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2020

Age- and sex-specific reference ranges are needed for the aldosterone/renin ratio

Solanki, P., Gwini, S. M., Doery, J. C. G., Choy, K. W., Shen, J., Young, M. J., Fuller, P. J. & Yang, J., 1 Sep 2020, In : Clinical Endocrinology. 93, 3, p. 221-228 8 p.

Research output: Contribution to journalArticleResearchpeer-review

miR-196b-5p-enriched extracellular vesicles from tubular epithelial cells mediated aldosterone-induced renal fibrosis in mice with diabetes

Hu, R., Li, X., Peng, C., Gao, R., Ma, L., Hu, J., Luo, T., Qing, H., Wang, Y., Ge, Q., Wang, Z., Wu, C., Xiao, X., Yang, J., Young, M. J., Li, Q. & Yang, S., 1 Jul 2020, In : BMJ Open Diabetes Research & Care. 8, 1, 12 p., e001101.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Novel mineralocorticoid receptor mechanisms regulate cardiac tissue inflammation in male mice

Ong, G. S. Y., Cole, T. J., Tesch, G. H., Morgan, J., Dowling, J. K., Mansell, A., Fuller, P. J. & Young, M. J., 1 Aug 2020, In : Journal of Endocrinology. 246, 2, p. 123-134 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Utility of adrenocorticotropic hormone in adrenal vein sampling despite the occurrence of discordant lateralization

Chee, N. Y. N., Abdul-Wahab, A., Libianto, R., Gwini, S. M., Doery, J. C. G., Choy, K. W., Chong, W., Lau, K. K., Lam, Q., MacIsaac, R. J., Chiang, C., Shen, J., Young, M. J., Fuller, P. J. & Yang, J., 13 May 2020, (Accepted/In press) In : Clinical Endocrinology. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Cardiomyocyte transcription is controlled by combined mineralocorticoid receptor and circadian clock signalling

Fletcher, E., Kanki, M., Morgan, J., Ray, D. W., Delbridge, L. M., Fuller, P. J., Clyne, C. D. & Young, M. J., 1 Apr 2019, In : Journal of Endocrinology. 241, 1, p. 17-29 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist

Fuller, P. J., Yao, Y. Z., Jin, R., He, S., Martín-Fernández, B., Young, M. J. & Smith, B. J., 10 Sep 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18578-18583 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)
2018

Does modifying the timing of meal intake improve cardiovascular risk factors? Protocol of an Australian pilot intervention in night shift workers with abdominal obesity

Bonham, M. P., Leung, G. K. W., Davis, R., Sletten, T. L., Murgia, C., Young, M. J., Eikelis, N., Lambert, E. A. & Huggins, C. E., 1 Mar 2018, In : BMJ Open. 8, 3, e020396.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Timeless Is a Novel Estrogen Receptor Co-activator Involved in Multiple Signaling Pathways in MCF-7 Cells

Magne Nde, C. B., Casas Gimeno, G., Docanto, M., Knower, K. C., Young, M. J., Buehn, J., Sayed, E. & Clyne, C. D., 11 May 2018, In : Journal of Molecular Biology. 430, 10, p. 1531-1543 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2017

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor null mice: Informing cell-type-specific roles

Cole, T. J. & Young, M. J., 1 Jul 2017, In : Journal of Endocrinology. 234, 1, p. T83-T92 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice

Bienvenu, L. A., Morgan, J., Reichelt, M. E., Delbridge, L. M. D. & Young, M. J., 1 Nov 2017, In : Journal of Molecular and Cellular Cardiology. 112, p. 8-15 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice

Fletcher, E. K., Morgan, J., Kennaway, D. R., Bienvenu, L. A., Rickard, A. J., Delbridge, L. M. D., Fuller, P. J., Clyne, C. D. & Young, M. J., 1 Sep 2017, In : Endocrinology. 158, 9, p. 2906-2917 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2016

Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor

Dinh, Q. N., Young, M. J., Evans, M. A., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2016, In : Brain Research. 1637, p. 146 - 153 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Cardiac tissue injury and remodeling is dependent upon mr regulation of activation pathways in cardiac tissue macrophages

Shen, J. Z. L., Morgan, J., Tesch, G. H., Rickard, A. J., Chrissobolis, S., Drummond, G. R., Fuller, P. J. & Young, M., 1 Aug 2016, In : Endocrinology. 157, 8, p. 3213-3223 11 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Deletion of Rac1GTPase in the myeloid lineage protects against inflammation-mediated kidney injury in Mice

Nagase, M., Kurihara, H., Aiba, A., Young, M. & Sakai, T., 3 Mar 2016, In : PLoS ONE. 11, 3, p. 1-17 17 p., e150886.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)
2015

Aldosterone-mediated renal sodium transport requires intact mineralocorticoid receptor DNA binding in the mouse

