20052020

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Article
2020

Alterations in the methylome of the stromal tumour microenvironment signal the presence and severity of prostate cancer

Lawrence, M. G., Pidsley, R., Niranjan, B., Papargiris, M., Pereira, B. A., Richards, M., Teng, L., Norden, S., Ryan, A., Frydenberg, M., Stirzaker, C., Taylor, R. A., Risbridger, G. P. & Clark, S. J., 18 Mar 2020, In : Clinical Epigenetics. 12, 1, 18 p., 48.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Comprehensive evaluation of targeted multiplex bisulphite PCR sequencing for validation of DNA methylation biomarker panels

Lam, D., Luu, P. L., Song, J. Z., Qu, W., Risbridger, G. P., Lawrence, M. G., Lu, J., Trau, M., Korbie, D., Clark, S. J., Pidsley, R. & Stirzaker, C., 22 Jun 2020, In : Clinical Epigenetics. 12, 1, 16 p., 90.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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2019

Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target

Lee, R. S., Zhang, L., Berger, A., Lawrence, M. G., Song, J., Niranjan, B., Davies, R. G., Lister, N. L., Sandhu, S. K., Rubin, M. A., Risbridger, G. P., Taylor, R. A., Rickman, D. S., Horvath, L. G. & Daly, R. J., 1 Apr 2019, In : Neoplasia. 21, 4, p. 389-400 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Establishing a cryopreservation protocol for patient-derived xenografts of prostate cancer

Porter, L. H., Lawrence, M. G., Wang, H., Clark, A. K., Bakshi, A., Obinata, D., Goode, D., Papargiris, M., Clouston, D., Ryan, A., Norden, S., Corey, E., Nelson, P. S., Isaacs, J. T., Grummet, J., Kourambas, J., Sandhu, S., Murphy, D. G., Pook, D., Frydenberg, M. & 2 others, Taylor, R. A. & Risbridger, G. P., 1 Aug 2019, In : Prostate. 79, 11, p. 1326-1337 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Proteomic profiling of human prostate cancer-associated fibroblasts (CAF) reveals LOXL2-dependent regulation of the tumor microenvironment

Nguyen, E. V., Pereira, B. A., Lawrence, M. G., Ma, X., Rebello, R. J., Chan, H., Niranjan, B., Wu, Y., Ellem, S., Guan, X., Wu, J., Skhinas, J. N., Cox, T. R., Risbridger, G. P., Taylor, R. A., Lister, N. L. & Daly, R. J., 1 Jul 2019, In : Molecular & Cellular Proteomics. 18, 7, p. 1410-1427 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Tissue engineered human prostate microtissues reveal key role of mast cell-derived tryptase in potentiating cancer-associated fibroblast (CAF)-induced morphometric transition in vitro

Pereira, B. A., Lister, N. L., Hashimoto, K., Teng, L., Flandes-Iparraguirre, M., Eder, A., Sanchez-Herrero, A., Niranjan, B., Melbourne Urological Research Alliance (MURAL), Frydenberg, M., Papargiris, M. M., Lawrence, M. G., Taylor, R. A., Hutmacher, D. W., Ellem, S. J., Risbridger, G. P. & De-Juan-Pardo, E. M., 1 Mar 2019, In : Biomaterials. 197, p. 72-85 14 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression

Lorent, J., Kusnadi, E. P., van Hoef, V., Rebello, R. J., Leibovitch, M., Ristau, J., Chen, S., Lawrence, M. G., Szkop, K. J., Samreen, B., Balanathan, P., Rapino, F., Close, P., Bukczynska, P., Scharmann, K., Takizawa, I., Risbridger, G. P., Selth, L. A., Leidel, S. A., Lin, Q. & 3 others, Topisirovic, I., Larsson, O. & Furic, L., 2 Dec 2019, In : The EMBO Journal. 38, 23, 19 p., e101323.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2018

