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Personal profile


Professor Moira O'Bryan is Head of the School of Biological Sciences in the Faculty of Science, and leads the Male Infertility and Germ Cell Biology Laboratory. This group studies sperm development and function and the causes of human male infertility.

Moira graduated from The University of Melbourne in 1994, after which she was awarded an Andrew Mellon Foundation Fellowship to work at arguably the leading academic institute in the world for contraceptive development, The Population Council in New York. She was awarded both an Australian Research Council (ARC) post-doctoral Fellowship and a National Health and Medical Research Council (NHMRC) Peter Doherty Fellowship and returned to Australia in 1996 to work at Monash Institute of Medical Research (nee Monash Institute of Reproduction and Development) at Monash University, where she established a highly productive lab working on sperm development and the genetics of male infertility. Moira was awarded a NHMRC R.D. Wright Fellowship in 2001, a Monash University Senior post-doctoral Fellowship from the Faculty of Medicine in 2005 and NHMRC Senior Research Fellowships in 2006 and 2009. In 2009 Moira and her lab moved to the Department of Anatomy and Developmental Biology where she was Deputy Head of Department. In 2015 Moira was appointed Monash Biomedicine Discovery Institute Lead for Development & Stem Cells, and in 2016 she also took on the role of Deputy Director of this Institute. In 2017 she accepted the position of Head of the School of Biological Sciences.

Moira has received research based awards from the Australian Academy of Science, The Fertility Society of Australia, The Endocrine Society of Australia, and the Society for Reproductive Biology from whom she received the 2006 Research Centre for Reproductive Health Award for Excellence in Reproductive Biology. In 2008 she was named by the American Society of Andrology as 'The Young Andrologist of the Year', in 2010 she received the Dean's Award for Research Excellence from Monash University, and in 2017 she received the Vice Chancellor's Diversity and Inclusion Award. Moira is currently a member of the ARC College of Experts.

In addition to a strong commitment to research excellence, Moira has achieved a substantial track record for the promotion of science through her position as a past national director of The Australian Society for Medical Research, and as a member of the Australian Academy of Science National Committee for Cell and Developmental Biology. She has also made significant contributions to the infrastructure of Australian medical research through the establishment of The Australian Phenome Bank and the Australian Centre for Vertebrate Mutation Detection, the Monash Male Infertility Repository and the Australian Phenomics Network.

Focus of the Male Infertility and Germ Cell Biology Laboratory include: cilia/flagellar development and function, genetic causes of human infertility, DNA repair mechanisms, sperm head shaping and the transcriptional and translational control of germ cell expressed genes.


  • sperm development
  • sperm function
  • male infertility

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Projects 2000 2022

Mechanisms of manchette function.

O'Bryan, M. K.


Project: Research

Health and fertility of young men conceived using intra-cytoplasmic sperm injection

McLachlan, R. I., Halliday, J., Amor, D. J., Lane, M., McBain, J., O'Bryan, M. K., Rombauts, L. & Saffery, R.

Monash IVF Group Limited


Project: Research

IRTG: International Research Training Grant (IRTG)_Renewal of Molecular pathogenesis of male reproductive disorders project

Meinhardt, A., Loveland, K. A. L., Bhushan, S., Ellem, S. J., Hedger, M. P., O'Bryan, M. K., O'Donnell, L., Stanton, P., Risbridger, G. P., Baker, M. A., Hobbs, R. M., Loveland, B., Exintaris, B., Western, P. S., McLachlan, R. I., Whittaker, M. R., Wagenlehner, F. M. E., Bergmann, M., Diemer, T., Fietz, D., Fijak, M., Konrad, L., Linn, T., Middendorff, R., Pilatz, A., Schagdarsurengin, U., Schuppe, H. C., Steger, K. & Scheiner-Bobis, G.


Project: Research

Research Output 1997 2018

Cep55 overexpression causes male-specific sterility in mice by suppressing Foxo1 nuclear retention through sustained activation of P13K/Akt signaling

Sinha, D., Kalimutho, M., Bowles, J., Chan, A-L., Merriner, D. J., Bain, A. L., Simmons, J. L., Freire, R., Lopez, J. A., Hobbs, R. M., O'Bryan, M. K. & Khanna, K. K. 17 Apr 2018 (Accepted/In press) In : FASEB Journal. 16 p.

Research output: Contribution to journalArticleResearchpeer-review

The antidepressant fluoxetine alters mechanisms of pre- and post-copulatory sexual selection in the eastern mosquitofish (Gambusia holbrooki)

Bertram, M. G., Ecker, T. E., Wong, B. B. M., O'Bryan, M. K., Baumgartner, J. B., Martin, J. M. & Saaristo, M. 1 Jul 2018 In : Environmental Pollution. 238, p. 238-247 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A mutation in the viral sensor 2’-5’-oligoadenylate synthetase 2 causes failure of lactation

Oakes, S. R. , Gallego-Ortega, D. , Stanford, P. M. , Junankar, S. , Au, W. W. Y. , Kikhtyak, Z. , von Korff, A. , Sergio, C. M. , Law, A. M. K. , Castillo, L. E. , Allerdice, S. L. , Young, A. I. J. , Piggin, C. , Whittle, B. , Bertram, E. , Naylor, M. J. , Roden, D. L. , Donovan, J. , Korennykh, A. , Goodnow, C. C. & 2 others O’Bryan, M. K. & Ormandy, C. J. 1 Nov 2017 In : PLoS Genetics. 13, 11, 24 p., e1007072

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Expression of ciliated bronchial epithelium 1 during human spermatogenesis

Pleuger, C., Fietz, D., Hartmann, K., Schuppe, H. C., Weidner, W., Kliesch, S., Baker, M., O'Bryan, M. K. & Bergmann, M. 1 Jul 2017 In : Fertility and Sterility. 108, 1, p. 47-54 8 p.

Research output: Contribution to journalArticleResearchpeer-review