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Research Output

2020

Age- and sex-specific reference ranges are needed for the aldosterone/renin ratio

Solanki, P., Gwini, S. M., Doery, J. C. G., Choy, K. W., Shen, J., Young, M. J., Fuller, P. J. & Yang, J., 1 Sep 2020, In : Clinical Endocrinology. 93, 3, p. 221-228 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Identifying new cellular mechanisms of mineralocorticoid receptor activation in the heart

Young, M. J., Kanki, M., Fuller, P. J. & Yang, J., 1 Jul 2020, (Accepted/In press) In : Journal of Human Hypertension. 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

miR-196b-5p-enriched extracellular vesicles from tubular epithelial cells mediated aldosterone-induced renal fibrosis in mice with diabetes

Hu, R., Li, X., Peng, C., Gao, R., Ma, L., Hu, J., Luo, T., Qing, H., Wang, Y., Ge, Q., Wang, Z., Wu, C., Xiao, X., Yang, J., Young, M. J., Li, Q. & Yang, S., 1 Jul 2020, In : BMJ Open Diabetes Research & Care. 8, 1, 12 p., e001101.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Novel mineralocorticoid receptor mechanisms regulate cardiac tissue inflammation in male mice

Ong, G. S. Y., Cole, T. J., Tesch, G. H., Morgan, J., Dowling, J. K., Mansell, A., Fuller, P. J. & Young, M. J., 1 Aug 2020, In : Journal of Endocrinology. 246, 2, p. 123-134 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Primary aldosteronism is a public health issue: challenges and opportunities

Libianto, R., Fuller, P. J., Young, M. J. & Yang, J., 1 Jul 2020, In : Journal of Human Hypertension. 34, 7, p. 478–486 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Structural determinants of activation of the mineralocorticoid receptor: an evolutionary perspective

Fuller, P. J., Yao, Y. Z., Yang, J. & Young, M. J., 28 May 2020, (Accepted/In press) In : Journal of Human Hypertension. 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

1 Citation (Scopus)

Utility of adrenocorticotropic hormone in adrenal vein sampling despite the occurrence of discordant lateralization

Chee, N. Y. N., Abdul-Wahab, A., Libianto, R., Gwini, S. M., Doery, J. C. G., Choy, K. W., Chong, W., Lau, K. K., Lam, Q., MacIsaac, R. J., Chiang, C., Shen, J., Young, M. J., Fuller, P. J. & Yang, J., 13 May 2020, (Accepted/In press) In : Clinical Endocrinology. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Aldosterone, the Mineralocorticoid Receptor and Mechanisms of Cardiovascular Disease

Young, M. J. & Adler, G. K., 1 Jan 2019, Vitamins and Hormones. Litwack, G. (ed.). Academic Press, p. 361-385 25 p. (Vitamins and Hormones; vol. 109).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Cardiomyocyte transcription is controlled by combined mineralocorticoid receptor and circadian clock signalling

Fletcher, E., Kanki, M., Morgan, J., Ray, D. W., Delbridge, L. M., Fuller, P. J., Clyne, C. D. & Young, M. J., 1 Apr 2019, In : Journal of Endocrinology. 241, 1, p. 17-29 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Mechanisms of Mineralocorticoid Receptor Signaling

Fuller, P. J., Yang, J. & Young, M. J., 1 Jan 2019, Vitamins and Hormones. Litwack, G. (ed.). Academic Press, p. 37-68 32 p. (Vitamins and Hormones; vol. 109).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

3 Citations (Scopus)

Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist

Fuller, P. J., Yao, Y. Z., Jin, R., He, S., Martín-Fernández, B., Young, M. J. & Smith, B. J., 10 Sep 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18578-18583 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)
2018

Aldosterone; action and function

Fuller, P. J. & Young, M. J., 2018, Reference Module in Biomedical Sciences: Encyclopedia of Endocrine Diseases. 2nd ed. Elsevier, Vol. 3. p. 540-545 6 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Does modifying the timing of meal intake improve cardiovascular risk factors? Protocol of an Australian pilot intervention in night shift workers with abdominal obesity

Bonham, M. P., Leung, G. K. W., Davis, R., Sletten, T. L., Murgia, C., Young, M. J., Eikelis, N., Lambert, E. A. & Huggins, C. E., 1 Mar 2018, In : BMJ Open. 8, 3, e020396.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Timeless Is a Novel Estrogen Receptor Co-activator Involved in Multiple Signaling Pathways in MCF-7 Cells

Magne Nde, C. B., Casas Gimeno, G., Docanto, M., Knower, K. C., Young, M. J., Buehn, J., Sayed, E. & Clyne, C. D., 11 May 2018, In : Journal of Molecular Biology. 430, 10, p. 1531-1543 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2017

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor null mice: Informing cell-type-specific roles

Cole, T. J. & Young, M. J., 1 Jul 2017, In : Journal of Endocrinology. 234, 1, p. T83-T92 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)