Enduring epigenetic landmarks define the cancer microenvironment

Pidsley, R., Lawrence, M. G., Zotenko, E., Niranjan, B., Statham, A., Song, J., Chabanon, R. M., Qu, W., Wang, H., Richards, M., Nair, S. S., Armstrong, N., Nim, H. T., Papargiris, M., Balanathan, P., French, H., Peters, T., Norden, S., Ryan, A., Pedersen, J. & 9 others, Kench, J. G., Daly, R. J., Horvath, L., Stricker, P., Frydenberg, M., Taylor, R. A., Stirzaker, C., Risbridger, G. P. & Clark, S. J., 1 May 2018, In : Genome Research. 28, 5, p. 625-638 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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24 Citations (Scopus)

Intraductal carcinoma of the prostate can evade androgen deprivation, with emergence of castrate-tolerant cells

Porter, L. H., Hashimoto, K., Lawrence, M. G., Pezaro, C., Clouston, D., Wang, H., Papargiris, M., Thorne, H., Li, J., Investigators, K., Ryan, A., Norden, S., Moon, D., Bolton, D. M., Sengupta, S., Frydenberg, M., Murphy, D. G., Risbridger, G. P. & Taylor, R. A., 1 Jun 2018, In : BJU International. 121, 6, p. 971-978 8 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy

Lawrence, M. G., Obinata, D., Sandhu, S., Selth, L. A., Wong, S. Q., Porter, L. H., Lister, N., Pook, D., Pezaro, C. J., Goode, D. L., Rebello, R. J., Clark, A. K., Papargiris, M., Van Gramberg, J., Hanson, A. R., Banks, P., Wang, H., Niranjan, B., Keerthikumar, S., Hedwards, S. & 32 others, Huglo, A., Yang, R., Henzler, C., Li, Y., Lopez-Campos, F., Castro, E., Toivanen, R., Azad, A., Bolton, D., Goad, J., Grummet, J., Harewood, L., Kourambas, J., Lawrentschuk, N., Moon, D., Murphy, D. G., Sengupta, S., Snow, R., Thorne, H., Mitchell, C., Pedersen, J., Clouston, D., Norden, S., Ryan, A., Dehm, S. M., Tilley, W. D., Pearson, R. B., Hannan, R. D., Frydenberg, M., Furic, L., Taylor, R. A. & Risbridger, G. P., 1 Nov 2018, In : European Urology. 74, 5, p. 562-572 11 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)
2017

Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories

Taylor, R. A., Fraser, M., Livingstone, J., Espiritu, S. M. G., Thorne, H., Huang, V., Lo, W., Shiah, Y-J., Yamaguchi, T. N., Sliwinski, A., Horsburgh, S., Meng, A., Heisler, L. E., Yu, N., Yousif, F., Papargiris, M., Lawrence, M. G., Timms, L., Murphy, D. G., Frydenberg, M. & 8 others, Hopkins, J. F., Bolton, D., Clouston, D., McPherson, J. D., Van Der Kwast, T., Boutros, P. C., Risbridger, G. P. & Bristow, R. G., 9 Jan 2017, In : Nature Communications. 8, 10 p., 13671.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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80 Citations (Scopus)

Kallikrein-related peptidase 4 induces cancer-associated fibroblast features in prostate-derived stromal cells

Kryza, T., Silva, L. M., Bock, N., Fuhrman-Luck, R. A., Stephens, C. R., Gao, J., Samaratunga, H., Australian Prostate Cancer BioResource, Lawrence, M. G., Hooper, J. D., Dong, Y., Risbridger, G. P. & Clements, J. A., 1 Oct 2017, In : Molecular Oncology. 11, 10, p. 1307-1329 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Systematic Review Links the Prevalence of Intraductal Carcinoma of the Prostate to Prostate Cancer Risk Categories