Cole, T. J., Terella, L. R., Morgan, J., Alexiadis, M., Yao, Y-Z., Enriori, P., Young, M. J. & Fuller, P. J., 2015, In : Endocrinology. 156, 8, p. 2958 - 2968 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Cardiomyocyte Mineralocorticoid Receptor Activation Impairs Acute Cardiac Functional Recovery After Ischemic Insult

Bienvenue, L. A., Reichelt, M. E., Morgan, J., Fletcher, E. K., Bell, J. R., Rickard, A. J., Delbridge, L. M. & Young, M. J., 2015, In : Hypertension. 66, 5, p. 970-977 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

GEMIN4 functions as a coregulator of the mineralocorticoid receptor

Yang, J., Fuller, P. J., Morgan, J., Shibata, H., Clyne, C. & Young, M. J., 2015, In : Journal of Molecular Endocrinology. 54, 2, p. 149 - 160 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Interleukin-11 alters placentation and causes preeclampsia features in mice

Winship, A. L., Koga, K., Menkhorst, E., Van Sinderen, M., Rainczuk, K., Nagai, M., Cuman, C., Yap, J., Zhang, J-G., Simmons, D., Young, M. J. & Dimitriadis, E., 29 Dec 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. 15928-15933 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

Mineralocorticoid receptors in the heart: lessons from cell-selective transgenic animals

Young, M. J. & Rickard, A., 2015, In : Journal of Endocrinology. 224, 1, p. R1 - R13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
2014
26 Citations (Scopus)

Conditional overexpression of liver receptor homolog-1 in female mouse mammary epithelium results in altered mammary morphogenesis via the induction of TGF-beta

Lazarus, K., Brown, K. A., Young, M. J., Zhao, Z., Coulson, R., Chand, A. L. & Clyne, C., 2014, In : Endocrinology. 155, 5, p. 1606 - 1617 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Duelling receptors: estrogen receptor versus mineralocorticoid receptor in the cardiovascular system

Fuller, P. J. & Young, M. J., 2014, In : Endocrinology. 155, 11, p. 4117 - 4119 3 p.

Research output: Contribution to journalArticleOther

2 Citations (Scopus)

Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure

Rickard, A., Morgan, J., Chrissobolis, S., Miller, A. A., Sobey, C. G. & Young, M. J., 2014, In : Hypertension. 63, 5, p. 1033 - 1040 8 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Identification and characterization of a ligand-selective mineralocorticoid receptor coactivator

Rogerson, F. M., Yao, Y. Z., Young, M. & Fuller, P. J., 1 Oct 2014, In : The FASEB Journal. 28, 10, p. 4200-4210 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice

Armani, A., Cinti, F., Marzolla, V., Morgan, J., Cranston, G., Antelmi, A., Carpinelli, G., Canese, R., Pagotto, U., Quarta, C., Malorni, W., Matarrese, P., Marconi, M., Fabbri, A., Rosano, G. M., Saverio, C., Young, M. J. & Caprio, M., 2014, In : The FASEB Journal. 28, 8, p. 3745 - 3757 13 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Myeloid mineralocorticoid receptor activation contributes to progressive kidney disease

Huang, L., Nikolic-Paterson, D. J., Han, Y., Ozols, E., Ma, F., Young, M. J. & Tesch, G. H., 2014, In : Journal of the American Society of Nephrology. 25, 10, p. 2231 - 2240 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Use of phage display to identify novel mineralocorticoid receptor-interacting proteins

Yang, J., Fuller, P. J., Morgan, J., Shibata, H., McDonnell, D. P., Clyne, C. & Young, M. J., 2014, In : Molecular Endocrinology. 28, 9, p. 1571 - 1584 14 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
2013

Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: A focus on the cardiomyocyte

Bienvenu, L. A., Reichelt, M. E., Delbridge, L. M. D. & Young, M. J., Nov 2013, In : Clinical Science. 125, 9, p. 409-421 13 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Targeting the mineralocorticoid receptor in cardiovascular disease

Young, M. J., 2013, In : Expert Opinion on Therapeutic Targets. 17, 3, p. 321 - 331 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2012

Aldosterone and the mineralocorticoid receptor in the cerebral circulation and stroke

Dinh, Q. N., Arumugam, T. V., Young, M. J., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2012, In : Experimental & Translational Stroke Medicine. 4, 1 (Art. No.: 21), p. 1 - 21 21 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis

Rickard, A. J., Morgan, J., Bienvenue, L., Fletcher, E., Cranston, G., Shen, J., Reichelt, M., Delbridge, L. M. D. & Young, M. J., 2012, In : Hypertension. 60, 6, p. 1443 - 1450 8 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Corticosteroids, heart failure, and hypertension: a role for immune cells?

