, 10 p., 484357.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)

CARFMAP: a curated pathway map of cardiac fibroblasts

Nim, H. T., Furtado, M. B., Costa, M. W., Kitano, H., Rosenthal, N. A. & Boyd, S. E., 2015, In : PLoS ONE. 10, 12, 16 p., e0143274.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Monocyte/macrophage-derived IGF-1 orchestrates murine skeletal muscle regeneration and modulates autocrine polarization

Tonkin, J., Temmerman, L., Sampson, R. D., Gallego-Colon, E., Barberi, L., Bilbao, D., Schneider, M. D., Musaro, A. & Rosenthal, N. A., 2015, In : Molecular Therapy. 23, 7, p. 1189 - 1200 12 p.

Research output: Contribution to journalArticleResearchpeer-review

99 Citations (Scopus)

One small step for muscle: a new micropeptide regulates performance

Tonkin, J. & Rosenthal, N. A., 2015, In : Cell Metabolism. 21, 4, p. 515 - 516 2 p.

Research output: Contribution to journalComment / DebateResearchpeer-review

Open Access
File
8 Citations (Scopus)
5 Citations (Scopus)

Utilising the resources of the International Knockout Mouse Consortium: the Australian experience

Cotton, L. M., Meilak, M., Templeton, T., Gonzalez, J., Nenci, A., Cooney, M. A., Truman, D., Rodda, F., Lynas, A., Viney, E. M., Rosenthal, N. A., Bianco, D. M., O'Bryan, M. K. & Smyth, I. M., 2015, In : Mammalian Genome. 26, 3-4, p. 142 - 158 17 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

VISIONET: intuitive visualisation of overlapping transcription factor networks, with applications in cardiogenic gene discovery

Nim, H. T., Furtado, M. B., Da Costa, M., Rosenthal, N. A., Kitano, H. & Boyd, S. E., 2015, In : BMC Bioinformatics. 16, 1 (Art. No: 141), p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)
2014

Age-related changes in tissue macrophages precede cardiac functional impairment

Pinto, R. I. A., Godwin, J. W., Chandran, A., Hersey, L. K., Ilinykh, A., Debuque, R., Wang, L. & Rosenthal, N. A., 2014, In : Aging Clinical and Experimental Research. 6, 5, p. 399 - 413 15 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

A tribute to Sir John Gurdon

Rosenthal, N. & Zernicka-Goetz, M., 1 Jul 2014, In : Differentiation. 88, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair

Furtado, M. B., Da Costa, M., Pranoto, E. M. A., Salimova, E., Pinto, R. I. A., Lam, N. T., Park, A., Snider, P., Chandran, A., Harvey, R. P., Boyd, R. L., Conway, S., Pearson, J. T., Kaye, D. M. & Rosenthal, N. A., 2014, In : Circulation Research. 114, 9, p. 1422 - 1434 13 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

Extracellular matrix considerations for scar-free repair and regeneration: Insights from regenerative diversity among vertebrates

Godwin, J. W., Kuraitis, D. & Rosenthal, N. A., 2014, In : International Journal of Biochemistry and Cell Biology. 56, p. 47 - 55 9 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice

Johannesson, B., Sattler, S., Semenova, E., Pastore, S., Kennedy-Lydon, T. M., Sampson, R. D., Schneider, M. D., Rosenthal, N. A. & Bilbao, D., 2014, In : Disease Models and Mechanisms. 7, 8, p. 977 - 985 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease

Bilbao, D., Luciani Silverman, L., Johannesson, B., Piszczek, A. & Rosenthal, N. A., 2014, In : EMBO Molecular Medicine. 6, 11, p. 1423 - 1435 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
43 Citations (Scopus)

Intramyocardial cell delivery: Observations in murine hearts

Poggioli, T., Sarathchandra, P., Rosenthal, N. & Santini, M. P., 24 Jan 2014, In : Journal of Visualized Experiments. 83, e51064.

Research output: Contribution to journalArticleOtherpeer-review

5 Citations (Scopus)

Macrophages in cardiac homeostasis, injury responses and progenitor cell mobilisation

Pinto, R. I. A., Godwin, J. W. & Rosenthal, N. A., 2014, In : Stem Cell Research. 13, 3 (Part B), p. 705 - 714 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
43 Citations (Scopus)

Microarray profiling to analyse adult cardiac fibroblast identity

Furtado, M. B., Nim, H. T., Gould, J. A., Costa, M. W., Rosenthal, N. A. & Boyd, S. E., 2014, In : Genomics Data. 2, p. 345 - 350 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
13 Citations (Scopus)

Preparing the ground for tissue regeneration: from mechanism to therapy

Forbes, S. J. & Rosenthal, N. A., 2014, In : Nature Medicine. 20, 8, p. 857 - 869 13 p.