Porter, L. H., Lawrence, M. G., Ilic, D., Clouston, D., Bolton, D. M., Frydenberg, M., Murphy, D. G., Pezaro, C., Risbridger, G. P. & Taylor, R. A., Oct 2017, In : European Urology. 72, 4, p. 492-495 4 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
2016

A single nucleotide polymorphism genotyping platform for the authentication of patient derived xenografts

El-Hoss, J., Jing, D., Evans, K., Toscan, C., Xie, J., Lee, H., Taylor, R. A., Lawrence, M. G., Risbridger, G. P., MacKenzie, K. L., Sutton, R. & Lock, R. B., 9 Aug 2016, In : Oncotarget. 7, 37, p. 60475-60490 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling

Pidsley, R., Zotenko, E., Peters, T. J., Lawrence, M. G., Risbridger, G. P., Molloy, P., Van Djik, S., Muhlhausler, B., Stirzaker, C. & Clark, S. J., 7 Oct 2016, In : Genome Biology. 17, 1, 17 p., 208.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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212 Citations (Scopus)
2015

Establishment of primary patient-derived xenografts of palliative TURP specimens to study castrate-resistant prostate cancer

Lawrence, M. G., Pook, D. W., Wang, H., Porter, L. H., Frydenberg, M., Kourambas, J., Appu, S., Poole, C., Beardsley, E. K., Ryan, A. J., Norden, S., Papargiris, M., Risbridger, G. P. & Taylor, R. A., 2015, In : Prostate. 75, 13, p. 1475 - 1483 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

Takizawa, I., Lawrence, M. G., Balanathan, P., Rebello, R., Pearson, H. B., Garg, E., Pedersen, J. S., Pouliot, N., Nadon, R., Watt, M. J., Taylor, R. A., Humbert, P. O., Topisirovic, I., Larsson, O., Risbridger, G. P. & Furic, L., 2015, In : Oncotarget. 6, 2, p. 604 - 616 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Patient-derived Xenografts Reveal that Intraductal Carcinoma of the Prostate Is a Prominent Pathology in BRCA2 Mutation Carriers with Prostate Cancer and Correlates with Poor Prognosis

Risbridger, G. P., Taylor, R. A., Clouston, D., Sliwinski, A., Thorne, H. J., Hunter, S. M., Li, J., Mitchell, G. W. E., Murphy, D. G. M., Frydenberg, M., Pook, D. W., Pedersen, J. S., Toivanen, R., Wang, H., Papargiris, M., Lawrence, M. G. & Bolton, D. M., 1 Mar 2015, In : European Urology. 67, 3, p. 496 - 503 8 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)
2014

DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation

Pellacani, D., Kestoras, D., Droop, A. P., Frame, F. M., Berry, PA., Lawrence, M. G., Stower, M. J., Simms, M. S., Mann, V. M., Collins, A. T., Risbridger, G. P. & Maitland, N. J., 2014, In : Cell Death and Differentiation. 21, 5, p. 761 - 773 13 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
2013

A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer-associated fibroblasts in human prostate cancer

Clark, A. K., Taubenberger, A. V., Taylor, R. A., Niranjan, B., Chea, Z. Y., Zotenko, E., Sieh, S., Pedersen, J. S., Norden, S., Frydenberg, M., Grummet, J., Pook, D. W., Stirzaker, C., Clark, S., Lawrence, M. G., Ellem, S. J., Hutmacher, D. & Risbridger, G. P., 2013, In : Biomaterials. 34, 20, p. 4777 - 4785 9 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

A preclinical xenograft model of prostate cancer using human tumors

Lawrence, M. G., Taylor, R. A., Toivanen, R., Pedersen, J. S., Norden, S., Pook, D. W., Frydenberg, M., Australian Prostate Cancer BioResource, Papargiris, M., Niranjan, B., Richards, M. G., Wang, H., Collins, A. T., Maitland, N. J. & Risbridger, G. P., 2013, In : Nature Protocols. 8, 5, p. 836 - 848 13 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)
2012

