Associate Professor Mitchell Lawrence leads the Genitourinary Laboratory and is a Laboratory Head in the Prostate Cancer Research Group within the Department of Anatomy and Developmental Biology and Monash Biomedicine Discovery Institute, Monash University. His research on prostate and penile cancer begins and ends with patients. Working with patient advocates, support groups, community organisations and clinicians, A/Prof Lawrence identifies critical clinical challenges facing patients. He tackles these challenges by leading multidisciplinary studies into tumour biology, pathology, and novel therapies.

A/Prof Lawrence collaborates with the Melbourne Urological Research Alliance (MURAL) to transform samples of life-threatening tumour tissues, generously donated by patients, into new tools for prostate cancer research. This includes patient-derived xenografts (PDXs), organoids and cancer-associated fibroblasts from diverse forms of cancer. Using these patient-derived cells, A/Prof Lawrence’s research is uncovering why some patients’ tumours are more aggressive than others and demonstrating how these tumours can be treated more effectively. This has led to changes in international clinical practice, concurrent clinical trials, and partnerships with industry.

A/Prof Lawrence’s career highlights include a Fulbright Postgraduate Award, ANZUP Best of the Best Translational Award, the Endocrine Society of Australia Mid-Career Research Award, and the Endocrine Society of Australia-Society for Endocrinology Travel Exchange. In 2023, A/Prof Lawrence was selected for the Monash University Research Talent Accelerator program.

A/Prof Lawrence’s research has been supported by the National Health and Medical Research Council, the Victorian Government, Cancer Australia, Cancer Council Victoria, the Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP), Therapeutic Innovation Australia, the Australia-Germany Joint Research Cooperation Scheme, the CASS Foundation, the Endocrine Society of Australia, Harold and Cora Brennen Benevolent Trust, the Prostate Cancer Foundation of Australia, and Rotary Club of Manningham.

A/Prof Lawrence’s research is aligned with the Monash Impact 2030 Global Challenge of Thriving Communities. Prostate cancer is truly a global health challenge. It is the most common male cancer in 114 countries, including Australia, and causes 375,000 deaths globally each year. Prostate cancer has a major impact on patients, their partners, families and communities - and it is a growing challenge. As communities thrive, the prevalence of prostate cancer increases, likely due to higher life expectancy and changing diets. The scale of this challenge requires innovative solutions that cross borders and disciplines.

Penile cancer is also an important clinical challenge. It is a rare malignancy that can be disfiguring and life-threatening. There is very limited research into penile cancer and this is slowing the progress to improve patient outcomes.

The main goal of A/Prof Lawrence’s research is to fast-track new treatments. He uses samples of life-threatening tumour tissues (generously donated by patients) to test the drugs of the future. Working with scientists, clinicians, industry, philanthropic organisations and patient advocates, his research is already making a difference, leading to new clinical trials and improvements in international guidelines for treating cancer.

A/Prof Lawrence’s latest studies are also designed to have a positive global impact on patient survival, quality of life, and equitable access to cancer care. He is studying the ability of inexpensive and widely accessible drugs to block tumour growth. With experts in cardiovascular disease, he is also examining how cancer treatments impact heart health. These studies could be transformative for patients with prostate and penile cancer, helping them to live well, no matter where they live.

Thousands of Australians fundraise for prostate cancer. To formalise his commitment to the community, A/Prof Lawrence has co-led the Monash Prostate Cancer Research Support Group since 2013: the only laboratory formally affiliated with the Prostate Cancer Foundation of Australia (PCFA) Support Group Network. Through this scheme, he organises yearly laboratory open days for patients and families to see prostate cancer research first-hand.

A/Prof Lawrence has presented talks on prostate cancer awareness and research to several PCFA support groups (Box Hill, Bayside, Eltham, Essendon, Prostate Heidelberg, Prostate Melbourne, Ringwood, South-Eastern, Young Men’s), Rotary Clubs (Essendon, Manningham, Monash, Nunawading) and other community organisations (Biggest Ever Blokes’ Lunch). He has also written guest blogs and research updates for community newsletters and been interviewed for podcasts.

In recognition of these activities, A/Prof Lawrence was awarded the inaugural Science Communication and Community Engagement Award from the Biomedicine Discovery Institute.

A/Prof Lawrence has organised national and international conferences as co-chair of the Endocrine Society of Australia Program Organising Committee (2021-23) and a convenor of the international Workshop on Patient-Derived Models of Prostate Cancer (2021, 2023, 2025).

A/Prof Lawrence also contributes to the culture of research as chair of the Melbourne Urological Research Alliance Prostate Access Committee; member of the Kathleen Cuningham Foundation Consortium for research into Familial Breast cancer (kConFab) Biospecimen Subcommittee; member of the Endocrine Society of Australia Scientific Strengthening Committee; and member of the Endocrine Society of Australia Council.

Undergraduate

A/Prof Lawrence is a mentor for the Biomed Undergraduate Scholars Program, supervisor for Cancer Council Victoria Summer Vacation Scholars, and supervisor for Research-in-Action students (DEV3990, PHY3990). He is also a guest lecturer for DEV3022 (“Normal and Perturbed Prostate Development”). A/Prof Lawrence also supervised 11 First Class Honours students.

Postgraduate

A/Prof Lawrence’s PhD students have received prestigious prizes and awards including: Professor Joseph Sambrook Prize (Familial Aspects of Cancer Conference); Gail Risbridger/Novartis Junior Scientist Award from the Endocrine Society of Australia (x3); Best Three-Minute Thesis from the Australian Society of Medical Research; awards for student talks (Department of Anatomy and Developmental Biology PhD student symposium, Biomedicine Discovery Institute Graduate Symposium); and several poster prizes (Australian Prostate Cancer Collaborative Research Alliance, Cell Signalling and its Therapeutic Implications Conference, Endocrine Society of Australia).