If you made any changes in Pure these will be visible here soon.

Personal profile


Professor Moira O'Bryan is Head of the School of Biological Sciences in the Faculty of Science, and leads the Male Infertility and Germ Cell Biology Laboratory. This group studies sperm development and function and the causes of human male infertility.

Moira graduated from The University of Melbourne in 1994, after which she was awarded an Andrew Mellon Foundation Fellowship to work at arguably the leading academic institute in the world for contraceptive development, The Population Council in New York. She was awarded both an Australian Research Council (ARC) post-doctoral Fellowship and a National Health and Medical Research Council (NHMRC) Peter Doherty Fellowship and returned to Australia in 1996 to work at Monash Institute of Medical Research (nee Monash Institute of Reproduction and Development) at Monash University, where she established a highly productive lab working on sperm development and the genetics of male infertility. Moira was awarded a NHMRC R.D. Wright Fellowship in 2001, a Monash University Senior post-doctoral Fellowship from the Faculty of Medicine in 2005 and NHMRC Senior Research Fellowships in 2006 and 2009. In 2009 Moira and her lab moved to the Department of Anatomy and Developmental Biology where she was Deputy Head of Department. In 2015 Moira was appointed Monash Biomedicine Discovery Institute Lead for Development & Stem Cells, and in 2016 she also took on the role of Deputy Director of this Institute. In 2017 she accepted the position of Head of the School of Biological Sciences.

Moira has received research based awards from the Australian Academy of Science, The Fertility Society of Australia, The Endocrine Society of Australia, and the Society for Reproductive Biology from whom she received the 2006 Research Centre for Reproductive Health Award for Excellence in Reproductive Biology. In 2008 she was named by the American Society of Andrology as 'The Young Andrologist of the Year', in 2010 she received the Dean's Award for Research Excellence from Monash University, and in 2017 she received the Vice Chancellor's Diversity and Inclusion Award. Moira is currently a member of the ARC College of Experts.

In addition to a strong commitment to research excellence, Moira has achieved a substantial track record for the promotion of science through her position as a past national director of The Australian Society for Medical Research, and as a member of the Australian Academy of Science National Committee for Cell and Developmental Biology. She has also made significant contributions to the infrastructure of Australian medical research through the establishment of The Australian Phenome Bank and the Australian Centre for Vertebrate Mutation Detection, the Monash Male Infertility Repository and the Australian Phenomics Network.

Focus of the Male Infertility and Germ Cell Biology Laboratory include: cilia/flagellar development and function, genetic causes of human infertility, DNA repair mechanisms, sperm head shaping and the transcriptional and translational control of germ cell expressed genes.

Research area keywords

  • sperm development
  • sperm function
  • male infertility

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2000 2023

Research Output 1989 2020

Expression and purification of recombinant mouse CRISP4 using a baculovirus system

Gaikwad, A. S., Lee Loh, K., O'Connor, A. E., Reid, H. H. & O'Bryan, M. K., 1 Mar 2020, In : Protein Expression and Purification. 167, 6 p., 105543.

Research output: Contribution to journalArticleResearchpeer-review

An optimised STAPUT method for the purification of mouse spermatocyte and spermatid populations

Dunleavy, J. E. M., O'Connor, A. E. & O'Bryan, M. K., 30 Nov 2019, In : Molecular Human Reproduction. 25, 11, p. 675-683 9 p.

Research output: Contribution to journalArticleResearchpeer-review

CBE1 Is a Manchette- and Mitochondria-Associated Protein With a Potential Role in Somatic Cell Proliferation

Pleuger, C., Lehti, M. S., Cooper, M., O'Connor, A. E., Merriner, D. J., Smyth, I. M., Cottle, D. L., Fietz, D., Bergmann, M. & O'Bryan, M. K., 1 Nov 2019, In : Endocrinology. 160, 11, p. 2573-2586 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Context-specific behavioural changes induced by exposure to an androgenic endocrine disruptor

Bertram, M. G., Martin, J. M., Saaristo, M., Ecker, T. E., Michelangeli, M., Deal, N. D. S., Lim, S. L., O'Bryan, M. K. & Wong, B. B. M., 10 May 2019, In : Science of the Total Environment. 664, p. 177-187 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility

Lim, S., Kierzek, M., O'Connor, A. E., Brenker, C., Merriner, D. J., Okuda, H., Volpert, M., Gaikwad, A., Bianco, D., Potter, D., Prabhakar, R., Strünker, T. & O'Bryan, M. K., 1 Apr 2019, In : Endocrinology. 160, 4, p. 915-924 10 p.

Research output: Contribution to journalArticleResearchpeer-review