Chronic in vivo nitric oxide deficiency impairs cardiac functional recovery after ischemia in female (but not male) mice

Bienvenu, L. A., Morgan, J., Reichelt, M. E., Delbridge, L. M. D. & Young, M. J., 1 Nov 2017, In : Journal of Molecular and Cellular Cardiology. 112, p. 8-15 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Coregulators as mediators of mineralocorticoid receptor signalling diversity

Fuller, P. J., Yang, J. & Young, M. J., 1 Jul 2017, In : Journal of Endocrinology. 234, 1, p. T23-T34 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

21 Citations (Scopus)

Deoxycorticosterone/Salt-Mediated Cardiac Inflammation and Fibrosis Are Dependent on Functional CLOCK Signaling in Male Mice

Fletcher, E. K., Morgan, J., Kennaway, D. R., Bienvenu, L. A., Rickard, A. J., Delbridge, L. M. D., Fuller, P. J., Clyne, C. D. & Young, M. J., 1 Sep 2017, In : Endocrinology. 158, 9, p. 2906-2917 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Mineralocorticoid receptor signaling as a therapeutic target for renal and cardiac fibrosis

Tesch, G. H. & Young, M. J., 29 May 2017, In : Frontiers in Pharmacology. 8, MAY, 9 p., 313.

Research output: Contribution to journalShort SurveyOtherpeer-review

Open Access
26 Citations (Scopus)

Mineralocorticoid regulation of cell function: The role of rapid signalling and gene transcription pathways

Ong, G. S. Y. & Young, M. J., 1 Jan 2017, In : Journal of Molecular Endocrinology. 58, 1, p. R33-R57 25 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

21 Citations (Scopus)
2016

3C. 3-Ketosteroid receptors: Mineralocorticoid receptor

Fuller, P. J. & Young, M. J., 2016, IUPHAR/BPS Guide to PHARMACOLOGY.

Research output: Other contributionOther

Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor

Dinh, Q. N., Young, M. J., Evans, M. A., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2016, In : Brain Research. 1637, p. 146 - 153 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Aldosterone secretion and action

Fuller, P. J. & Young, M. J., 2016, Endocrinology: Adult and Pediatric. Jameson, J. L., De Groot, L. J., de Kretser, D. M., Giudice, L. C., Grossman, A. B., Melmed, S., Potts Jr, J. T. & Weir, G. C. (eds.). 7th ed. Philadelphia PA USA: Elsevier, Vol. 2. p. 1756-1762 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Cardiac tissue injury and remodeling is dependent upon mr regulation of activation pathways in cardiac tissue macrophages

Shen, J. Z. L., Morgan, J., Tesch, G. H., Rickard, A. J., Chrissobolis, S., Drummond, G. R., Fuller, P. J. & Young, M., 1 Aug 2016, In : Endocrinology. 157, 8, p. 3213-3223 11 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Deletion of Rac1GTPase in the myeloid lineage protects against inflammation-mediated kidney injury in Mice

Nagase, M., Kurihara, H., Aiba, A., Young, M. & Sakai, T., 3 Mar 2016, In : PLoS ONE. 11, 3, p. 1-17 17 p., e150886.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

Endocrine affairs of the heart

Fuller, P. J. & Young, M. J., 1 Jul 2016, In : Endocrinology. 157, 7, p. 2578-2582 5 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

3 Citations (Scopus)

Mineralocorticoid receptor antagonists - pharmacodynamics and pharmacokinetic differences

Yang, J. & Young, M. J., 1 Apr 2016, In : Current Opinion in Pharmacology. 27, p. 78-85 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)
2015

Aldosterone-mediated renal sodium transport requires intact mineralocorticoid receptor DNA binding in the mouse

Cole, T. J., Terella, L. R., Morgan, J., Alexiadis, M., Yao, Y-Z., Enriori, P., Young, M. J. & Fuller, P. J., 2015, In : Endocrinology. 156, 8, p. 2958 - 2968 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Cardiomyocyte Mineralocorticoid Receptor Activation Impairs Acute Cardiac Functional Recovery After Ischemic Insult

Bienvenue, L. A., Reichelt, M. E., Morgan, J., Fletcher, E. K., Bell, J. R., Rickard, A. J., Delbridge, L. M. & Young, M. J., 2015, In : Hypertension. 66, 5, p. 970-977 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Corticosterpoid receptors

Fuller, P. J., Yang, J. & Young, M. J., 2015, Nuclear Receptors : From Structure to the Clinic. McEwan, I. J. & Kumar, R. (eds.). 1st ed. Cham Switzerland: Springer, p. 17-39 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

GEMIN4 functions as a coregulator of the mineralocorticoid receptor

Yang, J., Fuller, P. J., Morgan, J., Shibata, H., Clyne, C. & Young, M. J., 2015, In : Journal of Molecular Endocrinology. 54, 2, p. 149 - 160 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Interleukin-11 alters placentation and causes preeclampsia features in mice