Shen, J. & Young, M. J., 2012, In : Endocrinology. 153, 12, p. 5692 - 5700 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis

Bienvenue, L., Morgan, J., Rickard, A. J., Tesch, G. H., Cranston, G., Fletcher, E. V., Delbridge, L. M. D. & Young, M. J., 2012, In : Endocrinology. 153, 7, p. 3416 - 3425 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Mechanisms of ligand specificity of the mineralocorticoid receptor

Fuller, P. J., Yao, Y-Z., Yang, J. & Young, M. J., 2012, In : Journal of Endocrinology. 213, 1, p. 15 - 24 10 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Mechanisms of mineralocorticoid salt-induced hypertension and cardiac fibrosis

Young, M. J. & Rickard, A., 2012, In : Molecular and Cellular Endocrinology. 350, 2, p. 248 - 255 8 p.

Research output: Contribution to journalArticleOther

45 Citations (Scopus)
2011

Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats

Lim, A., Ma, F., Nikolic-Paterson, D., Ozols, E., Young, M., Bennett, B., Friedman, G. & Tesch, G., 2011, In : American Journal of Nephrology. 34, 4, p. 337 - 346 10 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Identification of ligand-selective peptide antagonists of the mineralocorticoid receptor using phage display

Yang, J., Chang, C., Safi, R., Morgan, J., McDonnell, D., Fuller, P., Clyne, C. & Young, M., 2011, In : Molecular Endocrinology. 25, 1, p. 32 - 43 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice

Mellor, K. M., Bell, J. R., Young, M., Ritchie, R. & Delbridge, L. M. D., Jun 2011, In : Journal of Molecular and Cellular Cardiology. 50, 6, p. 1035-1043 9 p.

Research output: Contribution to journalArticleResearchpeer-review

130 Citations (Scopus)
2010

Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats

Young, M. J., Morgan, J., Brolin, K., Fuller, P. J. & Funder, J. W., Jun 2010, In : Endocrinology. 151, 6, p. 2622-2628 7 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Localization and regulation of aromatase liver receptor homologue-1 in the developing rat testis

Sierens, J., Jakody, I., Poobalan, Y., Meachem, S. J., Knower, K. C., Young, M. J., Sirianni, R., Pezzi, V. & Clyne, C., 2010, In : Molecular and Cellular Endocrinology. 323, 2, p. 307 - 313 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2009

Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure

Rickard, A., Morgan, J., Tesch, G. H., Funder, J. W., Fuller, P. J. & Young, M. J., 2009, In : Hypertension. 54, 3, p. 537 - 543 7 p.

Research output: Contribution to journalArticleResearchpeer-review

194 Citations (Scopus)

Mediators of mineralocorticoid receptor-induced profibrotic inflammatory responses in the heart

Wilson, P., Morgan, J., Funder, J. W., Fuller, P. J. & Young, M. J., May 2009, In : Clinical Science. 116, 9, p. 731-739 9 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Purification and characterization of recombinant human mineralocorticoid receptor

Clyne, C. D., Chang, C. Y., Safi, R., Fuller, P. J., McDonnell, D. P. & Young, M. J., 10 Apr 2009, In : Molecular and Cellular Endocrinology. 302, 1, p. 81-85 5 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2008

6th International Symposium on aldosterone and ENaC: From gene to disease: 3-7 October 2007, Zermatt, Switzerland

Fuller, P. J. & Young, M. J., Mar 2008, In : Expert Opinion on Therapeutic Targets. 12, 3, p. 377-382 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

A direct effect of aldosterone on endothelin-1 gene expression in vivo

Wong, S., Brennan, F. E., Young, M. J., Fuller, P. J. & Cole, T. J., 2007, In : Endocrinology. 148, 4, p. 1511 - 1517 7 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Aldosterone in Australia and Mineralocorticoids in Melbourne: More than just physiology

Fuller, P. J. & Young, M. J., Apr 2007, In : Australian Biochemist. 38, 1, p. 4 - 7 4 p.

Research output: Contribution to journalArticleOther

Does glucocorticoid receptor blockade exacerbate tissue damage after mineralocorticoid/salt administration?

Rickard, A. J., Funder, J. W., Morgan, J., Fuller, P. J. & Young, M. J., Oct 2007, In : Endocrinology. 148, 10, p. 4829-4835 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2006

Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats

Lam, E., Funder, J. W., Nikolic-Paterson, D. J., Fuller, P. J. & Young, M. J., 2006, In : Endocrinology. 147, 7, p. 3623 - 3629 7 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

The role of the glucocorticoid receptor in mineralocorticoid/salt-mediated cardiac fibrosis

Rickard, A. J., Funder, J. W., Fuller, P. J. & Young, M. J., 2006, In : Endocrinology. 147, 12, p. 5901 - 5906 6 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)