Estrogen receptor beta activation impairs prostatic regeneration by Inducing apoptosis in murine and human stem/progenitor enriched cell populations

Hussain, S., Lawrence, M. G., Taylor, R. A., Lo, C. Y-W., Frydenberg, M., Ellem, S. J., Furic, L. & Risbridger, G. P., 2012, In : PLoS ONE. 7, 7, 9 p., e40732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
27 Citations (Scopus)

Long terminal repeats act as androgen-responsive enhancers for the PSA-kallikrein locus

Lawrence, M. G., Stephens, C. R., Need, E. F., Lai, J., Buchanan, G. & Clements, J. A., 2012, In : Endocrinology. 153, 7, p. 3199 - 3210 12 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The kallikrein 14 gene is down-regulated by androgen receptor signalling and harbours genetic variation that is associated with prostate tumour aggressiveness

Lose, F., Lawrence, M. G., Srinivasan, S., O'Mara, T., Marquart, L., Chambers, S., Gardiner, R. A., Aitken, J. F., Spurdle, A. B., Batra, J., Clements, J. A. & Australian Prostate Cancer BioResource, 2012, In : Biological Chemistry. 393, 5, p. 403 - 412 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2011

Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells

Lawrence, M. G., Margaryan, N. V., Loessner, D., Collins, A., Kerr, K. M., Turner, M., Seftor, E. A., Stephens, C. R., Lai, J., APC BioResource, Postovit, L-M., Clements, J. & Hendrix, M. JC., 2011, In : Prostate. 71, 11, p. 1198 - 1209 12 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)
2010

A variant of the KLK4 gene is expressed as a cis sense-antisense chimeric transcript in prostate cancer cells

Lai, J., Lehman, M. L., Dinger, M. E., Hendy, S. C., Mercer, T. R., Seim, I., Lawrence, M. G., Mattick, J. S., Clements, J. A. & Nelson, C., Jun 2010, In : Rna-A Publication of the Rna Society. 16, 6, p. 1156-1166 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2009

Direct progesterone receptor and indirect androgen receptor interactions with the kallikrein-related peptidase 4 gene promoter in breast and prostate cancer

Lai, J., Myers, S. A., Lawrence, M. G., Odorico, D. M. & Clements, J. A., 1 Jan 2009, In : Molecular Cancer Research. 7, 1, p. 129-141 13 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2007

Epithelial - Mesenchymal and mesenchymal - Epithelial transitions in carcinoma progression

Hugo, H., Ackland, L., Blick, T., Lawrence, M. G., Clements, J. A., Williams, E. & Thompson, E. W., 2007, In : Journal of Cellular Physiology. 213, 2, p. 374 - 383 10 p.

Research output: Contribution to journalArticleResearchpeer-review

807 Citations (Scopus)

Epithelial-mesenchymal transition in prostate cancer and the potential role of kallikrein serine proteases

Lawrence, M. G., Veveris-Lowe, T. L., Whitbread, A. K., Nicol, D. L. & Clements, J. A., Jun 2007, In : Cells Tissues Organs. 185, 1-3, p. 111-115 5 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
2006

The role of kallikrein-related peptidases in prostate cancer: Potential involvement in an epithelial to mesenchymal transition

Whitbread, A. K., Veveris-Lowe, T. L., Lawrence, M. G., Nicol, D. L. & Clements, J. A., 1 Jun 2006, In : Biological Chemistry. 387, 6, p. 707-714 8 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)
2005

Kallikrein 4 (hK4) and prostate-specific antigen (PSA) are associated with the loss of E-cadherin and an epithelial-mesenchymal transition (EMT)-like effect in prostate cancer cells

Veveris-Lowe, T. L., Lawrence, M. G., Collard, R. L., Bui, L., Herington, A. C., Nicol, D. L. & Clements, J. A., Sep 2005, In : Endocrine-Related Cancer. 12, 3, p. 631-643 13 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)