Research output: Contribution to journalArticleResearchpeer-review

255 Citations (Scopus)

Progressive replacement of embryo-derived cardiac macrophages with age

Molawi, K., Wolf, Y., Kandalla, P. K., Favret, J., Hagemeyer, N., Frenzel, K., Pinto, R. I. A., Klapproth, K., Henri, S., Malissen, B., Rodewald, H-R., Rosenthal, N. A., Bajenoff, M., Prinz, M., Jung, S. & Sieweke, M. H., 2014, In : Journal of Experimental Medicine. 211, 11, p. 2151 - 2158 8 p.

Research output: Contribution to journalArticleResearchpeer-review

202 Citations (Scopus)

Scar-free wound healing and regeneration in amphibians: immunological influences on regenerative success

Godwin, J. W. & Rosenthal, N. A., 2014, In : Differentiation. 87, 1-2, p. 66 - 75 10 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Signs of cardiac autonomic imbalance and proarrhythmic remodeling in FTO deficient mice

Carnevali, L., Graiani, G., Rossi, S., Banchaabouchi, M. A., Macchi, E., Quaini, F., Rosenthal, N. A. & Sgoifo, A., 2014, In : PLoS ONE. 9, 4 (Art. No.: e95499), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

The International Journal of Biochemistry & Cell Biology: Editorial

Rosenthal, N. & Grounds, M. D., 2014, In : International Journal of Biochemistry and Cell Biology. 56, p. 2-3 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

1 Citation (Scopus)
2013

Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction

Zarrinpashneh, E., Poggioli, T., Sarathchandra, P., Lexow, J., Monassier, L., Terracciano, C., Lang, F., Damilano, F., Zhou, J. Q., Rosenzweig, A., Rosenthal, N. A. & Santini, M. P., 2013, In : PLoS ONE. 8, 11, 13 p., e80268.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
18 Citations (Scopus)

A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo

Shavlakadze, T., Chai, J., Maley, K., Cozens, G., Grounds, G., Winn, N., Rosenthal, N. & Grounds, M. D., 2013, In : Journal of Cell Science. 126, 19, p. 4536 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

1 Citation (Scopus)

Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver

Lexow, J., Poggioli, T., Sarathchandra, P., Santini, M. P. & Rosenthal, N. A., 2013, In : Disease Models and Mechanisms. 6, 6, p. 1470 - 1476 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
41 Citations (Scopus)

Combinatorial therapies for cardiac regeneration

Lexow, J., Poggioli, T., Rosenthal, N. & Santini, M. P., 2013, In : Recent Patents on Regenerative Medicine. 3, 1, p. 34-46 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Functional characterization of a novel mutation in NKX2-5 associated with congenital heart disease and adult-onset cardiomyopathy

Da Costa, M., Guo, G., Wolstein, O., Vale, M., Castro, M. L., Wang, L., Otway, R., Riek, P., Cochrane, N., Furtado, M. B., Semsarian, C., Weintraub, R., Yeoh, T., Hayward, C. S., Keogh, A., Macdonald, P., Feneley, M. P., Graham, R. M., Seidman, J. G., Seidman, C. E. & 3 others, Rosenthal, N. A., Fatkin, D. & Harvey, R. P., 2013, In : Circulation: Cardiovascular Genetics. 6, 3, p. 238 - 247 10 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Isolation and analysis of single cells from the mouse heart

Pinto, R. I. A., Chandran, A., Rosenthal, N. A. & Godwin, J. W., 2013, In : Journal of Immunological Methods. 393, 1-2, p. 74 - 80 7 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Macrophages are required for adult salamander limb regeneration

Godwin, J. W., Pinto, R. I. A. & Rosenthal, N. A., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 23, p. 9415 - 9420 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
329 Citations (Scopus)

Molecular Tools in Cancer Research

Costa, M. W. & Rosenthal, N., 22 Oct 2013, Abeloff's Clinical Oncology. Niederhuber, J. E., Armitage, J. O., Tepper, J. E., Doroshow, J. H. & Kastan, M. B. (eds.). 5th ed. Philadelphia PA USA: Academic Press, p. 2-21.e1

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Stem Cells and the Regenerating Heart

Rosenthal, N. & Santini, M. P., 2013, Handbook of Stem Cells. Academic Press, Vol. 2. p. 595-601 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Stem Cells and the Regenerating Heart

Rosenthal, N. & Santini, M. P., 4 Nov 2013, Essentials of Stem Cell Biology: Third Edition. Academic Press, p. 281-289 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2012

An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile

Pinto, A. R., Paolicelli, R., Salimova, E., Gospocic, J., Slonimsky, E., Bilbao-Cortes, D., Godwin, J. W. & Rosenthal, N. A., 2012, In : PLoS ONE. 7, 5, 11 p., e36814.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
165 Citations (Scopus)

Beyond knockouts: cre resources for conditional mutagenesis

Murray, S. A., Eppig, J., Smedley, D., Simpson, E. M. & Rosenthal, N. A., 2012, In : Mammalian Genome. 23, 9-10, p. 587 - 599 13 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)