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Personal profile

Biography

Research Group Head, Cardiovascular Endocrinology
Centre for Endocrinology and Metabolism

A leading authority on the role of hormones, such as MR signalling mechanisms, in cardiovascular disease, Dr Young completed a CJ Martin Postdoctoral Fellowship at the Baker Institute of Medical Research and the University of Texas Southwestern Medical Centre, USA. Her studies performed in the late Keith Parker laboratory on SF-1 null mice enabled animals unable to produce steroid hormones to survive which opened up studies in adults on the role of the orphan nuclear receptor SF-1. These studies identified an important novel role for SF-1 in the brain and in the control of leptin signalling. Dr Young continued working with transgenic mouse models and steroid hormone signalling upon her return to Dr Tim Cole’s laboratory at the Baker Institute and also returned to her doctoral work on cardiac remodelling with Professor John Funder.

Dr Young joined PHI in 2002 as a Senior Research Officer and established the Cardiovascular Endocrinology Laboratory in 2005. Dr Young’s research has discovered that mineralocorticoid receptor (MR) activation in the heart drives cardiac fibrosis and inflammation, which leads to heart failure. Her work has been validated by several large clinical trials but the use of MR antagonists is limited by significant renal side effects (hyperkalaemia). She received the Best Basic Research Paper published in Hypertension in 2009 from the American Heart Association for her work on the role MR in macrophages and regulation of cardiac remodelling and blood pressure control. Dr Young’s work has been funded by 6 NHMRC project grants (4 as CIA) as well as by industry, the National Heart Foundation and philanthropic organisations.

Dr Young’s research team comprises 3 PhD students, 2 post doctoral fellows and a senior research assistant. This team includes 2 Endocrine Fellows (FRACP). Several high profile awards have been received by students while training with Dr Young including an NHMRC/INSERM training fellowship, a commendation for the ASMR Victorian Premier’s Award, the Novartis New investigator Award (ESA) and an RACP Post Doctoral Fellowship.

Dr Young serves as a Senior Editor for The Journal of Endocrinology and the Journal of Molecular Endocrinology and the Journal of Steroid Biochemistry and Molecular Biology, and also held editorial roles for Endocrinology and Journal of Steroid Biochemistry and Molecular Biology and is an appointed member of the Faculty of 1000, Physiology.

Research area keywords

  • aldosterone
  • mineralocorticoid receptor
  • cortisol
  • cardiac fibrosis
  • macrophages
  • hypertension

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Projects

Research Output

Aldosterone, the Mineralocorticoid Receptor and Mechanisms of Cardiovascular Disease

Young, M. J. & Adler, G. K., 1 Jan 2019, Vitamins and Hormones. Litwack, G. (ed.). Academic Press, p. 361-385 25 p. (Vitamins and Hormones; vol. 109).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Cardiomyocyte transcription is controlled by combined mineralocorticoid receptor and circadian clock signalling

Fletcher, E., Kanki, M., Morgan, J., Ray, D. W., Delbridge, L. M., Fuller, P. J., Clyne, C. D. & Young, M. J., 1 Apr 2019, In : Journal of Endocrinology. 241, 1, p. 17-29 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Mechanisms of Mineralocorticoid Receptor Signaling

Fuller, P. J., Yang, J. & Young, M. J., 1 Jan 2019, Vitamins and Hormones. Litwack, G. (ed.). Academic Press, p. 37-68 32 p. (Vitamins and Hormones; vol. 109).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Molecular evolution of the switch for progesterone and spironolactone from mineralocorticoid receptor agonist to antagonist

Fuller, P. J., Yao, Y. Z., Jin, R., He, S., Martín-Fernández, B., Young, M. J. & Smith, B. J., 10 Sep 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 37, p. 18578-18583 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)