Winship, A. L., Koga, K., Menkhorst, E., Van Sinderen, M., Rainczuk, K., Nagai, M., Cuman, C., Yap, J., Zhang, J-G., Simmons, D., Young, M. J. & Dimitriadis, E., 29 Dec 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. 15928-15933 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

Mineralocorticoid receptors in the heart: lessons from cell-selective transgenic animals

Young, M. J. & Rickard, A., 2015, In : Journal of Endocrinology. 224, 1, p. R1 - R13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
2014
26 Citations (Scopus)

Conditional overexpression of liver receptor homolog-1 in female mouse mammary epithelium results in altered mammary morphogenesis via the induction of TGF-beta

Lazarus, K., Brown, K. A., Young, M. J., Zhao, Z., Coulson, R., Chand, A. L. & Clyne, C., 2014, In : Endocrinology. 155, 5, p. 1606 - 1617 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Duelling receptors: estrogen receptor versus mineralocorticoid receptor in the cardiovascular system

Fuller, P. J. & Young, M. J., 2014, In : Endocrinology. 155, 11, p. 4117 - 4119 3 p.

Research output: Contribution to journalArticleOther

2 Citations (Scopus)

Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure

Rickard, A., Morgan, J., Chrissobolis, S., Miller, A. A., Sobey, C. G. & Young, M. J., 2014, In : Hypertension. 63, 5, p. 1033 - 1040 8 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Identification and characterization of a ligand-selective mineralocorticoid receptor coactivator

Rogerson, F. M., Yao, Y. Z., Young, M. & Fuller, P. J., 1 Oct 2014, In : The FASEB Journal. 28, 10, p. 4200-4210 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Mineralocorticoid receptor antagonism induces browning of white adipose tissue through impairment of autophagy and prevents adipocyte dysfunction in high-fat-diet-fed mice

Armani, A., Cinti, F., Marzolla, V., Morgan, J., Cranston, G., Antelmi, A., Carpinelli, G., Canese, R., Pagotto, U., Quarta, C., Malorni, W., Matarrese, P., Marconi, M., Fabbri, A., Rosano, G. M., Saverio, C., Young, M. J. & Caprio, M., 2014, In : The FASEB Journal. 28, 8, p. 3745 - 3757 13 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Myeloid mineralocorticoid receptor activation contributes to progressive kidney disease

Huang, L., Nikolic-Paterson, D. J., Han, Y., Ozols, E., Ma, F., Young, M. J. & Tesch, G. H., 2014, In : Journal of the American Society of Nephrology. 25, 10, p. 2231 - 2240 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Use of phage display to identify novel mineralocorticoid receptor-interacting proteins

Yang, J., Fuller, P. J., Morgan, J., Shibata, H., McDonnell, D. P., Clyne, C. & Young, M. J., 2014, In : Molecular Endocrinology. 28, 9, p. 1571 - 1584 14 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)
2013

Frontiers in research review: aldosterone and salt: heart and kidney-introduction

Young, M. J., Fuller, P. J., Stowasser, M. & Mihailidou, A. S., 2013, In : Clinical and Experimental Pharmacology and Physiology. 40, 12, p. 872 - 875 4 p.

Research output: Contribution to journalLetterOther

1 Citation (Scopus)

Mineralocorticoid receptors and the heart, multiple cell types and multiple mechanisms: A focus on the cardiomyocyte

Bienvenu, L. A., Reichelt, M. E., Delbridge, L. M. D. & Young, M. J., Nov 2013, In : Clinical Science. 125, 9, p. 409-421 13 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Targeting the mineralocorticoid receptor in cardiovascular disease

Young, M. J., 2013, In : Expert Opinion on Therapeutic Targets. 17, 3, p. 321 - 331 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2012

Aldosterone and the mineralocorticoid receptor in the cerebral circulation and stroke

Dinh, Q. N., Arumugam, T. V., Young, M. J., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2012, In : Experimental & Translational Stroke Medicine. 4, 1 (Art. No.: 21), p. 1 - 21 21 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis

Rickard, A. J., Morgan, J., Bienvenue, L., Fletcher, E., Cranston, G., Shen, J., Reichelt, M., Delbridge, L. M. D. & Young, M. J., 2012, In : Hypertension. 60, 6, p. 1443 - 1450 8 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Corticosteroids, heart failure, and hypertension: a role for immune cells?

Shen, J. & Young, M. J., 2012, In : Endocrinology. 153, 12, p. 5692 - 5700 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis

Bienvenue, L., Morgan, J., Rickard, A. J., Tesch, G. H., Cranston, G., Fletcher, E. V., Delbridge, L. M. D. & Young, M. J., 2012, In : Endocrinology. 153, 7, p. 3416 - 3425 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Mechanisms of ligand specificity of the mineralocorticoid receptor

Fuller, P. J., Yao, Y-Z., Yang, J. & Young, M. J., 2012, In : Journal of Endocrinology. 213, 1, p. 15 - 24 10 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)